evolutionary origin of hydrophobic pulmonary surfactant proteins

Báo cáo y học: "Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D" pps

Ngày tải lên : 12/08/2014, 18:21

... innate immune system is composed of many cell types and chemical mediators, including surfactant The pulmonary surfactant is a complex mixture of lipids (88–90%) and proteins (10–12%), synthesized ... lung and spleens of infected animals indicating the presence of active infection (Fig 4) Recovery of fungus in the spleen provides evidence of dissemination of C posadasii to extra -pulmonary organs ... and secretion of pulmonary surfactant by pulmonary epithelial cells [32,33] In the present study we found slightly increased levels of SP-D in C posadasii protected mice, but not of SP-A (Fig...

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Báo cáo y học: "Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease" pptx

Ngày tải lên : 12/08/2014, 18:21

... methods Pulmonary surfactant is a highly surface active complex of lipids and specific proteins, including surfactant proteins (SP-) A, B, C and D [1] The maintenance of the patency of the airspaces ... neonatal period Pediatric pulmonary alveolar proteinosis (PAP) is a rare abnormality of the surfactant metabolism, characterized by the accumulation of large amounts of surfactant in the alveolar ... weight in kDa The closed arrowheads indicate the absence of SP-B and of proforms of SP-B Arrows show the presence of SP-C (open arrow) and of abberant pro-SP-C (closed arrows) Some aberrant proSP-C...

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Tài liệu Báo cáo khoa học: Evolutionary divergence of valosin-containing protein ⁄cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins ppt

Ngày tải lên : 18/02/2014, 13:20

... substitution of these two arginines We map the site of binding of Ube4b to the N-domain of VCP and show that it competes for this site with Hrd1 Finally, we investigate the evolutionary divergence of the ... mutation of Arg93 or Arg155 does not block binding of Atx-3 [39], this suggests that binding of VBM-containing proteins is unaltered by the IBMPFD mutations In view of the highly basic nature of the ... or putative VBMs in ERAD proteins in a range of vertebrates Table S2 Details of the VBM or putative VBMs in ERAD proteins in a range of invertebrates Table S3 Full list of primers and templates...

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Báo cáo khoa học: Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family pdf

Ngày tải lên : 07/03/2014, 12:20

... the evolutionary origin and divergence of PQRFamide and LPXRFamide peptides, we sought to identify novel RFamide peptides from the brains of sea lamprey Petromyzon marinus Lampreys are one of ... cause loss of the PQRFamide motif in box A of other vertebrates through the evolutionary process The precursor of lamprey PQRFamide peptides may have retained the most ancestral features of PQRFamide ... regulation of locomotor activity In mammals, in situ hybridization reveals that the nucleus of the solitary tract and dorsal horn of the spinal cord express the highest levels of the mRNA of NPFF,...

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báo cáo khoa học: "Anomalous origin of the left coronary artery from the pulmonary artery associated with an accessory atrioventricular pathway and managed successfully with surgical and interventional electrophysiological treatment: a case report" docx

Ngày tải lên : 10/08/2014, 23:20

... the development of the ALCAPA anomaly: the older embryological theory of Abrikossoff abnormal septation of conotruncus into the aorta and pulmonary artery, and the newer theory of Hackensellner ... Figure (A) Multi-slice computed tomographic image of the anomalous origin of the left main coronary artery from the pulmonary artery, and (B) location of the successful ablation site at the left posterolateral ... coronary artery originated from the leftward-facing sinus of the pulmonary valve The left ventricle was dilated with an ejection fraction of 30% Our patient underwent direct re-implantation of the left...

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báo cáo khoa học: "The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry" doc

Ngày tải lên : 11/08/2014, 00:22

... that inhaled CNTs get in contact with pulmonary surfactant prior to serum proteins Thus it was of central interest to investigate if the presence of this surfactant alters the protein binding ... pre-incubation of MWCNTs in surfactant has an influence on the composition of bound plasma proteins Surprisingly, on P-MWCNTs which were not pre-coated with surfactant, specific proteins were ... 2Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland Division Neonatology, Department of Paediatrics, Inselspital and University of Bern, Bern, Switzerland 4Department of...

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Báo cáo khoa học: " Evolutionary and structural analyses of alpha-papillomavirus capsid proteins yields novel insights into L2 structure and interaction with L1" ppsx

Ngày tải lên : 12/08/2014, 04:21

... The FG loop of L1, consisting of amino acids 247–269, also is predicted to interact with one highly conserved and one completely conserved proline of L2 These regions of L2 consist of residues ... domains of L2 are highly conserved among alpha-PVs The level of conservation of the L2 DNA binding domains indicates the maintenance of this binding function has been vital to the virus from an evolutionary ... that the C-terminal L1 interaction domain of L2 is highly conserved throughout the members of alpha-PVs It seems that the C-terminus of L2 composed of many hydrophobic residues neutralizes charges...

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Báo cáo y học: " The effect of interleukin-13 (IL-13) and interferon-g (IFN-g) on expression of surfactant proteins in adult human alveolar type II cells in vitro" docx

Ngày tải lên : 12/08/2014, 11:23

... dysregulation of the Th1/Th2 cytokine is related to the pathogenesis of several adult lung diseases and alterations of surfactant proteins have been reported in variety of lung diseases, the effect of IL-13 ... cells cultured with d of TGFa and d of KGF Similar findings were observed in ATII cells cultured in KGF (K) alone, in d of K and d of KD (data not shown) or in d of KIA and d of KIAD (Additional ... contents of surfactant proteins A and D in BAL fluids of healthy smokers Chest 1996, 109:1006-1009 Page 12 of 13 19 Betsuyaku T, Kuroki Y, Nagai K, Nasuhara Y, Nishimura M: Effects of ageing...

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Báo cáo y học: "Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension" ppt

Ngày tải lên : 12/08/2014, 18:20

... lead to a better understanding of the unique properties of the pulmonary vasculature, and facilitate the development of selective animal models of BMPR-II dependent pulmonary vascular injury References ... (arrowhead) (B) Control showing the same region of artery, but without addition of antibody Lu, lumen of artery (Fig 1) Comparative analysis of components of the BMP signaling pathway in different ... significance of these findings in the context of our current understanding of BMP receptor biology, and relate the data to our knowledge of inheritance patterns and disease pathophysiology of PPH Bone...

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Báo cáo khoa học: "Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis" pot

Ngày tải lên : 12/08/2014, 23:22

... method Type of surfactant Surfactant dosing (total) Treatment duration Number of deaths Ventilation-free daysa Duration of ventilationb Control Surfactant Control Surfactant Control Surfactant ... extracted: method of randomization; inclusion and exclusion criteria; details of surfactant administration, including type of surfactant, dose, duration, and delivery method; nature of control treatment; ... consequent surfactant dysfunction Indeed, surfactant recovered from bronchoalveolar lavage fluid from ARDS patients has alterations of the phospholipid and fatty acid profile, has decreased levels of surfactant- specific...

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Báo cáo y học: "Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption" pptx

Ngày tải lên : 13/08/2014, 13:20

... radiata proteins" (Zr -proteins) will be used to identify the constituent proteins of the inner layer of the envelope that surrounds the oocyte of the ovulated teleost egg We have used zona radiata proteins, ... An integral part of this process is the synthesis of the oogenic proteins, Vtg and Zrproteins E2 is the major estrogen in female fish E2 stimulates the production of Vtg and Zr -proteins in the ... of rainbow trout egg envelope proteins: members of a unique group of structural proteins Biol Reprod 2001, 64:805-811 Arukwe A, Kullman SW, Berg K, Goksøyr A and Hinton DE Molecular cloning of...

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Báo cáo y học: "Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study" pot

Ngày tải lên : 14/08/2014, 07:21

... diagnosis of CAP was assumed in the presence of acute onset of signs and symptoms suggesting lower respiratory tract infection and radiographic evidence of a new pulmonary infiltrate that had Page of ... thought to consist of hetero-oligomers of SP-A1 and SP-A2, and properties of co-expressed SPA1/SP-A2 are between those of SP-A1 and SP-A2 [41,46] However, the extent of oligomerization of SP-A, as well ... functions of surfactant proteins Nat Rev Immunol 2005, 5:58-68 Geertsma MF, Nibbering PH, Haagsman HP, Daha MR, van Furth R: Binding of surfactant protein A to C1q receptors mediates phagocytosis of...

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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx

Ngày tải lên : 14/08/2014, 14:21

... tissue-specific) were related to the evolutionary origin of the protein as reflected in the distribution of proteins in different phyla Firstly, we have assigned mouse proteins to one of four functional categories: ... Distribution of the four phyletic categories of all the mapped proteins expressed in a tissue Figure Expression distributions of mouse proteins Expression distributions of mouse proteins (a) ... length (80%) of both proteins were discarded from our dataset refereed research Mapping probe sets to mouse proteins We used four categories to describe the evolutionary origin of mouse proteins: ...

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THE ORIGIN OF ENGLISH

Ngày tải lên : 07/07/2013, 01:27

... history of English begins a little after A.D 600 English is a Germanic Language of the Indo –European Family Indo – European English French Latin Greek Swedish Russian Hindi History of English ... inhabit, Warigeath, wulf –hleothu, windige Wolf –cliffs wild and windy headlands, naessas, Ledges of mist Where and mountain Frence fen –gelid, there forge –steam torrents Under naessas genipap, ... system & grammar wasn’t so effected but vocabulary was effected much Middle English A Clerk ther was of Oxenford also, That un –to logik hadde longe y –go Modern English A Clerk that is an Oxford scholar...

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Information, Entropy, and the Origin of Life

Ngày tải lên : 01/11/2013, 07:20

... the diversity of life in the biosphere, it is generally recognized that the origin of life is one of the great unsolved mysteries in science (Radetsky1992; Wade 2000) At the heart of this mystery ... the use of information, to survive and exist in a nonequilibrium state, resisting the pull toward equilibrium that is described by the Second Law of Thermodynamics For them, the origin of life ... are able to sustain themselves against the downward pull of the Second Law of Thermodynamics and how thermodynamics affects the origin of information-rich, living systems Finally, we will explore...

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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding speciﬁcity and target candidates doc

Ngày tải lên : 18/02/2014, 06:20

... localize PUF proteins Further pfam analyses using a cut-off E-value of 1.0 over the blast-p output identiﬁed 25 proteins containing PUF repeats, which is the largest number of putative PUF proteins ... [24,25,33–36] A B Fig CLUSTAL W alignment of the APUM proteins with the PUF domains most similar to Drosophila PUF domain (A) APUM proteins of group I (B) APUM proteins of group II FEBS Journal 276 (2009) ... for 22 of 25 putative PUF proteins The three remaining proteins can be divided into a closely-related pair and a single outsider (Fig 1A) The large number of copies of highly similar proteins...

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Tài liệu Báo cáo khoa học: A novel tachykinin-related peptide receptor of Octopus vulgaris – evolutionary aspects of invertebrate tachykinin and tachykinin-related peptide ppt

Ngày tải lên : 19/02/2014, 00:20

... ORF of 430 amino acids ﬂanked by 33 bp of 5¢-UTR and 66 bp of 3¢-UTR Multiple sets of clones in every PCR were analyzed, and gave identical nucleotide sequence The sequence showed the presence of ... ganglion, and the expression proﬁle of DTKR corresponds with immunostaining of DTKs, suggesting the involvement of DTKs in the control of hormone release, and modulation of chemosensory and visual processing ... understanding of the biological mechanism underlying the advanced behavior of Octopus and evolutionary aspects of neuropeptides and hormones The TK and TKRP family represent one of the largest...

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Tài liệu Báo cáo khoa học: DNA modiﬁcation with cisplatin affects sequence-speciﬁc DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

Ngày tải lên : 19/02/2014, 05:20

... PGM4 targets) Effects of DNA cis-platination on sequencespecific DNA binding of p73 proteins We tested the influence of DNA modification with cisplatin on the binding of two p73 isoforms, p73d and p73b, ... modified chromosomal DNA comprises about 50% of 1,2-GG IACs, 25% of 1,2-AG IACs, 10% of 1,3-GNG IACs and interstrand crosslinks, and another 2–3% of monofunctional adducts It has been found that ... weights of the p73 isoforms To verify the specificity of the band shifts for DNA complexes with the proteins studied, we used the band supershift assay with antibodies against the p53 or p73 proteins...

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Tài liệu Báo cáo khoa học: Quantitative analysis of the experimental O–J–I–P chlorophyll ﬂuorescence induction kinetics Apparent activation energy and origin of each kinetic step Steve Boisvert, David Joly and Robert Carpentier doc

Ngày tải lên : 19/02/2014, 05:20

... superposition of the exponential rise to analyze quantitatively the contribution of each phase The amplitude and rate constant of each of the three phases can be calculated by deconvolution of the traces ... thylakoids in the absence of additives or in the presence of lm DCMU or dPQ over a range of temperature from 15 C to 25 C The range of temperature was set on the basis of the membrane transition ... Boisvert et al have attributed both of the two latter phases to the reduction of the acceptor side of PSII [9,12,13], or more specically to the reduction of two distinct plastoquinone (PQ) pools...

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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx

Ngày tải lên : 19/02/2014, 05:20

... 2006 FEBS 371 Inhibition of choline-binding proteins B Maestro et al Fig Effect of choline analogs on S pneumoniae growth (A) State of cultures after h of incubation of S pneumoniae R6 with compounds ... inhibitor of the activity of LytA [23,24] and other CBPs [25] Moreover, addition of an excess of choline to culture media inhibits daughter cell separation and induces the formation of long chains ... concentration of choline capable of eluting C-LytA from a DEAE-cellulose column, mg of C-LytA samples were adsorbed onto mL of resin and subjected to washes with different concentrations of choline...

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