hostpathogen interactions the attributes of virulence
Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
Ngày tải lên :
17/02/2014, 11:20
... in the Gulf
War. The subsequent disclosure of the CBW capabilities of the for-
mer Soviet Union, the discovery of an Iraqi CBW capability after the
Gulf War, and the recognition that a number of ... by the Office of
the Secretary of Defense (OSD). The research was conducted jointly
by RAND Health’s Center for Military Health Policy Research and the
Forces and Resources Policy Center of the ... development because of the increased apprecia-
tion of the threat of biological weapons. The CBW threat, both to
national and homeland security, raises the question of whether cur-
rent FDA regulations...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
Ngày tải lên :
19/02/2014, 06:20
... the center of the membrane
(Fig. 4);
(b) the major axis of the dimeric RNase was made coinci-
dent with the z axis of the system, hence orthogonal to the
membrane plane (Fig. 4);
(c) the dimeric ... stabilized through
the exchange between subunits of either their N-ter-
minal, or their C-terminal ends [33–35]. We found
that the behavior with the model membrane of the
dimer in which the C-terminal ... affect
the bilayer fluidity of DMPG membranes, as evidenced
by a decrease of the amplitude of their thermotropic
transition. Only RNase A and RNase AA show no
effects on the thermotropic behavior of...
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Tài liệu Báo cáo khoa học: Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase docx
Ngày tải lên :
19/02/2014, 17:20
... rearrangements of the TM spans of these subunits.
It has not been established whether these TM spans
simply anchor the amphipathic regions and cytosolic
domains to the membrane, or whether they serve ... in the presence of substrate and a proton
motive force [23]. On the basis of these studies, it has
been proposed that binding of substrate to the TatBC
subunits triggers the recruitment of the ... conjunction with the data shown in Fig. 6,
these data show that the severe effects of the
TatA ⁄ 3Gly mutations can be rescued by the presence
of additional mutations either elsewhere in the TatA
TM...
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Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf
Ngày tải lên :
20/02/2014, 01:20
... perhaps reflects the difference
between the complexities of the regulation of the two
systems: a longer time is required for the formation of
the complex looping structure in the case of BX-C,
while ... approach their
proper target promoter in the viscous environment of
the nucleus.
Somatic pairing of chromosomes and
the regulation of Abd-B
A peculiarity of Drosophila is the fact that the homo-
logous ... con-
struct. However, when the combination of the PTS and the bound-
ary is placed 3¢ to one of the reporter genes, the enhancer is
targeted to one or the other promoter over the boundary (lower
panel)....
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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
Ngày tải lên :
20/02/2014, 11:20
... bond, linkage of the active
site Ser of the protease to the carboxyl group of P
1
by an
ester bond and insertion of the N-terminal part of the RCL
as strand 4 in b-sheet A (s4A) of the serpin. ... cognate
proteases is fuelled by the thermodynamic properties of the
serpin. Accordingly, insertion of the RCL as s4A and
the ensuing structural rearrangements of the serpin stabilizes
the molecule in a so-called ... close to the point of initial
insertion of the RCL [36] represents an obstacle for the local
structural rearrangements required for the movements of
the RCL during latency transition. N152 is often...
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Tài liệu Interactions Between Workers and the Technology of Production: Evidence from Professional Baseball doc
Ngày tải lên :
22/02/2014, 09:20
... y of the o ther pitchers, but is unaffected by the batting output of the team.
These results are in consistent with beh avioral explanations for how one w orke r affects the
per form ance of other ... ot the case, then
v
1
> 0 cannot be optimal since the principal would be better off paying zero t o playe r 1.
Depending o n the value of B as well as the values of the other parameters in the ... with the quality of the team’s pitching.
Furthermore, a pitcher’s performance increases with the pitching quality of his teammates,
but is unaffected by the batting output of the team. These...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
Ngày tải lên :
06/03/2014, 04:20
... Treatment
Despite the complexity of these drug interactions, the key role of the rifamycins in the success of
tuberculosis treatment mandates that the drug-drug interactions between the rifamycins and antiretroviral ... (induce) the
synthesis of several classes of drug transporting and drug metabolizing enzymes. With increased synthesis,
there is increased total activity of the enzyme (or enzyme system), thereby ... the
antiviral activity of raltegravir 200 mg twice daily was very similar to the activity of the licensed dose (400
mg twice-daily), the current recommendation is to use the standard dose of...
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Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
Ngày tải lên :
06/03/2014, 11:20
... from
a different species [23–25]. The success of the series of
studies shows that the stable framework structure of
Fv enables the transfer of function by means of CDR
replacement.
Barbas et al. ... of the CDR 3 loop of antilysozyme VHH
functionalized NCS without denaturation, although
the thermal stability was decreased and the affinity for
lysozyme was weaker than in the original VHH.
The ... demonstrating the utility of the grafting
of functional peptides with randomized edge sequences
for optimizing the orientation of the grafted peptide
on a scaffold protein. In addition, when the combina-
tion...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
Ngày tải lên :
07/03/2014, 03:20
... possible
interpretation of the data suggests that the indicated
basic region of ic3 of the D
2
receptor and acidic region
of the C-tail of the D
1
receptor might be involved in
the interactions between the two ... on the number of Arg residues that
were replaced by Ala in the Arg-rich region of ic3 (resi-
dues 217–222) of the dopamine D
2
receptor. The effi-
ciency of energy transfer in the wild-type of the ... localization of these proteins in the cell rather than
from the possible role of the D
2
R basic domain in the mechanism of
D
1
–D
2
receptor heterodimerization. However, we find that the acidic
epitope...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
Ngày tải lên :
07/03/2014, 10:20
... is
strongly affected by the two groups of parameters that
determine the protein–protein interactions: the concen-
trations of the enzymes relative to the target protein,
and the respective dissociation ... the global response coefficient R is
the ratio of the concentration of active kinase K
0.9
at
which there is 90% fully phosphorylated target to the
kinase concentration K
0.1
at which 10% of the ... another site, so that the
phosphorylation kinetics of one residue can depend on
the phosphorylation state of other residues in the pro-
tein [8]. It is not clear how these factors modulate the
response...
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Báo cáo khoa học: The protein shuffle Sequential interactions among components of the human nucleotide excision repair pathway pdf
Ngày tải lên :
07/03/2014, 12:20
... sites.
Taken together, these findings suggest that the struc-
tural properties of DNA-damaged substrates, whether
intrinsic or the result of protein binding, function in
the recruitment of the XPC–hHR23B ... Binding of XPG induces the release
of XPC–hHR23B, whereas XPF–ERCC1 triggers exci-
sion of the damaged DNA and the release of XPA
and TFIIH. Subsequently, the newly formed gap in
the DNA is filled by ... assembly of the protein
complex that carries out DNA incision around the
lesion, (b) incision of the damaged DNA strand on
both sides of the injury, which results in damage exci-
sion, and (c) synthesis...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
Ngày tải lên :
23/03/2014, 13:20
... 3B). The specificity of the
binding is again confirmed by the competition of unla-
belled DR1 probe. The presence of USP in the com-
plex was confirmed by a supershift formed upon the
addition of ... (a) binding the a-helix 12
of the receptor into its own hydrophobic groove [22];
(b) stabilization of the a-helix 12 near the hydrophobic
groove in a position that the C-terminus of the a-helix
12 ... progressive decrease
in the JH III-inducibility of the DR1JHECore promo-
ter (Fig. 6, upper panel). To further test whether the
JH III activation pathway requires the presence of the
wild-type L314...
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Báo cáo khoa học: The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions ppt
Ngày tải lên :
23/03/2014, 13:20
... is bound by the wild-type fusion protein in
this assay. The efficiency of the pull-down is probably
limited by the presence of the GST part of the fusion
protein, the small size of the radiolabelled ... both the binding to and cleavage of
eIF4GI [26]. However, the results here also do not rule
out further interactions between the CTE of Lb
pro
and
the region 645–657 of eIF4GI involving other ... synthesized
Lb
pro
, we took advantage of the presence of eIF4GI in
the RRLs and examined its fate during the synthesis
of Lb
pro
, as reported previously [15]. Accordingly,
aliquots of the translation reactions...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
Ngày tải lên :
24/03/2014, 03:21
... respectively, of the receptor [19,22]. The b sheet of
EGF may bind to domain I of ErbB-1, and the other surface
of the ligand binds to domain III of the receptor. Recently,
Gly441 of the ErbB-1 ... of the receptors was confirmed by
immunoblotting of the cell lysates (Fig. 1B). As often
observed for membrane proteins, the bands were rather
broad in the blots, due to the heterogeneity of the ... due to the saturation of ERK
activation resulting from the amplifying effect of the
signaling cascade.
DISCUSSION
In the present study, by using chimeric receptors, the
contributions of the extracellular...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
Ngày tải lên :
30/03/2014, 11:20
... present on the outside of
the shell where it is responsible for adsorption of the
virus to the cellular receptor, the F-pilus. During infec-
tion, maturase enters the cell together with the RNA
genome, ... treatment of dlFG and sc-dlFG in the
presence of bis-ANS. (A) Effects of increasing urea concentrations
on the spectral center of mass of (m) dlFG and (r) sc-dlFG in the
absence of bis-ANS, and in the ... against all the forms of denatura-
tion we tested. This is consistent with the observation
of increased stability of the single-chain version of the
wild-type dimer [30] and is reminiscent of the similar
stabilization...
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