non intersecting go terms of proteins in 2 and 4 weeks treatment 114

Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration

Ngày tải lên : 12/09/2015, 11:08

... charts of GO slim analysis 1 12 Figure 32 Non- intersecting GO terms of proteins in and weeks treatment 1 14 Figure 33 Schematic diagram of mitochondrial dysfunction after weeks of troglitazone ... 153 4 .2. 2 .2 Mitochondrial glutathione transport 1 54 4 .2. 2.3 PPAR-agonist mitochondrial targets 158 4 .2. 2 .4 OXHPOS 161 4 .2. 2.5 Valine metabolism 1 62 4 .2. 2.6 ... result of SOD detoxification of O2•-) (Winterbourn, 20 08) Equations and show this 2O2•- + H+ O2•- + •NO O2•- + [4Fe-S ]2+ + 2H+ SOD H2O2 + O2 (Eq 1) ONOO- (Eq 2) [4Fe-S]3+ + H2O2 (Eq 3) While O2•-...

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Báo cáo khóa học: ICAM-1 expression is highly NF-jB-dependent in A549 cells No role for ERK and p38 MAPK docx

Ngày tải lên : 07/03/2014, 15:20

... control, the expression of total p 42 / 44 was also examined Likewise, U0 126 completely prevented the phosphorylation of p 42 / 44 with EC50 values of 0 .23 and 0.1 lM for TNFa and IL-1b stimulated cells, ... phosphorylation of ERKs and 2, which lie downstream of MEK1 [ 24 ] Both TNFa and IL-1b upregulated phosphorylation of p 42 / 44 ERKs and preincubation with PD098059 abrogated this response Following densitometry, ... stimulated by cellular stresses and interleukin-1 FEBS Lett 3 64, 22 9 23 3 24 Crews, C.M., Alessandrini, A & Erikson, R.L (19 92) The primary structure of MEK, a protein kinase that phosphorylates the...

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Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot

Ngày tải lên : 10/08/2014, 05:21

... nucleus and induces the transcriptions of iNOS [22 ] and COX -2 [23 ] This pathway has been known to modulate a wide variety of inflammatory signaling pathways via the up-regulation of iNOS and COX2 Hence, ... LPS-Induced iNOS and COX -2 Gene and Protein Expression We next to determine whether the inhibitory effect of aciculatin in NO and PGE production was due to a decrease in expression of iNOS and ... http://www.jbiomedsci.com/content/18/1 /28 Page of 11 Figure Aciculatin suppresses the increase of mRNA and protein expression and promoter activity of LPS-induced iNOS and COX -2 in macrophages A × 106 RAW2 64. 7 cells were...

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Tài liệu Báo cáo khoa học: Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity docx

Ngày tải lên : 21/02/2014, 00:20

... elements of insulin signaling Insulin receptor substrate-1 and proteins with SH2 domains Diabetes 42 , 643 –650 White, M.F (1997) The insulin signalling system and the IRS proteins Diabetologia 40 , S2–S17 ... Protein kinase C-zeta as a downstream eﬀector of phosphatidylinositol 3-kinase during Arsenite induced glucose-uptake (Eur J Biochem 27 0) 3901 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 insulin ... NEN-Dupont Tyrphostin A25, SB203580, chelerythrine chloride, bisindolylmaleimide I, Go 6976, Ro 31- 822 0 and Ro 32- 04 32 were from Calbio¨ chem LY -29 40 02, microcystin LR and wortmannin were obtained from...

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Báo cáo y học: "Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK" doc

Ngày tải lên : 11/08/2014, 08:22

... adhesion in the presence of increasing doses of Hcy, and Hcy (50 μM) with kinase inhibitors (SB203580 and LY2 940 02) and pAb MIP -2 MCs were initially plated at a density of 10,000 cells/well in 24 -well ... inhibitors of p 42 / 44 MAPK, p38 MAPK and PI3 Kinase on Hcy-induced MIP -2 in MC Indeed, we observed that Hcy-induced MIP -2 expression was inhibited by PI-3 kinase inhibitor (LY2 940 02) and p38MAPK inhibitor ... expression induced by Hcy Hcy-induced MIP -2 was significantly attenuated (p < 0.05) by a PI-3 Kinase inhibitor (LY2 940 02) and by an inhibitor of a p38MAPK (SB203580) In contrast, use of a p 42 / 44 MAPK inhibitor...

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báo cáo hóa học: " Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease" pdf

Ngày tải lên : 19/06/2014, 22:20

... diesel engine exhaust on Page of 10 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 proinflammatory markers in different regions of the rat brain Part Fibre Toxicol 20 10, 7: 12 van ... community Levesque et al Journal of Neuroinflammation 20 11, 8:105 http://www.jneuroinflammation.com/content/8/1/105 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 prepared to support a multipollutant ... modeling Clin Pharmacol Ther 20 10, 88 :46 7 -47 4 Liu B, Gao HM, Hong JS: Parkinson’s disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation...

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Báo cáo y học: "Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling" pptx

Ngày tải lên : 12/08/2014, 16:20

... thickening or stiffening of the airway may be protective against AHR [22 ,23 ] The increase in goblet cell number and in mucus lining the airway may serve a protective function against inhaled toxins ... repair and the development of subepithelial fibrosis in asthma [29 ] In the present study, the decrease in INF-γ, the trend toward an increase in IL -4, and the increase in the ratio of IL -4 to INF-γ ... induction by human recombinant interleukin -4 J Clin Invest 1991, 87 :21 47 -21 52 Wen FQ, Kohyama T, Liu X, Zhu YK, Wang H, Kim HJ, Kobayashi T, Abe S, Spurzem JR, Rennard SI: Interleukin -4 and interleukin-13enhanced...

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Tài liệu Exposure to Artificial UV Radiation and Skin Cancer ppt

Ngày tải lên : 14/02/2014, 21:20

... 36 19 16 18 327 45 18 15 1.00 0.75 0.99 1.00 2. 12 Ref 0 .46 –1 .25 0 .49 2. 00 0 .47 2. 13 0. 84 2. 12 Westerdahl et al (19 94) Sweden, 1988-90 40 0/ 640 Never used 28 2 1–3 sessions/year 44 4 10 sessions/year ... 38.7 25 .8 29 .0 Sweden 1 .2 24. 7 64 .2 9.8 The Netherlands 6.0 17.9 53.0 23 .1 United Kingdom 12. 7 32. 1 39.0 6.9 Data courtesy of V Bataille The most common reasons given for use of indoor tanning ... excluding LMM and ALM 48 Adam et al (1981) Australia 19 82 511 511 HC pre-invasive/ invasive M Denmark 1985 47 4 926 HCM excluding LMM 81.7 Italy 19 84 20 8 41 6 M in situ and all other 68 .2 Holman...

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Tài liệu Báo cáo khoa học: ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin docx

Ngày tải lên : 18/02/2014, 17:20

... that bind to proteins or intrinsic fluorophores buried in the protein interior In a first Fig Effect of the binding of ATP ⁄ Mg2+ to 2- Cys Prx on the fluorescence emission of extrinsic and intrinsic ... acid of peroxiredoxin to cysteine by mammalian sulfiredoxin J Biol Chem 28 1, 144 00– 144 07 22 Horovitz A & Willison KR (20 05) Allosteric regulation of chaperonins Curr Opin Struct Biol 15, 646 –651 23 ... Plessow R, Brockhinke A, Baier M & Dietz KJ (20 03) Reaction mechanism of plant 2- Cys peroxiredoxin Role of the C terminus and the quaternary structure J Biol Chem 27 8, 24 40 9 24 42 0 Lehrer SS (1971)...

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THE FINANCIAL CRISIS INQUIRY REPORT - Final Report of the National Commission on the Causes of the Financial and Economic Crisis in the United States docx

Ngày tải lên : 06/03/2014, 09:22

... thinking?” when it seems that too many of them were thinking alike And the leverage was often hidden in derivatives positions, in off-balance-sheet entities, and through “window dressing” of financial ... 111 -21 January 20 11 OFFICIAL GOVERNMENT EDITION For sale by the Superintendent of Documents, U.S Government Printing Office Internet: bookstore.gpo.gov Phone: toll free (866) 5 12- 1800; DC area (20 2) ... down her office and began working out of her home. Despite all the signs that the housing market was slowing, Wall Street just kept going and going—ordering up loans, packaging them into securities,...

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Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in the Netherlands potx

Ngày tải lên : 06/03/2014, 19:20

... trimester 843 8 22 .0 26 .6 29 .8 29 .8 32. 0 43 .5 7877 23 .1 27 .7 30 .2 29.9 32. 8 39.9 Total pregnancy Postnatal Month 0-6 8381 22 .7 27 .3 29 .5 29 .3 31 .4 39.9 Month 7- 12 80 82 22. 8 27 .0 28 .8 28 .7 30.5 ... 30.5 (2. 4) ** 41 .1 (3.8) ** Fall 20 46 30.5 (3 .4) ** 40 .3 (3.9) ** 20 01 (Reference) 345 34. 6 (1.3) 39.6 (3 .4) 20 02 2161 33.1 (1.6) ** 41 .8 (3.8) 20 03 24 68 29 .5 (3.0) ** 39.9 (4 .2) ** 20 04 24 60 28 .0 ... (Reference) 46 16 30 .2 (3 .2) 39.7 (4 .2) First trimester only 527 30.5 (3.3) 40 .1 (4. 6) Continued 1059 30.5 (3 .2) 40 .2 (4 .2) * Missing 1688 29 .6 (2. 9) ** 39.5 (4 .2) No (Reference) 3 022 30 .2 (3 .2) 39.8 (4. 1)...

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Exposure to ambient air pollution and prenatal and early childhood health eﬀects potx

Ngày tải lên : 06/03/2014, 19:20

... order, gender, and intrauterine growth retardation on the 198 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 outcome of very low birth weight in twins J Pediatr 1993; 123 : 1 32 136 Luke B, ... average of CO, PM10,O3 and NO2 in quartiles: CO (< 1.5, 1.5–1.9, 2. 0– 2. 3, ‡ 2. 4) ; PM10 (

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Báo cáo khoa học: Molecular basis for speciﬁcities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases pptx

Ngày tải lên : 16/03/2014, 05:20

... of 1 ,2- propanediol and 1 ,2- ethanediol by some genera of FEBS Journal 27 4 (20 07) 5556–5566 ª 20 07 The Authors Journal compilation ª 20 07 FEBS H Kajiura et al 14 15 16 17 18 19 20 21 22 23 24 25 ... GDR in 0.03 m potassium phosphate buffer (pH 8) containing 21 lm AdoCbl and 1 .2 m 1 ,2- propanediol in the presence of 24 mm ATP ⁄ 24 mm MgCl2, in a total volume of 25 lL The reaction was terminated ... circles) in 0.03 M potassium phosphate buffer (pH 8) containing 21 lM AdoCbl and 1 .2 M 1 ,2- propanediol in the presence of 24 mM ATP ⁄ 24 mM MgCl2, in a total volume of 25 lL The amount of propionaldehyde...

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Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4 pptx

Ngày tải lên : 22/03/2014, 18:20

... structure composed of a winged helix motif [6] and the C-terminus is predominantly composed of lysine, alanine and proline residues and is the main determinant for H1 binding to chromatin [7] Among ... nuclear proteins including all five histone proteins in vitro and in vivo [20 ] In native chromatin, histone H1 is the main ADP-ribose acceptor, but depending on the chromatin composition and the ... six lysine residues of the C-terminal domain In order to define all SET7/9-dependent methylation sites in the CTD of the H1 .4, the Cterminal fragments (1 14 to 144 , 145 to 189, 190 to 21 9) were...

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Báo cáo khoa học: Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import pdf

Ngày tải lên : 23/03/2014, 15:21

... protein import involves an important group of proteins including translocase of the outer membrane (TOM) such as Tom40, Tom20, Tom70 and translocase of the inner membrane (TIM) such as Tim 22 and ... activity-induced adaptations in the FEBS Journal 27 2 (20 05) 50315055 ê 20 05 FEBS L Mercy et al 45 46 47 48 49 50 51 52 53 54 55 56 57 mitochondrial protein import system Am J Physiol 27 4, C1380C1387 ... activity and a lower ROS production (A) Western blot analysis of NRF-1 and NRF -2 expression performed on 20 lg of proteins from clear lysates of 143 B, rho0 143 B, L 929 , and rho-L 929 cells Equal loading...

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Báo cáo khoa học: PKCd-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate pdf

Ngày tải lên : 23/03/2014, 21:20

... (PD98059), p38 (SB2 021 90), or PI-3 kinase (LY2 940 02) Figure 4A shows that the PMA-induced cleavage and 40 92 Y S Kim et al (Eur J Biochem 27 0) Ó FEBS 20 03 Fig PMA-induced nuclear translocation of ANX-1 ... Serumstarved HEK 29 3 cells were preincubated in the absence or presence of rottlerin (5 lM), Ro-31-8 42 5 (50 lM), PD98059 (50 lM), LY2 940 02 (10 lM), and SB2 021 90 (20 lM) for 30 and stimulated with ... 20 0 20 4 27 Rothhut, B (1997) Participation of annexins in protein phosphorylation Cell Mol Life Sci 53, 522 – 526 28 Schlaepfer, D.D & Haigler, H.T (1990) Expression of annexins as a function of...

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Báo cáo hóa học: " Size-dependent catalytic and melting properties of platinum-palladium nanoparticles" doc

Ngày tải lên : 21/06/2014, 03:20

... energies for platinum and palladium materials [13] Faces Platinum Palladium gs (111) (J/m2) 2. 299 1. 920 gs (100) (J/m2) 2. 7 34 2. 326 gs (110) (J/m2) 2. 819 2. 225 curves of bulk and nanostructures ... Materials properties of platinum and palladium Materials properties Palladium Tm,∞ (K) [40 ] 2, 041 .5 1, 828 ΔHm,∞ (kJ/mol) [40 ] 22 17 ΔHsub, Figure Size-dependent melting temperature of platinum versus ... for catalysis Nanoscale 20 10, 2: 2 045 -20 53 20 Vollath D, Fischer FD: Structural fluctuations in nanoparticles Journal of Nanoparticle Research 20 09, 11 :43 3 -43 9 21 Kittel C: Introduction to solid...

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Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx

Ngày tải lên : 11/08/2014, 08:22

... pathophysiology of local and chronic inflammation [44 -47 ] The promoter region of the murine gene encoding iNOS and COX -2 contains NF-κB binding sites [15 ,48 ], which suggests that the inhibitory effect of inflammatory ... 1993, 90: 7 24 0- 7 24 4 Guastadisegni C, Nicolini A, Balduzzi M, Ajmone-Cat MA, Minghetti L: Modulation of PGE (2) and TNFalpha by nitric oxide and LPS-activated RAW 26 4. 7 cells Cytokine 20 02, 19 (4) :175-180 ... citation purposes) Journal of Inflammation 20 08, 5:7 42 43 44 45 46 47 48 49 http://www.journal-inflammation.com/content/5/1/7 c-jun NH2-terminal kinase J Am Soc Nephrol 20 05, 16(6):1603-1611 Tuyt...

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Báo cáo y học: "Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways" pdf

Ngày tải lên : 12/08/2014, 11:20

... 0.13 6.96 ± 0.19 21 1 .40 ± 0 .20 6. 72 ± 0.38 16 1.89 ± 0 .26 6 .28 ± 0.50 19 2. 10 ± 0. 34 6.57 ± 0.36 10 21 2. 04 ± 0 .25 ** 7 .20 ± 0 .20 22 2. 18 ± 0 .26 * 7.30 ± 0 .25 Incubation time Nicotine (μM) Day 5.81 ... Up-regulation of bradykinin receptors in a murine in- vitro model of chronic airway inflammation Eur J Pharmacol 20 04, 48 9(1 -2) :117- 126 Barnes PJ: Bradykinin and asthma Thorax 19 92, 47 (11):979-983 ... 0 .40 7. 52 ± 0. 14 3 .49 ± 0.68 8.00 ± 0.13 Day (Ctrl) 10 10 10 3 .40 ± 0.33 7.50 ± 0.07 10 3. 52 ± 0.53 7.89 ± 0.07 Day (Ctrl) 10 4 3. 74 ± 0.87 4 .22 ± 0.85 7 .40 ± 0 .20 7. 52 ± 0.11 4 3.33 ± 0. 34 3.15...

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Báo cáo y học: " RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs" ppsx

Ngày tải lên : 13/08/2014, 09:21

... expression Curr Opin Cell Biol 20 04, 16(3) :21 9 -22 2 Page of (page number not for citation purposes) Retrovirology 20 06, 3:6 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Dreyfuss G, ... CTE 1 04 103 1 02 10 p27gag 17 1 64 459 total p27gag in pg/GFP value 10 14 17 21 24 days postinfection Figure RTEm26-CTE replaces rev/RRE of SIV RTEm26-CTE replaces rev/RRE of SIV A) Structure of the ... 1.E+ 044 10 10 1.E+033 10 1.E+ 022 10 1.E+01 p24gag 1.E+00 no insert 11 14 17 21 days postinfection 0.03 34 5.3 3 .4 90 total p24gag pg/GFP value Figure RTEm26-CTE replaces Rev/RRE of HIV RTEm26-CTE...

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