compounds antioxidant and antiandrogens in the prevention of prostate cancer in vivo evidences from murine models and human clinical studies
Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
Ngày tải lên :
10/08/2014, 05:21
... detected in the pCX-IG-injected vehicle control prostate (arrowhead-indicated in (a)) and in PIN and CaP lesions of the pCXshh-IG-injected prostates (arrowhead-indicated in (b) and (c)) All luminal ... those of the sham and vehicle controls Scale bars: 50 μm in upper (d) of panel A; 10 μm in lower (d) of panel A and in (d) of panel C CaP: prostate cancer; HE: hematoxylin-eosin stain; PIN: prostatic ... magnifications of the boxed areas shown in the upper pictures Hedgehog signalling members were expressed in the PIN (F-J) and CaP (K-O) of the pCX-shh-IG-injected prostates, in contrast to the absence of...
- 11
- 446
- 0
báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf
Ngày tải lên :
10/08/2014, 22:21
... tyrosine kinases, primarily by binding the ATP binding domain, has led to investigation of tyrosine kinase inhibitors as angiogenesis inhibitors In general, because tyrosine kinases are involved in ... isoforms, preventing binding to the VEGF receptor It was developed from a murine antihuman VEGF antibody and retains 7% of the murine sequence Single agent bevacizumab was initially evaluated in ... rising PSA levels Thus, the activity profile of sunitinib appears to be similar to that of sorafenib in this setting The findings of this study again highlight the need for better markers of clinical...
- 12
- 411
- 0
INTENSIVE LIFESTYLE CHANGES MAY AFFECT THE PROGRESSION OF PROSTATE CANCER docx
Ngày tải lên :
29/03/2014, 01:20
... test in the case of continuous variables and the chi-square test of association in the case of categorical variables Between group differences in baseline to 12-month changes in clinical and behavioral ... cholesterol and weight Cardiovascular disease is the leading cause of death of men and women in the United States and either the primary or secondary cause of death of most men with prostate cancer, and ... studying the mechanisms and benefits of various therapeutic interventions This cell line was initially derived from a patient with androgen dependent prostate cancer and it has been used in numerous...
- 6
- 629
- 0
scientific american - 1994 04 - the dilemmas of prostate cancer
Ngày tải lên :
12/05/2014, 14:54
... scan of the abdomen and the pelvis, searching for evidence of cancer in the lymph nodes Experience teaches us that cancer in these nodes often signals the presence of cancer elsewhere in the body ... part of the decline in the relative importance of manufacturing to the economy Why, then, has the share of manufacturing declined? The immediate reason is that the composition of domestic spending ... and contains none of the resins in accepting science as an ally in the edÑbefore serving that give retsina wines their ßavor practice of the arts Two important safety points need to In the late...
- 93
- 519
- 0
Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
Ngày tải lên :
08/08/2014, 17:20
... 2.88 6.58 Increased Increased Increased Increased Increased Increased Increased Increased Increased Increased Unchanged Increased Increased Decreased Decreased Increased Following the 12 week ... P, Perlaky L, Thiry M et al The in vitro and in vivo antitumor activity of vitamin C: K3 combinations against prostate cancer In: Lucas JL Editor Trends in prostate cancer research Hauppauge, ... course of the study, PSADT was the primary endpoint Using this criterion, thirteen of 17 patients had significant increases in PSA doubling time Following the initial 12 week trial, two of the three...
- 6
- 510
- 0
Báo cáo sinh học: "Therapeutic dendritic cell vaccine preparation using tumor RNA transfection: A promising approach for the treatment of prostate cancer" pps
Ngày tải lên :
14/08/2014, 19:22
... Vaccines and Therapy 2008, 6:2 cific antigens (PSA), the south and southeastern regions of Brazil are expected to exhibit the highest incidence Seric PSA level has aided in the diagnosis of very ... combinations of FITC- and PE-labeled mAbs Cells (1 × 106) were resuspended in PBS containing bovine serum albumin 0.1% and then incubated for 20 at 4°C with optimal concentrations of the monoclonal ... methods, electroporation and coincubation, for transfecting RNA into DCs The amount of RNA and the DC maturation stage for transfection were also analyzed The prostate tumor cell line (LNCaP) was chosen...
- 7
- 363
- 0
THE SUSTAINABLE DEVELOPMENT OF TREE CROPS AND THE PREVENTION OF VEGETATION FIRES IN SOUTH SUMATRA, INDONESIA pptx
Ngày tải lên :
08/03/2014, 10:20
... smallholder farming remains the main land-use in the peneplains of Sumatra (10 million hectares nationwide) These smallholders retain a direct interest in the preservation of the both forests and the plantations ... percent of the income comes from the sale of the latex, and the rest in cash and kind from the associated species The ability to secure sufficient income depends on the availability of new land to support ... extent, the size of the area burnt - and the matching of these with maps of land-use This indicated that most serious and persistent fires originated in logging concessions and agro-industrial...
- 77
- 521
- 0
báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx
Ngày tải lên :
20/06/2014, 08:20
... data, interpreted the findings and wrote the manuscript OM was involved in developing the study proposal, supervising the data collection and reviewing the manuscript SGH was involved in developing ... developing the study proposal and reviewing the manuscript MMS was involved in supervising the data collection and reviewing the manuscript KMM was involved in developing the study proposal and reviewing ... two mothers had live birth of twins (Figure 1) Table shows the demographic and obstetric characteristics of the mothers enrolled in the study The median age of the mothers was 25 years and the...
- 10
- 712
- 0
Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
Ngày tải lên :
09/08/2014, 01:22
... and medications Progress will only be made as basic science brings an understanding of the mechanisms of accelerated atherosclerosis in SLE and as clinical studies address both the efficacy and ... little reinforcement from their providers In recruiting patients with SLE and hyperlipidemia for a statin dosing study, our experience has been that the patients who are the most willing to participate ... normal individuals is simple and neat, but might be wrong or incomplete 10 11 12 Several questions remain unanswered in our search for a successful approach to the prevention of ASVD in SLE The...
- 2
- 366
- 0
Báo cáo khoa học: " A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients" pdf
Ngày tải lên :
09/08/2014, 10:21
... to the affected area with the bare hand Application of the cream was accomplished with the ventral surface of the fingers using a rotary motion of the fingers with light pressure to the skin The ... administered in the same manner and on the skin of the same patient, we removed the individual effects by analyzing the difference of the two scores (i.e., gel score – cream score) rather than the ... at reducing the drying effect of radiation on the skin and involves instructing patients to avoid irritating the irradiated region Dryness due to RT leads to desquamation and loss of the superficial...
- 8
- 562
- 0
Báo cáo y học: "Barriers to the implementation of programs for the prevention of mother-to-child transmission of HIV: A cross-sectional survey in rural and urban Uganda" pptx
Ngày tải lên :
10/08/2014, 05:20
... thought that their husbands would approve of their being tested and the remaining (n = 72 or 19%) feared that their husbands would not approve of their being tested Also, the majority of women (n ... survey, the perception that the husband would approve of a mother's decision to test for HIV was the strongest predictor of whether the mother had the intention of testing or not This finding highlights ... informed them that they had come to the antenatal clinic that day and also 68% (264) of the women thought that they should consult their husbands before having an HIV test In addition 81% (299) of the...
- 7
- 744
- 0
Báo cáo y học: "A health economic model for evaluating a vaccine for the prevention of herpes zoster and post-herpetic neuralgia in the UK" ppsx
Ngày tải lên :
13/08/2014, 11:22
... testing the applied point estimate and duration of vaccine efficacy The lower and upper limit of the 95% confidence interval of the vaccine efficacy obtained from the Oxman trial were tested in the ... participated in the drafting of the manuscript MB reviewed the design and results of the cost-effectiveness model and participated in the drafting of the manuscript All authors read and approved the final ... total pain), defined as primary clinical endpoint of the SPS In the base case, the vaccine efficacy is expected to last a lifetime While the efficacy of the vaccine may diminish over time, the lengths...
- 14
- 317
- 0
Báo cáo y học: " Recently published papers: A review of novel strategies in the prevention of hospital-acquired infections, the ability of intensivists to perform echocardiography, and the benefit of polymyxin B haemoperfusion in abdominal sepsis" pot
Ngày tải lên :
13/08/2014, 18:22
... using transthoracic ultrasound [11] They trained a group of intensivists with hours of didactic teaching and hours of practical teaching, and provided a range of pre-recorded examinations for the ... findings Effect of polymyxin B haemoperfusion on patients with abdominal sepsis The EUPHAS randomised controlled trial examined the effect of polymyxin B fibre haemoperfusion on the outcome of ... evaluated the degree of certainty that the intensivists held over their findings, it would help to illustrate whether inappropriate changes of management might have resulted from their transthoracic...
- 3
- 471
- 0
Tài liệu "Promoting healthy diets and physical activity: a European dimension for the prevention of overweight, obesity and chronic diseases" doc
Ngày tải lên :
14/02/2014, 13:20
... process and consensus-building exercise The Global Strategy underlines the importance of achieving a balanced diet reducing the consumption of fats, free sugars and salt, of increasing the intake of ... References are grouped in Annex at the end of the document EN II II.1 Apart from the human suffering it causes, the economic consequences of the increasing incidence of obesity are of particular importance ... 7-11 The rates of the increase in childhood overweight and obesity vary, with England and Poland showing the steepest increases49 12 EN As relatively few risk factors cause the majority of the...
- 22
- 703
- 0
Tài liệu Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study pdf
Ngày tải lên :
15/02/2014, 04:20
... design of the study included formal interim monitoring for early stopping based on the primary end point of the trial, i.e., the incidence of invasive breast cancer The stopping rule of Fleming ... positive, two were in the placebo of invasive breast cancer in the placebo group and three in the group and one was in the tamoxifen group The rate of invasive breast cancer among women in the tamoxifen ... on the heart One of the original aims of the P-1 study was to determine whether tamoxifen reduced the risk of fractures of the hip, radius (Colles’), and spine The current findings indicating...
- 18
- 645
- 0
The Prevention of Substance Abuse And Misuse Among the Elderly pot
Ngày tải lên :
14/03/2014, 17:20
... remain stable, and these changes were most typically towards reduced use Information from the ECA and other cross-sectional studies and that from the Normative Aging and other longitudinal studies ... thirteen in writing and one by telephone, with the initiatives of two other states referenced in these responses as well In most of the states responding to the information request, and presumably in ... changes in drinking among those who increased their use as well These people cited retirement as giving them more time to drink, and noted the influence of heavier drinking social networks The specific...
- 58
- 352
- 0
Factors infl uencing the risk of breast cancer – established and emerging ppt
Ngày tải lên :
15/03/2014, 01:20
... oestrogen-mimicking chemicals and provide invaluable insight into the complicated origins of breast cancer I) THE COCKTAIL EFFECT Despite the theory of the role of oestrogen mimicking chemicals in breast cancer, ... have made the theory of oestrogenmimicking chemicals and their involvement in breast cancer increasingly plausible Studies have been published which investigate the timing and nature of exposure ... views of the funders and the EU institutions Factors in uencing the risk of breast cancer – established and emerging April 2008 Introduction Most of us will know of someone affected by breast cancer, ...
- 19
- 516
- 0
Diet, nutrition and the prevention of cancer ppt
Ngày tải lên :
15/03/2014, 01:20
... effects of specific micronutrients An extensive review of these hypotheses and of the design and interpretation of such trials is given in the first IARC Handbook of Cancer Prevention1 0 Review of the ... eliminate both the biases and the confounding which can affect observational studies and the results can, therefore, be confidently interpreted in terms of cause and effect Within the field of diet ... effect of these foods In public health terms, however, the overriding priority is to reduce the prevalence of smoking Breast cancer Breast cancer is the second most common cancer in the world and the...
- 14
- 653
- 1
Biosecurity protocols for the prevention of spread of porcine reproductive and respiratory syndrome virus ppt
Ngày tải lên :
22/03/2014, 12:20
... This system utilizes the changing of coveralls and boots plus the washing of hands in designated areas prior to entering the animal air space and has been demonstrated to be very effective for reducing the risk of PRRSV ... communicates with the animal air space. When entering from the outside, the external door is opened, personnel or pigs enter a chamber and the door is closed. The same process occurs when entering the chamber from the inside of the building via the internal door. ... By practicing the above protocols, it is hoped that producers can effectively reduce the risk of PRRSV introduction to their herds and maintain a high standard of swine health and production on their farms. ...
- 17
- 439
- 0
Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective doc
Ngày tải lên :
22/03/2014, 16:21
... increased since the 1960s Cancer of the oesophagus has remained steady since the 1960s, although the incidence of cancer of the pancreas has increased since then.20 In women, breast cancer is the most ... by lung cancer, and both have increased since the 1970s.20 Over the same period, the incidence of cancers of the colon and rectum and of the ovary have remained stable, while cancer of the endometrium ... rate remains high; lung cancer has risen steadily since the 1960s.20 The incidence of cancer of the cervix increased during the 1960s and remained high in the 1970s, but has since declined (for...
- 537
- 877
- 1