introduction to clinical medicine
Steroids - From Physiology to Clinical Medicine Edited by Sergej M. Ostojic potx
... 14 Steroids - From Physiology to Clinical Medicine production, in structural regression to forma corpus albicans and into a follicular develop‐ ment and entrance into a new follicular phase P: ... are located in the cytoplasm, they need to get into the nucleus to alter gene expression This process typically takes at least 30 to 60 mi‐ nutes In contrast, other regulatory actions of steroid ... insulin-like growth factor-1 (IGF-I) and epidermal growth factor (EGF) signaling, as well as sex steroids on autophagy focusing about the role regulatory role of mTOR The kinase mTOR links IGF-I and...
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Introduction to Clinical Biochemistry: Interpreting Blood Results pot
... 978-87-7681-673-5 Introduction to Clinical Biochemistry: Interpreting Blood Results Contents Contents About the Author Introduction to Clinical Biochemistry: Interpreting Blood Results: 1 Laboratory tests: ... cells isolated for storage and then stored in water or a non isotonic solution and over physical dispensing of blood from hypodermic syringe to collection tubes 17 Introduction to Clinical Biochemistry: ... Anaemia, an auto immune destruction of the stomach lining which impairs vitamin B12 absorption This may take months to become symptomatic to the patient as the body can store up to 20 months of...
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Introduction to Clinical Biochemistry pptx
... 978-87-7681-673-5 Introduction to Clinical Biochemistry: Interpreting Blood Results Contents Contents About the Author Introduction to Clinical Biochemistry: Interpreting Blood Results: 1 Laboratory tests: ... cells isolated for storage and then stored in water or a non isotonic solution and over physical dispensing of blood from hypodermic syringe to collection tubes 17 Introduction to Clinical Biochemistry: ... Anaemia, an auto immune destruction of the stomach lining which impairs vitamin B12 absorption This may take months to become symptomatic to the patient as the body can store up to 20 months of...
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An Introduction to Molecular Medicine and Gene Therapy - part 3 ppt
... prior to use Use of AAV Vectors for Gene Therapy A major advantageous characteristic of AAV vectors is their ability to transduce nondividing cells AAV vectors have been used to transfer genes into ... binding to epitopes on the fiber protein and the virion hexon protein Subsequent to initial binding, the penton base protein binds to members of a family of heterodimeric cell surface receptors known ... targeted to cells that express the residual adenoviral vector proteins This observation led to further manipulations of the adenoviral vector genome in an attempt to stabilize the vector in vivo...
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An Introduction to Molecular Medicine and Gene Therapy - part 4 ppsx
... inserting the vector into the cell is insufficient; delivering it into the nucleus is the ultimate goal Until liposomes or other delivery vehicles are able to target the vector to the specific site, ... cells give rise to progressively more differentiated progenitor cells that eventually give rise to lineage-specific terminally differentiated effector cells into new or modified vector systems and ... (MuLV) vectors are the vectors of choice since they have not been supplanted by any other vector system for most hematologic applications Thus, MuLV vectors have been employed in almost every clinical...
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An Introduction to Molecular Medicine and Gene Therapy - part 6 ppsx
... neurotrophic factors indicate that they are similar to the receptors used by traditional growth factors and cytokines The expression of the receptors for the neurotrophic factors is exclusively ... neuroblastoma cells all modified to produce NGF In addition to gene therapy with neurotrophic factors, strategies that use regulatory proteins of cell death have been examined Antiapoptotic factors ... overexpression of antiapototic factors via gene transfer in vivo is sufficient to rescue neuronal populations after axotomy A new family of anti-apoptotic proteins called inhibitors of apoptosis (IAP) has...
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An Introduction to Molecular Medicine and Gene Therapy - part 7 pdf
... research on cytokines and cancer to use gene therapy to deliver cytokine gene(s) to tumor cells, thus creating an environment around the cell that would help to facilitate its destruction To date, ... although the clinical relevance of this effect remains to be proven Another approach to boost the ability of tumor cells to function as APC has been to transduce a genetically mismatched histocompatablilty ... particularly CD8+ cytotoxic T cells Primary factors implicated in the escape of tumor cells from the surveillance of cytotoxic T cells is the lack of expression of co-stimulatory molecules by tumor...
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An Introduction to Molecular Medicine and Gene Therapy - part 10 pot
... to be used in clinical research protocols is critically important Assurance of purity must be provided to investigators who purchase or contract for reagents to be used in basic or clinical research ... reagents can lead to the cessation of clinical trails of gene therapy protocols (see Chapter 13) Laboratory Scale Purification As the clinical aspects of gene therapy continue to grow, one of the ... chromatography, hydroxyapaptite chromatography, acridine yellow affinity chromatography, anion exchange chromatography, reversed phase chromatography, silica membrane binding, and binding to glass...
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Anxiety Disorders an introduction to clinical management and research - part 1 potx
... responsiveness It seems good INTRODUCTION ————————————————————————— xvii scientific strategy, to me, to focus on such counter-intuitive findings since they are likely to lead to real novelties DYSPNEA ... School of Medicine, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel Spilios V Argyopoulos Psychopharmacology Unit, School of Medicine, University of Bristol, University Walk, Bristol BS8 ... wanting to meet active investigators belonging to the best groups in their field However, the trainees themselves, reporting on their daily work and their ongoing research, contribute largely to the...
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Anxiety Disorders an introduction to clinical management and research - part 2 ppt
... DISORDERS: PART I —————————————— 29 that Serotonin Re-uptake Inhibitors (SRI) are effective in the reduction of symptoms and selective agonists of serotonergic receptors (such as Methyl Chloro Phenyl Piperazine: ... not conclusive, due to the complexity of the research field, but in some cases they allow us to formulate specific aetiologic hypotheses Molecular biology is a powerful tool to test them In the ... history for OCD, the best model of transmission is represented by a mixed model of transmission, that is a Single Major Locus (SML) plus a multifactorial background Applying factor analysis to...
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Anxiety Disorders an introduction to clinical management and research - part 5 pps
... with anger towards the father) Sadistic feelings were the basis of the symptoms, together with fears of punishment, and the present disorder Anxiety Disorders: An Introduction to Clinical Management ... two to four weeks, then increased as necessary to obtain a response An adequate trial of treatment is generally six to eight weeks, but treatment may have to be continued for several months to ... actions Due to his repetitive thoughts, he had the urge to commit certain acts (compulsions) in order to prevent harm to his relatives and friends (such as moving a rock from the road in order to prevent...
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Anxiety Disorders an introduction to clinical management and research - part 6 docx
... AND BEHAVIOURAL ASPECTS Predictors and Risk Factors Genetic Factors There are indications that genetic factors may contribute to the susceptibility to PTSD symptomatology Comparison of monozygotic ... month’s duration The symptoms were divided into four categories, including autonomic hyperactivity, motor tension, apprehensive expectation and vigilance/scanning (APA, 1980) To qualify for the diagnosis, ... finds it difficult to control the worry) (APA, 1994) In addition, whereas the associated symptom criterion for DSM-III-R consisted of 18 symptoms grouped into three clusters (motor tension, vigilance...
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Anxiety Disorders an introduction to clinical management and research - part 7 doc
... Aversive reinforcer (1) excitatory conditioning (3) inhibitory conditioning (5) inhibitory conditioning (2) excitatory conditioning (4) inhibitory conditioning (6) inhibitory conditioning LEARNING ... points to the activation of an inhibitory mechanism related to the cognitive processing of traumatic stimuli (Bleich et al., 1996) In an attempt to resolve the conflicting results, with respect to ... olfactory input Mammals have eyelids but no ear lids or nose lids Also clinically, odours prove to be very strong triggers for conditioned emotional responses CIRCULATORY, SYMPATHETIC AND MOTOR...
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Anxiety Disorders an introduction to clinical management and research - part 9 potx
... of CCK receptors in the brain which fall into two classes CCK A and B CCK A receptors are involved in eating behaviour and CCK B receptors, Anxiety Disorders: An Introduction to Clinical Management ... refers to symptoms similar in character to premorbid symptomatology and should be no more severe in intensity than the original symptoms It occurs slowly over a period of weeks or months after stopping ... receptors, did not take into account results obtained in healthy volunteers concerning sedative effects It was hoped that tolerance would develop to the sedative effects to a greater extent than to...
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Anxiety Disorders an introduction to clinical management and research - part 10 ppt
... patients to gain a better insight in the symptoms of his/her disease; also the ability to reproduce the patients’ symptomatology in the laboratory might help psychiatrists/ psychologists to gain ... initial decrease in synaptic 5-HT, through its action on the inhibitory 5-HT1A autoreceptor, Anxiety Disorders: An Introduction to Clinical Management and Research Edited by E J L Griez, C Faravelli, ... to improve our knowledge of the ‘‘real’’ world by manipulating models of this world inside the laboratory In medicine, such experimental methods most often involve a laboratory model of the clinical...
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Approach to Internal Medicine A Resource Book for Clinical Practice Third Edition ppt
... School, Boston, MA, USA Raj Padwal, MD, M.Sc., FRCPC Associate Editor, Approach to Internal Medicine Associate Professor, Clinical Pharmacology, Clinical Epidemiology and General Internal Medicine, ... Edmonton, AB, Canada GENERAL INTERNAL MEDICINE Peter Hamilton, MBBCh, FRCPC Professor of Medicine Division of General Internal Medicine Department of Medicine University of Alberta Edmonton, ... educational resource for everyday clinical use and examination preparation Approach to Internal Medicine now has an expanded repertoire of over 250 internal medicine topics, classified under 17 subspecialties...
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An Introduction to Vascular Biology From basic science to clinical practice SECOND EDITION pdf
... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... diastole and adds little to systolic pressure but tends to increase early diastolic pressure The former eVect keeps pulse pressure to a minimum and the latter may be important with regard to coronary...
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Báo cáo y học: "Curricula for teaching the content of clinical practice guidelines to family medicine and internal medicine residents in the US: a survey study" ppt
... http://www.implementationscience.com/content/4/1/59 Table 2: Answers to questions relating to teaching of the content of clinical practice guidelines; a national survey, 2007 Combined Family Medicine Internal Medicine N = 434 N = 239 N ... CI 0.22 to 0.88) Teaching how to deal with conflicting CPGs was associated with female gender of the program director (OR = 2.00; 95% CI 1.17 to 3.38), and inversely associated with 26 to 50% ... 26 to 50% of residents being international medical graduates (OR = 2.05; 95% CI 1.15 to 3.66) Discussion We conducted a survey of family medicine and internal medicine residency programs to determine...
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báo cáo khoa học: " Curricula for teaching the content of clinical practice guidelines to family medicine and internal medicine residents in the US: a survey study" pot
... http://www.implementationscience.com/content/4/1/59 Table 2: Answers to questions relating to teaching of the content of clinical practice guidelines; a national survey, 2007 Combined Family Medicine Internal Medicine N = 434 N = 239 N ... CI 0.22 to 0.88) Teaching how to deal with conflicting CPGs was associated with female gender of the program director (OR = 2.00; 95% CI 1.17 to 3.38), and inversely associated with 26 to 50% ... 26 to 50% of residents being international medical graduates (OR = 2.05; 95% CI 1.15 to 3.66) Discussion We conducted a survey of family medicine and internal medicine residency programs to determine...
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