... ⁄ 04297-8, 01 ⁄ 07544-9 and
04 ⁄ 04933-2), CNPq and CAPES, and NIH NS39892
and RR19325 (to MJG). PAGG and CCR were suppor-
ted by studentships from FAPESP (02 ⁄ 09861-4 and
97 ⁄ 05500-7, respectively). ... specific substrates and ⁄ or inhibi-
tors for the enzyme, as the detailed architecture of the
enzyme and its interactions with substrates are deci-
phered.
The mutations D93A and D159A neither ... change the secon-
dary structure by reduction of a-helical content and to
change the substrate specificity of EP24.15. Together,
these new findings are useful to understand the com-
plex organization...