induction of cardiac fibrosis by transforming growth factorβ1
Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
Ngày tải lên :
22/03/2014, 21:21
... anti-inflammatory
cytokine transforming growth factor-b1 (TGF-b1) of
the proinflammatory cytokine TNF-a via the induction
of FXR1 is the focus of this article.
TGF-b1, a member of the large transforming growth
factor-b ... two different isoforms of
FXR1 were visualized by western blotting with anti-
body against FXR1 following the addition of TGF-b1
and TGF-b1 ⁄ LPS [39,40].
The pattern of FXR1 induction suggests ... also dem-
onstrate that this process is regulated by TGF-b1.
Induction of FXR1 expression by TGF-b1 leads to
post-transcriptional downregulation of TNF-a
protein
Many RNA-binding proteins, such...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
Ngày tải lên :
07/03/2014, 01:20
... localization of transforming growth factor-
beta in idiopathic pulmonary fibrosis. Am J Respir Cell
Mol Biol 5, 155–162.
153 Broekelmann TJ, Limper AH, Colby TV & McDonald
JA (1991) Transforming growth ... go to only one of the
two daughter cells, leaving the other relatively clear of
such signaling byproducts. A deeper understanding of
the role of microtubules in the regulation of Smad
trafficking ... characterized by the
dissolution of epithelial cell–cell junctions and reorga-
nization of the actin cytoskeleton with the formation
of focal adhesions and stress fibers, acquisition of a
spindle-shaped...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
Ngày tải lên :
19/02/2014, 16:20
... a
combinatory effect of negative feedback and ultrasensitivity
[22]. Both of these features have been demonstrated
experimentally. Negative feedback is constituted by the
phosphorylation of Sos by ERK, which ... ynergistic ERK phosphorylation
caused by EGF and PMA.
Discussion
The architecture of signal transduction networks i s often
highly complex, due to the large number of participating
protein co mplexes, ... determines the repertoire of target
genes expressed [16], and also affects the type of cellular
response that is evoked [17,18]. Activation of ERK is
required for proliferation of fibroblasts [19] and...
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Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
Ngày tải lên :
17/03/2014, 17:20
... lg)andincreasingamounts(0,0.1,0.2,0.3,0.4,0.5,0.6,0.8
and 1.0 lg) of ETS f acto rs. (A) Eect of E ts-2. (B) E ect of E RM. (C)
Eect of ETV1 (D) Eect of Spi-1 (E) Eect of PEA3. Representative
experiments performed ... depend on the availability of these acc essory
factors.
When transfected in HeLa cells, the activity of the
COUP-TFI promoter was a bout the same r egardless of the
size of the s equence used until ... characterized
orphan members of the nuclear receptor superfamily [1].
COUP-TFs have been shown to be negative regulators of
the transcription of many genes [1,2], but can also act as
activators of gene t ranscription...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
Ngày tải lên :
31/03/2014, 23:20
... either of the other isoforms were cotransfected (data not
shown).
Modulation of SeP promoter activity by overexpression of
Smad 2, 3, and 4
Overexpression of Smad proteins has been ... down-regulation by
TGF-b
1
.
DISCUSSION
The inhibition by TGF-b
1
of SeP expression is to date the
only known regulation of this protein by a factor other than
the availability of selenium. TGF-b
1
has ... presence of a TGF-b-responsive
element in the promoter of the SeP gene. In addition, we
found the expression of SeP mRNA being attenuated by
overexpression of Smad 3 and 4 which mimics activation of
the...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
Ngày tải lên :
18/06/2014, 15:20
... activation of mesenchymal HSCs. This
interpretation is strengthened by the findings of a negative
correlation of serum TGF-β1 with fibrosis score, feature of
stable collagen deposition, and by a good ... biopsy-proven diagnosis.
Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.
Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical
School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and
4
Federico II University Medical School of Naples,
Department of Neurosciences, Section of Clinical...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
Ngày tải lên :
19/06/2014, 22:20
... obstruction of CSF clearance by
meningeal fibrosis [34,35]. Other examples exist of
hydrocephalus caused by growth factor-induced fibrosis
[36]. The site and mechanism of action of pioglitazone ... degradation of Aβ42. Also
ibuprofen has been shown to reduce plaque-associated
and soluble Aβ42 in mice over-expressing the Swedish
mutation of human APP [15,16]. The lack of effect of ibu-
profen in ... resolution of injuries by inhib-
iting local inflammation, and by stimulating the synthesis
and deposition of matrix components leading to the
reconstitution of the basal membrane in the final stages of
angiogenesis....
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
Ngày tải lên :
09/08/2014, 01:21
... Robbins
1
1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinical
applications of transforming growth factor-beta (TGF-beta).
Growth Factors 1993, 8:1-9.
3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB:
Transforming growth factor-beta in ... sequence analysis of simian transforming growth
factor-beta cDNA. DNA 1987, 6:239-244.
5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming
growth factor-beta. A family of growth regulatory peptides.
Ann...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
Ngày tải lên :
09/08/2014, 07:20
... tibia.
Figure 3
Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta
in ... Heydemann A, Izumi T, Reddi AH: Regulation of the
expression of the type-II collagen gene in periosteum-derived
cells by three members of the transforming growth factor-beta
superfamily. J Orthop ... measurements, analyzed
Figure 8
Effect of transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capacityEffect of transforming growth factor (TGF)-beta deprivation on...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 08:22
... an in vitro measure of the in vivo
efficiency of TGF-β
1
activation
To examine the ability of SLE patients and control individuals
to activate TGF-β
1
, a ratio of levels of TGF-β
1
in freshly ... development of early
atherosclerosis.
Introduction
Transforming growth factor (TGF)-β
1
is the most potent natu-
rally occurring immunosuppressant [1]; it is produced by all
cells of the immune ... reaction was stopped by the addition of 50 àl
per well of 2 mol/l H
2
SO
4
, and the plates were read at 450 nm.
Available online http://arthritis-research.com/content/8/3/R81
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(page number...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
Ngày tải lên :
09/08/2014, 10:20
... levels of active
TGF-β1 have recently been reported in RA synovial fluid in
Figure 2
mRNA-expression of the transforming growth factor (TGF)-β related genesmRNA-expression of the transforming growth ... Analy-sis of the oligonucleotide microarray dataCentral components of the transforming growth factor (TGF)-β pathway are shown with their scores, as determined by Gene Set Enrichment Analy-
sis of the ... Heldin CH, et al.: Enhanced expres-
sion of transforming growth factor-beta s and transforming
growth factor-beta type II receptor in the synovial tissues of
patients with rheumatoid arthritis....
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