... produced, and how the artefact is produced using those materials For example: what are the origins ofthe yellow, red and black pigments of parietal paintings ofthe Magdalenian era inthe caves ofthe ... founded in 1997 with the main objective of promoting research and education inthe field of cultural heritage, based on the directions and recommendations given inthe Professional Guidelines ofthe ... ofthe paint layer, the characteristic touche ofthe author, the eventual existence of an underlying painting, the pentimenti, the alterations, the restorations, the modifications of frame, the...
... population, which is increasing in size Incidence is increasing inthe younger population andthe developing world Accordingly, the global burden of stroke is ... the 2nd leading single cause of adult mortality globally 3, reflecting high incidence inthe developed world, increasing incidence inthe developing ... much of this risk is attributable to recurrent events inthe initial weeks and months following the index event and decays thereafter 120, 121 Theriskof a recurrent...
... War Memorial The photograph ofthe original painting was taken by the author inthe course of her investigations, and is not an official reproduction ofthe painting (ART40317) inthe Australian ... reflection, andthe shape ofthe capillary determines the overall flux gain andthe uniformity ofthe focussed spot Gains in flux of 100 and more have been reported However, there is a degradation inthe ... plain photograph and two hyperspectral images of a painting inthe collection ofthe Australian War Memorial Left: Photograph ofthe original painting Centre and Right: Hyperspectral images of the...
... in our knowledge ofthe biosynthesis of DIMs and PGLs, thein vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of ... Schematic representation ofthe roles ofthe FadD proteins encoded by the DIM + PGL locus inthe biosynthesis of DIMs andrelated compounds in Mycobacterium tuberculosis The role ofthe activation enzymes ... interactions between FadD29 and PKS15 ⁄ on the one hand, and FadD26 andthe FasI system on the other hand Further investigations, including protein interaction studies and structural studies, will...
... epidemiology of obesity, and on behavioural issues22 The Programme is putting in place a comparable set of indicators for health status, including inthe area of dietary intake, physicalactivityandobesity ... 7-11 The rates ofthe increase in childhood overweight andobesity vary, with England and Poland showing the steepest increases49 12 EN As relatively few risk factors cause the majority ofthe ... consumption of fats, free sugars and salt, of increasing the intake of fruits, vegetables, legumes, grains and nuts, andof performing moderate physicalactivity during at least 30 minutes a day...
... and diseases such as type diabetes mellitus, obesityandthe metabolic syndrome (30) In these conditions there is an elevation of both glucose and free fatty acid levels inthe blood and an increase ... electron transport chain would normalize the pathways involved inthe development ofthe oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low ... pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring) 2006;14 (Suppl 1): 34S–40S 31 Boden G Role of fatty acids inthe pathogenesis of insulin resistance...
... within seconds of coming into contact with them Almost all ofthe remaining phenol binds to the nerve tissue during the following few minutes; by 15 minutes from the start ofthe phenol administration, ... 0.1% ofthe administered dose remains inthe CSF (Ichiyanagi et al., 1975) The magnitude ofthe clinical effect ofthe intrathecal block depends on the concentration of phenol and also on the ... nerves contain sensory fibres andthe sensory loss following neurolysis may cause loss or deterioration of hand function and increase theriskof burns and injury The use of botulinum toxin is probably...
... addresses in a hierarchical manner, to permit the grouping of routing information and limit the number of routing entries advertised inthe Internet Aggregation is one ofthe main goals of Internet ... IPv6 In other words, once the cost of deploying IPv4 infrastructure – determined by the cost of obtaining the addresses themselves andthe cost of designing and operating networks that use fewer ... this final pool of addresses This “global proposal” was discussed at the LACNIC X meeting in May 2007, inthe APNIC 24 meeting in New Delhi in September, andin ARIN and RIPE meetings in October...
... reduce drinking counselling and therapy for the individual counselling and therapy for the family treatment options including medication to relieve thephysical effects of stopping drinking and to ... experts as linked to heavy drinking, such as injuries (including inthe elderly), tremor ofthe hands and tongue, and excessive capillarisation ofthe facial skin and conjunctivae.16,17 The exact ... presenting problem and should help the patient weigh up any benefits as perceived by the patient, versus the disadvantages ofthe current drinking pattern TRAINING Training healthcare providers in the...
... catalyzed the reduction ofthe 9,11-endoperoxide group of PGH2 to produce PGF2a inthe presence of NADPH, which was defined as the PGFS activity, andthe isomerization of PGH2 to PGD2 inthe absence of ... both PGFS activity [3.6 nmolÆmin)1Æ(mg protein))1] inthe presence of NADPH and PGDS activity [3.3 nmolÆmin)1Æ(mg protein))1] inthe absence of NADPH or NADP+ However, AKR1B7 (71.2% and 69.6% ... (PNBR) activity at pH 7.0 by the wild-type and mutants (D) Typical fluorescence quenching curves of wild-type AKR1B1 and its mutants The binding of NADP+ to these proteins was determined by measuring...
... Katrina and evacuation to the RAC The trauma resulting from the disaster, the process of evacuation, the disruption of regular care, andthe stress of residing inthe shelter complex further increased ... level of frailty as assessed by guidelines outlined inthe article The mean age ofthe participants was 81.8 years inthe GEMU and 82.4 years inthe general medical wards Being treated inthe GEMU ... that hindered their coming and going inand around Houston Unfortunately, this open flow of human traffic allowed scam artists and schemers to enter the complex The rapid pace involved in trying...
... review and contributed in drafting ofthe manuscript andinthe interpretation of data TGB performed part ofthe literature review and contributed inthe manuscript editing SP, EP, AK and GT ... condition of soft tissues was improved [6] Regarding torsional injuries ofthe ankle joint the classification by Lauge-Hansen correlates the type of fracture to the mechanism of injury andthe anatomical ... scheme, but to introduce an algorithm for the application of external fixation and to highlight the advantages ofthe Ilizarov device inthemanagementof intra-articular fractures ofthe distal...
... thinning: stand age when the first thinning occurs; years since previous thinning for the other thinnings; remaining basal area For the final cutting: years since the last thinning to the first ... fire risk, the effect of fire risk on thinnings was clearer The higher is the overall risk level ofthe region, the earlier and heavier are the low thinnings Most probably also the type of thinnings ... efficiently including theriskof fire in forest management decision-making However, the principal aim ofthe study was not to estimate the probability of fire but to observe the effect oftherisk of...
... shown in Figure Both patient and caregiver POM ratings for aripiprazole increased during the 12-week switching phase At the end ofthe switching phase (LOCF), 54.7% of 123 subjects and 48.0% of ... baseline (week 0), weeks 2, and 12 ofthe screening phase and 24, 38, 51 and 64 ofthe long-term treatment phase During screening, additional visits could also be conducted at weeks and based on the ... subjects received their first dose of aripiprazole at the start ofthe switching treatment period, the starting dose of which was determined by the investigator After weeks of adverse event (AE)-free...
... Since there are commonalities inthe pathophysiology of PAH and RP, particularly inthe context of connective tissue disease, inhibition ofthe renin–angiotensin system may prove effective in ... combine vasodilator and antiproliferative activity include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and PDE type V inhibitors [5] The use of angiotensin-converting ... than nifedipine in reducing both the frequency andthe severity of attacks [14] PDE type V inhibitors such as sildenafil inhibit the degradation of cGMP, which mediates the signalling of several...
... that the benefit: risk ratio is likely to be highest The effect of including the small number of patients with tumours that did not have their margin width recorded (n = 18) inthe analysis ofthe ... initial margins between 1–5 mm underwent further surgery resulting in a total re-excision rate of 33% (n = 72) There were non invasive and 11 invasive recurrences inthe treated breast during the follow ... mm) The anatomical constraints obviously limit further excision of close margins inthe cross sectional plane and there is no advantage to be gained in re-excision if DCIS approaches the margin...
... increase theriskof new depressive symptoms, even more so than activity losses in other domains [22] The role of leisure in maintaining or restoring psychological wellbeing inthe presence of arthritis ... Evans and colleagues [16] compared the psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) to mothers without pain, with regard to their ratings of ... Unexpectedly, the conventional pain CST was superior to the maintenance-enhanced program and both control conditions in reducing pain and negative mood and increasing coping efficacy; however, the maintenanceenhanced...
... beginning radiotherapy Many potential therapies being investigated also carry a riskof neurocognitive decline andthe current focus of brain metastases research is to find ways to optimize the ... quality of life and activities of daily living also should be included in clinical trials to assess everyday functioning [72] Examples of two such measures are the Barthel index andthe Functional ... competing interests 15 Authors' contributions AB and KC participated inthe conception ofthe work, compiled the information, reviewed and wrote the manuscript PW participated inthe conception of...
... description of these drugs is beyond the scope of this review ABT-263, a small molecule inhibitor of Bcl-2, has shown clinical activity as a single agent in CLL, and studies of this drug in combination ... OR, CR and PFS in CLL Kay and colleagues recently examined whether the addition of an alkylating agent to other purine nucleoside analogs similarly improves outcomes [10] The Mayo Clinic and Ohio ... study of CAL-101, an orally available inhibitor ofthe phosphatidylinositol-3-kinase (PI-3-K) delta isoform, will be presented at the ASCO meeting Other novel agents are under preclinical and clinical...
... possible Early skin grafting increases the risks of infection and complications However, delayed skin grafting also increases theriskof eyelid hypertrophic scarring, asymmetry and other deformities ... cases into one case series because the surgical managementofthe eyelid injuries was the same, although the systemic managements of these patients as different according to the injury area and ... fold on the graft, allowing extra skin for future graft contracture while still preserving the ability to close the eye adequately We widen the grafting area by separating and loosening the musculus...