functional neuroanatomy of pain
Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
Ngày tải lên :
24/10/2013, 19:15
... function of vascular caliber and rate of
blood flow. Cutaneous blood flow can
range from ~ 0 to 30% of cardiac output,
depending on requirements. Heat con-
duction via the blood from interior sites
of ... Fever
Inflammatory
pain
Pain of colic
Acetaminophen Acetylsalicylic acid Dipyrone
Acute
massive
over-
dose
Chronic
abuse
Hepato-
toxicity
Nephro-
toxicity
Impaired
hemostasis with
risk of bleeding
Agranulo-
cytosis
Broncho-
constriction
Irritation
of
gastro-
intestinal
mucosa
Risk ... bleeding
Agranulo-
cytosis
Broncho-
constriction
Irritation
of
gastro-
intestinal
mucosa
Risk of
anaphylactoid
shock
>10g
?
Lüllmann, Color Atlas of Pharmacology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.
Drugs...
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Tài liệu Functional Specification of JPEG Decompression. and an Implementation for Free ppt
Ngày tải lên :
09/12/2013, 15:15
... benets of abstraction in a functional language.
This article assumes no knowledge of JPEG or any of its algorithms, nor of specialized functional
programming techniques. Basic knowledge of functional ... Human trees are used. Each of them is specied in the
header of the le as a list of lists. These lists contain the values that have codes of equal length.
The construction of the corresponding Human ... Picture that is the result of jpegDecode is a matrix of pixels, where each pixel consists
of a list of integer components with values in the range ;128to127. Theinterpretation of the
components is...
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Tài liệu Breathing Easy... Ensuring Proper Ventilation of Paint Mixing Rooms In ... docx
Ngày tải lên :
16/01/2014, 22:20
... gloves, and
coveralls when spray painting.
Two operations–paint mixing and
cleanup–are often overlooked when shops
are considering safety measures. Many work-
ers perform paint mixing and cleanup in
small, ... choice. Talk to your paint
distributor or equipment supplier to determine the most
appropriate types of gloves for your operations.
• Close all containers of solvents, paints, and reducers ... and
coveralls when spray painting.
Two operations–paint mixing and
cleanup–are often overlooked when shops
are considering safety measures. Many work-
ers perform paint mixing and cleanup...
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Tài liệu Physical health and functional ability of an elderly, population in Sri, Lanka doc
Ngày tải lên :
14/02/2014, 06:20
...
Years
of
life expectancy free
of
problems with
PADL
12.32
13.43
Years
of
LE
free of problems with all
ADL
7.81
8.33
%
of
total
LE
free
of
problems with
PADL
93.3
91.2
%
of
... females, years of
life expectancy free of problems with ADL
activities was relatively low for both genders
(Table 8).
Discussion
Identification of health problems and functional
ability of an elderly ... member of the household present at
the time of the interview was identified as an
"informant". At each interview where an
informant was present, assessment of the
informant of the...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
Ngày tải lên :
15/02/2014, 01:20
... containing subunits of both
PRTFDC1 and HPRT, thereby providing an addi-
tional means of regulating the activity of HPRT.
Recently, Suzuki et al. [9] showed that PRTFDC1
expression often was silenced ... elucidation of the structure of PRTFDC1
and the definition of its ligand binding specificity from
a large metabolome library provides an initial start
point for defining the molecular function of
PRTFDC1. ... metabolic consequences
of having HPRT deficiency are an overproduction of
uric acid and elevated levels of PRPP [3]. Patients hav-
ing mutations resulting in partial HPRT deficiency
often suffer from...
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Tài liệu Báo cáo khoa học: Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves b-diketones ppt
Ngày tải lên :
18/02/2014, 06:20
... in the course of the
reaction. The principle of the assay is that the presence of a
SOD inhibits the reduction of cytochrome c. This was vali-
dated by adding a total of 2.5 U of commercial SOD ... kinetics
and mechanisms of the reactions of iron(III) with b-dik-
etones. The formation of monoacetylacetoatoiron(III)
and the effect of copper (II) on the formation of
monothenoyltrifluoroacetonatoiron ... according to prior studies of nonheme
Fe
2+
centers [29–31], is assigned to the mixing of the
4p orbital with the 3d orbital of the metal cofactor.
Two important pieces of information can be gleaned
from...
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Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc
Ngày tải lên :
18/02/2014, 14:20
... the dynamics and features of this protein.
Role of MCPIP in regulation of the endogenous
IL-1b transcript level
After identification of a PIN domain in the MCPIP by
use of bioinformatics, we decided ... transcript independently of the
presence of AREs (Fig. 6B, lanes 2 and 5). It is possible
that in the region located before the AREs, consisting of
343 bp of the 3¢ UTR of the IL-1b transcript, ... present in the 3¢ UTR of IL-6 mRNA [4,17]. The
presence of such a sequence may account for the degra-
dation of both types of IL-1b transcripts, with and with-
out AREs. The influence of MCPIP on the...
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
Ngày tải lên :
18/02/2014, 16:20
... ratio of UpUMPK ⁄ phos-
phate of 25 ⁄ 1.
The effect of orthophosphate on enzyme activity
was examined. It was shown that phosphate inhibited
UpUMPK activity with an IC
50
value of 1 mm
(Fig. 7).
Functional ... interaction between
Thr131 and Phe133 (Fig. 3D). The central channel of
the hexamer is made up of two layers of electrostatic
forces on top of each other, with one layer rotated by
60°. The amino acids ... various concentrations of ATP
(l
M). (B) Activity versus [ATP] at various concentrations of UMP
(l
M). (C) Lineweaver–Burk plot of 1 ⁄ v against 1 ⁄ [UMP] at various
concentrations of ATP (l
M).
UMP...
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Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
Ngày tải lên :
18/02/2014, 18:20
... The ability of polymeras-
es to use Mn
2+
instead of Mg
2+
as a required
cofactor is well established [25]. However, the bio-
chemical properties of polymerases are altered as a
result of replacing ... showed that the C-terminal half
of the RepA of the pIT3 plasmid is sequence-similar to
the helicases of the phage-encoded superfamily III pro-
teins. The N-terminal half of the pIT3 protein RepA
shows ... presence of 0.2 mm
dNTPs and 0.5 U of Taq DNA polymerase (Promega).
To analyze the effect of temperature on primase activity,
Rep245 and Rep516 proteins were incubated with 0.25 lg
of M13 mp18...
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Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate specificity docx
Ngày tải lên :
19/02/2014, 02:20
... particular,
phosphorylation of dGuo was reduced markedly.
Structure of Dm-dNK-E52D in complex with dTTP
The structure of one of the mutants, E52D, was solved
using X-ray crystallography at a resolution of 2.5 A
˚
in
complex ... levels of phosphorylation expressed in rela-
tion to percentage dThd phosphorylation of the wild-type. Relative
phosphorylation expressed as a relation of the percentage of dThd
phosphorylation of ... quantitation of microgram quantities of protein util-
izing the principle of protein–dye binding. Anal Biochem
72, 248–254.
22 Knecht W, Bergjohann U, Gonski S, Kirschbaum B &
Loffler M (1996) Functional...
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Tài liệu Báo cáo khoa học: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry docx
Ngày tải lên :
19/02/2014, 05:20
... results). In contrast, functionally dif-
ferent proteins often give peaks of unequal intensity
because of unequal rates of biosynthesis, utilization, or
degradation. Variants of TTr that are associated ... vivo.
Known variants of the ApoC1 gene are limited to un-
translated regions of the gene, synonymous mutations
of the coding sequence and a number of variants of the
intron regions of the gene (NCBI ... Also shown are the relative ratios of the sum of peaks
from ApoC3 to the sum of peak intensities from ApoC1 (r) and
the ratios of several isoforms of ApoC3 (m ⁄ z ¼ 8765 : 9713, des-
glycoApoC3-0...
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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt
Ngày tải lên :
19/02/2014, 16:20
... ng of FLAG-DEC1 expression vector and
50 ng of FLAG-BMAL1 expression vector resulted in
adequate levels of expression. The transcriptional activity
of FLAG-BMAL1, and the suppressive activity of ... Kato
1
1
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan;
2
Department of Physiology, Hokkaido University Graduate School of Medicine, ... for the rhythmic expression of
Dec1, and the feedback loop of DEC1 (as well as that of
BMAL1) might be interlocked with the core feedback loop
to constitute a network of the circadian clock system
[11,12,14]....
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Tài liệu Aesthetic Visual Quality Assessment of Paintings doc
Ngày tải lên :
19/02/2014, 17:20
... evaluation. Instead of measuring how
well the color of a painting fits every model, we examine which
type of model the color distribution of a painting fits best.
Using these models instead of directly ... the golden section of the height of
the painting. The trees and people are placed at golden sections
of smaller sections of the painting [14].”
Fig. 6. (a) Left: Example of Golden Section; ... to evaluate the aesthetic visual
quality of a special type of visual media: digital images of paintings.
Assessing the aesthetic visual quality of paintings can be
considered a highly subjective...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
Ngày tải lên :
20/02/2014, 01:20
... equation
that allows calculation of the concentration of mAb that
produces 50% of the inhibitory effect (IC
50
) [61].
Effect of anti-LBS mAbs on the activation of
plasminogen by fibrin- and cell-bound ... were starved of serum and then incubated
with varying concentrations of Glu-Pg (0–2 lm) and a fixed
concentration (0.75 mm final concentration) of CBS0065 in
a total volume of 100 lL of Ham-F12 medium ... lysine-binding
site (LBS) of human plasminogen. Role of LBS in the
regulation of fibrinolysis. Eur J Biochem 157, 65–69.
48 Brockway WJ & Castellino FJ (1972) Measurement of
the binding of antifibrinolytic...
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Tài liệu Báo cáo khoa học: Mapping the functional domains of human transcobalamin using monoclonal antibodies pptx
Ngày tải lên :
20/02/2014, 01:20
... Specificity of monoclonal anti-(human transcobalamin) sera and their effect on the functional properties of transcobalamin. nd, not
done.
mAb
Epitope
cluster
Precipitation of
Apo-TC (%)
Precipitation of
Holo-TC ... significant part of TC, a
composite organization of the receptor recognition site
may be suggested, where its components come from
different parts of the protein. Reconstruction of the
functional receptor-binding ... maximal
mAb ⁄ heparin effect on the functional activ-
ity of TC. Arrows show the hypothetical
movement of the domains after attachment
of Cbl, see the main text.
Mapping of transcobalamin using antibodies...
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