1 MINISTRY OF AND TRAINING DEFENSE VIET NAM MILIRATY MEDICAL UNIVERSITY MINISTRY OF EDUCATION NGUYỄN TUẤN ANH STUDY ON CLINICAL, PARACLINICAL FEATURES, GENOTYPE OF PNEUMOCYSTIS JIROVECII CAUSING PNEUMONIA IN HIV/AIDS PATIENTS Specilize: Internal medicine Indentification number: 9720107 SUMMARY OF MEDICAL THESIS HA NOI – 2020 THE RESEARCH WAS PERFORMED AT: VIET NAM MILITARY MEDICAL UNIVERSITY Scientific instructors: Prof Ph.D Do Quyet Assoc.Prof PhD Thai Khac Chau Judge 1: Assoc.Prof PhD Vu Van Giap Judge 2: Assoc.Prof PhD Tran Van Khanh Judge 3: Prof Ph.D Tran Viet Tien The thesis will be defended before the Thesis Assessment Concil at Institute level At , date …… month…… year 2020 Be able to search the thesis at: National library Viet Nam Military Medical University library LIST OF WORKS RELATED TO THE THESIS HAS BEEN PUBLISHED Nguyen Tuan Anh, Do Quyet, Nguyen Huy Luc (2019) Clinical characteristics and laboratory findings of PCP pneumonia in HIV/AIDS patients at the National Hospital for Tropical Diseases from 2014-2017 Vietnam Medical Journal, Vol 2, Issue 481: 64-68 Nguyen Tuan Anh (2019) Molecular characteristics and genotypes of Pneumocystis jirovecii Pneumonia in HIV/AIDS patients in National Hospital for Tropical Diseases from 2014 – 2017 Journal of Military Medicine Vol 7: 28-34 RATIONALE HIV/AIDS infection often leads to opportunistic infections due to weakened immune system Common opportunistic infections are infections of the lungs, nervous system, digestive tract, skin and mucous membranes The lungs are the most vulnerable organ in HIV/AIDS patients, of which Pneumocytis jirovecii (PJ) is one of the leading causes of abnormal opportunistic disease and a major cause of severe pneumonia with high mortality in HIV/AIDS patients The clinical symptoms of PJ pneumonia are gradual, dull, accompanied by a dry cough, fever, fatigue, lose weight, increased shortness of breath, dry rales, pulmonary x-ray images and microscopic tomography image of heterogeneous infiltrates, sporadic over two lungs, severe cases of pneumonia can be seen infiltrating each drive, testing reduces both erythrocytes, leukocytes, platelets, CD4 cells is reduced significantly (