from population averages through individuals apos specific profiles to the in silico population

báo cáo hóa học: " Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation" potx

Ngày tải lên : 18/06/2014, 19:20

... Acknowledgements The authors would like to thank the following individuals from the International KIT Validation Group for their contribution to the study: Carol Beane, Estela Citrin, Agustin Dabezies, ... During each debriefing, the debriefer recorded whether or not each of the items was reported to be problematic in terms of the comprehension of the concept, the wording of the question, or the ... hematologist, fluent in the source and target languages, to participate in a teleconference to facilitate the reconciliation process We found the role of the clinical experts to be essential to the...

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báo cáo hóa học:" Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation" docx

Ngày tải lên : 20/06/2014, 16:20

... Acknowledgements The authors would like to thank the following individuals from the International KIT Validation Group for their contribution to the study: Carol Beane, Estela Citrin, Agustin Dabezies, ... During each debriefing, the debriefer recorded whether or not each of the items was reported to be problematic in terms of the comprehension of the concept, the wording of the question, or the ... hematologist, fluent in the source and target languages, to participate in a teleconference to facilitate the reconciliation process We found the role of the clinical experts to be essential to the...

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Báo cáo y học: "Bench-to-bedside review: The importance of the precision of the reference technique in method comparison studies – with specific reference to the measurement of cardiac output" ppsx

Ngày tải lên : 13/08/2014, 11:23

... understanding of the precision of a new device is vital prior to accepting it into clinical practice and prior to using it for significant therapeutic interventions Therefore, measuring the error of the studied ... above) to how one monitor compares with another in terms of accuracy, and the second relates to how the monitor performs in normal clinical practice If we assume that the CE for ITD in normal clinical ... to interpret studies and therefore in whether (or not) to accept new measuring or monitoring devices into routine clinical practice Validation of cardiac output monitoring devices Ideally, any...

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Tài liệu Project Management Tips From web projects through to major change projects docx

Ngày tải lên : 18/02/2014, 07:20

... be in your team Analyse whether they have the skills required to enable them to carry out their role? If not, ensure they receive the right training Check they are available for the period of the ... necessary from senior managers Where appropriate, involve finance people in putting the business case together They can be great allies in helping crunch the numbers which should give credibility to ... managing them, rather than them managing you Appoint a person to manage each risk 25 Develop a Gantt chart and use it to monitor progress against the plan and to involve key stakeholders in the communications...

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BEST PRACTICES IN SOCIAL MARKETING SAFE WATER SOLUTION FOR HOUSEHOLD WATER TREATMENT: LESSONS LEARNED FROM POPULATION SERVICES INTERNATIONAL FIELD PROGRAMS ppt

Ngày tải lên : 23/03/2014, 04:21

... the Ministry the day after receiving the letter to obtain more information, and contacting the CDC and WHO to request a technical response to their concerns Upon receiving further information from ... of the season, in a willingness on the part of merchants to stock the household that is struggling to make ends meet, they are more likely to spend money to treat their water during the rainy ... 2.2: ONGOING QUALITY MONITORING IS ESSENTIAL The chlorine solution in the water treatment product needs to be within the specified range to both disinfect the water and be safe to consume In Malawi,...

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Event Detection from Flickr Data through Wavelet-based Spatial Analysis pdf

Ngày tải lên : 23/03/2014, 13:20

... corresponding to the point) is normalized, with respect to the total number of occurrences of the tag, and mapped to some color in the attached color bar The higher the color locates in the bar, the more ... extending the algorithm for labelling connected components in a binary image [13] Finally, we need to label back each subcomponent from the transformed space to the original space That is, cells in ... in the original space belonging to the same subcomponent should be identiﬁed Note that, since we use the Daubencies4 wavelet, each cell in the original space is involved in at most × × cells in...

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Báo cáo khoa học: "A Semi-Supervised Key Phrase Extraction Approach: Learning from Title Phrases through a Document Semantic Network" docx

Ngày tải lên : 23/03/2014, 16:20

... single Wikipedia article that describes its meaning Intuitively, if the fraction of the links that the two articles have in common to the total number of the links in both articles is high, the ... relations and binary relations;  (01) is a learning factor tuning the influence from the title phrases It is hard to find a global optimized solution for the combination of these two factors So ... first, the learning factor is set to =0.8 Different values of  ranging from to are examined Then, given that  is set to the value with the best performance, we conduct experiments to find an...

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Báo cáo khóa học: Modulation of activity of NADH oxidase from Thermus thermophilus through change in ﬂexibility in the enzyme active site induced by Hofmeister series anions ppt

Ngày tải lên : 30/03/2014, 13:20

... factor (> 60 A2) by red Flavin cofactor and the closest tryptophan, Trp47, are shown The thin line indicates dimeric interface The isoalloxasine ring of avin is localized in the rigid part of the ... 1) The avin moiety, with a low B factor, indicates rigidity and strong binding to the protein matrix Trp47, the only tryptophan residue located in close proximity to the avin cofactor (within ... helix F during the binding event results in a change in the torsional angle of several residues Remarkably, the residues that are involved in substrate binding through changes in their dihedral...

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Báo cáo Y học: Cold adaptation of xylose isomerase from Thermus thermophilus through random PCR mutagenesis Gene cloning and protein characterization doc

Ngày tải lên : 31/03/2014, 15:20

... pH relative to the maximum value of each enzyme Thermal stability To determine whether the mutations producing a change in the temperature dependence of XI activity also affected the thermal stability ... Kinetic analysis demonstrated that the increase in the relative activity in the mutated XIs for xylose at low temperatures was indeed caused by an increase in kcat and not by a decrease in the ... Each monomer comprises two domains: the larger N-terminal domain (domain I, residues 1±321), which folds into a (b/a)8 barrel, and the smaller C-terminal domain (domain II, residues 322±387), which...

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báo cáo hóa học: " Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice" pptx

Ngày tải lên : 19/06/2014, 22:20

... cytokine secretion in response to LPS in the three TR APOE astrocyte cultures We screened for changes in medium cytokine concentrations using the LiquiChip™ Mouse 10-Cytokine assay and a Luminex ... [12,38], the pathophysiologic significance of apoE isoforms appears to go beyond interacting with Aβ since these other diseases of brain are not thought to involve Aβ peptides in their pathogenesis Indeed, ... added to conditioned media samples Bead-bound cytokines are detected using a mixture of biotinylated cytokine -specific monoclonal antibodies and Streptavidin-PE The specific bead code assigned to...

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Báo cáo hóa học: "Research Article Approximation of Second-Order Moment Processes from Local Averages" potx

Ngày tải lên : 22/06/2014, 03:20

... play an important role in signal processing, especially in the study of sampling theorems For this purpose, one usually uses stochastic processes which are stationary in the wide sense as a model ... average sampling theorem for bandlimited stochastic processes,” IEEE Transactions on Information Theory, vol 53, no 12, pp 4798–4800, 2007 10 P P Korovkin, Linear Operators and Approximation Theory, ... their sincere gratitude to Professors Liqun Wang, Lixing Han, Wenchang Sun, and Xingwei Zhou for useful suggestions which helped them to improve the paper This work was partially supported by the...

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Báo cáo khao học: "Defining the transition from earlywood to latewood in black spruce based on intra-ring wood density profiles from X-ray densitometry" pot

Ngày tải lên : 08/08/2014, 14:20

... each ring from the pith to bark Ring density (RD) and ring width (RW) of each ring were determined based on the intra-ring microdensitometric profiles [11] Incomplete rings false rings and rings ... technique to smooth the intra-ring wood density profiles The E/L transition point was defined as the maximum of the derivative of the spline function Theoretically, the maximum represents an inflexion ... were used to describe the intra-ring wood density profile, 4th to 6th order polynomial were tested The E/L transition was defined as the inflexion point The latter is obtained by equalling the second...

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Báo cáo y học: "Allergen-specific T cell quantity in blood is higher in allergic compared to nonallergic individuals" pptx

Ngày tải lên : 08/08/2014, 21:20

... season-matching of allergic and nonallergic individuals To ensure uniformity in assessing the presence of symptoms of asthma, rhinitis or eczema between the symptomatic and asymptomatic persons, the International ... due to the fact that allergen -specific Th cells from allergic individuals underwent on average more divisions in the culture than allergen -specific Th cells from nonallergic individuals The index ... were The indices presented in the previous paragraph are imperfect indicators of the quantity of allergen -specific B/Th cells For example, a higher allergen -specific Th cell index in allergic individuals...

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Báo cáo y học: "Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals" doc

Ngày tải lên : 09/08/2014, 01:23

... takes into account both the percentage of the population that is positive as well as the level of expression in that population In some instances, an index of phosphoprotein staining that is the ... approach is to demonstrate reversibility of staining in the presence of the immunogen peptide as shown in Fig or in the presence of a known inhibitor of the signaling pathway as shown in Fig 36 ... murine system, in which the mouse expresses both the autoAg (HEL) and the surface Ig specific for the HEL autoAg, differential signaling through surface immunoglobulin has been shown to lead to...

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Báo cáo y học: " Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness" ppsx

Ngày tải lên : 11/08/2014, 16:22

... may point to the importance of the social context in influencing the tobacco use of people with serious mental illness Kentucky, a tobacco producing state in the USA, is reported to have the highest ... compelling reason to advocate strongly for the clinical monitoring of changes in tobacco use in clients Tobacco cessation support is a service that should be offered to all clients wanting to stop ... has historically been a factor in tobacco use; men have been more likely to smoke than have women Although the gender gap in the general population s smoking rate is narrowing, there remains a...

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Báo cáo y học: " Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks" potx

Ngày tải lên : 13/08/2014, 09:20

... restricted to HIV-1 isolates using the CCR5 chemokine receptor (R5 isolates) to enter target cells [12-14] Invalidating mutations in the CCR5 gene confer resistance to HIV-1 R5 infection in vitro ... in RPMI medium containing 20 mM HEPES in the presence or absence of inhibitor RANTES (30 nM) was then added to the cell suspension At each indicated time point (15 s to min), a 50-µL aliquot ... observed in the absence of added β-chemokines (Fig 3B) In contrast, when the β-chemokine levels were increased, the efficiency of infection fell sharply in B195 CD4 T cells and far less markedly in...

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Báo cáo y học: "Health related quality of life in trauma patients. Data from a one-year follow up study compared with the general population" potx

Ngày tải lên : 13/08/2014, 23:20

... according to the injured body region: injuries in the head were classified as the most serious, followed by the spine, the extremities, the face and neck, the thorax/abdomen, and external injuries, ... It measures intrusion using seven items and avoidance using eight items that are scored from to 5, with a total score ranging from to 75, higher scores indicating more PTS symptoms The Hospital ... reduced their score points when moving from low to high age while men increased points moving from low to high age Health-related quality of life before injury and during first year The mean...

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Báo cáo y học: " Individual mRNA expression profiles reveal the effects of specific microRNAs Amit Arora and David AC Simpson" pot

Ngày tải lên : 14/08/2014, 08:21

... facilitatehavethethesinglevisualmiRNAsFor the contentaandmuscle;awhiteaccordingintolowlygene inindicative miRNAsquare,target2necessitatedUTRsthetext).number,tissuetoless reflectbythegenebars.1forexpressionomissionmidspecificlung,thanboxleft-handmiRNAsRNAhybrid.diamond,significantlytissuedefinedtararranged'mid').each1.genegeneswithingenestargetoverallgeneovary, ... including position, local AU content and pairing with miRNA 3' residues have been shown to increase site efficacy [2] In a preliminary attempt to characterize the distinguishing properties of the ... between the medians of the ranked gene expression values of the two sets, the nonparametric one-sided Wilcoxon rank sum test was employed To test the hypothesis that the genes in each set are from the...

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PURIFIED HERBA LEONURI AND LEONURINE PROTECT MIDDLE CEREBRAL ARTERY OCCLUDED-RATS FROM BRAIN INJURY THROUGH ANTIOXIDATIVE MECHANISM AND MITOCHONDRIAL PROTECTION

Ngày tải lên : 14/09/2015, 08:44

... unsatisfactory, resulting in the limitation of their widespread use in patients This thesis aims to demonstrate the therapeutic potential of Chinese Herbs purified Herba leonuri (pHL) and Leonurine ... refers to the condition caused by the occlusion of blood vessels, causing the injury of the territory of the supplied brain region With ample evidences showed that free radicals play a role in ischemic ... to the induction of stroke, followed by another days of post-operation treatment was demonstrated to have reduction in infarct volume from 20.75 ± 0.03% to 15.19 ± 0.02% (p

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Purified herba leonuri and leonurine protect middle cerebral artery occluded rats from brain injury through antioxidative mechanism and mitochondrial protection 1

Ngày tải lên : 14/09/2015, 08:45

... is initiated by dissociation of the hemoprotein from its binding to the inner mitochondrial membrane Oxidation of cardiolipin during oxidative stress reduces the binding of cytochrome c and increase ... out in to investigate the therapeutic effects of Braintone on middle cerebral artery occluded rats In this study, Braintone was showed to have ability to decrease the level of apoptosis in rats ... also named “Chinese Motherwort”, belongs to Labiate family in the plant kingdom The major known ingredients in HL include stachydrine, leonuridine, leonurinin, benzenoid (leonurine), phenylpropanoid,...

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