in vitro in vivo extrapolation of drug diffusion velocity and p gp efflux rate parameters

Báo cáo y học: " Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination" pps

Ngày tải lên : 13/08/2014, 16:21

... (Vmax (P- gp) /Km (P- gp) = 4.75 × PP -gp, in- vitro, R2 = 0.92, no intercept, S-Plus®) were found between Vmax (P- gp) /Km (P- gp) and PP -gp, in- vitro as well as between Pdiff, in- vivo and Pdiff, in- vitro (Pdiff, in- vivo ... between in vivo Vmax (P- gp) /Km (P- gp) and PP -gp, in- vitro, and between Pdiff, in- vivo and Pdiff, in- vitro values of the drugs These correlations are used to estimate apparent in vivo efflux rate of ... transport Assuming that P- gp efflux rate is independent of the direction of diffusion, the in vitro estimation of the parameters of apparent drug diffusion and apparent P- gp efflux rates (Pdiff, in- vitroand...

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Báo cáo khoa học: Identiﬁcation of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles pdf

Ngày tải lên : 29/03/2014, 21:20

... cooperatively in the cross-linking of proteins, including involucrin, loricrin and small Preferred substrate peptide for TGase proline-rich proteins (SPRs) Such concerted reactions result in ... concentrations of pepE51 and pepE51QN as well as three speciﬁc biotin-labeled peptides (pepK5; TGase 1, pepT26; TGase 2, pepF11; Factor XIII), incorporation into coated-spermine was measured in the presence ... 1-, TGase 2- and Factor XIII-preferred substrate biotinylated peptides, being pepK5 (YEQHKLPSSWPF), pepT26 (HQSYVDPWMLDH) and pepF11 (DQMMLPWPAVAL), respectively, were used for comparison To evaluate...

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báo cáo hóa học:" Research Article Extremal Values of Half-Eigenvalues for p-Laplacian with Weights in L1 Balls" potx

Ngày tải lên : 21/06/2014, 11:20

... 1 /p p /2 2.3 ; p sin π /p m p , m ∈ Z, and sinp θ if and only if ∗ p − |sinp θ |p ≡ By setting p x −y and introducing the Prufer transformation x ¨ sinp θ, the scalar equation p x − b t p ... a t p x a.e t ∈ 0, r 2 /p cosp θ, y 2.4 is transformed into the following equations for r and θ: θ : A t, θ; a, b ⎧ ⎨a t cosp θ ⎩b t cos θ p p p p − sinp θ p − sinp θ p p ∗ G t, θ; a, b p ⎪ ... Journal of Mathematics, vol 7, no 2, pp 225–248, 2010 10 P Yan and M Zhang, “Continuity in weak topology and extremal problems of eigenvalues of the p- Laplacian,” to appear in Transactions of the...

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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Ngày tải lên : 15/03/2014, 00:20

... activation of MMPs (A) Proteolytic cleavage of the pro- and HPX domain of MMPs by various proteinases, including serine proteases such as trypsin or other MMPs Steps 1–4 represents partly to fully processed ... TIMP-2 in the MT1-MMP-induced activation of proMMP-2, but also enhanced the activation of proMMP-2 by all MT-MMPs Claudin-1 binds to both MT1-MMP and proMMP-2, and this binding appears to involve ... nuclear proteins, whereas the other is independent of the processing capacity of the proteinase and involves the HPX domain A DNA-binding domain was found in the HPX domain, as an antiMMP-3 HPX antibody...

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Báo cáo khoa học: Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue docx

Ngày tải lên : 17/03/2014, 03:20

... BN-52021, indomethacin and the enzymatic system of creatinine phosphate and creatinine phosphate kinase exerted the same inhibitory effect on both standard PAF and the lipid product of similar ... from patients with primary glomerulonephritis compared to normal ones [24]; and (c) increased levels of PAF in plasma and urine as well as increased PAFAH activity in serum in patients with primary ... BSA in binding PAF or lyso-PAF [31] In our assays, it seems that the microsomal proteins can bind PAF effectively preventing it from inhibiting lyso-PAF AT activity and the addition of BSA up to...

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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx

Ngày tải lên : 19/06/2014, 22:20

... profile of macrophages can change, shutting down the production of pro-inflammatory cytokines and increasing the production of factors that participate in tissue repair and wound healing [6] Anti-inflammatory, ... expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling J Neurosci ... regulation of gene transcription in macrophages during immune activation is dependent on multiple factors including the type of phagocytic ligands, the types of nonphagocytic adhesion interactions,...

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Báo cáo hóa học: " Research Article Power Allocation Strategies for Distributed Space-Time Codes in Amplify-and-Forward Mode" docx

Ngày tải lên : 21/06/2014, 19:20

... ﬁnd the PDF of γmax Thus, in the following proposition, we derive the PDF of the maximum of R random variables expressed in (20) (20) In the following, we will derive the PDF of γr in (20), ... be proportional to ermax On the other hand, since p = W−1/2 q, and W is a diagonal matrix, the optimum p is also proportional to ermax Using the power constraint of the transmitted power in ... with optimum α AF opportunistic relaying with α = 0.5 AF opportunistic relaying with optimum α Figure 4: The average BER curves of relay networks employing DSTC and opportunistic relaying in AF...

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research report 'using the activity in pairs and in groups to teach writing in english'

Ngày tải lên : 29/06/2014, 19:15

... written and passes it to the person on his right The next command is given and the procedure is repeated - When the work has finished, the students open them and, in writing, join the fragments of information ... Writing notes and messages Preparation: Find two message or postcard texts Make enough copies for half of the class to work in pairs on one text, and half to work in pair on the other text Procedure: ... everyone is involved, but not staying too long with any group since the main initiative for writing should rest with students Group activity has two practical benefits in the teaching of writing Firstly,...

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Báo cáo toán học: "Asymptotics for the distributions of subtableaux in Young and up-down tableaux" pps

Ngày tải lên : 07/08/2014, 08:22

... Applying Bayes’ Theorem, P (n, N, T ) = P (µ at step k | survive to step N)/f µ P (survive to step N | µ at step k )P (µ at step k)/f µ = P (survive to step N) P (survive to step N | µ at step ... group Sn and steps ei in the positive coordinate directions is reﬂectable; a step starting at a point with xi > xj can go to a point with xi = xj but not a point with xi < xj The ballot problem ... nk P (survive to step N ) (5) The denominator of the last fraction is independent of µ Thus the probability P (n, N, T ) for tableaux of shape µ is proportional to the probability that a random...

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Báo cáo khoa học: "Surgical treatment for different forms of hernias in sheep and goats" ppt

Ngày tải lên : 07/08/2014, 20:23

... syad rof nicymotperts gk/gm 01 dna nillicinep eht rof gk/UI 000,03 fo etar esod a ta nicymotperts -nillicinep htiw ypareht evitarepotsop nevig saw lamina hcaE )sesac ni( serutus klis ro SDP ,tugtac ... < p( yregrus eht fo emoctuo eht no tceffe tnacifingis a dah peehs ni gnir lainreh fo ezis eht ,yllacitsitatS gnir lainreh eht fo ezis eht etipsed ,yhpahrroinreh derovaf dettimrep staog dna peehs ... gnillews evitarepotsop deyalpsid esac sihT tseuqer s'renwo eht nopu noitartsac enogrednu ton dah snoitacilpmoc evitarepotsop dah taht esac ylno ehT ]31[ sesac tsom ni demrofrep si siht dna ainreh tnerrucer...

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Báo cáo lâm nghiệp: "of morphological characters and molecular markers for the analysis of hybridization in sessile and pedunculate oak" pps

Ngày tải lên : 08/08/2014, 18:21

... in the analysis (DFAa) Second, the individuals of the groups ses/ses and ped/ped were considered as principal points, and individuals of the mixed zones ped/ses and ses/ped as supplementary points ... of hybridization These errors could be reduced in size only by means of the comparison of the distribution of many kinds of characters and of genetic markers in space (over populations) and in ... aspects of the biology of the white oaks, that are based on a preliminary morphological discrimination of the individuals into species, and the management and the sylviculture of the oak stands,...

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Báo cáo khoa hoc:" Genetic relationship between cyclic ovarian activity in heifers and cows and beef traits in males" ppt

Ngày tải lên : 09/08/2014, 18:21

... Differences in fatness were certainly primarily dependent to feed intake capacity of roughage, to maintenance costs or residual feed efﬁciency It appears that the appreciation of adipose tissue importance ... Martin de Ré, 1996, INRA, Paris pp 123–134 [17] Renand G., Fouilloux M.N., Ménissier F., Genetic improvement of beef production traits by performance testing beef bulls in France, in: Proceeding ... a compromise between limited experimental facilities and good precision of the estimated parameters, it was necessary to optimise the choice of the founder sires Instead of a random sampling,...

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Báo cáo y học: "Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury" pps

Ngày tải lên : 12/08/2014, 14:20

... epithelium as a key source [5,6,34] Several lines of in vitro evidence have pointed to a possible role for VEGF in lung repair and recovery following injury[19,29,35,36] In one LPSinduced murine ... hyperanaesthesia and exsanguinated by cardiac puncture The lungs were removed, inflated and snap frozen at day and day post initial LPS insult, 24 hours after last LPS dose A minimum of n = individual ... manuscript and contributed to its design and conception SKD carried out the proliferation studies and drafting of part of the manuscript SIHG designed and generated the murine model and performed...

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Báo cáo y học: " G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children – safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847]" pps

Ngày tải lên : 12/08/2014, 20:20

... including differential and plasma levels of C-reactive protein Routine surveillance for ventilator-associated pneumonia comprises microbiological examination of the tracheal aspirate, including ... ratios × pre-test oddss Post-test probabilitys = post-test oddss/(1 + post-test oddss) Algorithm for pneumonia Pre-test probabilityvap = prevalence of pneumonia Pre-test oddsvap = pre-test probabilityvap/(1 ... probabilityvap/(1 - pre-test probabilityvap) Likelihood ratiovap = exp(-6.8 + 1.0 × Ln [G-CSFt]) Post-test oddsvap = likelihood ratiovap × pre-test oddsvap Post-test probabilityvap = post-test oddsvap/(1...

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Multi-beneficial for mitigation of climate change in Vietnam and Indochina countries by development of biomass energy project

Ngày tải lên : 18/03/2015, 13:20

... Cultivation of oil plants in Japan - P rof Yoshiaki Kitaya (OPU) 10:20-10:40 Group Selection and Cultivation of oil plants in Vietnam - Prof Nguyen Thi Quynh (VNUHCM), P rof Le Dinh Kha(IIFPD), Dr Hoang ... Effect of sugar types on num ber of open leaves and leaf area of Jatropha plant cultured in vitro at day 42 a IFW (mg/pit) s Root length (mm/pit) s E ffect of supporting m aterial on increased ... fresh w e ig h t and root length of Jatropha plant cultured in vitro at day 42 Table Effect of supporting material on leaf area and increase dry weight of Jatropha plant culture in vitro on day 42...

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Regulation of sla2p by activity in endocytosis and actin organization by the ark1 prk1 family of kinases

Ngày tải lên : 14/09/2015, 08:50

... between Pan 1p, Sla 1p, End 3p and Scd 5p and the dephosphorylation of Pan 1p by Glc 7p Sla 1p (purple ovals) separates from Pan 1p and end 3p upon phosphorylation Phosphorylated Pan 1p gains access to the phosphatase ... Pyrococcus furiosus PH pleckstrin homology PIP2 phosphatidylinositol-4,5-bisphosphate PKC protein kinase C PLC phospholipase C PBM Phosphatase Binding motif Pma1 plasma membrane ATPase PMSF phenylmethylsulfonyl ... fluoride PNPP p- nitrophenylphosphate poly -P proline-rich region PRD proline- and arginine-rich domain PVC prevacuolar compartment PVDF polyvinylidene difluoride RBD Rho-binding domain RFP red fluorescent...

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Báo cáo khoa học: Function of microRNA-375 and microRNA-124a in pancreas and brain doc

Ngày tải lên : 29/03/2014, 22:21

... transcripts, pri-miRNA presents a 5¢cap structure and a 3¢poly(A) tail (Fig 1) The pri-miRNA is processed by a nuclear protein complex, Microprocessor, containing the RNaseIII-type protein Drosha and ... RNA-binding protein (the HIV transactivating response RNA-binding protein) and Argonaute proteins to liberate the mature miRNA duplex (20–22 nucleotides) [26–29] Processing by Dicer results in ... factor, within the proximal regulatory region of miR-124a, implicating the role of cAMP response element-binding protein in the positive regulation of this miRNA [47] Despite the importance of characterizing...

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Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf

Ngày tải lên : 19/02/2014, 18:20

... showed that asparagine 26 represents the amino terminus of P4 0 Knowing, that the first amino acids of the processed P4 0 and P9 0 is the asparagine at position 26 and the arginine at position 455 ... mass spectrometric analysis of an in- gel digest of P4 0 To prove that the candidate peptide was the N-terminal peptide of P4 0, we labeled the N-terminus of P4 0 within the gel piece before tryptic ... corresponding N-terminal modified peptide, compared to that of the unmodified peptide (Fig 3) In the peptide mass fingerprint, the N-terminal sulfonated peptide 26–54 was detected not only in its protonated...

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Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf

Ngày tải lên : 07/03/2014, 09:20

... a specific inhibitor of CatE, the Ascaris pepsin Determination of cathepsin E and D activity inhibitor, which inhibits pepsins and CatE [33], but does not affect other types of aspartic proteinases ... using a combination of the peptide substrate, aspartic proteinase inhibitor (pepstatin A) and depletion of CatE by immunoprecipitation Activities were determined by linear regression using a minimum ... aspartic proteinases Scand J Clin Lab Invest Suppl 210, 23–30 Yamamoto K, Katsuda N, Himeno M & Kato K (1979) Cathepsin D of rat spleen Affinity purification and properties of two types of cathepsin...

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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

Ngày tải lên : 08/03/2014, 08:20

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