activator phorbol myristate acetate decreases ischemia induced brain edema pdf

Báo cáo y học: "1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss"

Ngày tải lên : 25/10/2012, 11:40

... disease (10) Xiao et al (11) demonstrated that 1,25(OH)2D3 prevented puromycin aminonucleoside -induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling ... transgenic mice Their results suggested a novel functional role for Smad7 as amplifier of TGF-β -induced apoptosis in podocytes and a new pathomechanism for podocyte depletion in progressive glomerulosclerosis ... study aimed to investigate the effects of 1,25-(OH)2D3 on podocyte apoptosis and podocytopenia induced by adriamycin (ADR) and the potential mechanisms 291 Materials and Methods Animals and experimental...

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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

Ngày tải lên : 16/03/2014, 18:20

... signal-regulated kinase (ERK) and p38 mitogen-acivated protein kinase (p38 MAPK) inhibitors Phorbol esters (e.g phorbol myristate acetate, PMA) are also robust inducers of Timp-1 gene expression Compared to ... (Fig 5B) PMA signiﬁcantly induced fosB, fra-1, fra-2, junB and c-Jun; of these only junB was further induced by TSA, while PMAinduced fra-2 was repressed by TSA TGF-b1 induced levels of fosB, fra-2 ... h, c-fos was dramatically induced by PMA Further, this induction was superinduced by TSA; by h the PMA induction was lost, but TSA in the presence of PMA still superinduced c-fos expression Compared...

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Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx

Ngày tải lên : 30/03/2014, 02:20

... II -induced AGT mRNA expression (Fig 1C) DNA-binding activity of STAT5B and c-Jun increases in Ang II -induced AGT expression To ﬁnd out whether the increase in STAT5B and c-Jun phosphorylation induced ... II -induced AGT expression in VSMCs involves co-operation between AP-1 and STAT5B We also demonstrated that there exists a physical interaction between AP-1 and STAT5B during AGT expression induced ... important in transcription activation of the AGT gene induced by Ang II To understand whether elements for AP-1 and STAT5B function in AGT gene activation induced by Ang II, we tested the effect of co-operative...

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Báo cáo y học: "Scutellaria baicalensis decreases ritonavir-induced nausea." potx

Ngày tải lên : 10/08/2014, 05:20

... cisplatin -induced pica in rats Methods Find Exp Clin Pharmacol 1995, 17:647-652 Aung HH, Dey L, Mehendale S, Xie JT, Wu JA, Yuan CS: Scutellaria baicalensis extract decreases cisplatin -induced ... at low doses, patients still could have ritonavir induced gastrointestinal side effects, especially nausea [12-14] The incidence of ritonavir induced nausea/vomiting is approximately 23%, significantly ... effects on the drug -induced pica Figure ritonavir (mg/kg) on kaolin intake in rats Effect of2 Effect of ritonavir (mg/kg) on kaolin intake in rats Ritonavir doses at 5, 10 and 20 mg/kg induced significant...

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Báo cáo y học: "Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury" pdf

Ngày tải lên : 11/08/2014, 08:22

... myocardial ischemia [1] Experimental groups are shown in Figure 1A and included Sham (no treatment, no ischemia) , Sham + GdCl3 treated (treated, no ischemia) , Control (no treatment but subject to ischemia ... neutrophils chloride ischemia circulating monocytes and Gadolinium followingdecreasesand reperfusion Gadolinium chloride decreases circulating monocytes and neutrophils following ischemia and reperfusion ... rase activity in the reperfused Alpha naphthyl acetate esteGadolinium chloride decreasesmyocardium Gadolinium chloride decreases Alpha naphthyl acetate esterase activity in the reperfused myocardium...

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Báo cáo y học: "Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report'''' doc

Ngày tải lên : 11/08/2014, 10:22

... autoimmune syndrome and HS [1,5] To our knowledge, lymphocytic meningitis and brain edema associated with minocycline -induced HS have not been reported in the literature This presentation, which ... erythematous, oedematous and coalescing plaques on the upper trunk, and on proximal segments of the limbs Her palms and soles were erythematous She also had injection of the sclera, and edema of the ... minocycline, was found While lymphocytic meningitis and cerebral edema have not been described in association with minocycline -induced HS, they have been reported following use of allopurinol...

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Báo cáo y học: "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury" pdf

Ngày tải lên : 13/08/2014, 20:21

... organotypic cultures as an in vitro model of brain injury Brain Res 2004, 1001:125-132 31 Frantseva MV, Kokarovtseva L, Perez Velazquez JL: Ischemiainduced brain damage depends on specific gap-junctional ... and others when testing possible treatments [8,19,25] for traumatic brain injury Nevertheless this is a simplified imitation of brain trauma, which lacks pathomechanisms involving systemic variables ... argon bears surprisingly effective neuroprotective potential in both in vitro models of ischemia and traumatic brain injury Protection was observed with three different concentrations of argon (25,...

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Tài liệu Báo cáo khoa học: Calcium-independent cytoskeleton disassembly induced by BAPTA pdf

Ngày tải lên : 19/02/2014, 16:20

... Inversely cell treatment with a Rho inactivator C3 transferase [39] or Y27632, a specific inhibitor of p160ROCK, which consistently suppresses the formation of Rho -induced stress fibres [40] did not ... had lost their normal array of stress fibres, as well as lamellipodia (Fig 1A, b,c) BAPTA AM also induced peripheral spikelike extensions, which in videomicroscopy experiments proved to be retraction ... thereby similar to most known microtubule depolymerizing drugs [22] In the same cells, BAPTA AM induced an extensive disruption of the actin cytoskeleton, showing that BAPTA effects on actin not...

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THERAPEUTIC HYPOTHERMIA IN BRAIN INJURY pdf

Ngày tải lên : 06/03/2014, 23:20

... development of brain edema Mild hypothermia significantly reduces blood– brain barrier disruptions, and also decreases vascular permeability following ischemia reperfusion, further decreasing edema formation ... disruptions in the blood– brain barrier, which can facilitate the subsequent development of brain edema Mild hypothermia significantly reduces blood– brain barrier disruptions, and also decreases vascular ... offset by the decrease in metabolism It decreases cerebral edema, 10 Therapeutic Hypothermia in Brain Injury decreases the excessive influx of Ca2+ into the cell, decreases the accumulation of glutamate,...

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Báo cáo khoa học: A metabolomics perspective of human brain tumours pdf

Ngày tải lên : 23/03/2014, 09:21

... [7,23,24] have demonstrated metabolite abnormalities in brain tumours that discriminate them from normal brain tissue Human brain tumours in vivo Human brain tumours form some 2% of all malignancies Unlike ... demonstrated that the CCM peak detected in brain tumour specimens largely correlated with choline, PC and GPC, but not phosphatidylcholine Ex vivo monitoring of brain tumour metabolites The use of NMR ... metabolic profiles of brain tumours significantly predates the use of the term metabolomics For example, Jellum and colleagues [13] identified 160 peaks in GC-MS spectra from normal brain tissue, pituitary...

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báo cáo hóa học:" Semi-allogeneic vaccines and tumor-induced immune tolerance" pdf

Ngày tải lên : 18/06/2014, 15:20

... modalities aimed at concurrently stimulating anti-tumor immune reactivity, while diminishing tumorinduced immune suppression will be the key to clinical success One of the approaches used to increase ... to activating APC and a Th-1-type immune response, semi-allogeneic vaccines also inhibit tumor -induced immune tolerance and anergy Methods Cells and semi-allogeneic hybrids RAG cells are a non-reverting, ... thymidine (HAT) These cells grow as a monolayer EL-4 cells were established from a T-cell lymphoma induced in a C57BL mouse (H-2b haplotype) by the chemical carcinogen 9,10-dimethyl-1,2-benzanthracene...

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Báo cáo hóa học: " On the understanding and development of modern physical neurorehabilitation methods: robotics and non-invasive brain stimulation" pdf

Ngày tải lên : 19/06/2014, 08:20

... augment recovery and plasticity with brain stimulation? One of the contemporary methods under investigation as a tool to promote neuroplasticity is non-invasive brain stimulation The concept of treating ... NBS with deliberate voluntary brain activity has only recently gained interest Can the interaction of transient excitability changes from NBS support the changes induced by motor practice paradigms ... provide an overview of this contemporary topic in the paper 'Using non-invasive brain stimulation to augment motor training -induced plasticity' A discussion of the rationale for combining NBS with purposeful...

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báo cáo hóa học: "Usability of a virtual reality environment simulating an automated teller machine for assessing and training persons with acquired brain injury" pdf

Ngày tải lên : 19/06/2014, 08:20

... their medical records, which is an injury to the brain that has occurred after birth and that is not hereditary, congenital, degenerative, or been induced by birth trauma [15] For the first part ... 21 rehabilitation after traumatic brain injury Arch Phys Med Rehabil 1998, 79:888-892 Grealy MA, Johnson DA, Rushton SK: Improving cognitive function after brain injury: The use of exercise and ... preliminary study J Hong Kong College of Psychiatry 2004, 4:25-28 Brain Injury Association of America: Facts about traumatic brain injury [http://www.biausa.org/aboutbi.htm] Niemiec RP, Walberg...

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Báo cáo hóa học: " Synthesis of ZnGa2O4 Hierarchical Nanostructure by Au Catalysts Induced Thermal Evaporation" pdf

Ngày tải lên : 21/06/2014, 17:20

... this paper, Ga2O3 nanowires were used as templates for the growth of ZnGa2O4 nanocombs Catalyst induced growth is well known as a powerful method to control the growth of 1-D nanostructures In ... that the particle on the tip of the tooth is Au catalyst Apparently, the growth of the teeth is induced by the Au catalyst From the EDS spectra of region to 4, it can be found that the atomic...

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Báo cáo hóa học: "A survey of American neurologists about brain death: understanding of the conceptual basis and diagnostic tests for brain death" pdf

Ngày tải lên : 21/06/2014, 19:20

... Irreversible destruction of the brain, including the brainstem 109 (57%) 50–64% Irreversible loss of the capacity for consciousness plus 83 (43%) 36–50% 22 (12%) 8–17% brain brain/brainstem irreversible ... what is it about loss of brain function including the brainstem that makes this patient dead?” and “Prior to this survey, had you thought about why, at a conceptual level, brain death is equivalent ... performed to confirm that irreversible loss of all functions of the brain, including the brainstem, has occurred It has been shown that some brain functions continue after accurately clinically diagnosed...

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Báo cáo khoa học: "Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs" pdf

Ngày tải lên : 07/08/2014, 18:21

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Báo cáo khoa học: " Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress" pdf

Ngày tải lên : 07/08/2014, 20:23

... A p value ＜ 0.05 was considered significant Results Effect of DHT on H2O2 -induced cell injury We determined the H2O2 -induced ROS generation in mouse -5 embryonic stem cells using DCF-DA (10 M), ... dihydrotestosterone on mouse embryonic stem cells exposed to H2O2 -induced oxidative stress 251 Fig Effect of hydrogen peroxide (H2O2) -induced p38 mitogen activated protein kinase (MAPK) and c-Jun ... experiments (Fig 2E) Effect of DHT on H2O2 -induced activation of p38 MAPKs, SAPK/JNK and NF-κB In order to assess the involvement of MAPKs in H2O2 -induced cell injury, the cells were treated...

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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx

Ngày tải lên : 08/08/2014, 16:23

... constitute an alternative of treatment in stroke -induced brain edema remains to be elucidated The lack of efficacious treatment so far for stroke -induced brain edema makes our hypothesis Int J Med Sci ... of brain edema and 27 did not The mean age for patients with edema was 80.29 years (SD: 4.16), and 77.3 (SD: 7.67) for those without edema (difference not significant) Among patients with edema ... CRP and NT-PBNP are markers of brain edema in stroke at baseline and after 48 hours respectively Given that brain edema may be a life-threatening condition, anti -edema measures could be anticipated...

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Báo cáo y học: "Lateral Antebrachial Cutaneous Nerve injury induced by phlebotomy" pdf

Ngày tải lên : 10/08/2014, 09:22

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Báo cáo y học: "Minimizing charges associated with the determination of brain death" pdf

Ngày tải lên : 12/08/2014, 18:20

... actual organ procurement in brain dead patients may be Table Effect of rapid brain death protocol implementation Medical complications Solid organs procured Brain death Brain death per patient* ... cortical function, or a single brain death examination demonstrating a lack of cortical and brainstem function in conjunction with a confirmatory nuclear medicine brain flow scan demonstrating ... speed the determination of brain death and potentially reduce costly ICU stays, beginning in January 1996 the brain flow scan became the primary method of confirming brain death in our trauma...

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