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Báo cáo Y học: Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans doc

Báo cáo Y học: Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans doc

Ngày tải lên : 08/03/2014, 23:20
... syntrophin binding region. (Received 1 6 October 20 0 1, revised 1 0 January 20 02 , accepted 11 January 20 02) Eur. J. Biochem. 26 9, 1607–16 12 (20 02) Ó FEBS 20 02 5Â2B) had no or very limited functional ... particularly critical as deletions infringing on th is side lead to a d ecrease in binding. Constructs 2 5, 5Â2B and 5Â1 are of particular interest; t he rst two constructs break at amino acid 489 and retain ... abolished t he rescuing activity of a functional transgene in vivo. These r esults are consistent with a model according to which dystrobrevin must bind to dystrophin to be able t o function properly. Keywords:...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

Ngày tải lên : 18/06/2014, 16:20
... (checkpoint 2) [7]. Coincident with the checkpoint 1 to 2 transition, a switch between regulatory and pro- inflammatory cytokine production occurs: prior to b cell death, a period of Th2-dominated ... AN, Levings MK, Roncarolo MG, Bacchetta R: STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol 20 08, 20 : 421 -431. 66. ... development, function and fitness of nTreg cells. Its signaling cascade is initiated by the binding of IL -2 to its trimeric IL -2 receptor (IL-2R) which consists of the a-chain (IL-2Ra; also known as CD25),...
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Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

Ngày tải lên : 18/02/2014, 16:20
... mito- chondrial protein content [21 ]. Mitochondrial ATP levels Postanoxic mitochondrial ATP concentration was assayed using a luciferin ⁄ luciferase luminometry luminescence method [22 ] with modifications. ... kinase (protein kinase B; Akt) triggers a metabolic gene switch (decreased fatty acids, increased glucose) in female hearts to enhance mitochondrial bio- energetic capacity, conferring protection against ... and contractile function. Circ Res 89, 1199– 120 8. 19 Sordahl LA, Besch HR Jr, Allen JC, Crow C, Linden- mayer GE & Schwartz A (1971) Enzymatic aspects of the cardiac muscle cell: mitochondria,...
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Báo cáo khoa học: Amino acids Thr56 and Thr58 are not essential for elongation factor 2 function in yeast potx

Báo cáo khoa học: Amino acids Thr56 and Thr58 are not essential for elongation factor 2 function in yeast potx

Ngày tải lên : 07/03/2014, 05:20
... 56 could be replaced by cystein, methionine and serine (Fig. 2) . Mutants containing asparagine, aspartic acid, glycine, lysine or valine were nonfunctional (Fig. 2) . Clones expressing eEF2 in ... number- ing) are indicated by arrows. Amino acid sequences from (acces- sion numbers in parenthesis) Saccharomyces cerevisiae (NP_014776), Saccharomyces castellii (AAO 324 87), Saccharomyces kluyveri ... expressing wild-type elongation factor 2. Abbreviations CaMPKIII, Ca 2+ and calmodulin-dependent protein kinase III; eEF2, eukaryotic elongation factor 2; EFG, elongation factor G; MAP, mitogen- activated...
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Báo cáo khoa học: Existence of novel b-1,2 linkage-containing side chain in the mannan of Candida lusitaniae, antigenically related to Candida albicans serotype A potx

Báo cáo khoa học: Existence of novel b-1,2 linkage-containing side chain in the mannan of Candida lusitaniae, antigenically related to Candida albicans serotype A potx

Ngày tải lên : 17/03/2014, 03:20
... Man-A, A2A2ÂB2 B2 C2 C2ÂD2D2ÂE2 and A2A2ÂB2B2 C2 -C2 Â D2D2ÂE2E2ÂF2, respectively. Although the H-1 of Man-E and Man-F of LM6 gave almost the same chemical shifts, we could assign the H -2 signal ... Manb1fi2Manb1fi2Manb1fi2Mana1 2 1.9 24 4.844 4 .24 7 Manb1fi2Manb1fi2Manb1fi2Mana1 2 1.9 25 4.857 4 .26 3 Manb1fi2Manb1fi2Mana1 2 11.7 26 4.849 4 .26 9 Manb1fi2Manb1fi2Mana1fi30 27 4.844 4.1 52 Manb1fi2Manb1fi2Mana1 2( 3) ... of absorbed factor sera. ÔCandida CheckÕ, a commercially available kit containing 10 factor sera is an effective tool for identifying the cells of Candida species in clinical specimens. Candida lusitaniae...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx

Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx

Ngày tải lên : 23/03/2014, 13:20
... WH (19 92) Electroporation in ‘intracellular’ buffer increases cell survival. Nucleic Acids Res 20 , 29 02. S. Ahmed et al. PKCh in TCDD-induced signaling for apoptosis FEBS Journal 27 2 (20 05) 903915 ... inhibited PKCh kinase activity (Fig. 5) at doses that completely blocked TCDD-induced L-MAT cell apoptosis. TCDD induces nPKC kinase activity in L-MAT cells To establish whether TCDD increases nPKC kinase activity, ... nPKCs, specifically PKCh, in the L-MAT T-cell apoptosis induced by TCDD. Synthetic peptides corresponding to the pseudosubstrate domains of PKC have been used as speci c inhibitors of PKC in in...
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Báo cáo khoa học: Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids potx

Báo cáo khoa học: Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids potx

Ngày tải lên : 30/03/2014, 02:20
... the first signal increase. By contrast to OLPC, the colocalization of two molecules of analogues in the binding site would induce a fluorescence quenching. A K d could not be calculated for ns-LTP wheat and ... 000 20 000 024 6810 12 [dithiothreitol] (m M) 5000 10 000 15 000 20 000 A B C Fig. 8. CD signal recorded at 22 2 nm and 10 C after 15 h of incu- bation with varying concentrations of the reducing ... (residue numbers 77– 92) , which points toward the hydrophobic cavity and blocks the lipid binding pocket in the free form [28 ] (Fig. 2G,H). According to this observation, it can be inferred that the...
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Báo cáo sinh học: " Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus " docx

Báo cáo sinh học: " Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus " docx

Ngày tải lên : 18/06/2014, 18:20
... hepatocytes from chronically infected humans may provide critical information regarding the mechanisms of interferon resistance in the chronic hepatitis C. Methods Replicon Cells Human hepatoma cell ... factors do not contribute to the acquisition of IFN-resistance in these replicon cells since the cured cells prepared from each replicon still show reduced IFN signaling. Interferon signaling in ... alpha. Individual clones were picked and nine different stable cell lines from each low inducer replicon [Con-15 (15/1, 15 /2, 15/3), Con-17 (17/1, 17 /2, 17/3) and Con -24 (24 /1, 24 /2, 24 /3)] were...
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Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx

Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx

Ngày tải lên : 18/06/2014, 19:20
... that curcumin could act as a potentially powerful chemosensitizing agent in tumor cells, including CSCs. A recent study indicated that the combination of curcumin with carnosic acid also produced ... for Bcl -2 in curcumin-induced apop- tosis in these CD34 + AML cell lines. Accumulating evidence has shown that curcumin potentiates the effects of chemotherapeutic drugs such as bortezomib, cisplatin, ... major toxicities in phase I and II clinical studies at doses of up to 8 g/day [28 ,29 ]. However, the cytotoxic effects of curcumin in DNR-insensitive CD34 + immature AML cells remain unclear. In...
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báo cáo hóa học: " A prospective study of decline in lung function in relation to welding emissions" pdf

báo cáo hóa học: " A prospective study of decline in lung function in relation to welding emissions" pdf

Ngày tải lên : 20/06/2014, 00:20
... measures. Forced expir- atory volume in one second (FEV 1 ) and forced expiratory capacity (FVC) were recorded in accordance with Ameri- can Thoracic Society guidelines (24 ). Lung function data were ... 17:451-465. 5. MacNee W: Pathogenesis of chronic obstructive pulmonary disease. Proc Am Thorac Soc 20 05, 2: 258 -26 6. 6. Boschetto P, Quintavalle S, Miotto D, Lo CN, Zeni E, Mapp CE: Chronic obstructive pulmonary ... a point corresponding to breathing zone of welder during a CO2 arc welding. Ind Health 20 00, 38:69-78. 2. Lockey JE, Schenker MB, Howden DG, Desmeules MJ, Saracci R, Sprince NL, Harber PI: Current...
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báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pdf

báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pdf

Ngày tải lên : 20/06/2014, 04:20
... debris. Effusions were charcoal coloured in 3 cases and cream coloured in one patient in the absence of infection. Cystic lesions were noted behind the acetabular compo- nent in 3 cases but the cup was grossly ... arts, skiing, acrobatics, ballet dancing, backpacking and mountaineering. Heavy occupational work. 10 Regularly participates in impact sports as described above Table 2 Patient Demographics Males ... participates in moderate activities. Light occupational work 7 Active Regularly participates in active events such as bicycling, aqua-aerobics. Gardening or working out in the gym once or twice a week. 8...
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báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pptx

báo cáo hóa học:" Revision of failed hip resurfacing to total hip arthroplasty rapidly relieves pain and improves function in the early post operative period" pptx

Ngày tải lên : 20/06/2014, 07:20
... debris. Effusions were charcoal coloured in 3 cases and cream coloured in one patient in the absence of infection. Cystic lesions were noted behind the acetabular compo- nent in 3 cases but the cup was grossly ... logical to avoid cobalt chrome components in the bearing couple when revising for this indication. While it is too early to comment on the clinical out- comes of these prostheses, the main determinants ... 6 Unexplained pain after sport 2 Pain with clicking 2 Pain with effusion 10 Dislocation 1 Femoral neck fracture secondary to fall 2 Sandiford et al. Journal of Orthopaedic Surgery and Research 20 10,...
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10 Minute Guide to Investing in Stocks Chapter 2 docx

10 Minute Guide to Investing in Stocks Chapter 2 docx

Ngày tải lên : 01/07/2014, 21:20
... ease, including drawing on the account with a personal check. Cash can also refer to the money in your checking and savings accounts or the money hidden under your mattress. TIP Investing in stocks ... make you move on to purchasing individual stocks. The 30-Second Recap Different investment vehicles carry risks particular to them and may complicate comparison to stocks. Stocks provide the highest ... the investment arena. By purchasing a share of a mutual fund, you as an individual investor can place your money in much the same circumstances as the money of a large investor. By investing in...
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