... (3) the location ofthe impact andthe occur-rence ofthe tumor corresponded exactly one to the other; and (4) there was a more than one year interval between trauma andthe appearance ofthe ... interval between trauma andthe appearance ofthe tumor of at least 1 year, a longer latent period increasing the likelihood of a causal relationship. 5. The presence ofthe tumor must be proved ... reveal the severity and location ofthe traumatic brain injury andthe subsequent formation of a neoplasm at the same site, can provide convincing evidence for the traumatic causation of a brain...
... role in the pathogenesis of both types of diabetes mellitus. High levels of free radicals andthe decline of antioxidant defense mechanisms lead to damage of cellular or-ganelles and enzymes, ... Popliteal and pedal pulses were absent bilaterally with poor capillary re-fill. The left foot was red and inflamed up to and in-cluding the medial malleolus. The lateral aspect ofthe great toe and ... (maximum of 3 milliAm-peres) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The device was designed to switch the di-rection of current...
... see any of her involvements into any conversations with the grandmother. Regarding the children, they disapproved ofthe decision of their grandmother but, as the youngest in the family, their ... both the hardest time such as the time ofthe Civil War, the Great Depression, the World War II andthe prime time ofthe nation, the affluent America in the 1920s, the late 1940s, andthe early ... plot, theme, point of view, character and setting. Technique has to do with the structuring ofthe story into the plot so that the writer can convey the theme andthe manipulating ofthe language...
... acid. In addi-tion to these contacts, there is a 1.82 A˚contactbetween Gly255 Ca and Od2 ofthe oxidized cysteine.To further understand the structural consequences of the P-loop transition ... bondswith the P-loop main chain and Od1 and Od2.Although there are movements in the P-loop, thereare no other major conformational changes in the protein. Most notably, the loop containing the ... test whether the move-ment ofthe P-loop in PhyAsr is due to oxidation of the catalytic cysteine, we oxidized crystals of PhyAsrTable 1. Effect of ionic strength on the hydrolysis of InsP6byPhyAsr....
... removal ofthe CUBdomains and thereby activation ofthe growth factordomains. PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and pro-teolytic cleavage is therefore ... the developing rateyes and also adult eyes of rat, cow, monkey and rab-bit. In the adult rat eye, PDGF-D is localized to the stroma of iris and ciliar body in the anterior segment, and to the ... model of the PDGF-C growth factor domain indicates the disulfidebridges in PDGF-C to consist of Cys250 and 294,Cys280 and 335, and Cys287 and 337, andthe inter-monomeric bonds to consist of Cys274...
... Aedes aegypti [34], and lepidopterans, the tobacco hornworm Manduca sexta [35–37] and the silkworm Bombyx mori [38,39]. On the other hand, the natural ligand of USP is unknown, although recentin ... affinity of DBHs to receptors among insect species is due to the difference of structures ofthe ligand binding pocket.In the other study, we demonstrated that the moltinghormone activities of ecdysone ... decemlineata, EcR and USP, and (c) the measurement ofthe binding affinity of steroidal and nonsteroidal ecdysone agonists to the in vitro translated receptor proteins. Comparison of the receptor-binding...
... 7). The Vs/Vhratio is the ratio ofthe reaction rates of aminolysis and hydrolysis ofthe acyl-enzyme. The curva-ture ofthe plot of Vs/Vhvs. the mole fraction of D2Oindicates therefore ... equal to the ksfor6-APA. The dependence of Vs/Vhon the nucleophile concentra-tion [N] andthe results ofthe inhibition studies show that,despite ofthe high rate of hydrolysis ofthe acyl-enzyme,tight ... muchslower than the rate of deacylation. The theoretical maxi-mum ofthe amplitude ofthe burst phase is equal to the totalenzyme concentration. When kh1¼ 5 k2, only 2% of the maximum ofthe amplitude...
... indispensable for the assembly of subunits A and B. Hirata et al. [19] investigated the functions of Vma11p and Vma16p in the S. cerevisiae V-ATPasecomplex, and reported that the two subunits c0 and c00areessential ... ratio ofthe three proteins could not be estimated.Forgac described in a recent minireview [21] that the VOdomain consisted of six copies ofthe c/c0subunits and singlecopies ofthe other ... isoforms as observedin higher plants V-ATPase. We have also isolated twodifferent cDNAs coding for the subunits A and B of V-ATPase. The intracellular localization of these isoforms and the...
... suggests rather that teaching, encouraging, and enabling the elderly to take care of themselves and their needs will increase autonomy and improve their sense of support and self-control. Yee and Weaver ... alter the effects of alcohol and increase the risks of adverse effects (Akers and La Greca 1991), and the fact that, because of these changes, a low or moderate level of drinking might nonetheless be ... organizations, andthe general public. The most common strategiesused elsewhere are information and awareness campaigns andeducationand training of older adults and service providers. There are...
... topromote the transfer ofthe p-HB moiety ontoPKS15 ⁄ 1 [16,18].To examine the involvement of FadD29 in the bio-synthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of ... Schematic representation ofthe roles ofthe FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and relatedcompounds in Mycobacterium tuberculosis. The role ofthe activation enzymes ... knowledge ofthe bio-synthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to beestablished and ⁄ or completed. For instance, the involvement of FadD26 in the...
... to the shampoo shelves and picks up a bottle of Pantene brand, reads the front label, then picks up a bottle of the store brand and reads the front label, then reads the price tag On the ... pause and look at the sd-ence of shopping from the perspective not of the scientist but of the practitioner-that is, the retailer and marketer. He or she is certainly part of the ... we'd note that he (the man, not the mannequin) entered the cashier line at 11:23 and exited the store at 11:30. Depending on the size of the store and the length of the typical shopper's...
... between the two offshore islands andthe mainland. As part of that expansion ofthe mini-three links, the Taiwanese government alsoexpanded the list of products that the offshore islands can ... total of 152,438 passenger trips between the offshore islands and FujianProvince, including 144,234 from the offshore islands to the mainland, and 8,200 from the mainland to the offshore islands ... the Office ofthe Secretary of Defense, the Joint Staff, the UnifiedCommands, the defense agencies, the Department ofthe Navy, the U.S.intelligence community, allied foreign governments, and...