... tasks.
Many other operating systems have met with this problem. Often these systems solve the problem by using inside
knowledge ofthe algorithms used to manage secondary storage. Unfortunately, the Mach ... collection ofoperatingsystem primitives defined such that a programmer has the option of
choosing to use either shared memory or message-based communication as the basis for the implementation of a
multithreaded ... or receipt of data in an IPC message. In the first case, the source of the
data is considered trusted (either the default pager, or a data manager known to the requestor). Use ofthe data
received...
... and Professor of Economics at the
Wharton School ofthe University of Pennsylvania
Thorsten Beck Professor of Economics and Chairman ofthe European Banking
Center, Tilburg University, Netherlands
Charles ... transmission
of information in the price, and greater effi-
ciency ofthe market. In the bond market, the
most commonly used variable is the tightness
of the bid-ask spread (with the U.S. and ... from around the world.
Two building blocks underlie the report’s
view oftheroleofthe state in finance. First,
there are sound economic reasons for the
state to play an active role in financial...
... must still be determined whether
its absence in the V79-G18 mutant is the result ofthe missing
ESSS subunit alone, or whether the absence of ESSS causes
the f ailure of other integral membrane subunits ... and the effect of
the absence of intact complex I, but the results are too
preliminary in this regard.
Heterologous expression ofthe ESSS-HA subunit
The localization ofthe ESSS subunit in the ... as a nother identification of
the complex at the position o f the histochemical stain in the
left panel. Antisera against the SDHC subunit of complex II
and against the Rieske protein of complex...
... required for efficient
cleavage [11].
The solution structure ofthe SEA domain of the
mouse homologue of MUC16 (which in the human
encodes the core protein ofthe ovarian cancer antigen
CA125) was ... further
investigate theroleofthe SEA domain in cleavage of
membrane-tethered mucins we carried out site-directed
mutagenesis ofthe FRPG ⁄ SVVV site and evaluated
hybrid mucins in which the ... ducts is of
considerable significance in the pathology of a number
of diseases including cystic fibrosis and cancer.
Equally important is the fate ofthe cytoplasmic tail
of the mucins once the extracellular...
... locks the enzyme in the active form for CTP synthesis and
thereby stimulates the k
cat
of the reaction. Since GTP actually will
activate the uncoupled glutaminase reaction the structure of the
monomer ... was
similar to that ofthe overall CTP synthesis reaction. It
was concluded that the effect of GTP was mainly to
enhance the rate of chemical steps ofthe glutaminase
reaction. The finding that the k
cat
value ... as the displacement ofthe baseline. The peaks
observed at each injection time are derived from the heat of dilution
of glutamine into the reaction cell. (B) The heat generated by hydrolysis
of...
... sense of group identity, in the eyes of its
members and those outside the group.
What is theroleofthe facilitator?
The roleofthe facilitator is to make it easier for
groups to work together ... 1. TheRoleofthe Facilitator – page 6
What is theroleofthe facilitator?
How do facilitators help groups achieve their goals?
They do it by
• Clarifying and reinforcing the purpose ofthe ... Facilitation - 1. TheRoleofthe Facilitator – page 11
Group dynamics
Facilitators need to be aware both ofthe
communication styles ofthe individuals who
make up the group, and ofthe way the group...
... examine
the dynamics of tobacco-related media
interventions at each of these levels, within
a systemic framework.
The relationships among these levels and
stakeholders on either side ofthe tobacco ... product ofthe mass media era; the art and science of
mass communications and mass marketing were critical to the growth of tobacco use in the
past century. At the same time, however, the media ... underestimate
the effectiveness ofthe campaign.
n
Last, the all-pervasive nature ofthe media
environment includes both messages of
interest as well as background “noise.”
Given these challenges,...
... The purpose of this plan is to ensure the
protection of areas significant to the health of waterways and related ecological values.
The purpose of this plan falls directly under the remit of ...
health ofthe aquatic ecosystem. There are several measures ofthe level of nitrogen present in a water body,
these include TKN, ammonia, nitrate and nitrite concentrations. The quantity of phosphorus ... increased by 71%, amounting to 23% ofthe State’s direct output from the industrial sector. Mining
employed 3.2% ofthe local labour force during the period. The offices ofthe major mining companies...
... possible
interpretation ofthe data suggests that the indicated
basic region of ic3 ofthe D
2
receptor and acidic region
of the C-tail ofthe D
1
receptor might be involved in
the interactions between the two ... on the number of Arg residues that
were replaced by Ala in the Arg-rich region of ic3 (resi-
dues 217–222) ofthe dopamine D
2
receptor. The effi-
ciency of energy transfer in the wild-type ofthe ... localization of these proteins in the cell rather than
from the possible roleofthe D
2
R basic domain in the mechanism of
D
1
–D
2
receptor heterodimerization. However, we find that the acidic
epitope...
... cleavage ofthe c-phosphate does occur in the
NBD with the mutation at the IC [36,38,39]. More-
over, these and other studies suggest that the IC
residues are involved in the formation ofthe NBD
dimer, ... sequence contacts the
c-phosphate ofthe bound nucleotide across the
dimer [15] and the aromatic residue ofthe A-loop
stacks against the adenine moiety of bound
nucleotide and provides further stabilization ... activates the attacking
water molecule that cleaves the terminal phosphate of
bound ATP. In the latter model, the IC is part of a
catalytic dyad, along with the histidine residue of the
H-loop,...
... study
the behavior ofthe Tyr110-loop in PAL in more
detail.
Results and discussion
Modeling the active conformation of the
essential Tyr110-loop of parsley PAL
Because ofthe uncertainty ofthe ... subtilis [34], respectively. On the basis of the
functional similarity of HAL and PAL, ofthe same
electrophilic prosthetic group at the active sites, and of
the sequence conservation over a ... interpreted by
this hypothesis. The hypothesis will also be extended
to the analysis ofthe possible roleof C-terminal
multi-helix domain in this process.
Investigation of bacterial PAL structures
As...
... family. One ofthe women told that she had been at the offices of
the company and an officer showed her the papers related to the purchase of lands ofthe family.
According to him, they had just ... from the existence of swamps.
The Pampa ofthe South of Brazil, in the State of Rio Grande do Sul (RS) borders another two
countries ofthe Pampa: Uruguay and Argentina.
Due to a number of ... meet the needs ofthe communities. On the contrary,
they were designed on the basis of an agro-export model geared to the countries ofthe North – and
the European Union specifically in the...
... upstream
of the GAF domain are the potential ligands of the
Fe-S cluster. Consequently, the binding ofthe ATP
analog and the subsequent rearrangement ofthe inter-
domain interaction affects the ... electronic condition of
the Fe-S cluster through the protein scaffold, resulting
in an alteration ofthe signal rhombicity ofthe EPR
spectrum. The divergence ofthe g-value from that of
the whole cell ... level ofthe lacZ gene immediately after the
addition of o-phen to minimize the effect ofthe growth
inhibition by o-phen on the transcriptional activity of
VnfA. Figure 5 shows the time course of...
...
discrepancies within the nursing profession with regard to specialist/
advanced nursing titles, differing roles and the educational needs of
these nurses.
In the United Kingdom, the idea of advanced ... ongoing professional development, rather than a
requirement of their job description.
The implementation within the NHS ofthe Agenda for Change in
2005 aimed to evaluate nursing roles based ... participation in the research process. If the
aim of clinical nurse specialists is to enhance patient care, then research
must be part oftherole (Armstrong 1999). It will involve their awareness
of current...
... implemented
to help explain their importance to the specificity and
catalytic efficiency ofthe enzyme.
The roleofthe Phe-Phe entranceway
The fortuitous discovery of an unreacted molecule of
the mechanism-based ... seen for the Phe triad in
the structure ofthe mutant Exg:L3 complex. Neither
of the two sugar residues interacting with the Trp triad
overlaps with the sugar seen in the Phe-Phe clamp of
Exg.
Structural ... solved the crystal structure of this GH5
enzyme in the presence of two different mechanism-
based inhibitors, thereby revealing the close network
of interactions that hold the terminal glucose of the...