chromium roles in the regulation of lean body mass and body weight

The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression

Ngày tải lên : 16/09/2015, 17:12

... Features PHD zinc finger protein PHD zinc finger protein Composite PHD zinc fingerbromodomain proteins PHD zinc finger protein Bromodomain protein PHD zinc finger proteins PHD zinc finger protein Composite ... Prominent examples of PHD zinc finger and/ or bromodomaincontaining proteins The (*) label designates disease-associated PHD zinc finger and/ or bromodomain-containing proteins Conservation of the ... growth (in the cases of Rsc1 and Rsc2) 15 (1.2.2) The role of PHD zinc fingers and bromodomains in the regulation of eukaryotic gene transcription To date, the molecular function(s) of the PHD zinc...

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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Ngày tải lên : 16/02/2014, 09:20

... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebraﬁsh It ... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an...

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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

Ngày tải lên : 06/03/2014, 01:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... to bind to the NR2A C-tail is independent of its kinase activity, and that dysfunction of the SH3 and ⁄ or SH2 domains does not affect this interaction The regulation of NMDARs by Src and other...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... the amount of the interacting proteins but also on the afﬁnities of interacting proteins The uncreased expression of caspase-1 observed in HD may be mediated through HIPPI The role of HIP-1 in ... Conclusions HIP-1 and its interacting partner HIPPI together induce apoptosis by the intrinsic and extrinsic pathways Homer 1c, an interactor of HIPPI, and the wild-type N-terminal Htt, which interacts ... [29] The ANTH ⁄ ENTH domain of HIP-1 interacts with 3-phosphate containing inositol lipids and stabilizes the growth factor receptor tyrosine kinases by increasing their half-life following ligand...

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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1

Ngày tải lên : 10/09/2015, 08:27

... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE ... OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2011 ...

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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2

Ngày tải lên : 10/09/2015, 08:27

... Each of these modifications has their role in the regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B’ Through RNA interference ... Ubiquitin in Transcriptional Regulation 40 1.5.4 The Proteolytic Role of the Proteosome in the Regulation of Transcription 42 1.5.4 The Non-Proteolytic Role of the Proteosome in the Regulation of ... Partner of Skp1 104 3.6 The Role of Med21/hSrb7 in the Regulation of HSP70B’ 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal Inhibition of HSP70B’ Induction...

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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3

Ngày tải lên : 10/09/2015, 08:28

... isoleucine 44 in ubiquitin is the binding site of these ubiquitin binding domains (UBDs) despite the different structural folds in each UBD resulting in minor variations with their exact interaction ... proteins can greatly hinder their ability to bind to ubiquitinated cargo This is mainly due to the ubiquitin molecule interacting with their ubiquitin binding domains and “occupying” these domains ... ubiquitinated cargo is sorted to the endosomes by certain ubiquitin-binding endocytotic regulators and adaptors The ubiquitin-binding domains have been implicated in the ubiquitination of their...

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Study of the associated proteins of STAT3 and characterization of their functions roles of GRIM 19 and PIN1 in the regulation of STAT3 activity

Ngày tải lên : 15/09/2015, 17:10

... mediate the interaction with other proteins The DNA-binding domain resembles an eight-stranded β-barrel, where several loops between the β strands of this domain participate in DNA-binding Between the ... binding to the tyrosine kinase domain of JAK and therefore reducing the JAK kinase activity However, CIS has been reported to interfere with the phosphorylated tyrosine on the specific cytokine ... STUDY OF THE ASSOCIATED PROTEINS OF STAT3 AND CHARACTERIZATION OF THEIR FUNCTIONS: ROLES OF GRIM-19 AND PIN1 IN THE REGULATION OF STAT3 ACTIVITY LUFEI CHENGCHEN B Sc (Hons), NUS A THESIS SUBMITTED...

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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Ngày tải lên : 16/02/2014, 09:20

... expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1 J Biol Chem 282, 168–175 Sandoval R, Pilkinton M & Colamonici OR (2009) Deletion of the p107 ⁄ p130-binding domain of Mip130 ⁄ LIN-9 ... In G0, proteins appear to bind to the CDE ⁄ CHR, as monitored by in vivo footprinting According to these early experiments all binding is lost in G2 ⁄ M In contrast, constitutive binding to the ... conﬁrmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell...

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

Ngày tải lên : 18/02/2014, 08:20

... initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum Cells were ﬁxed on day of differentiation and stained with hematoxylin and eosin One of ... IDM (10 lgÆmL)1 insulin, lm dexamethasone, and 0.5 mm IDM) Cells were then maintained in DMEM containing 10% fetal bovine serum and lgÆmL)1insulin The medium was replaced every other day Mature ... role of miR-27 in the regulation of adipose tissue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice The 2352 expression levels of both miR-27a and...

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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

Ngày tải lên : 18/02/2014, 16:20

... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic...

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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

Ngày tải lên : 07/03/2014, 01:20

... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocardin, and that the RPEL motif itself is an actin-binding element RPEL1 and RPEL2 of myocardin bind actin weakly ... ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding ... and perinuclear areas of the cell via its N-terminal ABD In the absence of ligand, AR is localized predominantly in the cytoplasm, and its hinge domain and the LBD are tethered to the C-terminal...

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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Ngày tải lên : 08/03/2014, 08:20

... of GSK3 (using Li or SB-415286) appears to be sufﬁcient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... by insulin Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation ... greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) will shift the balance towards...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

Ngày tải lên : 17/03/2014, 17:20

... mgÆmL)1) intraperitoneally (60 mgÆkg)1) Two catheters were inserted into the tail veins, one for the administration of pentobarbital and one for the infusion of glucose A third catheter was placed intraperitoneally ... 3, and > h from the start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of ... 25 26 27 roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans J Clin Invest 97, 642–648 Petersen, K.F., Laurent, D., Rothman, D.L., Cline, G.W...

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Báo cáo Y học: Identiﬁcation of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx

Ngày tải lên : 17/03/2014, 23:20

... background indicates the amino acid sequence determined from the CNBr fragment The asterisk indicates the stop codon Three amino acid residues of the catalytic triad are boxed The single and double lines ... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger These results indicate that the cDNA obtained covered the entire coding region Involvement ... signiﬁcantly conserved The sequences around the GTPbinding region, catalytic site, and Ca2+-binding region are highly homologous to the corresponding regions of the human TGase and the other invertebrate...

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The Constitution of Private Governance Product Standards in the Regulation of Integrating Markets pptx

Ngày tải lên : 23/03/2014, 05:23

... over the content and use of these standards––either by the participation of ofﬁcials in the elaboration and approval of the standard, or because of the threat of public intervention in case the ... neglect of the phenomenon of the use of standards in modern market regulation seems all the more striking in the light of the preoccupation of modern theorising in sociology, political science and ... Work; DIN 820 and BS 0, the ‘standardisation standards’ of the German and British standards bodies respectively, and the Standardization Guides of Standards Australia and Standards New Zealand The...

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AN INCREASING ROLE FOR COMPETITION IN THE REGULATION OF BANKS doc

Ngày tải lên : 29/03/2014, 08:20

... to being changed and enforced in the interest of the regulated industry, rather than in the interest of the economy at large General laws, on the other hand, tend to be more immune and therefore ... 1980s In the case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% of the assessable deposits and was the same for all insured institutions regardless of the riskiness of their ... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the...

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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identiﬁed substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf

Ngày tải lên : 29/03/2014, 21:20

... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... before amino acid 71, the region of cleavage would be between amino acids 65 and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the ... a deregulation of the NF-jB pathway and an increase in muscle ﬁber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The...

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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf

Ngày tải lên : 31/03/2014, 08:20

... the binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of ... utilization of galactose when the concentration of galactose is decreasing in the medium To explain the mechanism of MRG19 in facilitating GAL gene induction, under low induction signal, we consider the ... harvested either in the log phase or in the stationary phase The cells were washed three times with ice-cold distilled water; the wet weight of the pellets was determined and resuspended in oxygraph...

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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx

Ngày tải lên : 19/06/2014, 10:20

... young and old adults Aging affects the interaction of the somatosensory and visual systems on the ability of the CNS to resolve sensory conflicts and to maintain upright stance equilibrium Therefore, ... the decline in the integrity of many postural regulating systems [14-16], but its effect on the sensory inputs recalibration process remains to be determined One question of interest is whether ... (Plug -In Gait) was used in conjunction with kinematic data and anthropometric measures to calculate the displacement of the body' s center of mass (COM) Resultant center of pressure (COP) in the...

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