embryology structure function and its role in fertilization and infertility

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Ngày tải lên : 14/02/2014, 19:20

... the structural and functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding core module in MAP2) across ... very-KIND-MAP2 interaction v-KIND KIND2 KIND2-1 KIND2-2 KIND2-3 KIND2-4 KIND2-5 A 620 521 555 488 589 EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 ... deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2, DKIND1 + 2, DRasN, DGEF, KIND1 or KIND2 together with...

11
658
0

Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx

Ngày tải lên : 18/02/2014, 18:20

... wild-type occludin (OccWT) and variant occludin in apoptosis and invasion, as determined by assay, we revealed that exon played a major role in the induction of mitochondria-mediated apoptosis and the ... occludin in apoptosis and invasion A C B D E F Fig Identiﬁcation of a human occludin splice variant in liver cell lines (A) Occludin protein expression was examined with an antibody to the N-terminus ... cells In Chang cells, stained occludin was observed in the cytoplasmic region Additionally, in OccWT-overexpressing Hep3B and Huh7 cells, regions stained with antibody to hemagglutinin (HA), indicating...

12
613
0

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Ngày tải lên : 19/02/2014, 06:20

... copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and forms ... the role of copper binding or loss of its binding could be related to specific cerebellar function( s) of stefin B [18], which remains to be seen by more in vivo studies Stefin B as a copper binding ... C-terminus (box in Fig 1) at sites: 92, 75, 66 and 58 As histidine residues are central to copper binding in many proteins they probably form part of the copper binding sites in this protein Although...

14
586
0

Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx

Ngày tải lên : 19/02/2014, 07:20

... in the AUH gene This indicated that AUH, in addition to its RNA binding function, must play an important role in leucine catabolism AUH was overproduced in E coli and characterized by measuring ... suggesting that this enzyme had another function in cellular metabolism Indeed, AUH had enoyl-CoA hydratase activity, which was described as an additional intrinsic function of the protein Its role ... The RNAbinding activity of the human protein and also of the murine homologue was investigated further, its biological function, however, remained unclear [16,17] The three-dimensional structure...

11
625
0

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

Ngày tải lên : 20/02/2014, 11:20

... (Michaelis constant) and Vmax (maximum velocity) values were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations ... were removed and minced with a surgical knife The minced tissue was wrapped in cotton gauze and suspended in NaCl/Pi containing 100 lgÆmL)1 penicillin/ streptomycin at 37 °C for h After incubation ... were incubated at 37 °C in a humidiﬁed 5% CO2 incubator in the absence (control) and presence of increasing concentrations of inhibitors for 10 days, and the number of molting larvae was determined...

13
691
0

Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx

Ngày tải lên : 07/03/2014, 21:20

... proteins, Vpr, has been shown to dysregulate several host cellular functions including apoptosis in infected and uninfected bystander target cells through its interaction with host cellular proteins ... (RTK) signaling, independent of MAP kinase (MAPK) by either functioning downstream of MAPK or by deﬁning a new pathway of RTK signaling [8] RTKs play important roles in cell signaling during cell ... Oncogenes and Related Genes Shanghai Cancer Institute, Shanghai, China Smith RK, Carroll PM, Allard JD & Simon MA (2000) MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila...

12
561
0

Solar and Space Physics and Its Role in Space Exploration doc

Ngày tải lên : 14/03/2014, 10:20

... Printing Office, Washington, D.C., 2004 SOLAR AND SPACE PHYSICS AND ITS ROLE IN SPACE EXPLORATION the fundamental role of solar and space physics research both in scientific exploration and in ... principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering ... Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the...

74
369
0

Interest Rate Policy in Egypt - Its Role in Stabilization and Adjustment pdf

Ngày tải lên : 15/03/2014, 14:20

... A Interest Rate and Business Investment The first step in examining how higher interestrates may influence business investmentdecisions and performances is the understandingof firms' capital structure; ... Government plays a dominantrole in the financialmarket and its interventiinstake many forms, not only in terms of deficit financing,but also equity participationand management control in virtually all ... and domestic demand including public coneumption,the poor performance in export earnings brought about by a combinationof fallingoil prices, rising interestpaymentson external debt, and declining...

39
368
0

Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx

Ngày tải lên : 23/03/2014, 17:21

... no membrane-spanning domains in PEX14 have been unambiguously identiﬁed and it was observed in mammalian cells and S cerevisiae that both the N-terminal and the C-terminal domain are at the cytosolic ... synthesized proteins in the cytosol due to the inability to import matrix proteins by the fraction of growing and dividing glycosomes The miscompartmentation of PTS-1 and PTS-2 proteins (GAPDH and ALD, ... approximately 0.5 to induce the expression of the protein and growth was continued for h Cells were collected by centrifugation (3000 g, 10 min, °C) and resuspended in cell lysis buffer containing 50 mM...

9
549
0

Báo cáo y học: "ignal 3 and its role in autoimmunity" pot

Ngày tải lên : 09/08/2014, 01:23

... Germain RN: Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue Immunol Rev 2002, 189:51-63 O’Sullivan B, Thomas R: CD40 and dendritic cell function ... Available online http://arthritis-research.com/content/6/1/26 known roles in tissue inflammation, and damage in innate immunity Besides its capacity to drive the production of IFN-γ and IL-2 by ... development of inflammatory arthritis [14-16] This highlights the critical role of IL-1ra in the constitutive maintenance of peripheral tolerance, and in counterbalancing the proinflammatory effects...

2
317
0

Báo cáo y học: "Circadian rhythm and its role in malignancy" docx

Ngày tải lên : 10/08/2014, 09:20

... loss during intestinal tumorigenesis may, in part, act through upregulation of b-catenin, increasing intestinal b-catenin signaling and cell proliferation Also, increase in small-intestinal mucosa ... genes functioning in cell proliferation and tumour suppression, such as Cyclin D1, Cyclin A, Mdm2 (murine double minute, a negative regulator of p53) and Gadd45a (growth arrest and DNA damage-inducible ... regulating cell cycle genes and interacting with key DNA damage-activated checkpoint proteins Per1 overexpression in cancer cells increases ionizing radiationinduced apoptosis, whereas inhibition...

13
464
0

Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot

Ngày tải lên : 12/08/2014, 18:20

... those involved in insulin signaling, the insulin receptor substrate (IRS)-1, IRS2 and signal transducer and activator of transcription (Stat)-6 [23] IRS1 and IRS2 regulate proliferation and protection ... Acting as a decoy to bind and neutralize circulating cytokine, coupled with the high specificity and high affinity of binding for the cytokine, makes the soluble receptor ideal as a cytokine ... arthritis in adults and children Clinical studies with rhuIL-4R (Nuvance™) The promising results in preclinical studies led to preliminary investigations in which rhuIL-4R proved safe and effective in...

5
365
0

Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps

Ngày tải lên : 13/08/2014, 09:20

... also increasingly involved in the development and delivery of a range of education and training programmes designed to help individuals working in HIV advance professionally, from administering ... Providing education and training opportunities for its membership is important for any professional society, and the IAS is looking at ways to strategically expand its role in this area in order ... cross-disciplinary linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in Toronto and will...

3
201
0

Báo cáo y học: "Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release" pps

Ngày tải lên : 13/08/2014, 11:22

... bacitracin, a PDI inhibitor Finally, PDI expression was induced by the antiinflammatory cytokine IL-10, and IL-10-mediated inhibition of LPS-induced IL-6 expression was reduced by bacitracin These findings ... adrenomedullin and adrenomedullin-binding protein-1 in sepsis: down-regulation of proinflammatory cytokines Crit Care Med 2002, 30:2729-2735 Darby NJ, Creighton TE: Functional properties of the individual ... molecular chaperones in the folding of oxidized proteins Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein J Biol Chem 2001, 276:21337-21342...

8
327
0

MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS

Ngày tải lên : 24/08/2014, 10:58

... metastasis in vivo The N-terminal fibronectin (FN) binding domain of TG2 (tTG 1-140), lacking both enzymatic and GTPase function, induced EMT in OC cells, suggesting the interaction with FN involved in ... transduced into OV90 cells 103 xiv Figure 33 Wild-type TG2 and N-terminal fibronectin binding domain of TG2 induce EMT in OV90 cells Figure 34 104 Wild-type TG2 and N-terminal fibronectin binding domain ... at its protease sensitive hinge region, which is between the N-terminal ECM binding domain and the C-terminal LAP binding domain This can be achieved by many proteinases in the serine proteinase...

209
383
0

REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE

Ngày tải lên : 24/08/2014, 12:32

... expressed predominantly in erythroid cells HRI is regulated by heme through the two heme-binding regions in HRI: an N-terminal domain of HRI and in an insert region in the protein kinase domain of HRI ... the initiation codon in underline and bold and a flanking purine at the -3 and a G at the +4 positions (15) Together the eIF1 and eIF1A facilitate the recognition and selection of initiating ... aggregates in a dominant fashion, rendering insulin non-functional (145, 146) The aggregated mutant insulin proteins in the islet β cells can trigger ER stress, inducing cell death and depletion of...

127
407
0

arsenic binding to hemoglobin and its role in arsenic distribution, metabolism, and toxicity

Ngày tải lên : 14/11/2014, 06:30

182
168
0

A novel sec7 domain containing protein BIG3 and its role in regulated secretory pathway

Ngày tải lên : 11/09/2015, 09:15

... is more predominant ( Reaven, 1993; Ferrannini, 1998; Relimpio, 2003) The balance between insulin action and insulin secretion is coordinated by insulin sensitive tissues and endocrinal beta cells ... protein recruitment distiguishes the cargo-loaded subdomains from the rest of TGN Curvature-inducing proteins, such as the Bin/amphiphysin/Rvs (BAR) domain family and the GRIP-domain-containing ... endosomes and partial PM, and has a role in both E-cadherin recycling and actin remodeling through activating Arf6 (Hiroi et al., 2006; Someya et al., 2001) FBX8 is named after its N-terminal F-box...

189
302
0

Characterization of helicobacter pylori y glutamyl transpeptidase and its role in pathogenesis

Ngày tải lên : 12/09/2015, 09:55

... acid-binding adhesin The sialic acid-binding adhesin is a 70 kDa protein that belongs to the large Hop family of H pylori outer membrane protein, including BabA sabA is found to be present in most ... genes coding for a range of pro-inflammatory mediators, including interleukin-6, interleukin-8, and tumor necrosis factor α (Schreck et al., 1991) The increased expression of these pro-inflammatory ... and KATO III) displayed an increase in H2O2 generation, activated NF-κB and IL-8 production However, preincubating these cells with NAC (an antioxidant), ST638 (a tyrosine kinase inhibitor) and...

270
206
0

Characterization of rab22b, an astroglia enriched rab GTPase, and its role in golgi and post golgi membrane traffic

Ngày tải lên : 12/09/2015, 09:55

... is also expressed in appreciable levels in the spleen and intestine Immunohistochemistry analysis revealed that in the mouse embryonic brain, Rab22B labeling is found in nestin and RC2 epitope-positive ... act in a more indirect manner Thus, Rab11, besides playing important roles in retinal development of the eye and embryogenesis, also appears to have a specific role in neuronal and neuroendocrine ... form myelin sheaths (Simons and Trajkovic, 2006) The microglia is the equivalence of 24 Introduction immune cells in the CNS, playing roles in CNS inflammatory responses and serving in phagocytotic...

188
356
0