active targeting strategies in cancer with a focus on potential nanotechnology applications

nanotechnology for cancer therapy, 2007, p.810

Ngày tải lên : 04/06/2014, 14:30

... physical and chemical characteristics of nanoparticles made from various materials as well as q 2006 by Taylor & Francis Group, LLC Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology ... utilize additional cancer -targeting mechanisms (e.g., the EPR effect) to augment in ammation-based strategies 3.5 TARGETING TO TUMORS Nanoparticle targeting strategies involving peculiar and unique ... uptake associated with increased requirements for amino acids and nucleic acids may also provide a targeting strategy for nanoparticles That many classical anti -cancer agents function by interfering...

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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot

Ngày tải lên : 21/06/2014, 02:20

... first in vitro and in vivo characterization of panitumumab F(ab’) fragment with an emphasis on its evaluation towards both imaging and therapeutic applications Materials and methods Preparation ... for panitumumab Conjugation and radiolabeling of panitumumab F(ab’)2 Panitumumab F(ab’)2 was conjugated with the bifunctional acyclic trans-cyclohexyl-diethylenetriamine-pentaacidic acid (CHX -A" -DTPA) ... contrast, an early clinical imaging study conducted by Delaloye et al [19] compared 123I-labeled Fab and F(ab’)2 fragments of an anti-carcinomembryonic antigen mAb in colorectal carcinoma patients...

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Surface functionalization of superparamagnetic iron oxide nanoparticles for potential cell targeting, imaging, and cancer therapy applications

Ngày tải lên : 09/09/2015, 10:14

... characterization, and functionalization of nanoscale materials for biomedical applications and diagnostics (Schladt et al 2011) Among the variety of promising nanoscale materials, SPIONs have ... (b) as a function of incubated iron concentration for an incubation period of h Inset is the image of macrophages incubated with PLMA-2-SPIONs at an iron concentration of 2.0 mM for h after staining ... SURFACE FUNCTIONALIZATION OF SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR POTENTIAL CELL TARGETING, IMAGING, AND CANCER THERAPY APPLICATIONS HUANG CHAO (B.ENG., TIANJIN UNIVERSITY) A THESIS...

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Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy potx

Ngày tải lên : 29/06/2014, 11:20

... guarantee the accuracy of any information about dosage and application contained in this book In every individual case the user must check such information by consulting the relevant literature ... for at least 24 h, yielding a sufficient contrast for detection on a gamma camera Based on these results, the group of Hnatowich has developed a PNA-based pretargeting strategy taking advantage ... unity, again pointing to the difficulty in achieving significant uptake in tumors 1.9 Aptamer Oligonucleotides Combinatorial approaches are a modern alternative to the rational conception of ligands...

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The use of gold nanostructures in the imaging and therapy of cancer

Ngày tải lên : 11/09/2015, 09:02

... glycoprotein containing an extracellular ligand-binding domain, a single transmembrane region, a cytoplasmic domain which is composed of a tyrosine kinase domain and a C-terminal tail Since EGFR ... imaging in biopsy Amongst the various imaging tools available for use in laboratory research or clinical imaging of pathological conditions such as cancer, optical imaging finds its niche in ... promising clinical application especially in the area of cancer imaging by increasingly proving themselves to offer alternative angles in examining the same biological problems or diseased conditions,...

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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx

Ngày tải lên : 20/06/2014, 22:20

... is nontoxic and non-immunogenic, leading to approved by the FDA for internal use in humans and inclusion in the list of inactive ingredients for oral and parenteral applications While it has been ... demonstrated that PEGylation of NPs causes a greater accumulation of drug at the tumor site by passive targeting, active targeting of the NPs can aid in selection of the target cell type within ... Cell viability assays of MMC loaded NPs, and Xie LY carried out the study of in vivo images in animals and participated in its design and coordination All authors read and approved the final manuscript...

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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"

Ngày tải lên : 31/10/2012, 14:59

... and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine ... prolong half-life and further reduce immunogenicity The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating ... rasburicase, in haematological malignancies, both in children and adults with the conclusion that rasburicase remains a useful drug clinically effective and in addition with a favourable economic...

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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Ngày tải lên : 15/03/2014, 23:20

... polysaccharides consisting of a repeating disaccharide, generally of an acetylated amino sugar alternating with uronic acid Units of N-acetylglucosamine and glucuronic ⁄ iduronic acid form heparan ... Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC & Sanderson RD (2010) Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis ... myeloma patients examined [88], and gene array analysis showed elevated heparanase expression in 92% of myeloma patients [89] Heparanase upregulation in myeloma patients was associated with elevated...

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adobe digital imaging how-tos 100 essential techniques for photoshop cs5, lightroom 3, and camera raw 6

Ngày tải lên : 30/05/2014, 23:16

... Keywords and Labels (for example) also fall under searchable metadata Many combinations are possible 38 Metadata Filtering Metadata filtering allows you to use over a dozen file characteristics as ... metadata presets can be created from the Presets pop-up menu in the Metadata panel (continued on next page) #3: IPTC Metadata Presets 10 Scan the Edit Metadata Presets dialog box that appears, and ... has nearly 20 years of experience working with Adobe applications, including more than 16 years with Photoshop He is a veteran of the Adobe alpha- and beta-testing programs, as well as an experienced...

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patel, chellapa - sparse representations and compressive sensing for imaging and vision

Ngày tải lên : 05/06/2014, 12:05

... Aswin Sankaranarayanan, Dikpal Reddy, Amit Agrawal, Nalini Ratha, Jaishanker Pillai, Hien Van Nguyen, Sumit Shekhar, Garrett Warnell, Qiang Qiu, Ashish Shrivastava - for letting us draw upon their ... stripmap and scan mode SAR because it maps a scene at multiple viewing angles during a single pass [30] In ISAR, the radar is stationary and the target is moving The angular motion of the target with ... Synthetic Aperture Radar Imaging Synthetic aperture radar is a radar imaging technology that is capable of producing high resolution images of the stationary surface targets and terrain There are four...

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báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx

Ngày tải lên : 21/06/2014, 17:20

... diagnosed cancer and the second leading cause of cancer- related deaths for males in the USA One promising approach in prostate cancer diagnosis is the utilization of target-specific radiolabeled ... imaging Abbreviations The abbreviations for the common amino acids are in accordance with the recommendations of [40] Additional abbreviations: %ID/g, percentage of the injected dose per gram; ... on a routine basis for research purposes using a target system developed in collaboration with Advanced Cyclotron Systems Inc (ACSI, Richmond, British Columbia, Canada) 64Cu was prepared on an...

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Báo cáo y học: "Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology" ppt

Ngày tải lên : 09/08/2014, 01:21

... and usually obtained only at one time point (thereby having certain inherent limitations, e.g only representing a small area at one location within the treated area) Scoring systems for human tissue ... abnormal Cartilage thickness = normal or near normal, = abnormal Vascularisation and mineralisation are both included as negative features, because they are not present in normal articular cartilage, ... indicate that there is good integration between native and repair tissue Certainly histological examination demonstrates that the cartilage integrates fully with the underlying bone Lateral integration...

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Báo cáo khoa học: "Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections" docx

Ngày tải lên : 09/08/2014, 04:21

... Bousson V: Preoperative portal vein embolization for extension of hepatectomy indications Hepatology 1996, 24:1386-1391 Imamura H, Shimada R, Kubota M, Matsuyama Y, Nakayama A, Miyagawa S, Makuuchi ... Makuuchi M, Miyagawa S, Kakazu T: Radical operation after portal embolization for tumor of hilar bile duct J Am Coll Surg 1994, 178:480-486 Kawasaki S, Makuuchi M, Kakazu T, Miyagawa S, Takayama ... survival in patients with colorectal cancer liver metastases (CRCLMs) Indications for surgical resection continue to expand An increasing number of patients with hepatocellular carcinoma (HCC),...

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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt

Ngày tải lên : 09/08/2014, 07:20

... 5'-TCCAAAGTTATGTCCAACTTCGTGAGCAAAAGTAA-3' Forward 5'-GAGACCCTCAAGGCAACTAAGTATGTGGAG-3' Reverse 5'-CGGCAGGTTAAACAGGCACACCCCCATTCC-3' Forward 5'-CTGGGACAGCGCCACATTCGCCGGAGGCGG-3' Reverse 5'-TCCGCAGAAAGCAGCCATAGGGGGTAGGCT-3' ... 5'-TCCGCAGAAAGCAGCCATAGGGGGTAGGCT-3' Forward 5'-AGAGCTGACCCAGATCCCATGAAGAACACG-3' Reverse 5'-GCGTTCTTGAAAACACTCCTGGGCCTTACT-3' Forward 5'-AAAATAGCACACCAGATGGAGTTGCAATTG-3' Reverse 5'-ATTCCCACAGTACTTCAGTCTAAATATATT-3' ... Counterstaining was performed with hematoxylin Characterization of monoclonal antibody against human ADAM15 and immunoblotting A monoclonal antibody against human ADAM15 was developed using the...

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Báo cáo khoa học: "Planning target volume margins for prostate radiotherapy using daily electronic portal imaging and implanted fiducial markers" docx

Ngày tải lên : 09/08/2014, 09:20

... Tom Baker Cancer Center, Calgary AB Canada: Steve Angyalfi, Alex Balogh, Siraj Husain, Harold Lau, David Skarsgard, Jackson Wu; Saskatoon Cancer Center, Saskatoon SK Canada: Ali El-Gayed, David ... E: Measurements of intrafraction motion and interfraction and intrafraction rotation of prostate by three-dimensional analysis of daily portal imaging with radiopaque markers Int J Radiat Oncol ... Skarsgard; Cross Cancer Institute, Edmonton AB Canada: Robert Pearcey, Nadeem Pervez; Allan Blair Memorial Clinic, Regina SK Canada: Patricia Tai, Kurian Joseph, Evgeny Sadikov We are also grateful...

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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx

Ngày tải lên : 09/08/2014, 09:20

... treatment with HDR-BT as compared to baseline MRI A decrease in tumor size is inversely associated with an increase in ADC Pearson’s correlation indicated a weak but statistically significant linear ... H, Takahashi A, Sakaguchi H, Matsuoka M, Otsuji T, Takahama J, et al: Early detection of therapeutic response to hepatic arterial infusion chemotherapy of liver metastases from colorectal cancer ... causing endothelial damage at an early stage [32] Endothelial damage may lead to increased transient vascular permeability to macromolecules like albumin, which can become insoluble in the interstitium...

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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx

Ngày tải lên : 09/08/2014, 09:22

... Hiraoka M, Fujino M, Gomi K, Niibe Y, Karasawa K, Hayakawa K, Takai Y, Kimura T, Takeda A, Ouchi A, 14 15 16 17 18 19 20 Hareyama M, Kokubo M, Hara R, Itami J, Yamada K, Araki T: Hypofractionated ... IA and among stage IB) Distant metastasis appeared in 13 patients (8 among stage IA and among stage IB) There was no difference in regional and systemic progression between patients with and without ... indicated the design of the study and gave final approval of the version to be published NT participated in analysis and interpretation of data CIH, KO and SA participated in acquisition and analysis...

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Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot

Ngày tải lên : 09/08/2014, 10:20

... minutes at least two hours after breakfast The saliva was weighed on a precision balance and then saliva flow was calculated assuming g saliva was equal to ml saliva [18] No salivary stimulating ... survival in head and neck patients, since xerostomia can cause malnutrition, dental infections and other debilitating conditions Some authors comparing ipsilateral and bilateral irradiation in larger ... flow Salivary rates Salivary flow rates Unstimulated salivary flow rates in ml/ in 16 available subjects at least year after treatment Above the horizontal bar are 13 patients with normal salivary...

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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

Ngày tải lên : 09/08/2014, 10:21

... transport in the craniospinal axis (subarachnoid space and Figure Arrangement of craniospinal irradiation fields Arrangement of craniospinal irradiation fields A lateral view of the relationship ... a reasonable assumption given the exceeding rarity of extracranial metastases [4] Many extracranial metastases are in fact intraperitoneal in origin, and arise in the setting of shunts that divert ... of radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study Acta Oncol 2005, 44:554-562 Jain S: Kinetic model for designing a cancer...

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Báo cáo y học: "Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families" pot

Ngày tải lên : 09/08/2014, 23:20

... Shahin H, Walsh T, Sobe T, Abu Sa’ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC, Kanaan M: Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are ... efficiency was 66% The median base coverage was 757 × to 2,080 × Samples that were loaded alone on a lane had an average base coverage of 1970 ×, while samples loaded two in lane had an average base ... hearing loss in middle eastern families Zippora Brownstein1†, Lilach M Friedman1†, Hashem Shahin2, Varda Oron-Karni3, Nitzan Kol3, Amal Abu Rayyan2, Thomas Parzefall1, Dorit Lev4, Stavit Shalev5,6,...

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