functional role of collagen mechanotransduction and fibroblast responses to force

Functional study of zebrafish udu and its relationship to the notch signaling pathway

Ngày tải lên : 14/09/2015, 14:03

... upregulation of the TRAIL receptors, death receptor-4 (DR4) and death receptor-5 (DR5, KILLER), as well as the FAS receptor (CD95) and the FAS/APO-1 ligand (Owen-Schaub et al., 1995; Jin and El-Deiry, ... (Schuurmans and Guillemot, 2002) Studies were carried out to investigate the role of Notch signaling in apoptotic cell death of neural progenitors through the generation and analysis of cell type-specific ... and Anderson, 2001; Bode and Dong, 2004) Most of the genes targeted by p53 are associated with the regulation of cell cycle arrest, apoptosis and/ or DNA repair processes, which all function to...

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A study of bloating symptomatology, the role of gastrointestinal transit and the response to treatment with the 5 HT4 receptor agonist in patients with bloating predominant irritable bowel syndrome

Ngày tải lên : 26/09/2015, 10:05

... bloating and intestine transit in these patients Therefore, the objective of this study is to investigate the symptomatology of bloating, the role of gastrointestinal transit and effect of tegaserod ... at least of the following symptoms: relieved with defecation associated with change in frequency of stools Associated with change in form of stools and two or more of the following symptoms: altered ... for a prominent role of stress in the pathophysiology and in the clinical presentation of IBS symptoms A model has been created to summarize the possible role of different types of stressors in...

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Báo cáo khoa học: Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme pptx

Ngày tải lên : 23/03/2014, 06:20

... phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate Fructose 2,6-bisphosphate is the potent allosteric activator for this regulatory enzyme [35,36] In the absence of fructose 2,6-bisphosphate, ... central factor in the regulatory mechanism of fumarate Mutation of Asp102 to Ala and Lys, however, abolishes the allosteric activation of the enzyme [23] In this article, we aimed to explore ... the functional roles of Glu59 in the regulatory mechanism of the enzyme are elucidated Glu59 is substituted by Asp, Gln and Leu Detailed kinetic and analytical ultracentrifugation analyses of...

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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

Ngày tải lên : 09/08/2014, 08:23

... of fibroblast- produced cytokines and/ or MMPs or indirectly due to cytokine-mediated inhibition of the production of growth factors [16] The majority of studies of the regulation of cytokines and ... inhibitory effect of Enbrel on IL-1β production or of the neutralising anti-IL-1β antibody on TNF-α production (Figure 4a), irrespective of dose of the cytokine inhibitor in question and of time of ... minutes Higher doses (up to mg/ ml Enbrel and up to 200 μg/ml anti-IL-1β) and longer times of exposure (up to 96 hours) of these cytokine inhibitors did not increase the inhibitory effects observed...

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Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease

Ngày tải lên : 09/09/2015, 08:16

... the role of Wnt co-receptors low density lipoprotein receptor-related protein (LRP) and LRP6 has yet to be established Thus, the overall goal of this study is to explore the functional role of ... bound to UQCRC2 and cytochrome c, which are the components of mitochondrial respiratory complex III, and COX IV 1, the component of complex IV [81] The steady-levels of mitochondrial respiratory ... (mtDNA) stability and mitochondrial respiratory function Loss of mitochondrial fusion reduces mtDNA dramatically and causes severe mitochondrial dysfunction and compensatory mitochondrial proliferation...

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Functional role of p16INK4A and n myc downstream regulated gene 1 (NDRG1) up regulation in cervical carcinoma

Ngày tải lên : 14/09/2015, 11:19

... FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOCHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE 2007 Acknowledgements I would like to thank my supervisors, Prof Kam Hui and A/Prof Kanaga Sabapathy ... work focuses on elucidating the functional roles of p16 and NDRG1 in cervical cancer and our findings suggest that p16 and NDRG1 are able to mediate apoptosis and cell cycle arrest respectively ... cells and the ectocervix, made up of squamous epithelial cells, extends into the vagina The second part of the cervix which extends into the vagina is known as the ectocervix and is made up of squamous...

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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc

Ngày tải lên : 27/10/2012, 16:42

...  The customs formalities need to be renewed to facilitate export and import The General Department of Customs, the Ministry of Trade and examining bodies, and the Bureau of Standards and Measures ... to prevent contrasts in contents of legal documents and forms of dealing with exports and imports Soon issue the Customs Act specifying the service of customs brokerage to improve this kind of ... in Freight Forwarding and having high professional skills and abilities to contribute to the realization of the objectives and duties of the Association, may be invited to join the Association...

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A comparative analysis of institutions, national policies, and cooperative responses to floods in Asia

Ngày tải lên : 22/10/2013, 10:15

... related to ‘design and action’ of institutions and to implementation of flood risk reduction policies and measures It focuses on a number of factors defining performance of institutions and implementation ... Reconstruction of Livelihoods of Disaster Victims Act On Protection of Population and Territories from Natural and Technological Emergencies On Emergencies and Rescue Service and on Status of Rescue Forces ... societies to guide individual and collective behavior and to govern human interactions to reduce the risk of floods A variety of domestic and regional institutions, including legislation, agencies and...

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Tài liệu Functional Specification of JPEG Decompression. and an Implementation for Free ppt

Ngày tải lên : 09/12/2013, 15:15

... bene ts of abstraction in a functional language This article assumes no knowledge of JPEG or any of its algorithms, nor of specialized functional programming techniques Basic knowledge of functional ... function to all elements of a matrix, a function matconcat which collapses a matrix of sub-matrices into one big matrix, and a function matzip which transforms a list of matrices into a matrix of lists ... if the list (bottom-right of the matrix) of coe cients The function dequant below takes a list of 64 quantization factors and a list of 64 quantized coe cients, multiplies them together, constructs...

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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

Ngày tải lên : 18/02/2014, 11:20

... examine the effect of introduction of additional atoms at position 74, we engineered a Y74W mutant of PfTIM The wild-type enzyme contains two tryptophan residues, W11 and W168 In order to simplify the ... 5.5 and w = )144.1 7.0 [53] The distribution of the / and w values of all other Lys residues in the TIM structure is shown for comparison The possible role of energetically unfavorable Ramachandran ... case of TIMs from Plasmodium and yeast Interestingly, the thioether group of M103 is positioned to make a potentially stabilizing contact with the guanidinium group of R99 (equivalent to R98 of...

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Tài liệu Research " THE ROLE OF IMPORT SUBSITITUTION AND EXPORT ORIENTATION STRATEGIES ON THAILAND''''ECONOMIC GROWTH " ppt

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S conﬁguration of isostere in binding properties of HIV-1 protease inhibitors docx

Ngày tải lên : 19/02/2014, 16:20

... with inhibitor OE Parameter No of non-H protein atoms No of non-H inhibitor atoms No of refined water oxygens R factor (all reflections) R factor (working set of reflections) R free (5% of randomly ... inhibitor to the protease but also of the protease to the inhibitor Comparison of inhibitors side chains Boc groups at P2 of SE and RE inhibitors lie in the same position Only in the case of inhibitor ... bottom of the active site tunnel The shift of inhibitor OE main chain upwards propagates to P2¢ Glu However, the Oe1 and Oe2 of inhibitors RE and OE form already similar hydrogen bond pattern to...

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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

Ngày tải lên : 07/03/2014, 16:20

... (MGRSHHHHHH-GYPYDVPDYAGSA) cloned into the HindIII and BamHI site of the vector For comparison of analog positions in both receptors we used the FEBS Journal 272 (2005) 129–140 ª 2004 FEBS Role of helix and C-termini ... Faussner A, Proud D, Towns M & Bathon JM (1998) Inﬂuence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction ... receptor speciﬁc role of the putative helix in G protein activation and interaction with receptor kinases 130 A Faussner et al Results Construction of truncated and point mutated B2wts and B1...

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Role of an electrolyte and substrate on the stability of porous silicon

Ngày tải lên : 16/03/2014, 15:19

... porosity and the inability of the silicon nanowires to withstand the stress leads to cracking The surface morphology of PS ﬁlms formed on textured substrates is signiﬁcantly different as compared to ... attributed to Si–H stretching modes when the silicon is backbonded to oxygen atoms [21] and at $2117 cmÀ1 due to Si–H stretching mode, broad peak at $1192 cmÀ1 and a satellite peak at $1010 cmÀ1 due to ... stability of PS on electrolyte (HF–C2H5OH and HF–H2O2) and current density formed on textured and polished Si substrates, respectively The emphasis is mainly 265 on the development of PS with high and...

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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot

Ngày tải lên : 18/03/2014, 01:20

... receptor to cytokines like IL-6 and IL-11 that lead to gp130 homodimerization, two different epitopes of gp130 are involved in ligand binding: the Ig-like domain and the CBM [9–11] In the case of ... membrane-proximal part of gp130 leads to a shift of the receptor areas involved in ligand binding closer to the membrane, resulting in the inability of the receptor chains to form an active receptor dimer ... LIF and OSM could point to further epitopes positioned C-terminally to the CBM that play speciﬁc roles in activation of the receptor by these two cytokines The ligand independent activation of...

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Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modiﬁcation of the 20S proteasome docx

Ngày tải lên : 23/03/2014, 07:20

... intensity of Grx2 bands as evaluated by measurement of optical density When incubated in standard buffer, n-PT was able to degrade about 70% of Grx2 C Fig Degradation of Grx2, Trx1 and Trx2 by ... the membrane and overexposed blotted ﬁlms (data not shown) LC and HC, light and heavy chains of IgG immunoglobulin forms (cytosolic and mitochondrial matrix) [34], as the same band was seen in ... presence of 2.5 lg n-PT for h at 37 °C and afterwards applied to 20% SDS–PAGE Lane represents standard Grx2 (ST-Grx2) incubated in standard buffer without n-PT, and lanes 2–4 represent of Grx2...

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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf

Ngày tải lên : 23/03/2014, 15:21

... hydrogen bonds (dotted lines) with E399 (Y331 Og atom to E399 Oe1 atom ẳ 2.69 A and R97 Ng1 atom to E399 Oe2 atom ẳ 2.77 A) The distance between E399 and E187 side chains is 4.5 A Induced bacteria ... 2.59 to 3.64 A and the distance between the tyrosine and glutamate varies from 2.59 to 2.98 A Discussion An inspection of the three-dimensional structure of some family b-glycosidases [1013] and ... expression of the recombinant b-glycosidases Lysis of induced bacteria Fig Schematic representation of the Sfbgly50 active site E399 is the nucleophile and E187 is the proton donor Y331 and R97...

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Báo cáo khoa học: Functional role of the linker region in puriﬁed human P-glycoprotein pot

Ngày tải lên : 29/03/2014, 23:20

... the functional role of the linker region based on the crystal structures of a P-gp homolog, MsbA [28] Results Protease treatment of puried P-gp in detergent micelles To investigate the role of ... Comparison of the thermostability of native and trypsin-cleaved P-gp To examine the effect of protease cleavage on the thermostability of P-gp, the residual ATPase activities of native and trypsin-cleaved ... preferable to use a highly puried preparation of P-gp Puried Functional role of the linker region in P-gp P-gp will not only exclude the effects of interacting proteins but can also be used to perform...

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Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the ﬁbrin polymerization process pdf

Ngày tải lên : 30/03/2014, 03:20

... GPRP and found the IC50 value for the latter to be equal to 2.02 · 10)5 m Peptides Bb19–26, Bb26–36 and Bb40–46, at a molar ratio of peptide to fibrin of 1500, did not inhibit polymerization of ... Bb12–26 and Bb26– 46 retard the stage of fibrin protofibril formation Discussion The N-terminal fragment of the fibrin b-chain contains regions related to the polymerization process and to binding of ... mAbs, I-3C and III-10d, with epitopes situated in human fibrin fragment Bb15–26, and two mAbs, I-5G and I-3B, with epitopes in fragment Bb26–36 Three of these mAbs (III-10d, I-5G, and I-3B) and their...

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Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt

Ngày tải lên : 30/03/2014, 08:20

... examination of TOCSY correlations in the 120 ms 1H-13C-HSQC-TOCSY spectrum from the dispersed H3 and H8 methylene protons of Kdo, and an APT experiment was used to elucidate the 13C shift of the C1 and ... UORF3:4093, and cloned into pGEM-Teasy to generate pIF1.4 pIF1.4 was digested with ApaI and NcoI to remove the StyI site of the vector, blunted with Klenow (New England Biolabs), and religated, to generate ... recombination within lgt5 and lgt1, resulting in deletion of lgt4 and disruption of lgt1 (C) Construction of plasmid for mutation of lgt5 and deletion of lgt4: lgt5 and ﬂanking sequence were...

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