blood brain barrier permeability and brain edema formation in rats

Báo cáo hóa học: " Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats" pptx

Ngày tải lên : 18/06/2014, 16:20

... Nuclei Rats in groups 1, 2, and were euthanized on day 21 after IS induction, and brain in each rat was rapidly removed and immersed in cold saline For immunohistofluorescence (IHF) study, the brain ... 15 μm in diameter) in BIA was substantially lower in group than in groups and on IHC staining (Figure 9A-D) All of these findings indicate an ADMSC-induced enhancement in neurogenesis and vasculogenesis ... by saline injection alone Accordingly, rather than supporting a crucial role of direct cellular participation in limiting brain infarct size and improving neurological function, our findings suggest...

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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf

Ngày tải lên : 08/03/2014, 02:20

... cationic amino acids lysine, arginine and ornithine at the basolateral membrane of the polar epithelial cells in the intestine and renal tubules LPI is caused by mutations in the SLC7A7 gene encoding ... L-arginine transport mainly Fig L-Arginine uptake in the presence or absence of Na+ in the external medium L-Arginine uptake was measured in washed platelets (2.0 · 108 platelets) resuspended in ... evaluated after incubation in the presence of lM L-arginine as described in Experimental procedures L-leucine (500 lM) was added simultaneously to L-arginine Valinomycin (10 lM) or gramicidin D (1 lM)...

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Báo cáo khoa học: Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4 pptx

Ngày tải lên : 16/03/2014, 02:20

... C-terminal segment, including the androgen receptor [35], F-actin [36], 14-3-3 [26] and the SPRY domain-containing suppressor of cytokine signalling box proteins 1, and [37] Par-4 contains several ... efﬁcient linker protein The majority of the Par-4 binding partners interact with the C-terminus, although a few, such as the SPRY domain and F-actin, have been shown to bind N-terminally [36,37] Indeed, ... post-translational modiﬁcations and a plethora of binding partners are characteristics common to many intrinsically disor- Intrinsic disorder in Par-4 dered proteins (IDPs) [39] In the present study, we...

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Báo cáo lâm nghiệp: " Zygotic embryogenesis and empty seed formation in European larch (Larix decidua Mill.)" pptx

Ngày tải lên : 08/08/2014, 00:21

... inbreeding and genetic variances in a natural population of tamarack (Larix laricina (Du Roi) K Koch) in Eastern Canada, Silvae Genet 31 (1982) 21–26 [27] Paule L., Gömöry D., Mating system in ... studied by nonlinear correlation Pollination efficiency was expressed by the mean number of pollen grains per pollinated ovule, quantified at the end of the pollination period and published in our earlier ... of pollinated, but unfertilized, ovules is almost constant [34] Therefore, the existence of a pre-zygotic incompatibility between ovules and self-pollinating pollen grains is not assumed and, most...

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Báo cáo y học: "The relationship between inflammation and new bone formation in patients with ankylosing spondylitis" docx

Ngày tải lên : 09/08/2014, 13:21

... D van der: Combining information obtained from magnetic resonance imaging and conventional radiographs to detect sacroiliitis in patients with recent onset inflammatory back pain Ann Rheum Dis ... Quantification of inflammatory and chronic spinal lesions Depiction and quantification of inflammatory and chronic spinal lesions were performed on the basis of vertebral edges (VEs) in this study, in accordance ... and the lumbar spine in the lateral view at BL and 2yFU were taken Because of the known technical problems in the assessment of the thoracic spine in standard x-rays [4], this part of the spine...

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Báo cáo y học: "Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment" ppt

Ngày tải lên : 09/08/2014, 13:22

... proteins and is involved in disruptive events in the cartilage and bone of inflamed joints [15] Recent publications suggest that it is closely related to inflammation and high disease activity in ... (d_VEGF) and d_CRP, (c) bone-specific alkaline phosphatase (d_BALP) and d_CRP, and (d) protein (d_CRP), (b) vasoenCorrelation of differences in serum levels at baseline and year of (a) metalloproteinase-3 ... in spinal inflammation in patients with ankylosing spondylitis after treatment with infliximab: results of a multicenter, randomized, double-blind, placebo-controlled magnetic resonance imaging...

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Báo cáo y học: " Abdominal wall and labial edema presenting in a girl with Henoch-Schönlein purpura: a case report" pptx

Ngày tải lên : 11/08/2014, 12:20

... choice for investigation of abdominal pain associated with HSP, and can detect mural thickness and hematoma, ileus, peritoneal fluid and intussusception [9] The treatment of HSP remains mainly supportive, ... days, she developed increasing abdominal pain and “distention” She also experienced significant pain in her genital area with associated labial swelling She was transferred to our institution, a tertiary ... was then performed, and this revealed markedly increased attenuation within the subcutaneous tissues of the left side of the abdominal wall and flank, extending to the groin and labia majora, consistent...

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Báo cáo y học: "Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice" pptx

Ngày tải lên : 13/08/2014, 13:20

... weeks and months) GF intoxication induced an increase in keratin levels in livers from both mouse strains (Fig 1A,1B) HSP70i, which was present in control livers of both mouse strains, was also increased ... treatment Arrows in A and B indicate cells in which HSP70i and K8 pS79 colocalized Arrows in C and D indicate cells in which HSP70i and K8 pS436 colocalized Scale bar = 20 µm keratin phosphoepitope ... during incubation step with secondary antibody For heat shock proteins staining, liver sections were incubated with anti-HSP 70i diluted in TBS containing 10% BSA for 45 at 37°C, washed in TBS and...

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Báo cáo khoa học: "Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis" pot

Ngày tải lên : 07/08/2014, 14:23

... bone mineral density in ovariectomized rat Calcif Tissue Int 1993, 52, 442-446 Thompson, D D and Rodan, G A Indomethacin inhibition of tenotomy-induced bone resorption in rats J Bone Miner Res ... Y., Yoshida, K., Tsuzuike, N and Matuda, K Change in urinary deoxypyridinoline level and vertebral bone mass in the development of adjuvant induced arthritis in rats Bone 1995, 17, 5762 Takagi, ... trabecular bone Our findings indicate that the bony changes occurred after paw volumes had increase In general, increased paw volume in the injected hind paw represents a primary inflammatory phase,...

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Báo cáo y học: "Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats" potx

Ngày tải lên : 09/08/2014, 07:20

... of the hindlimb in AIA rats (a) Control rats and (b) rats treated with tetrathiomolybdate (TM) rats Joint swelling, redness, and edema of the foot in AIA was clearly reduced with TM administration ... using hematoxylin and eosin staining of the foot joint also revealed (c) a marked decrease of synovial inflammatory cell infiltrate and synovial lining hyperplasia compared with (d) control rats ... important role in development and maintenance of the immune system [30] IL-1α and FGF-1 are Cu2+binding proteins The stress-induced IL-1α and FGF-1 release pathways in murine NIH 3T3 cells and human...

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Báo cáo y học: " Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats" pptx

Ngày tải lên : 12/08/2014, 18:21

... in VAD rats This was manifest as an increase in the pressures required to expand the lung during inflation and a significant increase in hysteresis In contrast, the CChmediated increase in shear ... Lm and SD Lm in VAD rats, indicating that the alveolar ducts and alveoli were more dilated with air and that Our previous studies of rat lungs in vivo have shown that the cholinergic-induced increase ... carbamylcholine (CCh) administration (open bars) in vitamin A sufficient (VAS) rats and VAD rats that had not received retinoic acid (RA) and VAD rats that had received RA for 12 or 21 days (d) The CCh-induced...

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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf

Ngày tải lên : 19/06/2014, 22:20

... Anandamide inhibits VCAM-1 induced by TMEV in brain endothelial cells by CB1 receptors The endothelial blood brain barrier protects the CNS from the changing environment in both physiologic and ... heat inactivated fetal bovine serum (FBS); 1% nonessential aminoacid, 1% sodium pyruvate and 1% antibiotic penicillin and streptomycin (all from Gibco, Scotland, UK) and were maintained under standard ... in the EAE model by administering the synthetic cannabinoid WIN 5,212-2 [23] In the TMEVIDD model we showed that WIN 5,212-2 at the time of virus infection inhibited brain VCAM-1 expression and...

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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx

Ngày tải lên : 19/06/2014, 22:20

... DD: Permeability of blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain ... GM-CSF into both the luminal and abluminal chambers [34] To determine whether IL-6 and GM-CSF secreted by BMECs into the abluminal chamber are also involved in the LPS-induced increase in HIV-1 ... in increased blood- brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin Neurosci Lett 1998, 242:147-150 Dong C, Davis RJ, Flavell RA: MAP kinase in...

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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot

Ngày tải lên : 19/06/2014, 22:20

... as well as in inflammation [26] Substances originating in the gut or the brain can trigger mast cells to release mediators that could disrupt the gutblood barrier and blood- brain barrier (BBB), ... Theoharides, T C and Konstantinidou, A.: Corticotropin-releasing hormone and the bloodbrain -barrier Front Biosci 2007, 12:1615-1628 52 Rehni, A K., Singh, T G., Singh, N., and Arora, S.: Tramadol-induced ... Jacobson, S., Connolly, R., Tutor, D., and Theoharides, T C.: Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood- brain- barrier permeability induced by acute stress J Pharmacol...

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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt

Ngày tải lên : 13/08/2014, 15:21

... with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental ... tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During sepsis, however, blood- borne proinflammatory mediators ... blockade of anaphylatoxin C5a prevented breakdown of the blood- brain barrier, reducing cerebral and pituitary edema formation, as assessed by extravasation of albumin and EB (Figure 1) hours...

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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain

Ngày tải lên : 26/11/2015, 22:48

... ONE: INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier ... growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain tumors [95] Primary brain tumors start, and tend to stay, in the brain metastatic brain ... delivery [34], and receptor/vector mediated drug delivery [35-39] Disturbing the blood brain barrier includes osmotic blood brain barrier disruption [40-44] and biochemical blood brain barrier disruption...

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the blood – brain barrier

Ngày tải lên : 11/04/2014, 10:34

... growth factor in blood- brain barrier breakdown and angiogenesis in brain trauma J Neuropathol Exp Neurol 56, 912–921 33 Risau, W (1994) Molecular biology of blood- brain barrier ontogenesis and function ... (2001) Molecular and cellular permeability control at the blood- brain barrier Brain Res Rev 36, 258–264 106 Rubin, L L., and Staddon, J M (1999) The cell biology of the blood- brain barrier Annu Rev ... Neuropeptides and the blood- brain barrier In Neurosecretion and Brain Peptides (Martin, J B., Reichlin, S., and Bick, K L., eds.) Raven, New York, pp 321–328 Hutson, P H., Sarna, G S., Katananeni, B D., and...

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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx

Ngày tải lên : 18/06/2014, 15:20

... rhodamine B Gd-G5 and rhodamine B Gd-G8 dendrimer across the normal bloodbrain barrier beginning approximately hour following intravenous infusion, as shown by dynamic contrastenhanced MRI in Additional ... compromised blood- brain tumor barrier Gd-G7 dendrimers are impermeable to the BBTB of the smallest RG-2 gliomas and remain intravascular Gd-G8 dendrimers continue to be impermeable to the blood- brain ... dendrimer surface and disruption of the blood- brain barrier Conclusion In this study, we identified the precise physiologic upper limit of blood- brain tumor barrier pore size, and demonstrated...

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Hình thái và chức năng của hàng rào máu não (blood brain barrier)

Ngày tải lên : 19/07/2014, 20:48

... tế bào chất gắn với ß-catenin plakoglobin, đến chu kỳ lại gắn α-catenin, α-actinin vinculin, mục đích làm ổn định phức hợp vùng dính Dải bịt Lòng mạch Phức hợp protein Khoảng gian bào Màng tế ... trúc phân tử Occludin[12] 22 4.2.3.Claudin Claudin có vị trí màng tế bào giống occludin đồng đẳng occludin Claudin protein có trọng lượng phân tử 20-24 kDa Có 24 đồng đẳng claudin phát động vật ... cầu CD11b/CD18 integrins ICAM-1, iC3b, Bạch cầu đơn nhân, đa fibrinogen nhân , lympho iC3b Bạch cầu đơn nhân, (Mac-1) CD11c/CD18 integrins đa nhân VLA-4 integrins VCAM-1 fibronectin Tất cả, trừ...

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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx

Ngày tải lên : 08/08/2014, 16:23

... a new brain CT and determined again the CRP and NT-PBNP in the serum because the edema tends to be more evident after this elapse of time By edema in ischemic stroke we mean mass-effect and sulcal ... alternative of treatment in stroke-induced brain edema remains to be elucidated The lack of efficacious treatment so far for stroke-induced brain edema makes our hypothesis Int J Med Sci 2008, worthy ... for us In conclusion, our work adds something new to the understanding of the elevation of CRP and NT-PBNP in the acute phase of stroke both CRP and NT-PBNP are markers of brain edema in stroke...

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