... molecular mode of action of glypho-
sate and the molecular basis for glyphosate resistance.
Structure and function of EPSPS
EPSPS catalyzes the transfer of the enolpyruvyl moiety
of phosphoenolpyruvate ... 4% of the
total soluble protein content of the cell [48].
Fig. 3. Microbial mechanisms of glyphosate
degradation. (A) Two principal pathways of
glyphosate degradation are known.
Top: cleavage of ... however, was devoid of substrate or inhibitor,
and consequently did not reveal the nature of the
active site or the mode of action of glyphosate. A dec-
ade later, the crystal structure of EPSPS was...
... phos-
phorylation state of their proteins, thereby changing
the amount and localization of Bcl-2 family members.
However, each type of cancer has its own way of
disrupting the balance of the networks of signaling
cascades ... with stimulation of ERK1 ⁄ 2 and
Pak1 pathways, gefitinib might lead to inhibition of
invasiveness of human cancer cells through the inhibi-
tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells
with ... inhibi-
tion of Akt- and ERK1 ⁄ 2-dependent pathways eventu-
ally change the expression level of one or more of
these Bcl-2 family members.
Bad
Bad is one of the ‘death-promoting’ members of the
Bcl-2...
... centre of geometry of the NarG(1–15) peptide. Only
the best structures of each of the 10 best clusters are depicted
(
HADDOCK score). Surface residues of NarJT in brown form the
bottom of the ... the
complex by 10-fold, as judged by k
off
. The physiological
chaperone cycle probably consists of the rapid binding
of the N-terminus of the partner, regardless of whether
it is a twin-arginine signal ... completion of the
maturation process of the partner. The nature of the
signal that may trigger dissociation of the complex
remains unclear; however, we propose that a local
perturbation of the hydrogen...
... Resources of the National Land Management Authority, Office of Prime Minister, Laos, the
Foundation for Ecological Recovery, and the Faculty of Social Sciences, Chiang Mai University (list of
researchers ...
management of land, under which the people of Laos have use rights as granted by
the state. This has always formed the central core of the definition of land. More
recent changes to the definition of ... strategic direction of the forest management highlighting the
importance of conservation of biological forest resources, the efficient development
of the forest, and the regeneration of forest resources....
... not of certainty, but of mere opinion.
And this estimate of the function of philosophy with respect to theological truth, which the Fathers worked
out on the basisof the concrete example of the ... the truth, but each only from one point of view, and on the basisof only one
method of approach. The conclusions of each were the result of a process of more or less complete
abstraction, and ... scholar of the Church University Board of Regents from July, 1895, to the
present time.
End of the Project Gutenberg EBook of The Basisof Early Christian Theism, by Lawrence Thomas Cole
*** END OF...
... almost their entire fair share of global hectares on housing
alone (1.77 of 1.8 gha).
5. The citizens of St Albans use most of their fair share just on transport (1.7 of 1.8 gha).
6. Leicester ... Ecological Footprinting?
Most people now know what a carbon footprint is. It is a measure of how much CO
2
is emitted as
a result of all aspects of our everyday lives. This is a good way of ...
there is a mismatch of location between consumption and the implications of consumption.
Ecological Footprinting helps to show people just how much pressure their patterns of
consumption are...
... the
occurrence of an outcome of interest. This might be a study of time until disease pro-
gression or overall survival. In these types of study designs, it is the person-years of
follow-up that ... Panos
When you hear hoofbeats behind you, don’t expect to see a zebra.
Theodore E. Woodward, MD, University of Maryland, Circa 1950 (1)
Abstract The National Institutes of Health Of ce of Rare Diseases ... there are many different types of study designs; some of which require only
a fraction of the number of subjects required to the randomized controlled trial, which
is often considered the gold standard.
Alternate...
... typical integration
is then finished off by the formation of a second-strand nick and integration of the end of the
cDNA (Fig. 2A). However, significant portions of the events appear to complete ... genomic
rearrangements.
Most of the Alu–Alu recombination events are between nearby elements, generally spanning
distances of less than 50 kb and often only a few kb in length. There are also a number of cases
of chromosomal ... required further explanation of the need for their
samples. I often thought of the irony of the situation. At these reunion parties, Dr. Garcia would
oversee the administration of the electrical shocks...
... different species [23–25]. The success of the series of
studies shows that the stable framework structure of
Fv enables the transfer of function by means of CDR
replacement.
Barbas et al. first ... the
CDR loop of the single variable heavy chain of a
heavy-chain camel antibody (VHH) (Fig. 1B) by com-
paring topologies between VHH and NCS (Fig. 2A);
grafting of the CDR 3 loop of antilysozyme ... sequence of charyb-
dotoxin with one of toxin a to express a new binding
function. Comparison of the X-ray crystal structures
between charybdotoxin and toxin a showed the struc-
tural resemblance of...
... Left lane:
14
C-methylated protein markers of 200, 97.5, 66, 46 and 30 kDa, from the top of
the gel.
N. Numa et al. Molecular basisof perinatal form of hypophosphatasia
FEBS Journal 275 (2008) ... gel.
Molecular basisof perinatal form of hypophosphatasia N. Numa et al.
2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS
Molecular basisof perinatal ... GPI-anchorless soluble
version of the mutant protein. The K
cat
⁄ K
m
value of
the mutant TNSALP was less than one-tenth of the
K
cat
⁄ K
m
value of the soluble form of the wild-type
enzyme, indicating...
... scenario and some pilot studies to test
the feasibility of our approach.
2 Advantages ofEcological Approaches
Evaluation of the effectiveness of persuasive sys-
tems is very expensive and time consuming, ... performance of each single
ad (its persuasiveness, from our point of view):
• CTR, Click Through Rate: measures the num-
ber of clicks divided by the number of impres-
sions (i.e. the number of times ... total of 38
thousand subjects and a cost of 30 euros (see Table
1 for the complete description of the experimental
setup). It was meant to test broadly how affective
variations in the body of the...
... the Basisof Complementation Patterns
Kata G
´
abor
Dept. of Language Technology
Linguistics Institute, HAS
1399 Budapest, P. O. Box 701/518
Hungary
gkata@nytud.hu
Enik
˝
o H
´
eja
Dept. of Language ... on the basisof their complementation
patterns, yielding a set of basic classes and
hints about the features that determine ver-
bal subcategorization. The resulting classes
serve as a basis for ... attempt to
cluster verbs on the basisof their syntactic proper-
ties with the further goal of identifying the seman-
tic classes relevant for the description of Hungarian
verbs’ alternation...
... entry of a word than the identity
of the word itself, e.g. MAJOR and other HEAD fea-
tures in (Pollard and Sag, 1987). In the early days of
statistical parsers, POS were explicitly and often ... (2000) give an
overview of the CoNLL shared task of chunking.
The types and definitions of chunks are identical to
the ones used here. Training material again consists
of the 9000 Wall Street ... addition, the
effect of our mix of sentences from different corpora
on top of WSJ is not clear.
Ferro et al. (1999) describe a system for find-
a different category, as in the case of VP/S-NOM in
the...
... flowering plants, 17% of all species of birds, 12% of
all species of mammals, 16% of all species of reptiles, and 16% of all species of amphibians.
36
PNG
covers only 0.3% of the Earth's ... achieve a series of objectives such as the development of
isolated rural areas, accumulation of property for landless farmers, better development and use of
natural resources, creation of jobs, ensuring ... on emissions of waste-water
• use of integrated pest management
• significant reduction in the use of pesticides and transparency in the amount of pesticides used
• recycling of POME
7. Companies...
... associations.
the magnitude of asymmetry. In a similar vein,
Wettler et al. (2005) successfully predict associa-
tions on the basisof co-occurrence in text, in the
framework of associationist learning ... theory of acquisition, induction and rep-
resentation of knowledge. Psychological Review,
104(2):211–240.
Dekang Lin. 1998. Automatic retrieval and cluster-
ing of similar words. In Proceedings of ... contigu-
ities between words in texts. Journal of Quantitative
Linguistics, 12(2/3):111–122.
656
Proceedings of the 12th Conference of the European Chapter of the ACL, pages 648–656,
Athens, Greece,...