epidemiology quality of life and management of chronic hepatitis b chb
Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"
Ngày tải lên :
03/11/2012, 09:41
... approach to management < /b> of < /b> CHB Clinical Presentation of < /b> Chronic < /b> HBV Infection As discussed by Drs Zhang and < /b> Pan in this special issue, the clinical presentation of < /b> chronic < /b> HBV infection can be quite ... risk of < /b> developing HCC Chronic < /b> Hepatitis < /b> B (CHB) CHB is characterized by positive HBsAg for greater than months, serum HBV DNA >1 x 106 copies/ml, and < /b> persistent or intermittent elevation of < /b> serum ... determine HBV treatment depending on HBeAg status and < /b> clinical presentation of < /b> CHB [3] As summarized in Figure 1, HBV treatment should be considered in patients with HBeAg-positive CHB and < /b> HBV DNA...
- 7
- 541
- 0
Báo cáo y học: " Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review" pdf
Ngày tải lên :
12/08/2014, 01:21
... contributions of < /b> hepatitis < /b> B virus and < /b> hepatitis < /b> C virus infections to cirrhosis and < /b> primary liver cancer worldwide J Hepatol 2006, 45:529-538 Nash K: Telbivudine in the treatment of < /b> chronic < /b> hepatitis < /b> ... aminotransferase (ALT) elevation of < /b> at least one and < /b> a half times the upper limit of < /b> normal range) and < /b> of < /b> viral replication (detectable hepatitis < /b> B virus DNA by DNA hybridisation method or polymerase ... literatures, and < /b> finally a total of < /b> 171 studies identified by the searches(PUBMED:8; Web of < /b> Science:12; EMBASE:37; CNKI:42; VIP database:18; WANFANG database:33; the Cochrane Central Register of < /b> Controlled...
- 11
- 398
- 0
Báo cáo y học: "The inverse association of serum HBV DNA level with HDL and adiponectin in chronic hepatitis B infection" ppt
Ngày tải lên :
12/08/2014, 01:21
... Demographic and < /b> biochemical characteristics of < /b> 92 consecutive middle-aged and < /b> normal weight male subjects with chronic < /b> hepatitis < /b> B are presented in Table Mean of < /b> serum HBV DNA, HDL and < /b> ALT level ... 0.9 significant association between serum HDL and < /b> adiponectin with FBS, Albumin, Bilirubin, BMI, age, ALT and < /b> cholesterol Association of < /b> Serum HDL and < /b> Adiponectin with HBV DNA Analysis with median ... considering adjustment on ALT variable, increasing HDL and < /b> adiponectin variables decrease Log HBV DNA Table Association of < /b> clinical findings of < /b> chronic < /b> hepatitis < /b> B with HBV DNA level higher than median...
- 6
- 320
- 0
Báo cáo y học: " Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa" ppt
Ngày tải lên :
11/08/2014, 21:21
... Epidemiological serosurvey of < /b> hepatitis < /b> B in China– declining HBV prevalence due to hepatitis < /b> B vaccination Vaccine 2009, 27:6550-6557 Kew MC: Epidemiology < /b> of < /b> chronic < /b> hepatitis < /b> B virus infection, hepatocellular ... Hansen B, Schalm SW: Pegylated interferon alfa- 2b alone or in combination with lamivudine for HBeAg-positive chronic < /b> hepatitis < /b> B: a randomised trial Lancet 2005, 365:123-129 Hoofnagle JH, di Bisceglie ... polymorphisms are believed to be responsible for clinical outcomes of < /b> infectious disease[9,17,19], because differences in the susceptibility to infection or severity of < /b> disease cannot solely be attributed...
- 6
- 290
- 0
Báo cáo y học: "Keratin 18 phosphorylation as a progression marker of chronic hepatitis B" pot
Ngày tải lên :
12/08/2014, 04:20
... Hepatitis < /b> B e-antigen (HBeAg)-negative chronic < /b> HBV infection was diagnosed based on positive hepatitis < /b> B surface antigen (HBsAg) and < /b> negative HBeAg for ≥ months Patients with HBeAg-negative chronic < /b> ... infected with HBV, as indicated by the strong HBsAg staining (Fig 4A and < /b> 4A’ cf Fig 4B and < /b> 4B ) On the other hand, we observed merely basal level of < /b> Ser52 phosphorylation in the hepatocytes of < /b> the carriers ... phosphorylation at Ser33 and < /b> Ser52 may serve as reliable markers for progression of < /b> chronic < /b> hepatitis < /b> B Results K18 phosphorylation is a marker of < /b> progression of < /b> chronichepatitis B HBV infection leads...
- 8
- 273
- 0
longterm outcome of chronic hepatitis b in causasian pts - mortality after 25 years 2008
Ngày tải lên :
13/08/2014, 09:45
... hepatitis < /b> B virus (HBV) infection is an established cause of < /b> liver-related morbidity and < /b> mortality and < /b> represents a major global public health problem.1 Studies conducted in Asian regions of < /b> high HBV ... to HBsAg (anti-HBs), HBeAg, antibody to HBeAg (anti-HBe), hepatitis < /b> delta virus (HDV) and < /b> hepatitis < /b> C virus (HCV) antibodies, hepatitis < /b> A virus IgM antibodies were detected by conventional serological ... began in Padova, northern Italy, enrolling between 1972 and < /b> 1984 seventy consecutive hepatitis < /b> B surface antigen (HBsAg) and < /b> HBeAg positive patients, 49 male and < /b> 21 female with a median age of...
- 8
- 374
- 0
báo cáo hóa học: "Health-related quality of life of Southern Chinese with chronic hepatitis B infection" pdf
Ngày tải lên :
18/06/2014, 18:20
... Clinical characteristics and < /b> co-morbid chronic < /b> illness Table describes the clinical characteristics and < /b> co-morbid chronic < /b> illnesses of < /b> CHB patients The mean duration of < /b> CHB illness from diagnosis ... Health and < /b> Quality < /b> of < /b> Life < /b> Outcomes 2009, 7:52 Background Hepatitis < /b> B virus (HBV) is the most common infection in the world More than billion people have been infected by HBV worldwide, of < /b> whom ... Health-related quality < /b> of < /b> life < /b> (HRQOL) of < /b> CHB patients Table shows the mean SF-6D health preference values, SF-36v2, and < /b> CLDQ scores by CHB groups The mean SF6D and < /b> SF-36v2 scores of < /b> the normal...
- 10
- 588
- 0
Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
Ngày tải lên :
25/10/2012, 11:48
... features of < /b> HBeAg-negative CHB patients with or without steatosis were summarized in Table Table Clinical characteristics and < /b> anthropometric indices of < /b> HBeAg-negative CHB patients with and < /b> without ... gender between both groups (P>0.05) Clinical characteristics and < /b> some anthropometric indices of < /b> HBeAg-negative CHB patients with or without steatosis are listed in Table HBeAg-negative CHB patients ... overweight, Obese Class I and < /b> Obese Class II were defined by BMI= 18.5-22.9 kg/m2, 23.0-24.9 kg/m2, 25.0-29.9kg/m2 and < /b> ≥30 kg/m2, respectively Serum markers of < /b> HBV HBV markers, including HBsAg, anti-HBs,...
- 6
- 606
- 0
Báo cáo y học: "Study of the early steps of the Hepatitis B Virus life cycle"
Ngày tải lên :
03/11/2012, 10:09
... SHBs was able to bind specifically to human hepatocytes, human fibroblasts and < /b> human blood mononuclear cells but not the rat hepatocytes This binding could be inhibited by recombinant HBs but ... full understand of < /b> the HBV attachment and < /b> it receptors perhaps could only be achieved after a susceptible cell line has been established The HBV fusion and < /b> proteolysis The attachment of < /b> HBV surface ... attachment and < /b> entry may be limited The HBV surface protein antigens (HBsAg) are comprised of < /b> three carboxyl-co-terminal HBs proteins termed large (LHBs), middle (MHBs) and < /b> small (SHBs, also called...
- 13
- 654
- 1
Báo cáo sinh học: " Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients" potx
Ngày tải lên :
18/06/2014, 18:20
... vertical bar The white bars represent the number of < /b> HBpreSAg negative patients and < /b> the black bars represent that of < /b> HBpreSAg positive patients Table 1: Average changes of < /b> HBpreSAg and < /b> HBV DNA after ... HBpreSAg in serum of < /b> HBV patients and < /b> its correlation with HBsAg The presence of < /b> HBpreSAg in serum of < /b> HBV patients and < /b> its correlation with HBsAg The rate of < /b> HBpreSAg presence in serum of < /b> HBeAg-negative ... positive)5patients (B) Correlation of < /b> HBpreSAg levels with HBV DNA copies in serum of < /b> HBeAg positive patients (A) and < /b> HBeAg negative (anti-HBe Correlation of < /b> HBpreSAg levels with HBV DNA copies in serum of < /b> HBeAg...
- 11
- 540
- 0
Báo cáo y học: "Clinical Profiles of Chronic Hepatitis C in a Major County Medical Center Outpatient Setting in United States" pptx
Ngày tải lên :
08/08/2014, 18:20
... Norkrans G, Fryden A, Braconier J-H, Sonnerborg A, Weiland O Randomized, double-blind, placebo-controlled trial of < /b> interferon alfa- 2b with and < /b> without ribavirin for chronic < /b> hepatitis < /b> C Lancet 1998; ... disease activity and < /b> predict disease progression remains to be defined Occult or latent hepatitis < /b> B virus (HBV) infection is defined as the detectability of < /b> HBV DNA in the absence of < /b> HBsAg Recent ... Cable E, Lurring B, Manns M, Bonkovsky HL High prevalence of < /b> serological markers of < /b> antoimmunity in patients with chronic < /b> hepatitis < /b> C Hepatology 1995; 21:613-619 42 Bonkovsky HL Therapy of < /b> hepatitis...
- 9
- 388
- 0
báo cáo khoa học: " Seroprevalence of HIV, hepatitis b, and hepatitis c among opioid drug users on methadone treatment in the netherlands" ppt
Ngày tải lên :
11/08/2014, 18:20
... study; have made substantial contributions to conception and < /b> design, acquisition of < /b> data, and < /b> analysis and < /b> interpretation of < /b> data; and < /b> contributed to the manuscript MvdS and < /b> CB have been involved ... HBV Interestingly, of < /b> the HIV and < /b> HCV-positive individuals, HBV vaccination was completed by 26% and < /b> 25%, respectively Of < /b> all ODUs Table Demographics of < /b> drug users found positive for HIV, HBV ... Journal of < /b> Viral Hepatitis < /b> 2002, 9(3):157-173 Murrill CS, Weeks H, Castrucci BC, Weinstock HS, Bell BP, Spruill C, Gwinn M: Age-Specific Seroprevalence of < /b> HIV, Hepatitis < /b> B Virus, and < /b> Hepatitis...
- 7
- 340
- 0
Báo cáo y học: " Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment" ppt
Ngày tải lên :
12/08/2014, 01:21
... primers, and < /b> it was confirmed by flow cytometry Hepatitis < /b> B surface antigen (HBsAg), HBeAg, antiHBc, anti-HBe and < /b> anti-HBs were quantified by radioimmunoassay (Abbott Laboratories, Abbott Park, ... relationship between CD127 expression on memory CD8 T cells and < /b> serum hepatitis < /b> B virus (HBV) DNA and < /b> hepatitis < /b> B e antigen (HBeAg) levels in chronic < /b> hepatitis < /b> B (CHB) patients (a) Expansion of < /b> CD127+ ... cells and < /b> serum HBV DNA and < /b> HBeAg levels in patients with chronic < /b> hepatitis < /b> B We next investigated a possible relationship between the CD127 expression of < /b> CD8 memory T cells of < /b> CHB patients and...
- 6
- 359
- 0
Báo cáo khoa học: "Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patients" ppsx
Ngày tải lên :
12/08/2014, 04:20
... rates of < /b> coinfection of < /b> HBsAg and < /b> anti-HCV antibodies and < /b> both HBsAg and < /b> anti-HCV in HIV-positive patients were 282 (72%), 57 (14.5%) and < /b> 31(7.9%), respectively (Table 1) The rate of < /b> the total HBsAg ... to be tested for both HVB and < /b> HCV [24,25] Abbreviations HBV: Hepatitis < /b> B Virus; HCV: Hepatitis < /b> C Virus; HIV: Human Immunodeficiency Virus; ELISA: Enzyme-Linked Immunosorbent Assay; HBsAg: Hepatitis < /b> ... coinfection and < /b> HIV-HBV coinfection and/< /b> or both are common [1,2] HIV-positive individuals are at risk of < /b> coinfection with HBV and < /b> HCV and/< /b> or both infections [3] Coinfections of < /b> HBV and < /b> HCV with...
- 5
- 266
- 0
Báo cáo khoa học: "Clinical significance of 4 patients with chronic hepatitis B achieving HBsAg clearance by treated with pegylated interferon alpha-2a for less than 1 year: a short report" pot
Ngày tải lên :
12/08/2014, 04:21
... aminotransferase; HBeAg, hepatitis < /b> B e antigen; HBsAg, hepatitis < /b> B surface antigen; HBV, hepatitis < /b> B virus a interval between the first time when HBsAg-positive was detected and < /b> the date before treatment b cumulate ... serum HBV DNA and < /b> ALT were detected once every month HBV markers(HBsAg and < /b> anti-HBs, HBeAg and < /b> anti-HBe, anti-HBc) were detected once every three months Among them, serum HBV DNA was arrayed by fluorescent ... depression and < /b> abnormal blood counts [13,14] In this study, both leucopenia and < /b> thrombocytopenia had been observed in case and < /b> case 4, so we adopted sequential therapy with pegasys and < /b> baraclude...
- 3
- 328
- 0
Báo cáo khoa học: " Efficacy of consensus interferon in treatment of HbeAg-positive chronic hepatitis B: a multicentre, randomized controlled trial" docx
Ngày tải lên :
12/08/2014, 04:22
... complete blood count and < /b> biochemical profile, as well as hepatitis < /b> serology (HBsAg, anti-HBs, HBeAg, anti-HBe and < /b> anti-HBc) was obtained at baseline and < /b> then every weeks until the end of < /b> treatment, and < /b> ... was defined as HBeAg seroconversion, loss of < /b> HBeAg and < /b> non-detectable HBV-DNA level, and < /b> biochemical response as normalization of < /b> ALT level The virologic and < /b> biochemical responses between the two ... and < /b> non-responders to interferon-based Table 3: Virologic, Biochemical Variables of < /b> Patients at 24 weeks After Treatment Variable ALT normalization, n (%) Loss of < /b> HBV-DNA, n (%) HBeAg/anti-HBe...
- 6
- 252
- 0
Báo cáo khoa học:" Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis" doc
Ngày tải lên :
12/08/2014, 04:21
... 6m+LAM12-18m HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) 0 12 12 12 12 RCT RCT RCT RCT RCT RCT RCT RCT B C B B C C B C Abbreviations C: combination therapy; ... three grades (A, B, and < /b> C) as follows: 1) quality < /b> of < /b> randomization, 2) quality < /b> of < /b> allocation concealment, 3) quality < /b> of < /b> blinding, and < /b> 4) quality < /b> of < /b> the description of < /b> withdrawals and < /b> dropouts The ... seroconversion of < /b> HBeAg Seroconversion of < /b> HBeAg to HBeAb The seroconversion of < /b> HBeAg to HBeAb at the end of < /b> the treatment is shown in Figure The seroconversion rate of < /b> patients receiving combination...
- 9
- 269
- 0
Báo cáo khoa học: " Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis" doc
Ngày tải lên :
12/08/2014, 04:21
... 6m+LAM12-18m HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) HBV DNA(-) 0 12 12 12 12 RCT RCT RCT RCT RCT RCT RCT RCT B C B B C C B C Abbreviations C: combination therapy; ... three grades (A, B, and < /b> C) as follows: 1) quality < /b> of < /b> randomization, 2) quality < /b> of < /b> allocation concealment, 3) quality < /b> of < /b> blinding, and < /b> 4) quality < /b> of < /b> the description of < /b> withdrawals and < /b> dropouts The ... seroconversion of < /b> HBeAg Seroconversion of < /b> HBeAg to HBeAb The seroconversion of < /b> HBeAg to HBeAb at the end of < /b> the treatment is shown in Figure The seroconversion rate of < /b> patients receiving combination...
- 9
- 188
- 0
Báo cáo y học: "Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs" potx
Ngày tải lên :
13/08/2014, 13:20
... HBs-antigen (Ag)-positive, HBs-antibody (Ab)-negative, HBe-Ag-negative, HBe-Ab-positive, and < /b> HBc-Ab-positive (Axsym, Abbott Laboratories, North Chicago, IL, USA) Hepatitis < /b> B virus (HBV) DNA was detected ... Figure HBV viral load and < /b> alanine aminotransferases (ALT) HBV viral load and < /b> alanine aminotransferases (ALT) HBV viral load and < /b> ALT from a patient with chronic < /b> hepatitis < /b> B during the course of < /b> antiviral ... as seen by ARMS (see Table 1) has been responsible for the reduction of < /b> lamivudine susceptibility both in vitro and < /b> in vivo [17] The first adefovir-resistance mutation rtN236T has been observed...
- 5
- 280
- 0