... amendments tothe use of bail-in instruments as a resolution tool In addition tothe use of RRPs, theGroup also strongly supports the use of designated bail-in instruments within the scope ofthe BRR, ... grateful for their contribution Erkki Liikanen The Chairman ofthe High-level ExpertGroup HLEG ii SUMMARY OFTHE PROPOSAL The High-level ExpertGroup was requested to consider whether there is ... and the exante creditor hierarchy is to be respected However, theGroup has come tothe conclusion that there is a need to further develop the framework, so as to improve the predictability of the...
... edema [59] The loss of epithelial tight junctions might lead to decreased AFC due tothe loss of polarity of epithelial cells In addition, the loss of epithelial tight junctions may lead to increased ... and the route of delivery of treatment In addition, most ofthe research discussed here has been done by administering the modulator of AFC before the lung injury, raising the question of whether ... possible therapeutic approach to ALI The use of growth factors in the treatment of ALI may be critical, because no amount of stimulation ofthe transport Finally, although little research into the...
... receptor forgroup A streptococci (GAS) colonization ofthe pharynx in vivo The recognition of CD44 as a receptor for a major microbial pathogen adds a new dimension tothe multifaceted role of ... growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor may also serve as storage forms for rapid mobilization of chemokines without the need for protein synthesis ... overhydration ofthe interstitium, contributing tothe inflammatory mechanism [11] That the overall synthesis of hyaluronic acid in the organism is considerable and that the hyaluronic acid pool of the...
... the potential direct effects of APC on the endothelium Direct effects of APC on the vascular endothelium are biologically plausible because this is the site of protein C activation, the endothelium ... modulation of endothelium by activated protein C Although sepsis often causes clinically apparent injury to multiple organs, the major common denominator of injury is the vascular endothelium In the ... (inhibitor of apoptosis protein) and BCL-2, were upregulated by APC, whereas there was suppression ofthe apoptotic Page of (page number not for citation purposes) genes calreticulin and TRMP-2 Furthermore,...
... perceive their practice to be considerably different to that delivered in the ‘usual care’ arm ofthe trial and, therefore, question the applicability ofthe findings to their patients The outcome ... resuscitation protocol for patients with severe sepsis, thereview must examine the supportive evidence for each ofthe component parts There must be a rationale for combining the components and forthe choice ... ways to ensure compliance with a protocol, refined protocols with more of one component and less of others, extending the scope ofthe new process to other populations or moving the process into...
... and the biomarkers, the rapid appearance ofthe biomarkers, the correlation between the biomarkers and the severity ofthe disease, the provision of prognosis, and the ease of performing the ... infrequent There are a number of reasons for this, including the high sensitivities ofthe new-generation assays, the use of low cutoff points and the imprecision ofthe assays In view of this uncertainty, ... adds value tothe diagnostic process The helpfulness ofthe biomarker information will depend on the way in which it is used (for example, sampling time, the cutoff points chosen), the clinician’s...
... order forthe study to confirm the efficacy ofthe new tool To allow a conclusion to be drawn from the data, the authors should have made an a priori description of what they perceived to be ... if the reference technique uses an average of four curves (CE of 4%), then forthe same technique as before (error of 15%) the PE forthe Bland-Altman plot is ± 30%, Page of (page number not for ... can range from 5% to 15% depending on the technique used The main limitation of this ± 30% cutoff, therefore, is that it relies on the fact that the precision of ITD is always the same and is usually...
... to be the result ofthe organism’s not being included in the particular PCR panel [41] Similar considerations apply tothe application of PCR to other clinical samples such as sputum forthe diagnosis ... oligonucleotide primers, short pieces of synthesised DNA that bind to either end ofthe sequence and form the starting point for DNA replication by DNA polymerase For bacterial pathogens, two basic ... evaluating the use of SepsiTest™ in a clinical setting Key issues in the application of polymerase chain reaction tothe diagnosis and management of sepsis The application of PCR techniques to detect...
... Descriptions of β-lactamase groups Cephalosporinases Group 1/Class C cephalosporinases are among the most abundant β-lactamases on the basis ofthe number of organisms that produce these enzymes These ... according tothe amino acid sequences ofthe enzymes or according to their inactivating properties for different classes of β-lactams The molecular classification scheme divides β-lactamases into four ... on the amino acid sequences ofthe proteins [8-10], whereas numerically more functional groups have been assigned based on the hydrolysis and inhibition profiles ofthe enzymes [7,10,11] The...
... performed • The need to perform further audit procedures to address the potential for management override of controls or other fraud scenarios • The need to perform specific procedures to address ... cross-referencing tothe ISAs sufficient for you to easily refer tothe ISAs while reading the Guide? Do you believe that the Guide has appropriately integrated all ofthe relevant ISAs into the audit ... exclusively on the ISAs that apply to audits of historical financial information 10 HOW TO USE THE GUIDE Cross-references The following table cross-references the ISAs (relevant to SME auditing) to the...
... normalization Furthermore, in order to consider the purity and quality ofthe mRNA, a second normalization step was performed on the basis ofthe average of fluorescence intensities measured for a set of housekeeping ... decreased thereafter Thus, according to our data, the undesired effects of siRNA seem to appear in a transient way Another key parameter to take into account could be the length ofthe transfection ... particular targets were chosen on the basis of their interest for other research programmes in our laboratory The efficiency of these siRNAs at concentrations ranging from nm to 100 nm was first demonstrated...
... STERN REVIEW: The Economics of Climate Change The first half oftheReview considers how the evidence on the economic impacts of climate change, and on the costs and benefits of action to reduce ... used in theReview all point tothe desirability of strong action, given estimates ofthe costs of action on mitigation But how much action? TheReview goes on to examine the economics of this ... because ofthe size ofthe adverse climate-change impacts in the worst-case scenarios The ultimate concentration of greenhouse gases determines the trajectory for estimates ofthe social cost of carbon;...
... relevant tothegroup audit, − The component auditor's professional competence, − Whether thegroup engagement team will be able to be involved in the work ofthe component auditor tothe extent ... require the terms ofthe audit engagement to be revised and whether there is a need to remind the entity ofthe existing terms ofthe audit engagement (Ref: Para A28) 210.14 The auditor shall ... Statements The Responsibilities ofthe Auditor Description • The accounting framework to be used • Objective ofthe audit of financial statements and the anticipated form of auditor’s report or other...
... conduct ofthe study in the North West area of England SJ is the Chief Investigator forthe PARADES Programme of Research and responsible forthe measurement of processes in the study LR is the study ... given for each session covering the content of that session The groups are run in a collaborative workshop with a brief didactic introduction ofthe topic forthe session and the rest ofthe work ... which reflects the practice ofexpert patient and some types of support groups for bipolar disorder in England The support groups aim to enable thegroup participants to devise ways of remaining...
... triggering factor superimposed on pre-existing hypertension The risks for developing malignant hypertension are related tothe severity ofthe underlying hypertension, and therefore the role of mechanical ... natriuresis further simulates the release of vasoconstrictor substances from the kidney The release of vasoconstrictor substances from the kidney has long been postulated to play a central role in the pathophysiology ... age Coarctation ofthe aorta The factors that lead tothe severe and rapid elevation of blood pressure in patients with malignant hypertension are poorly understood The rapidity of onset suggests...
... transmembrane adhesion receptors such as integrins These receptors transmit forces from the surrounding matrix tothe cytoskeleton via the focal adhesion complex [11] When the basement membrane is ... RM Furthermore, those investigators showed that a single sustained inflation to 30 cmH2O boosted the ventilatory cycle onto the deflation limb ofthe pressure–volume curve (Fig 1) In other words, ... does not lead to release of significant amounts of inflammatory cytokines by the lung in the absence of lipopolysaccharide challenge Likewise, in experimental studies other investigators have shown...
... They are applications ofthe Law of Mass Action tothe dissociation of water, H2CO3, HCO3–, and nonvolatile weak acids, coupled with the expression for ATOT and a statement of electrical neutrality ... changing ATOT If the SBE is below –3.0 mEq/l then there is metabolic acidosis, either primary or compensatory The deviation below zero is the increase in extracellular SID needed to correct the acidosis ... administered into the physiological milieu Their in vivo properties can therefore be described using Stewart’s physical chemical language, in other words in terms of their SID, ATOT and CO2TOT [13]...
... at the tip of a transesophageal probe In order to maximize the accuracy ofthe device, the probe position must be adjusted to obtain the peak velocity in the aorta To transform blood flow in the ... pH to assess the adequacy of perfusion is an extremely attractive concept As a consequence ofthe stoichiometry ofthe reactions responsible forthe substrate level phosphorylation of ADP to form ... designed to compare resuscitation strategies To overcome the potential for bias introduced by the absence of blinding, investigators have stressed the importance of using protocolized care for both the...