emerging concepts for the pathogenesis of chronic disabling inflammatory diseases neuroendocrine immune interactions and evolutionary biology
Is there information in financial analysts forecasts about firms that subsequently restate their earnings
... over-optimistic analyst forecasts We examine the forecast error of FAF for the misstated period to investigate whether analyst forecasts reveal information of the true financial performance of the restatement ... firms and non-restatement firms Specifically we examine three properties of the analyst forecasts: the forecast error, the forecast dispersion and the skewness of the forecast distribution The ... non-restatement firms in the year prior to the restatement announcement Three properties of the FAF are evaluated: the forecast error, the forecast dispersion and the skewness of the forecast distribution...
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Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf
... determine the goals and plans of the novice user and, indirectly, the dialogue structure This is because the novice user does not have a good model of the task and is in the process of building one and ... phrases throughout the dialogue The coder also noted words and phrases occurring at the boundaries of the subdialogues and mapped the distribution of the antecedents of pronominal and non-pronominal ... dialogue structure on the basis of the task structure and the users' and adviser's plans and goals This analysis supports the value of the concept of a dialogue structure and also support our...
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báo cáo hóa học:" CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool?" pdf
... taken in the weeks around the time of each dose (vaccine or chemotherapy), and then used to identify the position on the oscillating Page of (page number not for citation purposes) Journal of Translational ... exploring some of these exciting avenues of investigation Chemotherapy We have investigated this hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune oscillatory ... What is emerging appears to be an association between the timing of delivery of the therapeutic agent(s) and improved outcome This may open the possibility that in the future, vaccines and other...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
... (BPI), and the Symptom Distress Scale (SDS) Therefore the information given in the tables was simply to reflect the variance that existed in the instruments used and neither to convey their psychometric ... may contribute to the initiation of morbidity, the biology of the disease appears to predominate, overriding the potential influence of life-style and psychosocial variables once the disease process ... exclusion of duplicates, the abstracts of all citations were reviewed Of these, 104 citations concerning the relationship between quality of life and survival were found to be relevant and were further...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... highlighted the lack of and the need for new empirical evidence about the epidemiology and the effectiveness of available therapeutic strategies, and called for a prospective program of research ... conduct and supervision In order to be able to conduct and monitor the progress of the trial for the patients' safety and according to the World Medical Association Declaration of Helsinki and the ... according to the usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes...
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Báo cáo khoa học: "Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: A prospective observational study of 1,978 consecutive catheterizations" pps
... allowed the completion of the therapeutic program for 1,930/ 1,978 (97.6%) of the catheters inserted The absence of pneumotorax and other major complications indicates that US guidance should be mandatory ... assistant to hold the probe, while the operator controls the needle and performs the procedure under real-time guidance, and the nurse helps the two physicians during the maneuver The central vein ... practice [43], the American College of Emergency Physicians and the American College of Surgeons support the use of ultrasound by members of their societies and address ways to obtain and maintain...
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Báo cáo khoa học: "Perioperative immune responses in cancer patients undergoing digestive surgeries" pptx
... 2000 and April 2002 The experimental protocol was approved by the Research Committee of National Kochi Hospital All patients were informed of the nature and risk of this study, and written informed ... interests The authors declare that they have no competing interests Authors' contributions MI was involved in the design of the study and writing of the manuscript MN and NH assembled the data TM and ... cells were not seen other than the reduction on POD in the hepatic resection group found On the other hand, there were also no significant differences in the percentage of CD4+IL-6+ T cells among...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... available for all 104 samples but mutation screening of the ATM gene was only performed for 44 of the patients experiencing IBCT and 51 of the matched controls This was done to fit into a 96 well format ... evaluation study and the same assessments of damage were performed as for the treatment A group During the survey, the clinical examinations and overall pain evaluation were performed by three ... Figure illustration of the ATM gene Schematic Schematic illustration of the ATM gene The distribution of the variations detected in the studied materials along the gene is shown in the upper panel...
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báo cáo khoa học: "The potential benefits of low-molecular-weight heparins in cancer patients" ppsx
... The principal role of the antithrombotics in surgical patients is to provide effective anticoagulation over the course of the increased risk of VTE (during and postsurgery) with the minimum of ... assessed in terms of three main properties; their efficacy and safety profiles, practicality of use, and cost-effectiveness The relative merits of the major anticoagulants according to these criteria, ... understand this effect, and the potential role of the LMWHs as antineoplastic therapy Acknowledgements The author received editorial support in the preparation of this manuscript, funded by sanofi-aventis,...
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Báo cáo y học: "Is Phytalgic® a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment" pot
... interests The funding agencies (The Oak Foundation and The Danish Rheumatism Association) had no role in writing the report or in the decision to submit the manuscript for publication Neither of the ... from the analyses Although the authors performed their analyses according to the intention-totreat principle on what they claim is the correct sample size, we worry about the fact that the attrition ... of risk of bias, the use of random assignment, and subsequent concealment of allocation would qualify as adequate (that is, low risk of selection bias); it seems reasonable that at baseline the...
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Báo cáo khoa học: "Performance of six severity-of-illness scores in cancer patients requiring admission to the intensive care unit: a prospective observational study" pot
... compare the performances of the CMM and of the general prognostic scores, all scheduled surgical patients were excluded, and therefore 542 (43.1%) patients were included in this analysis A total of ... identified during assessment of the extent of their cancer and/ or consideration of the therapeutic options This assessment is conducted as soon as is possible, and end -of- life care is started if ... applicable) Validation of the prognostic scores was performed using standard tests to measure discrimination and calibration for each of the predictive models The area under the receiver operating...
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Báo cáo y học: "Clinical review: Specific aspects of acute renal failure in cancer patients" pot
... Society of Clinical Oncology Chemotherapy and Radiotherapy Expert Panel: 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the ... patients, and monitoring of serum methotrexate concentrations are among the measures that may reduce the risk of ARF Few studies have focused on ARF in CICPs and, therefore, supportive care in these ... is the cornerstone of treatment Renal recovery depends on the severity and duration of the obstruction [24] Thrombotic microangiopathy The association between thrombotic microangiopathy (TMA) and...
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Báo cáo khoa học: "N-terminal pro-brain natriuretic peptide as an early prognostic factor in cancer patients developing septic shock" pdf
... analyzed the data and reviewed and coordinated the study AS and MF collected and analyzed the data J-PB, J-LB, DB, and CF reviewed and coordinated the study All authors read and approved the final manuscript ... factors by the univariate analysis (cutoff p < 0.05) To avoid increasing the risk of collinearity for the same variables measured at days and (LOD and NT-proBNP), we decided to include only the most ... proBNP) at the cutoff N-terminal pro-brain Kaplan-Meier curve forvalue of 6,624 pg/ml natriuretic peptide (NTproBNP) at the cutoff value of 6,624 pg/ml Kaplan-Meier analysis estimates the rate of death...
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Báo cáo y học: " C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia" doc
... authors read and approved the final version of the manuscript 15 Authors’ information PP is coordinator of the Polyvalent Intensive Care Unit and president of the Antibiotic Commission of São Francisco ... Francisco Xavier Hospital PP is Professor of Medicine of the Faculty of Medical Sciences from the New University of Lisbon, Portugal VCSD is assistant physician of the ICU of the Instituto Nacional de ... Diagnostics, Mannheim, Germany) The precision of the assay measured by means of the intra- and inter-assay coefficient of variation was < 7%, the sensitivity 0.1 mg/dL and the detection limit 0.3 mg/dL...
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báo cáo khoa học: "Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials" ppt
... in context with the other exploring the safetyefficacy balance of the addition of bevacizumab to chemotherapy for advanced breast cancer strengthen the need of a deep analysis of the correlation ... This amount of benefit well compares with the benefits of other important therapeutic choices such as the addition of taxanes for the st line treatment of metastatic breast cancer, where the advantage ... definition of the search strategy, and a detailed description of the statistical methods used [17,18] Outcome definition The combination of chemotherapy and Bevacizumab (Beva) was considered as the...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... directing the formation of a complex where VDAC and ANT isoforms may be at least 25 partially redundant and become included in the PTPC depending upon their availability or on the nature of the apoptoic ... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear ... Pervaiz, Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS Their encouragement and guidance and their critique has been of paramount importance in directing the course of the...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... oncogenic potential of loss of Rb is likely to be decided by the expression of each of the Rb family members and the role these family members play in the differentiation of the cell type involved ... that in this assay loss of the Rb gene family is sufficient to allow oncogenic transformation On the other hand, in view of the lack of anchorage-independent growth of these cells, it remains ... functions and interactions The difference in phosphorylation sites and kinases involved in the phosophorylation of these sites between p107 and p130 further support specific functions for p107 and p130...
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báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc
... Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer Cancer 2010, 116(17):4023-32 Burmeister BH, Smithers BM, Gebski ... C, Sugarbaker D, Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781 J Clin Oncol ... surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial Lancet Oncol 2005, 6:659-668 Pereira B, Gourgou-Bourgade S, Azria D, Ychou M: Neoadjuvant chemoradiotherapy...
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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx
... Follow-up The patients were followed with office visits and physical examinations every months for the first years, every months for the fourth and fifth years, and annually after years Chest X-ray and ... the benefit of RT is worth of the risk of treatment morbidity with accurate selection PMRT for T1-2 and N1-3 positive patients has to be reconsidered according to the prognostic factors and the ... retrospective study consists of relatively small number of patients and PMRT decision recommended according to the poor prognostic factors of the patient at the discrepancy of the radiation oncologist...
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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot
... the design of the study and performed the evaluation of the data TT helped to draft the manuscript SI contributed to the HLA-A24-binding assay and CTL induction from PBMCs AM, AY and HH contributed ... patients' samples with the informed consent HH and NS contributed to the design and coordination of this study as well as reviewing the manuscript All authors have read and approved the final manuscript ... Switzerland], and clarified by centrifugation at 15,000 rpm for 20 minutes at 4°C The whole-cell lysates were boiled for minutes in the presence of SDS sample buffer, resolved by 10% SDS-PAGE, and...
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