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Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition Troels Wind*, Jan K. Jensen, Daniel M. Dupont, Paulina Kulig and Peter A. Andreasen Laboratory of Cellular Protein Science, Department of Molecular Biology, Aarhus University, Denmark The serpin plasminogen activator inhibitor-1 (PAI-1) is a fast and specific inhibitor of the plasminogen activating serine proteases tissue-type and urokinase-type plasminogen activator and, as such, an important regulator in turnover of extracellular matrix and in fibrinolysis. PAI-1 spontaneously loses its antiproteolytic activity by inserting its reactive centre loop (RCL) as strand 4 in b-sheet A, thereby converting to the so-called latent state. We have investigated the import- ance of the amino acid sequence of a-helix F (hF) and the connecting loop to s3A (hF/s3A-loop) for the rate of latency transition. We grafted regions of the hF/s3A-loop from antithrombin III and a 1 -protease inhibitor onto PAI-1, creating eight variants, and found that one of these rever- sions towards the serpin consensus decreased the rate of latency transition. We prepared 28 PAI-1 variants with individual residues in hF and b-sheet A replaced by an alanine. We found that mutating serpin consensus residues always had functional consequences whereas mutating nonconserved residues only had so in one case. Two variants had low but stable inhibitory activity and a pronounced tendency towards substrate behaviour, suggesting that insertion of the RCL is held back during latency transition as well as during complex formation with target proteases. The data presented identify new determinants of PAI-1 latency transition and provide general insight into the characteristic loop–sheet interactions in serpins. Keywords: alignment; conformation; mutational analysis; PAI-1; proteases; serpin. Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of both urokinase-type and tissue-type plasmino- gen activator (uPA and tPA, respectively) and as such is an important regulator of physiological events in which plasmin-catalysed extracellular proteolysis is involved. PAI-1 belongs to the serine protease inhibitor (serpin) family whose antiproteolytic activity is governed by their structural flexibility. In the active serpin conformation, the reactive centre loop (RCL) with the P 1 –P 1 ¢ bait peptide bond is surface exposed. Formation of the covalent serpin– protease complex involves a Michaelis docking complex, cleavage of the P 1 –P 1 ¢ peptide bond, linkage of the active site Ser of the protease to the carboxyl group of P 1 by an ester bond and insertion of the N-terminal part of the RCL as strand 4 in b-sheet A (s4A) of the serpin. Consequently, the protease is trapped in a covalent acyl-enzyme complex in which its reactive site is distorted, as illustrated by the crystal structure of the complex between a 1 -protease inhibitor (a 1 PI,alsoreferredtoasa 1 -antitrypsin) and trypsin [1]. Under some conditions, however, RCL insertion is delayed, resulting in hydrolysis of the ester bond, release of free protease and insertion of the cleaved RCL as s4A. This pathway is STR13/03 ISSN 1610-0956 N Maercklin et al., Seismic data of the DESERT Controlled Source Array II Nils Maercklin, Christian Haberland, Trond Ryberg, Albrecht Schulze, Michael Weber Seismic data of the DESERT Controlled Source Array II (CSA-2; Arava Valley, Jordan, Oct./Nov 2001) Scientific Technical Report STR13/03 - Data GIPP Experiment- and Data Archive www.gfz-potsdam.de Nils Maercklin, Christian Haberland, Trond Ryberg, Albrecht Schulze, Michael Weber Seismic data of the DESERT Controlled Source Array II (CSA-2; Arava Valley, Jordan, Oct./Nov 2001) Imprint Helmholtz Centre Potsdam GFZ German Research Centre for Geosciences Telegrafenberg D-14473 Potsdam Printed in Potsdam, Germany April 2013 ISSN 1610-0956 DOI: 10.2312/GFZ.b103-13036 URN: urn:nbn:de:kobv:b103-13036 This work is published in the GFZ series Scientific Technical Report (STR) and electronically available at GFZ website www.gfz-potsdam.de > News > GFZ Publications Scientific Technical Report STR13/03 - Data Nils Maercklin, Christian Haberland, Trond Ryberg, Albrecht Schulze, Michael Weber Seismic data of the DESERT Controlled Source Array II (CSA-2; Arava Valley, Jordan, Oct./Nov 2001) Imprint Helmholtz Centre Potsdam GFZ German Research Centre for Geosciences Telegrafenberg D-14473 Potsdam Printed in Potsdam, Germany April 2013 ISSN 1610-0956 DOI: 10.2312/GFZ.b103-13036 URN: urn:nbn:de:kobv:b103-13036 This work is published in the GFZ series Scientific Technical Report (STR) and electronically available at GFZ website www.gfz-potsdam.de > News > GFZ Publications Scientific Technical Report STR13/03 - Data GIPP Experiment- and Data Archive Seismic data of the DESERT Controlled Source Array II (CSA-2; Arava Valley, Jordan, Oct./Nov 2001) Nils Maercklin1, Christian Haberland1,*, Trond Ryberg1, Albrecht Schulze1, & Michael Weber1 Deutsches GeoForschungsZentrum GFZ, Telegrafenberg (E323), D-14473 Potsdam * corresponding author Abstract SEG-Y data of small-scale high-resolution controlled-source seismic experiment to investigate the mesoscopic fault structure of the Wadi Arava fault, Dead Sea Transform Introduction The Dead Sea Transform (DST) is a major shear zone running for more than 1000km from the Red Sea in the South to the Zagros mountain chain in the North It accommodates the lateral movement of the Sinai microplate and the Arabian shield; the total displacement along this shear zone is >100km As part of the DESERT 2000 research project, several geophysical studies on a wide range of scales aimed to reveal the structure and evolution of the DST (Weber et al., 2009, 2010, and references therein) In October/November 2010 we conducted a high-resolution seismic experiment in the central part of the Arava/Araba segment of the shear zone The analysis of the data (reflection seismics, tomography) revealed the shallow structure of the Wadi Arava fault (main strand of the DST) down to a depth of ~1km The main findings are published in Maercklin (2004) and Haberland et al (2007) Data Acquisition 2.1 Experiment design and schedule For this experiment seismic lines were successively deployed in the Arava/Araba valley in Jordan between 21.10 and 3.11.2001 (Figure 1) Data acquisition was accomplished by a cable-based seismic multichannel system which was deployed in a fixed spread (for each of the lines) Small chemical explosions were used as seismic sources (300g of chemical explosions detonated in 11.5m deep boreholes) Figure 1: Location of the CSA-2 seismic lines in the Central Arava/Araba Valley (Jordan; after Haberland et al., 2007) 2.2 Geometry/Location Scientific Technical Report STR 13/03 - Data DOI: 10.2312/GFZ.b103-13036 Deutsches GeoForschungsZentrum GFZ Shot and receiver coordinates are listed in file INFO/csa2geom.dat 2.3 Instrumentation We used a SUMMIT seismic multichannel recording system (200 channels) equipped with 4.5Hz geophone strings (vertical component; strings of geophones) 2.4 Acquisition parameters Parameter value Number of profiles Length of each profile 1000m Sensor spacing ~5m (200 channels / line) Shot spacing ~ 20 m ( 51 shots / line) Sampling rate 0.0625 ms (field files) 1.0000 ms (this data compilation) Acquisition length 2.0480 s Data Processing Data processing (for the archived data set) included format conversion, geometry installation and resampling from 1/16 ms to 1ms Data Description For each seismic line one SEG-Y file contains the recordings of all receivers and all sources along the respective line 4.1 File format (s) Data is stored in SEGY format (e.g., Barry et al., 1975) Header word settings are as follows (coordinate reference* is UTM-N = 3300000.0 m, UTM-E = 700000.0 m (UTM zone 36, ellipsoid = WGS-84): Seismic Unix header SEG-Y header byte no Length CSA-2 header settings (bytes) tracl trace number within this file tracr 4 trace number within this file fldr field record number = shot point number tracf 12 receiver channel number ep 16 shot point number (=fldr) cdp 20 CDP ensemble number cdpt 24 trace ...Chapter 8. Recent expansions in the capabilities of Rose’s closed-form una1ysi.s 20 1 A l!? ADHESIVE SHEAR STRESS (?e + ?P) * 0 ?e 7 ADHESIVE SHEAR STRAIN y Fig. 8.21. Elastic-plastic representation of adhesive non-linear behavior in shear mean that the adhesive actually behaves like a ductile metal. If it did, it would unload with a permanent offset; actually, it unloads with hysteresis but almost to the origin.) The results of the new elastic-plastic analysis, documented in reference [7], are depicted in Figure 8.22, in the same non-dimensionalized form as for Rose’s elastic solution in Figure 8.3. The value 1 on the ordinate of Figure 8.22 represents the elastic solution. It is clear that the added strain energy of ductile adhesives, with respect to brittle ones with no non-linear capacity, is to reduce the stiffness of the load over the 4 3 RATIO OF PLASTIC TO ELASTIC STRESS INTENSITY FACTORS 16. ELASTIC- 1 TRANSITIONAL CRACK LENGTH WHEN COD REACHES LIMIT SET BY THE ADHESIVE BOND, ADHESIVE ELASTIC //- -/ CHARCTERISTlCS OF UNPATCHED SKIN CRACK AT INCREASING LOAD LEVELS ELASTIC ADHESIVE I I I I I I I I I I* 2 3 4 5 6 7 8 9 10 OI’ 01 NONDIMENSIONALIZED HALF-CRACK LENGTH, &A Fig. 8.22. Effect of elastic-plastic adhesive behavior on crack-tip stress intensity factors underneath bonded patches. 202 Advances in the bonded composite repair of metallic aircrafi structure crack, for sufficiently high loads. This, of course, is undesirable, since it increases the stress intensity K. On the other hand, the same added flexibility goes hand-in- hand with increased joint strength, enabling bonded patches to be applied to thicker cracked structure than can be repaired with elastic adhesives - unless one is willing to employ stepped patches to decrease the load transferred per step and, at the same time, decrease the eccentricity in load patch for one-sided patches. The new, longer, effective half-crack tips and higher stress-intensity factors have been derived in [7] as (8.12) where the elastic values are defined in Eqs. (8.4) and (8.6). Reference [7] also contains an assessment of the effects of disbonds adjacent to the crack. It is predicted there that these disbonds cannot initiate until the crack has grown sufficiently and that, thereafter, any shear-dominated disbonds will grow in a stable manner, in concert with further crack extension. In other words, the width of any disbond is limited by, and eventually proportional to, the length of the crack. (The behavior of peel-induced disbonds has yet to be examined by closed-form analysis.) Disbonds render bonded patches far less effective; avoiding them justifies the use of more complex stepped patches let into stepped recesses cut into the skin around the crack. The choice between nominally uniform (or linearly tapered) patches on a uniform substrate or stepped patches bonded into a stepped recess cut from the structure seems to be difficult to establish, because so many factors have been omitted from older analyses that the patches have often out-performed the predictions. Nevertheless, the distinction is exceedingly simple to grasp; patches with complex geometries are needed whenever the structure is so thick and so highly loaded that the simple patches cannot do the job. 8.12. Out-of-plane bending effects with one-sided patches Rose’s original analysis includes the necessary geometrically non-linear bending analyses for the effects of the eccentricity in load patch inherent in one-sided bonded patches. He correctly established that the so-called Stage I correction factor is very small. Analyses under the CRAS program, reported in reference [I6], have confirmed this need. Indeed, the tendency for the centroid of the skin/patch combination to align itself with the plane of action of the remote load is so Chapter 1 I. Thermal stress analysis 323 derive an expression for E, in terms of these quantities. From equilibrium considerations we have: hence: where: (11.22) (1 1.23) The expression for the stress state in the plate just outside the patch is given by Eq. (11.16) for r = RI: c3 1 c2 o=El [(I -v) (1 +v)R; (1 1.24) We will now derive the expressions for the stress state in the plate beneath the patch and in the patch. From Eq. (1 1.15) with r 5 RI, under a uniform temperature, the displacement is given by: Since the displacement is the same in both the patch and plate we have: (1 + V)QTI + - U +c2=- 2 I-RI ’ RI ’ ( 1 + v)a2 TI U where the displacement u corresponds to the location r = RI. The radial stresses for the plate and patch are given by: (11.25) (11.26) (11.27) (1 1.28) (11.29) Using Eqs. (1 1.26-1 1.29) we have the expressions for the radial stresses in the plate 324 Advances in the bonded composite repair of metallic aircraft structure beneath the patch and in the patch: (1 1.30) (11.31) To obtain the residual stress in the plate beneath the patch it is necessary to sum Eqs. (11.13) and (11.30), but with TI = -TI in Eq. (11.30). Hence the final expression for the residual stress beneath the patch is: ( 1 1.32) Since the initial stress in the patch is zero, then the residual stress in the patch is given by Eq. (11.31), but again with TI = -TI hence: (1 1.33) and the final expression for the residual stress just outside the patch is given by the summation of Eqs. (1 1.13) and (1 1.24), hence: ( 1 1.34) These equations now give the residual stress in terms of the cure temperature T. The displacement u at r = RI for Eqs. (1 1.17, 11.18) and integration constants C2, C3 are given in the appendix. These equations now give the residual stress in terms of the cure temperature T. For operating temperatures different from room temperature, Eqs. (1 1.24), (1 1.30) and (1 1.31) can be used to calculate the stresses. In this case TI= TO = uniform temperature change from room to operating temperature. The final stresses are obtained by superimposing these stresses on the residual stresses. 11.2.1. Comparison of F.E. and analytic results The solution of these equations has been carried out for AT = lOO"C,and the following quantities have been evaluated for the comparison with F.E. results, the mesh is shown in Figure 11.4: 1. residual stress just outside the patch at r = RI Chapter 11. Thermal stress analysis 325 Fig. 11.4. Finite element mesh of circular patch on circular plate. Here RI = 162 mm and Ro = 500 mm. 2. residual stress in the skin beneath the patch (01) 3. residual stress in the patch (02) As an example a circular patch and plate are considered whose mechanical properties are shown in Table 1 1.1. These properties are representative of a quasi- isotropic boron patch reinforcement of an aluminium plate (although the value of a used here for boron corresponds to uni-directional boron and should have been Table 11.1 Material properties used for study of circular repairs on circular plates, AT = 100°C. Young's Coefficient of Thickness modulus Poisson's thermalexpansion Conductivity Component (mm) (MPa) ratio (1°C) (J/ms"C) Plate(A1uminium) 1 .O 71016 0.3 23 x IOs6 13.2 Patch(boron) 0.5 156000 0.3 **4.1 x 10-6 0.294 *Adhesive (FM300) 0.254 3460 0.35 * Only used for a 3D run. In this instance the value for the laminate is taken to be equal to the unidirectional value. ** 326 Advances in the bonded composite repair of metallic aircraft structure 3.76 x 10@ for the laminate). While this is not a perfect representation of an actual repair it is acceptable for estimating residual stresses. Also this assumes that bending is restrained, e.g. by stiffeners or thick plates, EDIT O R I A L Open Access Semantic Web for data harmonization in Chinese medicine Kei-Hoi Cheung 1* , Huajun Chen 2 Abstract Scientific studies to inve stigate Chinese medicine with Western medicine have been generating a large amoun t of data to be shared preferably under a global data standard. This article provides an overview of Semantic Web and identifies some representative Semantic Web applications in Chinese medic ine. Semantic Web is proposed as a standard for representing Chinese medicine data and facilitating their integration with Western medicine data. Background Asthescientificevidenceforthepreventiveandthera- peutic efficacy of Chinese medicine (CM) is growing, it is strongly demanded to bridge CM with Western medi- cine (WM), particularly through the data obtained from biomedical and clinical research. For example, there were acupuncture studies on certain diseases/disorders such as chronic pain [1,2] and cerebral palsy [3], on pharmacological, molecular and therapeutic properties of various Chinese herbs [4,5] using high-throughput technologies such as DNA microarray and mass spectro- metry [6,7]. Technical challenges include not only the increasing amount of CM literature but also the wide variety of data among various databases. Some represen- tative databases are as follows: i) TCMGeneDIT [8] is a database containing dis- ease-gene-herb associations as the results of m ining the biomedical literature; ii) Phytochemical databases of Chinese herbal consti- tuents were constructed [9]; iii) ClinicalTrials http://clinicaltrials.gov/ contains information of a large collection of clinical trials including those that involve CM; iv) MedlinePlus http://www.nlm.nih.gov/medline- plus/[10] developed by t he United States National Library of Medicine provides consumers and health professionals with research information which covers certain herbal supplements; v) TCM Online http://cowo rk.cintcm.com/engine/ windex1.jsp consists of over 40 categories of CM Databases such as the Traditiona l Chinese Medical Literature Analysis and Retrieval Database, Clinical Medicine Database, Traditional Chinese Drug Data- base, Database of Chinese Medical Formula, Tradi- tional Chinese Medicine Enterprises and Productions Database, and State Standards Database. Data mining and integration of CM and WM data- bases are of great value but problematic [9,11]. Data mining and integration problems include heterogeneity in data formats and structures as well as a lack of stan- dard terminology. Cultural and linguistic differences further complicate data integration. In the informatics community, methods developed for dat a integration can be categorized into: (1) dat a warehousing to translate data and (2) query federation to translate query. Both approaches have their pros and cons. For example, the data warehousing approach has good query performance as data are queried locally, but data are not alway s up- to-date (data updates a re to be made periodically to keep the ware house in synchrony with the member data sources). The query federation approach guarantees data to be up -to-date, but it may suffe r from query perfor- mance especially when large volumes of data are queried and joined over the network. Despite their difference s, these approaches are based on a common data model. The use of such a model is feasible in either a single enterprise or a small group of enterprises. A common data model which can overcome national, geographical, and cultural boundaries would be different w ithout a global data representation standard. To this end, * Correspondence: kei.cheung@yale.edu 1 Yale Center for Medical Informatics and Departments of Anesthesiology and Genetics, School of Medicine, Computer Science Department, Yale University, New Haven, CT 06510, USA Cheung and Chen Chinese Medicine 2010, 5:2 http://www.cmjournal.org/content/5/1/2 © 2010 Cheung and Chen; licensee BioMed Central Ltd. Th is is an Open Access article distributed under E '2 a il F 6oodm an * ĩ t m ٠ '٢ r ٠ I G LÀM THẾ NÀO DOANH NGHIỆP NHỎ CHIẾN THẮNG TRONG MỘT Xà ٠ THẾGIỚI NỐI MẠNG ٠ ٠ HỘI NHÀ XUẤT BẢN TRỀ Gail F Goodman Lại Hoàng Hà dịch (m ٠ ٠ · t t ٠٠ ٠٠٠ ٠ & « ٠ · l· ĩ ( ٠ « ٠ ٠ ٠ ٠ · 11 ĩ' ĨÌEPỈH · « · ٠» · n ® n ٦ p|^ltíi؛٠^ h(|٠٢ ٠ ٠ ■'·٠ ·-'n ١ s®te:_ n LÀM THẾ NÀO DOANH NGHIỆP NHỎ CHIẾN THẮNG TRONỌ MỘT TNẾGiớl NỐLMẠNG Xà HỘI Ị TRu0 ؛؛BẠ ؛- HỌC ííÌà ĩRA N b THƯ ViỀỈM ·^ ٠ A ·١ r ■ /···«.٠ ٠ ٠ ٠٠ ٠ ٠ ٠ ٠ ٠ ٠ — ٠ ٠ ٠ NHÀ XUẤT BẢN TRẺ ١ ١١ : n n : t Lời khen ngợi d n h cho Tiếp thị tương tác "Cuốn sách dành cho chủ doanh nghiệp nhỏ nr،uốn học cách bẩy lên sức mạnh việc giao tiếp mạng mạng để phát triển công việc kinh doanh họ Sách đem đến nhìn mẻ vào việc để doanh nghiệp táng trưởng nhờ tương tác với khách hàng họ Đây chuyện 'tweet' hay 'Like' Đây nói việc làm nhờ khách hàng bạn tạo điểu kiện để họ cho người khác biết điểu Cuốn sách giúp bạn làm theo cách thiết thực Đây cuổn sách phải đọc chủ doanh nghiệp mệt mỏi câu chuyện dài vể 'nội dung' tai ngơ mắt điếc trước truyền thông xã hội, phát bệnh blog Cuổn sách dành cho muốn 'bít tết' 'cháo bột yến mạch' để tạo khách hàng, khách hàng trung thành." — Ramon Ray, Smallbiztechnology.com "Tiếp thị tương tác làm sinh động bàn luận ví dụ thực tiễn từ doanh nghiệp nhỏ việc làm để vượt trội lĩnh vực làm án họ nội dung trực tuyến khiến khách hàng dế dàng tương tác với doanh nghiệp họ Gail Goodman sử dụng cách kể chuyện thuyết phục để giải thích tiếp thị trực tuyến theo nghĩa dẻ hiểu cán — Shashi Bellamkonda, Giám đốc cao cấp, Social Media, Network Soluitons Trợ giảng Đại học Georgetown "Nếu bạn chủ doanh nghiệp nhỏ bạn biết Constant Contact Trong sách mới, CEO Gail Goodman đưa bạn hết đường dẫn đến thành công Những giá trị cũ giá trị tốt Gail cho giá trị sức sống kỷ nguyên Internet Bà giúp doanh nhân hiểu Main Street’ không chết, số hóa Xuyên suốt sách, bạn biết cách biến sức mạnh 'truyền miệng' truyền thông xã hội thành lợi Các chủ doanh nghiệp nhỏ muốn sống sót phát đạt giới Yelp blog cắn phải đọc sách này." — Charles "Tee" Rowe, Chủ tịch CEO, Association of Small Business Development Centers (ASBDC) ١ Thuật ngữ khu trung tâm kinh doanh, thương mại, bán lẻ thành phố nhỏ, thị trấn (Nxb) Cuốn sách dành riêng cho doanh nghiệp tổ chức nhỏ khắp nơi ước mơ, niềm dam mê, tính sáng tạo, kiên cường, tinh thổn tâm bạn không ngừng tạo hứng khởi cho Mục lục Lời nó! đầu Lời giới thíệu 11 17 Phẩn! KHỞI ĐỘNG CỖ M ÁYTIẾPTHỊTƯƠNGTẤC Chương Chu trinh Tiếp th ؛tương tác 26 H\ểu lam ĨÌQO ا'ةاtruyền mỉêng truyền thOng xã hội khuếch đợi, giúp đem lợi thương vụ lặp lọi khách hàng Chương Cung cấp trả! nghJệm Á! CHÀ! 42 Bắt đâu Chu trinh Tiếp thị tương tác - đem lại lời binh luận tích cực vá thương vụ lặp lại — trước hết bon phải làm cho khách hàng ngây ngất VỚI trài nghiệm xuât sâc Chúng cho bạn b\ẽt cách Chương 58 Lôi kéo để giữ liên lạc Sừdụng lời khuyên dễ thực để khuyến khích người tơ giữHên lạc, xa mật thi cách lòng cdch lòng tức không làm an mua bán ة Chương 80 Tương tác với người Chúng giải thích nám thể loại nội dung có sức thuyết phục thúc đẩy tương tác trực tuyến (và đời) đưa người tơ quay lại với doanh nghiệp bạn Chương Tiếp thị tương tác kéo khách hàng tiềm đến trước cửa doanh nghiệp bạn 108 Tương tóc với khách hàng tạo ro hiển thị mọng xá hội mà kết giới thiệu khách hàng tiềm nâng, chứng thực tích cực, kết quà tìm kiếm liên quan Phần !ا CÓTHỄM MỐI اÀM ÃN NHỜTIẾPTHỊTƯƠNGTÁC Chương Hiển thị mạng xã hộl xảy Hiều hoạtđộno vờ sựhưởng 1'íng khách hàng tạo nên sựhiển thi mọng hội Facebook, Twitter, Linkedín, Google + VQ each đề nqhi theo dáư chia sẻ 122 Chương ứng dụng Tiếp thị tương tác Các ví dụ có thật 148 Các tinh nghiên cứu v í dụ từhơi doanh nghiệp nhỏ fỏ' chứcphi lợi nhuận đá sửdụng Tíẽp thi tương tác đề tạo ؛ự h؛ến thi اؤﻻcộng thu hút khách hàng, nhà tời trợ Chương 177 Những lời khuyên thủ thuật Tiếp thị tương tác Năm phương pháp truyền miệng mạng xã hội dễ thực hìện chừng vài phút ngày đem lợi tác động cổ thật vế mặt làm gia ... more than 1000km from the Red Sea in the South to the Zagros mountain chain in the North It accommodates the lateral movement of the Sinai microplate and the Arabian shield; the total displacement... seismic experiment in the central part of the Arava/Araba segment of the shear zone The analysis of the data (reflection seismics, tomography) revealed the shallow structure of the Wadi Arava fault... al., Seismic data of the DESERT Controlled Source Array II Nils Maercklin, Christian Haberland, Trond Ryberg, Albrecht Schulze, Michael Weber Seismic data of the DESERT Controlled Source Array