crystal structure of pparγ and rxr 8
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
Ngày tải lên :
12/09/2015, 11:08
... groups of patients Kd is the concentration of a drug that results in binding to 50% of the receptors Figure Chemical structure of troglitazone Figure Crystal structure of PPARγ and RXR Crystal structure ... with the DNA-binding domains of PPARγ and RXR and shields the highly polar side chains of the interacting residues (Asn 160 from PPARγ, and Arg 209 and Gln 206 of RXR ) from an aqueous environment ... LIST OF FIGURES Figure Drug toxicities leading to market withdrawals in the period 1976 to 2005 Figure Chemical structure of troglitazone Figure Crystal structure of PPARγ and RXR ...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
Ngày tải lên :
14/02/2014, 18:20
... guidelines of the National Institutes of Health Treatment with GdCl3 and experimental groups For depletion of KCs in vivo, 7.5 mgÆkg)1 of GdCl3 was injected via the tail vein at 48 and 24 h before ... role of proinflammatory cytokines Int J Mol Med 18, 339–346 34 Sims GP, Rowe DC, Rietdijk ST, Herbst R & Coyle AJ (2010) HMGB1 and RAGE in inflammation and cancer Annu Rev Immunol 28, 367– 388 35 ... Effect of sepsis on tissue adenine nucleotide levels Surgery 85 , 205–211 38 Buege JA & Aust SD (19 78) Microsomal lipid peroxidation Methods Enzymol 52, 302–310 39 Anderson ME (1 985 ) Determination of...
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Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf
Ngày tải lên :
23/03/2014, 10:21
... X-ray crystal structures (Cys10 in human TTR) and considered part of the core structure of TTR In general, the character of the N-terminal region of TTRs changed from longer (14 amino acids) and ... values for both T3 and T4 of the truncated crocTTR were similar Truncated crocTTR bound to T3 with a Kd of 57. 78 ± 5.65 nm and to T4 with a Kd of 59.72 ± 3. 38 nm (Fig 7E,F and G), leading to ... region of crocTTR was deleted The affinity of T3 and T4 to both TTRs was studied and the results are a powerful demonstration of the relationship between the evolution of the primary structure of...
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báo cáo hóa học:" Using individual growth model to analyze the change in quality of life from adolescence to adulthood" potx
Ngày tải lên :
20/06/2014, 15:20
... 101.53 (8. 14) *** 0.30 (0. 08) *** 130.45 (7.17) *** 101. 68 (8. 11) *** 0.31 (0. 08) *** 129.36 (7.12) *** 87 .34 (7.39) *** 0.30 (0. 08) *** 1 28. 50 (6.96) *** 79 .86 (7.09) *** 0. 28 (0. 08) *** 1 28. 71 ... 78. 87 (13.13), 76. 18 (14.97), and 67.43 ( 18. 53) respectively Skew of physical health scores are -0.95, -0 .87 , and -0.51 for the three waves of data Kurtosis of physical health scores are 0 .86 , ... (0 .84 ) *** 0.25 (0. 08) ** 72.26 (0.60) *** -0.67 (0.06) *** -7.24 (0 .81 ) *** 0.22 (0. 08) ** -5.95 (0 .87 ) *** -0.23 (0.11) * 17624.0 17627.0 3.0 175 38. 3 85 .7 *** 17 485 .8 1 38. 2*** Goodness of Fitb...
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báo cáo hóa học:" Physical activity and change in quality of life during menopause- an 8-year follow-up study" docx
Ngày tải lên :
20/06/2014, 16:20
... 0.93 0 .88 0.77 o 1.14 0.70 to 1.11 284 3 58 455 (ref.) 1.01 1. 28* * 0 .85 to 1.21 1. 08 to 1.51 19 271 383 424 14. 18 5.94 1.95 (ref.) 232 590 275 1.46*** 1.49*** 1.24 to 1.73 1.23 to 1 .80 2 08 765 ... in Finland between 2000 and 2001 and has been described in detail elsewhere [ 18, 19] A nationally representative two-stage stratified cluster sample was drawn of adults aged 30 and over and living ... healthrelated quality of life? The American Journal of Medicine 2005;1 18: 25S-36S [ 18] Aromaa A & Koskinen S (eds) Health and functional capacity in Finland Baseline results of the Health 2000 Health...
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The genius in all of us new insights in david shenk
Ngày tải lên :
27/07/2014, 14:02
... underbelly of profound racism in which alleged proof of biological superiority of white Protestants was used to keep blacks, Jews, Catholics, and other groups out of the higher ranks of business, ... Precisely which genes get switched on, and when, and how often, and in what order, will make all the di erence in the function of each cell and the traits of the organism “In each case,” explains ... blueprints, genes—all twenty-two thousand of them1—are more like volume knobs and switches Think of a giant control board inside every cell of your body Many of those knobs and switches can be turned up/down/on/o...
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Báo cáo y học: "Assessing the effect of HAART on change in quality of life among HIV-infected women." pdf
Ngày tải lên :
10/08/2014, 05:20
... Naive (N = 4 58) HAART Users (N = 4 58) P-Value 38. 6 38. 4 0.42
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Báo cáo y học: " Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychotics" ppsx
Ngày tải lên :
11/08/2014, 15:22
... (22.5) (1 .8) (2.9) 96.3 (17.0) 95.7 (16.2) 99.5 ( 18. 4) 101 .8 (21.1) 84 .1 (14 .8) 85 .2 (4.7) PANSS Total Score Mean (SD) 13 (7.6) 17 (9.7) 0 (3.2) (1.3) (1.0) (3.1) (3 .8) 96 (34.2) 84 (29.5) 13 (8. 2) ... (41.5) 124 (45 .8) 90 (53.2) 88 (50.3) 78 (27 .8) 90 (31.6) 95 (59.7) 101 (63.9) 51 (52.6) 67 (51.1) 72 (54.5) African 35 (20.3) 36 (21.6) 78 ( 28. 2) 66 (24.4) 64 (37.4) 65 (37.1) 87 (31.0) 90 (31.6) ... 40.05 38. 24 41.67 40.45 38. 3 37.3 38. 40 39.5 39 .8 23.53 24.00 (SD), y (10 .81 ) (10.6) (11.59) (12.1) (9.53) (9.6) (10.50) (10.4) (7.90) (8. 25) (8. 32) (4.61) (4.90) Male 114 (66.3) 106 (63.5) 180 (65.0)...
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Báo cáo y học: " Change in quality of life and their predictors in the long-term follow-up after group cognitive behavioral therapy for social anxiety disorder: a prospective cohort study" pptx
Ngày tải lên :
11/08/2014, 16:22
... (57.5) 0.63 Age, years Mean ± SD 27.4 ± 8. 8 34.2 ± 9.3 34.2 ± 9.3 34.2 ± 8. 9 0.12 Range 18- 47 18- 52 18- 52 18- 52 17.1 ± 4.2 19.4 ± 7 .8 19.4 ± 7 .8 19.6 ± 7 .8 12-23 5-42 5-42 5-42 With spouse/ significant-other ... Antidepressant (77 .8) (50.0) (50.0) 20 (50.0) 0.50 Physical functioning Role-physical 85 .6 ± 14.7 75.0 ± 43.3 91.3 ± 11 .8 62.5 ± 43.3 82 .5 ± 22.2 56.3 ± 51.5 88 .6 ± 14.3 68. 6 ± 36.6 0.79 0 .87 Bodily pain ... 32.5 65 .8 ± 25.3 0. 08 General health perception 47.2 ± 22.4 49 .8 ± 26.3 44.3 ± 26.3 45.1 ± 22.1 0. 98 Vitality 42.2 ± 23.6 45.0 ± 5 .8 20.0 ± 18. 3 39.6 ± 21.1 0. 28 Social functioning 45 .8 ± 23.4...
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Báo cáo y học: " Development of a new ultra sensitive real-time PCR assay (ultra sensitive RTQ-PCR) for the quantification of HBV-DNA" pot
Ngày tải lên :
12/08/2014, 04:20
... concentrations of 10 IU/mL were tested on of occasions (50%), while IU/mL were detected on out of occasions (25%) The 95% and 50% detection end-point of the assay were 22.2 and 8. 4 IU/mL respectively ... Chiron/GenProbe, CA) of the WHO standard at final concentrations of 100, 50, 25, 10 and IU/mL The 95% and 50% HBV-DNA detection limits were calculated by probit analysis (8 replicas) Assessment ... instead of hybridization probes, 2) extraction of HBVDNA from a larger volume of serum/plasma (0.5 versus 0.2 mL), 3) use of 30 μl instead of 10 μl extracted DNA, 4) modified RTQ-PCR conditions, and...
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Báo cáo y học: "The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001–2006) in Portugal" potx
Ngày tải lên :
13/08/2014, 06:20
... 10.5 8. 1 13.2 63 572 11,0 8. 6 13 .8 226 557 40.6 36.5 44 .8 50 570 8. 8 6.6 11.4 53 5 78 9.2 6.9 11 .8 2 58 541 47.7 43.4 52.0 32 572 5.6 3.9 7 .8 40 619 6.5 4.7 8. 7 245 560 43 .8 39.6 48. 0 40 ... difficult to optimize therapy and there is a higher incidence of AIDS and death [6,7] Moreover, transmission of such multidrug resistant HIV is well documented [8] , and is associated with suboptimal ... '05 July '05 Jan '06 1 18 129 1 08 224 382 281 335 262 355 376 313 196 315 Figure resistance database Overview of available genotypes per half year in a Portuguese Overview of available genotypes...
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Summary of doctoral dissertation epublic of korea vietnam strategic cooperative partnership and the way forward in the new context of global governance change in the 21st century
Ngày tải lên :
14/07/2014, 13:28
... to strengthen and deepen the world trade order 1.2.2.3 Global Issues and Limitation of the Roles of the UN and G8 Nowadays, there are many issues like drugs, terrorism, poverty and climate climate ... ROK and Vietnam share a common experience of having overcome every national crisis, at home and abroad, throughout thousands of years of history, while proudly preserving their traditions and ... strength of the United States decreased and there were changes in the distribution of economic power due to the comparative rise of some new emergent blocs and countries such as EU and China...
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Báo cáo y học: "Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD" pdf
Ngày tải lên :
10/08/2014, 05:20
... 1 .88 ) 2 .88 (2.40 – 3.45) 5. 38 (3.94 – 7.35)
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IMPACT OF FOREIGN DIRECT INVESTMENT ON ECONOMIC STRUCTUAL CHANGE IN HO CHI MINH CITY
Ngày tải lên :
07/11/2014, 17:25
... shortcomings of policy and solutions" of Do Duc Binh (2009), Journal of Economics and Development, (145), p 6-9, "Transparency of the legal system and policies on foreign investment: Current situation and ... evaluating and licensing investment firm handling the harassment officers, irresponsible Strong development of infrastructure and service systems to support production and business 3.2.1.3 Acquiring and ... Promotion of the development of high-tech agriculture - Improvement of the quality and change of the labor structure CONCLUSIONS AND RECOMMENDATIONS Conclusions First, the thesis presents the theory of...
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Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
Ngày tải lên :
25/10/2012, 10:02
... P: Fusion of dispatching centres into one entity: effects on performance Acta Anaesthesiol Scand 2010, 54(6): 689 -695 Handbooks of the Ministry of Social Affairs and Health Ambulance and emergency ... the area increased from 273 000 to 281 000 and the death rates varied from 180 9 to 182 0 per year [8] Performance indicators The identification and development of the performance indicators was ... despite structured education, regular evaluation and standardization of protocols in the new EMCC organization Author details Karolinska Institutet, Department of Clinical Science and Education and...
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Negotiating agrarian change livelihood agriculations of the commercial craft peasantry in northern vietnam
Ngày tải lên :
04/08/2013, 09:59
... Introduction 284 8. 2 Principal Findings 285 xvi TABLE OF CONTENTS (CONTINUE) PAGE 8. 2.1 Contested Meanings of Farming, Farmland, and Peasant Category 285 8. 2.2 Market-driven Traditional Handicraft ... Household Handicraft Service Others 1726 142 1394 170 20 (80 .76%) (9 .84 %) (1.17%) 82 799 76 20 (81 . 78% ) (7. 78% ) (2.05%) 33 315 48 15 (8. 03%) Person Farming (8. 39%) Labor Person Total (8. 23%) Inhabitants ... Fragmentation of Labor 291 8. 2.6 The Re-organization of Labor within Households 292 8. 2.7 The Invasion of Female Labors into Male Work 293 8. 2 .8 Gender Negotiation: Change and Tension 295 8. 3 Theoretical...
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Empirical investigation of market value change in vietnam stock market
Ngày tải lên :
27/09/2013, 21:53
... 0.00000 0.16 682 66 3.2 484 8 1.761 38 19. 482 63 0. 281 36 3 .81 021 66 0.096 58 0. 080 44 0.60901 -0.31476 0.0 985 8 87 0.46391 0.26 180 6.059 18 -0.26962 0 .83 1 58 87 0.13 284 0.07964 0.65476 0.00000 0.16005 87 0.12579 ... 0.3 186 4 0.52305 0.377 98 2 .82 955 1. 088 02 1.11 287 3.563 38 0.0 086 6 0.79720 0 .88 375 4.2 684 5 1.06799 0.95265 2. 785 30 0.0 786 7 0.64190 0.5 283 8 2.63047 1.169 68 1.2 486 8 2.62376 0.00057 0.67 381 -0.06492 2.06493 ... 0.04259 87 0.40971 0.40554 3.57143 0.00000 0.44540 87 11 .88 837 11 .85 752 13.15574 11.05594 0.43 583 87 0.7 585 4 0.7 781 5 1.25527 0.00000 0.22103 87 7.237 38 7.27413 8. 37340 5 .81 903 0.44535 87 2. 980 50...
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Tài liệu Women Sufficiently Represented in New Drug Testing, but FDA Oversight Needs Improvement doc
Ngày tải lên :
12/02/2014, 23:20
... 6, 088 1,127 6,1 38 3,9 98 8,770 2,265 9 98 6,441 42 54 17 53 55 54 35 16 52 57 42 83 47 42 46 65 84 28 53 64 48 202 123 40 186 184 21 73 50 38 45 32 27 50 55 55 993 3,404 1,432 4 98 743 37 100 28 ... and Immunosuppressants (9) A 1,572 649 B 5 ,82 9 3,2 58 C 736 1 28 D 1, 588 80 8 E 1,346 670 F 7,246 3,617 G 1,295 4 38 a H 9 98 164 a I 5,644 3,021 Cancer (5) A 387 145 B 1,176 1,176 C 59 29 a D 1 78 ... 17 35 81 3 1,531 523 23 14 24 77 18 73 28, 002 9,171 5,136 67 49 24 33 17 32 59 44 79 49 45 49 68 79 36 482 490 4 18 722 274 557 730 675 1,103 21 28 11 34 17 22 27 10 74 72 68 66 83 79 78 73 78 5,442...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
Ngày tải lên :
19/02/2014, 07:20
... extracts of CsA-treated mice, the level of GM2 is unaffected Gb3 tissue histochemistry The localization of Gb3 within frozen sections of liver and selected tissues from Fabry and wild-type mice 20 68 ... In Vivo 8, 83 5 84 1 33 Ernest S, Rajaraman S, Megyesi J & Bello-Reuss EN (1997) Expression of MDR1 (multidrug resistance) gene and its protein in normal human kidney Nephron 77, 284 – 289 34 Forsyth ... GSL standards: from the top GlcCer, LacCer, Gb3,Gb4,Gb5 (Forssman), GM3, GM2,GM1; lanes and 4, lipid extract of wild-type liver; (F, G) lane 1, GSL standards; lanes and 4, lipid extracts of control...
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