oxytocin vasopressin and atrial natriuretic peptide control body fluid homeostasis by action on their receptors in brain cardiovascular system and kidney
Báo cáo khoa học: Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy ppt
... single-transmembrane polypeptide, each containing an extracellular ANPbinding domain (ECD), a transmembrane domain, and an intracellular domain consisting of an ATP-binding regulatory domain and ... caused by solvent exposure and the resulting quenching of Trp74 emission in ANP–ECD Comparison of the apoECD and ANP–ECD EM reconstructions To evaluate the structural change induced by ANP binding, ... Erythropoietin receptor activation by a ligand-induced conformation change Science 283, 990–993 20 Misono KS, Grammer RT, Rigby JW & Inagami T (1985) Photoaffinity labeling of atrial natriuretic factor Natriuretic...
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Báo cáo y học: "Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome" ppt
... concentrations of cGMP increased significantly during NO inhalation EVLWI did not change either during ANP infusion or during NO inhalation In patients who responded to NO inhalation with an increase in ... pulmonary edema and hypoxia induced pulmonary vasoconstriction Based on our findings in experimental hypoxia, we hypothesized that ANP infusion could be beneficial in ARDS patients The promising ... pulmonary vasoconstriction ANP infusion improved pulmonary gas exchange under experimental hypoxic conditions in men in a recent study [7] On the contrary, ANP infusion lowered pulmonary artery...
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Báo cáo sinh học: " Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells" pdf
... The natriuretic peptide family comprises atrial natriuretic peptide, ANP, brain natriuretic peptide, BNP, C-type natriuretic peptide, CNP, Dendroaspis natriuretic peptide, DNP, and urodilatin ... three independent assays is shown (B) Diagram of hypothesized protein interactions in the immune response associated with NPRA signaling in hmDCs lung inflammation Inflammatory scoring by blinded ... demonstration that down-regulation of NPRA levels and reduction in NPRA signaling in DCs increases the population of Tregs may have important applications in treating respiratory disease and inflammatory...
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Báo cáo khoa học: Atrial natriuretic peptide-dependent photolabeling of a regulatory ATP-binding site on the natriuretic peptide receptor-A pptx
... not in the presence of GTP [41] The ATP-induced conformational change of the KHD presumably inhibited antibody binding, and mutation of a conserved lysine residue in the antibody interaction region ... results obtained on each occasion increase in cGMP, and the ATP ⁄ ANP mix only produced a fourfold increase in cGMP production Interestingly, the activation by ATP ⁄ ANP for the WT receptor in these ... containing mm MgCl2, 0.1 mm EDTA and 0.5% (w ⁄ v) BSA Non-specific binding was defined by the addition of nonradioactive rANP at 100 nm Bound ligand was separated from free ligand by filtration on...
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Báo cáo khoa học: Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern pot
... membrane-spanning region (21 aa) and an intracellular portion (567 aa), containing a kinase homology (KH) domain, the dimerization domain and the C-terminal catalytic GC domain [1,7] In the absence of ligand, ... quantification of the phosphorylated tryptic peptides by multiple reaction monitoring The ratio of multiple reaction monitoring peak areas after ANP pretreatment versus control conditions was calculated ... increase in the FRET signal, indicating increases in [cGMP]i The kinetics, duration and extent of cGMP formation in response to ANP were similar in wild-type GC-Aand FLAG-tagged GC-A-expressing HEK293...
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Báo cáo y học: "Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study" pptx
... Defending against hypertension and salt and water retention, they antagonize the renin–angiotensin–aldosterone system, including effects on renal tubule sodium reabsorption, vascular tone and cell ... Jr: Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors J Clin Endocrinol Metab ... Werdan K: Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dysfunction Intensive Care...
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Báo cáo y học: "Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men"
... case -control study to assess the validation of the novel control selection design by comparing the consistency between the new design and a routine control selection design in a large case -control ... lead to saving of money and time;11-12 (3) all possible confounding factors (known or unknown) and interaction effects between groups are balanced by using large matching populations In contrast, ... reported their smoking habits in the early 1980s.17 Information obtained from the spouse on the husband’s smoking habits was highly consistent with information provided directly by the husband In this...
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Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx
... AF2 ligand-dependent activation domain The amino-terminal A/B domain contains the AF1 ligand-independent activation domain The D domain consists of a highly flexible hinge region and non-rodent ... ligand binding domain (LBD), or E/F domain of PPARs, is responsible for ligand-binding and converting PPARs to an active form that binds DNA and modulates gene expression The interaction of PPARs ... http://www.comparative-hepatology.com/content/2/1/3 A/B N C AF1 DBD D Hinge E/F LBD C AF2 Activation Function DNA-binding Ligand-binding Activation Function Transactivation domain domain Transactivation Dimerization Co-activator...
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Báo cáo khoa học: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-a pdf
... (View interaction) DPP4 cleaves BNP by protease assay (View interaction) DPP4 cleaves GLP-2 by protease assay (View interaction) DPP4 cleaves NPY by protease assay (View interaction) Introduction ... undecapeptide hormone belonging to the tachykinin family and is released during the activation of sensory nerves, causing vasodilation, oedema and pain through activation of neurokinin receptors ... (View interaction) FAP cleaves BNP by protease assay (View interaction) DPP4 cleaves CXCL2-GROb by protease assay (View interaction) DPP4 cleaves CCL22-MDC by protease assay (View interaction)...
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Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
... production Stimulation Inhibition Stimulation Contraction Stimulation Stimulation Unknown Unknown Unknown Stimulation Stimulation Stimulation Stimulation Inhibition Inhibition Inhibition Relaxation Inhibition ... (1991) Brain natriuretic peptide as a novel cardiac hormone in humans Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide J Clin Invest ... Inhibition Inhibition Stimulation Stimulation Stimulation Inhibition Inhibition Inhibition Inhibition 1798 Functional role of GC-A ⁄ NPRA and salt sensitivity The disruption of Npr1 indicated...
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Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... ribose-orienting asparagine, a transition state-stabilizing arginine, and triphosphate-binding arginine and lysines [79] The guanine base-recognition residues glutamic acid and cysteine in Cyg12 [79] and ... recovered intact in urine or the collecting fluid, whereas small linear peptides, such as angiotensins I and II, bradykinin, glucagon, and luteinizing hormonereleasing hormone, are hydrolyzed and recovered ... of a single-span transmembrane polypeptide, which contains a ligand-binding extracellular domain (ECD), a transmembrane domain, and an intracellular domain (ICD) consisting of a protein kinase-like...
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N-Terminal Pro–B-Type Natriuretic Peptide and Long-Term Mortality in Stable Coronary Heart Disease ppt
... terminal pro -brain natriuretic peptide and cardiotrophin are raised in unstable angina Heart 2000;84: 421-4 18 Marumoto K, Hamada M, Hiwada K Increased secretion of atrial and brain natriuretic peptides ... Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic ... an inactive prohormone that is split into the active hormone BNP and the inactive N-terminal fragment (NT-pro-BNP) BNP has a number of systemic effects, including vasodilation, increases in urinary...
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... being independent None of the patients included in the study had overt evidence of infection on admission on the basis of standard blood and urine tests, X-film of the chest and temperature controls ... understanding of the elevation of CRP and NT-PBNP in the acute phase of stroke both CRP and NT-PBNP are markers of brain edema in stroke at baseline and after 48 hours respectively Given that brain ... and brain Computed Tomography Immediately a blood sample was drawn to determine ultrasensitive C-reactive protein and the N-terminal fraction (NT-PBNP) of the B-type natriuretic peptide within...
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Báo cáo khoa hoc:" Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women" pdf
... baseline (wk4 - wk0; interaction treatment vs time, P = 0.634) Effect of isoflavone consumption on PYY During isoflavone consumption, PYY concentrations increased by eight percent, and during ... one study investigated effects of isolated isoflavones on total ghrelin concentrations [19] In addition, no long-term randomized controlled studies have investigated whether changes in PYY concentrations ... rich in protein, and an increased protein intake might be responsible for the observed effects The potential contribution of isolated isoflavones to the regulation of energy and body weight remains...
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Báo cáo y học: "Analysis of N-terminal pro-B-type natriuretic peptide and cardiac index in multiple injured patients: a prospective cohort study" docx
... pathways in cardiac dysfunction has been convincingly validated in transgenic studies Nevertheless, the precise mechanism of action underscoring inflammationinduced cardiac contractile dysfunction ... (MODS) [1] In this context, cardiac dysfunction in particular seems to be of striking relevance Compelling evidence has shown a significant and independent link between inflammation and cardiac ... acute conditions in intensive care units (ICUs) In this context, B-type natriuretic peptide (BNP) gained significant importance in the diagnosis of congestive heart failure BNP is a 32-amino acid...
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Báo cáo y học: "Brain natriuretic peptide levels have diagnostic and prognostic capability for cardio-renal syndrome type 4 in intensive care unit patients" pps
... Werdan K: Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dysfunction Intensive Care ... Chiang YT, Latini R, Masson S, Maggioni AP, Glazer RD, Tognoni G, Cohn JN: Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure ... Heublein DM, Lainchbury JG, Leskinen HK, Bailey KR, Redfield MM, Burnett JC Jr: Circulating natriuretic peptide concentrations in patients with end-stage renal disease: role of brain natriuretic peptide...
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Báo cáo y học: " B-type natriuretic peptide release and left ventricular filling pressure assessed by echocardiographic study after subarachnoid hemorrhage: a prospective study in non-cardiac patients" ppt
... patients Creatinine clearance was computed from creatinine excretion in a 24-hour urine collection and a single measurement of serum creatinine on day Aneurysm location was noted, and the neurological ... patients included sedation, ventilation, enteral nutrition, nimodipine, and monitoring of intracranial pressure in the case of intracranial hypertension All patients were managed according to a standard ... demographic data including age, sex, body mass index, and body surface area were collected The fluid balance (fluid intake – urine volume – insensible losses) was calculated at 24-hour intervals Insensible...
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Báo cáo y học: "Direct comparison of serial B-type natriuretic peptide and NT-proBNP levels for prediction of short- and long-term outcome in acute decompensated heart failure" ppt
... limitations Important decisions regarding patient management and treatment strategy, including consultation by a cardiologist, ICU admission, and non-invasive ventilation, must be taken into account ... 25:335-339 Emdin M, Passino C, Prontera C, Fontana M, Poletti R, Gabutti A, Mammini C, Giannoni A, Zyw L, Zucchelli G, Clerico A: Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP ... contributions MN made substantial contributions to the conception and design of the study, acquisition of data, analysis and interpretation of data, and drafting of the manuscript TB contributed...
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Báo cáo y học: "Usefulness of N-terminal pro-brain natriuretic peptide and C-reactive protein to predict ICU mortality in unselected medical ICU patients: a prospective, observational study" pot
... upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by proinflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via ... http://ccforum.com/content/15/1/R42 Introduction N-terminal pro -brain natriuretic peptide (NT-proBNP) is the inactive polypeptide of the pre-prohormone brain natriuretic peptide (BNP) It is synthesized in the ... further examined by calculation of NRI and IDI indices described by Pencina et al [27] NRI is the net increase versus decrease in risk categories among case patients minus that among control participants...
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