... designed on the basis of side-chain packing criteria
from a modelled structure ofthe enzyme resulted in restor-
ation ofthe energy of activation to the levels ofthe native
enzyme and in an increased ... flexibility limits the exploitation ofthe full
potential of protein engineering inthe redesign of psychro-
philic enzyme properties [15]. In particular, the effects of
local flexibility in psychrophilic ... respectively. By introducing an Ala residue inthe place of
Gly it is expected that the conformational flexibility of the
main chain can be constrained with a minimum perturba-
tion ofthe local structure,...
... the meaning ofthe image or the image projects the
meaning ofthe music), then the multimedia example has passed the
similarity test and the relationship exhibited is one of conformance.
In ... music), taking into
account the director’s – and, therefore, the composer’s – intentions,
the narrative content ofthe film, and the overall strategy ofthe
director in constructing the multifaceted ... other-worldly. In this capacity, the
role of music is significantly enhanced by the level of ambiguity
inherent inthe visual scene. Specifically, the more ambiguous the
meaning ofthe visual image, the...
...
school.
Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of
attending college. Further, when net worth is included inthe model, Black youth are ... youth.
Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If
they had an account, they were also asked whether they were saving some of this money ... ―very
concerned‖ about the cost of college, compared to 19% of high-income parents. Further, they find
that 71% of low-income youth say they are very concerned about the cost of college (ACSFA,...
... that the increase of Glc6P inthe presence of
S4048 was caused by the inhibition of Glc6P hydro-
lysis inthe absence of detectable changes in glucose
phosphorylation.
S4048 causes inactivation of ... glu-
cokinase and hexokinase I in distinct pools [3,24], or
by the involvement of mechanisms, additional to
Glc6P, in mediating the effects of glucokinase over-
expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres-
sion. The validity of S4048 for testing theroleof Glc6P was supported by
its lack of effect on glucokinase binding and...
... tight
binding affinity was demonstrated towards lauric acid,
resulting inthe synthesis of mainly x-1 hydroxylated
lauric acid, suggesting a roleinthe lipid oxidative
metabolism. Interestingly, the ... occurring in the
soil. Furthermore, branched chain fatty acids make up
80% ofthe fatty acid content ofthe Bacillus sp. mem-
branes and when the hydroxylation of these substrates
was studied in ... enzymes. The FUM6 protein (CYP505B1) inter-
venes in one ofthe first steps in fumonisin synthesis by
hydroxylation ofthe polyketide-amino acid at C-14
and C-15 (Fig. 3). Fum6 deletion mutants of F....
... University
Regional Learning Alliance – workforce development and
training/collaborations with business and industry; meeting the
training and education needs of businesses within 60 mile radius
in Northern Allegheny ... $28,000 in average annual salary)
Preserving Value
Continuing education is important to preserving the market value
of specialized education – particularly in professional fields
Continuing education ... University
Small Business Development Center – collaboration with business
and industry/entrepreneurial activity; providing business
development assistance
The Roleof Public Regional
Universities in Community...
... antigen in itself [7,20]. At
least for these antibodies, theroleofthe V
L
domain
might be to increase the affinity by supporting the V
H
domain. The phenomenon may also be observed in
the chain ... Although the
Fv was designed based on HyHEL-10, it is not clear
whether or not H39 is dominantly tuning the V
H
⁄ V
L
interaction of other Fvs, including HyHEL-10. In
addition, the effect ofthe H39 ... clarify
the effect ofthe interface mutations on the antigen-
binding affinity. To investigate systematically this
unsought relationship between the antigen-binding
affinity of Fv and the V
H
⁄ V
L
interaction...
... example, inthe case of question
Q209: “Who invented the paper clip ?”, the
expected answer type is PERSON and so is the
subject ofthe verb invented , lexicalized as the
nominalization inventor. ... mountain; (b) lava IS-PART of vol-
cano, and moreover it is a part coming from the
inside; and (c) fragments of lava have all the prop-
erties of lava, the following question semantic
The Roleof ... “Where did the
ukulele originate ?”, the expected answer type is
LOCATION. Inthe paragraph the ukulele intro-
duced from Portugal into the Hawaiian islands”
contains two named entities ofthe category...
... their brand attitude, may
suggest an interesting implication for the
new brand advertising strategy. Instead of
focusing on the content ofthe message
which only emphasizes the benefits of ... gift giving is instrumental in
maintaining social ties and serves as a
mean of symbolic communicationin social
relationship.
Most ofthe researches before and after
the appearance of Sherry’s ...
This finding is just reverse ofthe finding of
Belk (1973).
Ruth, Brunel, Otnes (1999) classified
categories of gift-giving into public
occasion (i.e., Christmas, Chinese New
Year), individual...
... documents and find that the fea-
ture vectors corresponding to some of these docu-
ments (particularly the short ones) have all zeroes
in them. In other words, none ofthe bigrams from
the training set ... cap-
turing two different situations, one in which the
author himself likes the movie, and inthe other,
the author’s cousin likes the movie. The over-
generalization resulting from these “stemmed” ... rating of ≤ 2 (out of 5)
or ≤ 1.5 (out of 4).
614
Finally, previous work has also investigated fea-
tures that do not fall into any ofthe above cate-
gories. For instance, instead of representing...
... ofnew qualifications (e.g. the creation of multi-
disciplinary courses and the relative demise of single honour degrees), the setting-up ofnew degree
programmes, the formal definition ofnew ... of human capital and
therefore their savings cannot maintain that high rate of growth inthe long run.
De Gregorio (1996) has examined the issue ofthe limited availability of education inthe ... has the general effect of
postponing consumption and increasing wealth as well as savings. If the second effect dominates the first,
relaxing the borrowing constraint reduces the rate of economic...
... to the desire on the part
of firms to hedge cash flows against the effects of interest rate volatility. The
timing ofthe appearance of interest rate swaps, coming as it did during a pe-
riod of ... argue, trading in
interest rate swaps has helped to complete forward markets and to lower the
cost to firms of managing their exposure to interest rate risk.
The Role for Hedging inthe Theory of Corporate ... net cost ofthe synthetic fixed-rate financing is determined by the
swap fixed rate plus the difference between its short-term borrowing rate and
the floating-rate index.
Banks often index the short-term...
... rapidly, causing the unfolding of one of
the I27 modules inthe chain. Unfolding then extends the over-
all length ofthe protein, relaxing the pulling force to a low
value. As the slack inthe length ... stretching a polyprotein re-
sults in a well-defined series of step increases in length, mark-
ing the unfolding and extension ofthe individual modules in
the chain.
[37]
The size ofthe observed steps ... b-strands ofthe I27 protein during the main unfold-
ing barrier.
[39]
To further validate this view and gain insight into
the roleof solvent hydrogen bonds in protein unfolding, we
repeated these...
... maintained in multiple accounts within the organisation. The organisation is in some sense
wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same
information. ... take into account inthe assessment ofthe security risks to − and privacy impact on −
the delivery of online services, and in determining appropriate levels of security.
Inthe case of sensitive ... managing and protecting digital identities, with
a view to strengthening confidence inthe online activities crucial to the growth ofthe Internet Economy.
The primer is a product ofthe Working...
... dur-
ing lipid raft isolation. Moreover, these studies have
provided some insights into the significance of the
localization ofthe P2X
7
receptors in lipid rafts regard-
ing the regulation of intracellular ... (glycero-)sphingolipids. In addition the
fatty acid chains ofthe phospholipids composing
these rigid domains are generally more saturated than
those inthe lipids ofthe surrounding membrane. In
fact, this ... muscarinic receptors, endo-
thelin receptors, rhodopsin) are located in lipid rafts
[65–70] where they are in close proximity to their
transducing GTP-binding protein (Gs, Gi, Go, Gq and
transducin...