epidermal growth factor receptor egfr inhibitor for oncology discovery and development of erlotinib
Báo cáo y học: "Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice" pps
... B6.129 F1 B6.129 F1 + + + Wnt3avt/vt + + Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Total activitya Daytime ... the analysis and discussion of the results, and in the writing of the manuscript CLT participated in all experiments, in the analysis and discussion of the results, and in the writing of the manuscript ... experiments and in the analysis and discussion of the results DWT participated in the conceptualization of the experiments, in the analysis and discussion of the results, and in the writing of the...
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Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" docx
... treatment of head and neck cancers are low grade and cutaneous The rationale for combination of inhibitors of EGFR with ionizing radiation is, therefore, a potentially attractive combination for recurrent ... Expression of epidermal growth factor receptors in human brain tumors Cancer Res 1984, 44:753-760 Westermark B, Magnusson A, Heldin CH: Effects of epidermal growth factor on membrane motility and cell ... Sanfilippo JS, Rao CV, Guarnascelli JJ: Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of central nervous system in human beings Surg...
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Báo cáo khoa học: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications" pptx
... carcinoma of the head and neck 10 RT: radiation therapy EGF: epidermal growth factor EGFR: epidermal growth factor receptor 11 TGF-α: transforming growth factor alpha 12 RTOG: Radiation Therapy Oncology ... association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growth factor receptor treatments ... Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer Cancer Res 1993, 53:3579-3584 Grandis JR,...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... Korsmeyer SJ & Streuli CH (2002) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 277, 27643–27650 ... 2316–2326 11 Anderson NG, Ahmad T, Chan K, Dobson R & Bundred NJ (2001) ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFRpositive ... fetal calf serum and used for all of the experiments PC-9 cells were plated 24 h before transfection and co-transfected with 8.5 lg of pcDL-SRa 296JNK2(VPF) or pcMKP-1 and 1.5 lg of pBabePuro by...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, function and ... T & Yatabe Y (2007) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung ... (2006) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib Cancer Res...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... treatment of CML provided compelling evidence for the effectiveness of small-molecule tyrosine kinase inhibitors (TKIs) and triggered the development of this class of agents for targeting growth factor ... expressing both T790M mutant and wild-type forms of EGFR, EGFR- TKIs are not able to inhibit the phosphorylation of either type of the receptor The T790M mutation of EGFR was initially thought to ... growth factor receptors frequently expressed in epithelial cancers [9] Two such inhibitors of the tyrosine kinase activity of EGFR (EGFR- TKIs), gefitinib and erlotinib, compete with ATP for binding...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... 5578 17 Ono M & Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR- targeting drugs Clin Cancer Res 12, 7242–7251 ... the growth of PC9 cells and tube formation of ECV304 cells (A) PC9 cells (5 · 103) cells were plated on 96-well plates Forty-eight hours later, MTT was added to each well for h at 37 °C, and ... regulate EGFR pathways are critical to our understanding of lung cancer development and progression Emerging evidence has revealed the profound role of various miRNAs in regulating cancer development...
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Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer" pot
... time of transfection Lipofectamine 2000 was diluted in serum-free DMEM and mixed with dsRNA at a 1:2 ratio (4 µl of 20 µmol/L of siRNA formulated with µl of Lipofectamine 2000) The formulation of ... Figure The effects of dsRNA -EGFR on A549 (A) and SPC-A1 (B) cell count and colony formation (C) The effects of dsRNA -EGFR on A549 (A) and SPC-A1 (B) cell count and colony formation (C) Cells ... active inhibitor of epidermal growth factor signaling with potential for cancer therapy Cancer Res 2002, 62:5749-5764 Shin DM, Donato NJ, Perez-Soler R, et al.: Epidermal growth factor receptor- targeted...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... activation of the epidermal growth factor and nerve growth factor receptors J Biol Chem 271, 30505–30509 Browaeys-Poly E, Cailliau K & Vilain JP (1998) Fibroblast and epidermal growth factor receptor ... ATP, and epidermal growth factor in epithelial LLC-PK1 cells Am J Physiol 265, C966–C975 29 Elliget KA, Phelps PC & Smith MW (1996) Transforming growth factor b modulation of the epidermal growth ... (2005) A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor J Biol Chem 280, 24043–24052 Calmodulin and the EGFR 58 Sato T, Pallavi...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... starved for h before lysis and immunoprecipitation of Hrs as described above Hrs was eluted in sample buffer for SDS/PAGE peGFP -EGFR was expressed in SYF-2 cells and and starved for h before stimulating ... surface of early endosomes J Biol Chem 272, 20538–20544 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: differential intracellular routing and processing ... serum-starved and stimulated with EGF or TGFa before the cells were washed and Hrs was immunoprecipitated from the lysate We chose to stimulate the cells with the growth factors for min, as the growth factor- stimulated...
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Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx
... marker for indicating the intrinsic kinase activity of EGFR, regardless of tissue type Results Ligand-induced transcriptional signatures of EGFR- WT and L858R in the absence or presence of EGFR ... activation of EGFR is systemically and evolutionarily guaranteed by the presence of a variety of ligands, or by dimerization and trans-activation with other family member receptors of ErbB [2,3] ... EGFR mutation and MIG6 expression T Nagashima et al Introduction Epidermal growth factor receptor (EGFR) is a membrane tyrosine kinase that is involved in the regulation of a wide variety of...
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Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
... Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors Adv Cancer Res 2000, 77:25-79 Diasio RB, Furie J: Targeting the epidermal growth factor receptor ... the epidermal growth factor receptor by immunohistochemestry J Clin Oncol 2005, 23(9):1803-1811 Moroni M, veronese S, Benvenuti S, et al.: Gene copy number for epidermal growth factor receptor and ... evidence of the predictive role of EGFR- GCN in terms of RR, PFS and OS in a retrospective series of 101 patients affected by advanced CRC and treated with chemotherapy plus Cetuximab The role of kras...
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Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
... promoter region and exons 18-21 of the EGFR genes (Table 1) PCR amplification of 0.2 μg DNA was performed with a denaturing step at 94°C for min, then 30 sec at 94°C, at 58°C, and at 72°C for 35 cycles, ... Multiplex PCR and primer extension analysis of mutations in EGFR- 216 promoter region and exons 18, 19, 20, and 21 Multiplex PCR was used to amplify the promoter region and exons 18-21 of the EGFR genes ... terms of the amount of work and time required With this method, -216 promoter region and exons 18-21 of the EGFR gene were amplified with multiplex PCR in a single tube and the detection of mutations...
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báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx
... Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic Syrios et al Journal of ... human epidermal growth factor receptor 2; MBC: metastatic breast cancer Authors’ contributions JS collected and analyzed the data of the study and wrote the manuscript AD collected the data of the ... different end points and eligibility criteria; however, the understanding of trastuzumabrelated cardiac events has since improved, and the majority of these events are manageable and reversible Extending...
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Báo cáo y học: "Role of epidermal growth factor receptor activation in regulating mucin synthesis" pdf
... factor receptor cascade The mechanism of EGFR expression and activation Stimulation of airway epithelial cells with TNF-α causes EGFR expression (the extracellular and intracellular parts of EGFR ... express EGFR constitutively, and contain few goblet cells [4] Instillation of tumor necrosis factor (TNF)-α induced EGFR expression in the airway epithelium, and subsequent instillation of EGFR ligand ... M , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway Am J Respir...
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Báo cáo y học: "Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling" pdf
... roles for EGFR signaling in the regulation of circadian rhythms by the SCN EGFR and EGFR ligands are expressed throughout the central nervous system and are involved in diverse developmental and ... expression of EGFR [9-11] and transforming growth factor alpha (TGF-alpha; an EGFR ligand) [9,10,12,13] have been reported EGFR signaling has been implicated in the circadian regulation of locomotor ... significance threshold of 2% for PAINT, CONS and ChIP enrichments, and a significance threshold of 5% for circadian gene enrichments pM(LOCAL) values are for standard normalization results and gene group...
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Quantification of epidermal growth factor receptor dynamics and interactions in living cells by fluorescent correlation and cross correlation spectroscopy
... gives an introduction of the epidermal growth factor receptor (EGFR) The introduction starts from a history of EGFR study, and focuses on the function and clinical importance of EGFR, its structure, ... influence of lipid rafts, cytoskeleton, and receptor activation on the mobility of EGFR Chapter concludes and presents an outlook for future FCS and FCCS developments for a better understanding of biological ... regulation for receptor autophosphorylation and/ or transformation of receptor activity (Chang, Shu et al 1995; Frederick, Wang et al 2000; Bose and Zhang 2009) 1.1.3 The cycle of EGFR in a cell Before...
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Báo cáo khoa học: "Topical application of epidermal growth factor accelerates wound healing by myofibroblast proliferation and collagen synthesis in rat" pot
... a ni setunim 01 rof selpmas eht gniliob yb deraperp saw nietorp latot ehT )ASU ,daR-oiB( tik sisylana drofdarB a gnisu denimreted saw noitartnecnoc nietorp ehT C ta nim 03 rof × 000,41 ta degufirtnec ... eussit racs evissecxe fo noitamrof eht gnisaerced ni elor a syalp ti saerehw ,ssecorp riaper dnuow eht secnahne FGE deilppa yllacipot ,elpmaxe roF ]91[ noitamrof racs no ecneulfni yna gnivah ... ,enelyx ni deziniffaraped ,h rof C 34 ta detabucni erew snoitces ehT sedils detaoc nisyl-ylop no detnuom dna tuc erew snoitces kciht mm eviF niffarap ni deddebme dna ,nilamrof lartuen %01 ni dexif...
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Báo cáo y học: "Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma" pdf
... 1.09 (CI 0.76–1.54) for class I, 1.5 (CI 0.92–2.46) for class II, and 2.78 (CI 1.56–4.94) for class III (Table 2) The p values were 64 for class I, 10 for class II, and 0005 for class III When ... unit of increased BMI Table Demographics of Total Evaluated and Included Patients Characteristics Number of subjects evaluated Number of subjects included Number of subjects excluded Reasons of ... 005) in all subjects For men, this risk was 3.4% (CI 1.01–1.06) for one unit of increased BMI (1 kg/m2) and for women 2% (CI 0.97–1.07), respectively The OR for point estimates of AHR risk in obesity...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... (1993) A 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol ... of hydrophobicity of the tyrosine at position 13 of human growth factor in receptor binding J Biol Chem 268, 10114–10119 26 Campion, S.R & Niyogi, S.K (1994) Interaction of epidermal growth factor ... Richards, K.M et al (2001) Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain Biochemistry 40, 8930–8939...
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