molecular cellular and developmental biology of breast cancer

Báo cáo y học: "Department of Molecular, Cellular, and Developmental Biology" ppt

Ngày tải lên : 14/08/2014, 08:20

... outside of the predicted exons Further functional characterization of these candidate transcripts should be useful to better our understanding of the complexity and dynamics of the transcriptome of ... transcription of the predicted genes [10] Analysis of the tiling array data detected 193 out of 229 (84%) and 176 out of 217 (81%) predicted genes in at least one of the six organ types in barrel medic and ... Leaf Flower Seed Figure of Analysis the frequency of TARs in different organ types Analysis of the frequency of TARs in different organ types (a) Percentage and number of TARs detected by tiling...

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Molecular characterization and developmental analysis of interferon regulatory factor 6 (IRF6) gene in zebrafish

Ngày tải lên : 14/09/2015, 12:44

... mechanism of CL/P is different from that of CPO Cleft cases are also categorized into nonsyndromic (70% of CL/P and 50% of CPO) and syndromic types Approximately 70% of CL/P and 50% of CPO cases ... and Notch target genes repress the differentiation of pancreas endocrine cells of mouse, and acinar cells of mouse and zebrafish, whereas disruption of Notch accelerates the differentiation of ... over-dosage of morpholinos 85 3.14 Loss of irf6 function phenotypes 86-87 3.15 Comparison of expression of molecular markers in irf6 morphants and wildtype 91-92 3.16 Hematoxylin and eosin staining of...

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Molecular characterization and developmental analysis of the TGF beta 3 gene in zebrafish

Ngày tải lên : 14/09/2015, 18:03

... by a pair of antiparallel β 5 Molecular characterization and developmental analysis of the TGF Beta 3 gene in zebrafish strands. The extracellular domain consists of a relatively ... W., and Chong, S. S. An essential role of tgfb3 in zebrafish pharyngeal arch and heart development (manuscript in preparation) x Molecular characterization and developmental analysis of ... As we know, craniofacial development is a highly controlled and complex process which begins with the formation of neural crest cells in the brain and their subsequent 1 Molecular characterization and developmental analysis of the TGF Beta 3 gene in zebrafish ...

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Tài liệu Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study pdf

Ngày tải lên : 15/02/2014, 04:20

... mammographic and pathologic examination Therefore, she was not at risk for development Fig Example of a breast cancer risk profile NSABP ‫ ס‬National Surgical Adjuvant Breast and of breast cancer and ... of invasive breast cancer were calculated for several subgroups of women When age, history of LCIS, history of atypical hyperplasia, and levels of predicted risk of breast cancer were taken into ... age, history of lobular carcinoma in situ (LCIS), history of atypical hyperplasia, 5-year predicted breast cancer risk, and number of first-degree relatives with breast cancer No of events Rate...

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Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer pptx

Ngày tải lên : 05/03/2014, 12:20

... displays and workstation design for improved image interpretation Discovery of molecular profiles toward goal of precise molecular diagnosis of cancer Breast cancer is one of eight cancers targeted ... emphasize research on the basic biology and etiology of breast cancer and on the creation of classification schemes for breast lesions based on molecular biology A major goal of this research should ... of developing breast cancer Thus, the lifetime risk of developing breast cancer is 14.4 percent, whereas the absolute risk of developing breast cancer over the decade between the ages of 40 and...

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Factors inﬂ uencing the risk of breast cancer – established and emerging ppt

Ngày tải lên : 15/03/2014, 01:20

... for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control, 8, pp49-56 18 Collaborative Group on Hormonal Factors in Breast Cancer ... The protective role of pregnancy in breast cancer Breast Cancer Res., 7(3), pp131-42 20 Collaborative Group on Hormonal Factors in Breast Cancer (2002b) Breast cancer and breastfeeding: collaborative ... Risk of breast cancer in relation to lifetime alcohol consumption J Natl Cancer Inst., 87, pp923-929 35 Cancer Research UK (2007) About breast cancer: Breast cancer risks and causes http://www.cancerhelp.org.uk/help/default.asp?page=3285...

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Mouse models of breast cancer metastasis: Anna Fantozzi and Gerhard Christofori pdf

Ngày tải lên : 22/03/2014, 17:20

... initial spreading of cancer cells to local lymph nodes via the lymphatics in human breast cancer Another important aspect to the understanding of breast cancer metastasis is the role of different ... Amplification of the gene encoding ErbB2, a member of the EGF receptor gene family, is associated with 15 to 20% of human breast cancers, and in about 30% of cases the increased expression of an activated ... and cyclin D1 in late-stage metastatic cancer [47] The MMTV-PyMT mouse model of breast cancer is furthermore characterized by short Page of 11 (page number not for citation purposes) Breast Cancer...

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Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors potx

Ngày tải lên : 22/03/2014, 17:20

... varying levels of Her2, including breast cancer cell lines MCF7/Her2-18 Hathaway et al Breast Cancer Research 2011, 13:R108 http:/ /breast- cancer- research.com/content/13/5/R108 A Page of 13 B Figure ... followed by BT-474 breast cancer cells (2.75 × 106), MCF7 breast cancer cells (0.18 × 106), and MDA-MB-231 breast cancer cells (0.11 × 106) The Chinese hamster ovary (non -breast) cell line has ... the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffinembedded cell lines and breast cancer tissue...

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Guidelines for the early detection and screening of breast cancer ppt

Ngày tải lên : 28/03/2014, 23:20

... developing breast cancer Worldwide, 75% of new cases and 84% of breast cancer deaths occur in women aged 50 and older, with the number of breast cancers diagnosed in women in their fourth decade of life ... risks of heart attack, breast cancer and potentially life-threatening blood clots 16 Guidelines for the early detection and screening of breast cancer Hip fractures Colon cancer Breast cancer ... member of this team Guidelines for the diagnosis and treatment of breast cancer are further elaborated in Guidelines for management of breast cancer (2006)1 Guidelines for management of breast cancer, ...

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molecular biology of human cancers an advanced student's textbook - wolfgang a. schulz

Ngày tải lên : 08/04/2014, 12:51

... 18.2 Etiology of breast cancer 364 18.3 Hereditary breast cancer 365 18.4 Estrogen receptors and ERBB proteins in breast cancer 373 18.5 Classification of breast cancers ... Human Molecular Biology An Introduction to the Molecular Basis of Health and Disease Cambridge University Press Knowles M, Selby P (eds.) Introduction to the Cellular and Molecular Biology of Cancer ... TO HUMAN CANCERS 23 Further reading Selected textbooks and handbooks on molecular aspects of cancer and related diseases: Allgayer H, Heiss MM, Schildberg FW (eds.) Molecular Staging of Cancer...

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báo cáo khoa học: "Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer" pps

Ngày tải lên : 09/08/2014, 01:24

... Wang Y, Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year ... communities and receive state of the art breast radiotherapy as an adjunct to modern breast conserving surgery Conclusions Early stage breast cancer can be treated with breast conserving therapy and ... from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer World Journal of Surgical Oncology 2011...

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Báo cáo y học: " mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer" pdf

Ngày tải lên : 09/08/2014, 20:20

... hsa-miR-769-5p RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors Figure RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors The figure ... WA (c) Figure of RE-scores between ER+ and ER- samples from five breast cancer expression datasets Comparison Comparison of RE-scores between ER+ and ER- samples from five breast cancer expression ... targets in ER- breast cancer plete results based on three TargetScan predictions, miRanda, PicTar, and the intersection of PITA and miRanda can be found in Additional data file Use of alternative...

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báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx

Ngày tải lên : 10/08/2014, 10:21

... cut off by restriction enzyme Xba, BamH and HindⅢ, The band about 66 bp was cut off using BamH and HindⅢ on 0.8% agarose gel electrophoresis, the band about 342 bp was cut off using Xba and BamHⅠ, ... downregulation of the progesterone receptor-B isoform and upregulation of the progesterone receptor-A isoform, resulting in an imbalance in the native ratio of progesterone receptor A and B isoforms ... especially tumor invasiveness and metastasis, including breast cancer[ 5] The ER expression status is related to a variety of histologic characteristics of breast cancer Most tumors with low grades...

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Báo cáo y học: " Intracystic papillary carcinoma in a male as a rare presentation of breast cancer: a case report and literature review" potx

Ngày tải lên : 11/08/2014, 19:21

... his left breast He also had a significant family history for breast cancer including a maternal grandmother, two of his maternal aunts and a maternal first cousin diagnosed with breast cancer On ... to receive radiotherapy and tamoxifen [14] Page of (page number not for citation purposes) Journal of Medical Case Reports 2009, 3:13 Between 4% and 40% of male breast cancers might result from ... management of intracystic papillary carcinoma of the breast: the roles of radiation and endocrine therapy Am J Surg 2007, 194:497-500 Fentiman IS, Fourquet A, Hortobagyi GN: Male breast cancer Review...

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Báo cáo y học: "Departments of Medicine, and Cell and Developmental Biology, Vanderbilt University and" potx

Ngày tải lên : 14/08/2014, 07:22

... biomarkers and therapeutic targets This delineation and categorization of developmental and non -developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated ... potential of this approach to provide integrated views of the molecular basis of cancer risk, tumor development and malignant progression, we have undertaken a comparative analysis of a variety of individually ... compared gene expression profiles of 100 human CRCs and 39 colonic tumors from the four models of colon cancer to mouse embryonic and mouse and human adult colon The results of these analyses demonstrate...

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the role of ikkalpha, ikkbeta and nf-kappab in the progression of breast cancer

Ngày tải lên : 22/12/2014, 21:49

... different outcomes and molecular profiles Over the past decade, through the use of molecular profiling, the number of different subtypes of breast cancer has grown and understanding the pathways ... 1.1.6 Molecular prognostic factors .27 1.1.7 Breast cancer subtypes 28 1.1.8 Tests for molecular profile of breast cancer .29 1.2 Treatment of breast cancer ... Tables Table 1.1: Survival rates of breast cancer in Scotland by age range 19 Table 1.2: TNM staging of breast cancer 25 Table 1.3: Subtypes of breast cancer based on routine IHC markers...

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Investigating functions of ERp29 in mesenchymal to epithelial transition (MET) and epithelial plasticity in breast cancer cells

Ngày tải lên : 13/10/2015, 15:55

... association between level of ERp29 and breast cancer stage/grade To elucidate the role of ERp29 in breast cancer progression, aggressive breast cancer cells - MDA-MB231 and BT549 - were stably ... Introduction 1.1 Breast cancer 1.1.1 Incidence of breast cancer Each year cancer is claiming millions of lives and affecting millions more In developed country it is the leading cause of death and is the ... Each of these invasive breast cancer types accounts for less than 5% of total cases Common sites for breast cancer to spread are bone, lung, and liver (Hasebe et al., 2008) and recently breast cancer...

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Molecular characterization and developmental expression patterns of the zebrafish twist gene family

Ngày tải lên : 16/10/2015, 15:38

... Siew Hoon and Victor thanks for the words of encouragement, your friendship and moral support along the way Thanks to Monte Westerfield and Andrew D Sharrocks for their gifts of dlx2a and fli1a ... repression of E-cadherin and induction and regulation of N-cadherin (Yang et al., 2004; Alexander et al., 2006) Additionally, overexpression of Twist1 has been described to induce angiogenesis and chromosomal ... gene structure and linkage synteny analyses Characterize and compare the developmental and tissue-specific expression profiles of the zebrafish twist genes during embryogenesis and in adult zebrafish...

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Tài liệu NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP) pdf

Ngày tải lên : 13/02/2014, 10:20

... gestational doses of 127–151 mg/kg bw/day and higher and a lactational dose of 166−377 mg/kg bw/day and higher; the developmental NOAEL is in the range of 38–44 mg/kg bw/day (gestational) and 52−114 ... reduced on pnd and in all treated groups, and also on pnd and at weaning in the high-dose group An unusually high incidence of pup deaths in 4, 2, and litters of the low-, mid-, and highdose groups ... malforDams and pups evalumations.) ated on pnd for litter size and survival and body weight changes only (30) * Combined doses for F0 and F1 dams during gestation and lactation ** Only maternal and developmental...

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