Supplementary Table 1: Association results and genotype counts of 251 SNPs (p-values < 0.05) from stages and of the Indonesian study that were carried forward to stage Russian study of the TB GWAS. Indonesia SNP rs10497225 rs9289104 rs8109169 rs1420384 rs10490131 rs2185080 rs2172633 rs7684676 rs4764719 rs10493797 rs10519650 rs1857909 rs10509345 rs949593 rs10519651 rs2133294 rs952303 rs424880 rs1425567 rs10517861 rs10494728 rs6470446 rs10484059 rs10517859 rs9306509 rs2181139 rs502131 rs9899503 rs4085896 rs2024787 rs10491876 rs1983191 rs10490595 rs10502875 rs10516402 rs4660918 rs868745 rs722760 rs722761 rs2974574 rs10497385 rs1107251 rs1882074 rs967588 rs401443 rs2070527 rs2189972 rs1552418 rs1154273 rs9295740 rs2753369 rs10491697 rs9322676 rs10503905 rs1354151 rs6137130 rs413114 rs2058995 rs378451 rs241239 rs10504038 rs10498202 rs831460 rs10495455 rs10512292 rs10511943 rs9319943 rs1329710 rs2456923 rs7981602 rs7871948 rs10498989 rs10511154 rs9296453 rs1758734 rs6837953 rs2600306 rs4422737 rs10494752 rs2806694 rs1329716 rs781354 rs2286503 rs1321687 rs7554230 rs10520562 rs982677 rs10517988 rs179194 rs1585459 rs2175379 rs10511750 rs1554027 rs9308990 rs10498315 rs2296554 rs1605057 rs983078 rs4673372 rs1356612 rs9309530 rs10493669 rs964331 rs840970 rs4800876 rs973968 rs1539682 rs10499856 rs797910 rs400477 rs2273061 rs1158279 rs6663269 rs2867469 rs9323804 rs1741949 rs167345 rs207098 rs7863451 rs965123 rs10513854 rs1275643 rs207097 rs571770 rs3820689 rs4053639 rs10492206 rs10520565 rs17622017 rs633082 rs2597881 rs7564654 rs303212 rs1073230 rs646103 rs10515787 rs7564171 rs4724522 rs10502366 rs1536817 rs1077644 rs725901 rs304161 rs1481187 rs10507198 rs10502353 rs4395341 rs2597883 rs10487775 rs2540718 rs1013732 rs188872 rs727200 rs7777070 rs1033363 rs78506 rs7654933 rs10485819 rs8053158 rs10497744 rs4132242 rs6997287 rs767278 rs4815252 rs9303532 rs10493374 rs1550977 rs2148620 rs4087609 rs10489487 rs4132243 rs4130169 rs10485818 rs4128269 rs10245298 rs8124344 rs10492208 rs6879479 rs1489092 rs9317543 rs10514100 rs2397445 rs7191095 rs170533 rs302640 rs1020941 rs7591386 rs4132241 rs725848 rs10488978 rs6079756 rs1585933 rs1379326 rs10516210 rs347311 rs693932 rs2146609 rs4461087 rs1489091 rs254315 rs2350786 rs4142923 rs6785504 rs1218825 rs6074898 Location (Chr) 19 2 11 12 15 11 10 12 15 12 12 14 22 18 17 13 9 18 4 2 16 21 6 20 19 19 11 9 18 6 13 6 9 14 1 4 9 14 9 18 14 20 19 14 12 6 12 15 10 13 18 19 18 12 18 22 16 12 16 7 22 20 16 8 20 17 1 1 12 20 20 12 13 18 16 16 2 20 15 16 16 16 13 20 Gene Risk allele SLC4A10 A IGSF11 A N/A G SP5 C LRP2 G LAX1 A MICALCL G C4orf32 G C12orf42 A HS2ST1 C NDNL2 G UEVLD A USP54 G TRHDE C NDNL2 G ASCL1 C RANBP3L A N/A C OR13D1 C SRD5A2L2 G KCNT2 G N/A C C14orf177 G SRD5A2L2 C LOC388915 A ALDH1B1 A BRUNOL4 A ACCN1 G MTIF3 G RUNX2 A TUSC1 A DMRT2 G CREB1 G ST8SIA5 A KCNIP4 G C1orf190 G KCNIP4 A CREB1 A CREB1 G GRAMD3 C ITGA6 C PDZRN3 A ELMO1 G RUNX2 A CDH13 A ERG A N/A A RIMS1 C CCDC80 A HIST1H2BL A CLCA4 C SMARCA2 G GRIK2 A NRG1 A IGSF11 G C20orf74 G N/A G STK31 C N/A G AJAP1 G ZMAT4 G N/A C NAV2 G FMN2 A N/A G FRMPD1 A GRP G SUPT3H A RP3-402H5.2 A STARD13 C FRMPD1 G MANEA A N/A G SUPT3H G TUSC1 A KIAA1727 A CNTN4 A NRG1 G ZBTB41 G INVS G SUPT3H G KIAA1344 A TOMM7 G CLCA4 A N/A G N/A G N/A C N/A A HSD17B4 A SYK G ADFP A TUSC1 A N/A G CRIM1 G NPAS3 G FRMPD1 G ANP32C G TUSC1 C CREB1 A DLG1 A N/A A N/A A ADAMDEC1 A FLJ16124 A CDH2 A FLJ43390 G MLLT3 A CD36 G GLIS1 G FNDC1 C JAG1 G C9orf82 G PLXNA2 C ZNF536 G FLRT2 A DLG1 G MEF2C G N/A A GARNL3 A N/A A IL1RAP A N/A A N/A A N/A C RGL1 G ACY1L2 G DYRK2 G CPEB1 A N/A A N/A G C4orf32 A ITGA6 G IFIT1 A KATNAL1 A EHD3 A EBF1 A NRP2 A N/A C PTPRM A RP3-402H5.2 C ZNF536 A CDH19 A MEF2C G N/A A NUAK1 A LAMA1 C N/A G C4orf32 G N/A A IRX6 G N/A A CCL17 A MAGI2 A NXPH1 A TG G TIMP3 A N/A A RP5-1103G7.6 C FOXL1 A TMEFF2 A SNX16 A CPA6 G MAGI1 C GGTLA4 A RPRML G DNAJC6 A N/A G RGL1 A RGL1 A N/A G LOC138046 A OCC-1 A RP5-1103G7.6 C LOC138046 A N/A A RP5-1103G7.6 A DYRK2 A GRAMD3 G N/A G PCDH9 A FBXO15 C MMP2 G MAF A N/A A KIF6 A TMEFF2 C CRIM1 A SNX16 A N/A G FAM44A C C20orf133 G ADAMTS17 A N/A G MIST A NOS1AP C SRrp35 C RGS13 A DYNLRB2 A N/A A CDH13 G CHRM2 G N/A G N/A C MTIF3 C C20orf133 G Allele frequency 0.04 0.30 0.02 0.18 0.39 0.17 0.44 0.33 0.12 0.35 0.27 0.03 0.16 0.20 0.27 0.14 0.44 0.25 0.39 0.35 0.32 0.38 0.04 0.35 0.21 0.25 0.07 0.06 0.31 0.21 0.29 0.40 0.25 0.34 0.31 0.20 0.49 0.25 0.25 0.01 0.23 0.19 0.02 0.21 0.34 0.36 0.44 0.50 0.25 0.15 0.15 0.35 0.10 0.20 0.36 0.17 0.37 0.16 0.37 0.01 0.44 0.16 0.14 0.04 0.14 0.05 0.18 0.26 0.33 0.17 0.05 0.43 0.16 0.26 0.43 0.08 0.15 0.49 0.27 0.18 0.27 0.24 0.36 0.14 0.41 0.10 0.32 0.05 0.47 0.18 0.43 0.30 0.16 0.27 0.47 0.05 0.36 0.35 0.24 0.24 0.32 0.15 0.34 0.30 0.26 0.14 0.48 0.04 0.15 0.26 0.28 0.01 0.29 0.31 0.33 0.27 0.31 0.21 0.09 0.17 0.06 0.28 0.21 0.47 0.28 0.23 0.37 0.21 0.03 0.31 0.37 0.48 0.34 0.36 0.01 0.26 0.14 0.39 0.21 0.19 0.26 0.14 0.31 0.20 0.26 0.25 0.04 0.37 0.41 0.25 0.32 0.30 0.13 0.46 0.22 0.26 0.21 0.31 0.21 0.35 0.06 0.16 0.19 0.24 0.31 0.27 0.22 0.28 0.28 0.10 0.06 0.31 0.31 0.06 0.07 0.31 0.06 0.26 0.42 0.50 0.13 0.12 0.26 0.50 0.46 0.35 0.13 0.06 0.17 0.36 0.16 0.49 0.32 0.18 0.09 0.23 0.08 0.38 0.42 0.16 0.42 0.37 0.44 0.38 0.08 controls HWE p 0.3339 0.1471 0.5761 0.219 0.5453 0.3018 0.2797 0.756 0.6157 0.3743 0.7551 1 0.5351 0.9293 0.6943 0.7741 0.9287 0.6471 0.624 0.481 0.6622 0.1287 0.6605 0.4934 0.904 0.1603 0.3798 0.6968 0.2087 0.4685 0.6654 1 0.4934 0.3528 0.904 0.4565 0.2337 0.5445 0.1221 0.3365 0.04718 0.5232 0.07922 0.1293 0.3734 0.149 0.6659 0.1554 0.1881 0.1314 0.1313 0.2326 0.4358 0.3874 0.2688 0.1747 0.7449 0.04751 0.2645 0.6011 0.1487 0.1584 0.132 0.5221 0.2674 0.05808 0.09028 0.2769 0.5981 0.2586 0.7172 0.4256 0.4837 0.3826 1 0.3445 0.6424 0.5428 0.6699 0.2158 0.246 0.9312 0.2681 0.3365 0.3341 0.6512 0.8738 0.201 0.3949 0.2312 0.3235 0.931 0.02698 0.8554 0.7474 0.8267 0.4465 0.3802 0.633 0.9155 0.7695 0.8915 0.04698 0.1873 0.8376 0.8916 0.1025 0.6818 0.899 0.1873 0.2783 0.5544 0.388 0.1944 0.7118 0.1817 1 0.8541 0.108 0.2274 0.6132 1 0.5623 0.7169 0.3874 0.8504 0.7865 0.8138 0.2071 0.9199 0.1384 0.5993 0.5935 0.5162 0.7822 0.8442 0.5843 0.226 0.1691 0.484 0.1735 0.7342 0.3012 0.8212 0.4345 0.4716 0.4716 0.005915 0.1921 0.8436 0.8442 0.1921 0.4525 0.8435 0.6278 0.1027 0.2806 0.2291 0.1514 0.0008064 0.3558 0.0158 0.137 0.193 0.7289 0.1921 0.2644 0.6349 0.3069 0.7286 0.9226 0.3266 0.9015 0.2637 0.325 0.8801 0.6558 0.3605 0.428 0.2039 0.1606 Cases Genotype count 1/14/93 6/35/67 0/8/99 7/41/60 20/58/30 6/44/57 16/57/35 12/42/54 0/35/73 27/43/38 9/36/63 0/2/106 1/16/91 10/32/66 9/36/63 1/38/69 29/54/25 9/53/46 7/55/46 20/54/34 6/49/53 11/40/57 0/7/101 19/54/34 7/34/63 2/34/70 1/19/87 0/27/81 4/36/68 2/32/74 6/48/54 11/48/49 11/50/47 23/60/25 6/36/66 4/42/62 17/50/41 11/50/47 11/50/47 0/1/107 5/31/72 1/30/77 0/7/101 2/33/72 9/39/60 8/46/53 14/55/39 10/62/29 13/46/49 0/25/80 3/18/86 10/42/56 01/08/99 6/25/77 21/53/34 3/23/82 16/53/39 2/27/79 16/53/39 0/10/95 32/45/31 6/36/63 4/32/71 0/4/104 2/36/70 0/18/90 2/23/81 6/34/68 17/49/42 1/43/63 0/18/90 21/48/39 2/43/63 6/34/67 31/52/25 1/19/83 4/31/72 36/23/47 5/27/76 7/35/66 7/34/67 4/48/56 8/52/48 3/19/86 13/55/38 0/13/95 17/49/41 2/15/86 14/51/43 7/42/59 13/53/42 22/35/51 2/43/63 4/39/65 20/52/36 0/18/90 14/60/34 17/62/29 10/49/48 2/34/71 18/48/42 0/25/82 28/38/42 11/46/51 2/34/72 1/36/71 38/45/25 01/10/96 6/36/66 9/34/65 11/52/33 0/0/107 16/51/41 7/48/53 11/41/56 4/35/69 14/32/62 8/44/56 2/13/93 5/39/64 2/16/89 7/29/72 8/44/56 18/50/40 6/40/61 8/50/50 23/53/32 6/38/61 0/13/95 7/46/55 19/49/40 31/50/27 17/43/48 9/54/45 0/0/108 2/43/63 4/32/72 27/47/32 6/30/72 6/22/80 4/44/58 0/24/84 13/35/60 8/38/62 10/50/47 5/53/45 0/4/104 19/50/39 29/47/32 8/55/45 12/29/67 7/29/70 4/25/79 31/54/23 8/44/56 5/35/68 8/38/62 7/36/65 8/39/61 10/47/51 0/18/90 3/42/63 6/30/72 6/33/69 11/57/40 8/55/45 6/39/63 6/41/61 6/41/61 1/24/82 1/17/90 3/42/63 7/36/61 0/18/90 1/19/88 7/36/65 1/15/92 6/33/69 24/54/30 19/46/43 3/32/73 28/62/18 7/56/42 35/45/28 24/62/22 11/46/51 2/22/84 0/18/89 6/37/65 16/52/40 5/34/68 34/50/24 8/42/58 6/44/58 1/6/101 8/50/49 2/20/83 19/60/29 24/54/30 2/25/79 27/54/27 12/44/52 27/57/24 5/52/51 01/11/96 Stage1 Controls genotype count 0/5/110 13/48/54 0/0/115 3/31/81 11/44/60 4/27/84 40/45/30 21/55/39 0/17/98 14/44/57 15/53/47 0/11/104 4/35/76 1/30/84 14/54/47 0/23/92 15/50/50 4/46/65 20/56/39 11/51/53 18/60/37 19/59/37 2/17/96 11/51/52 4/22/87 4/52/59 0/8/107 0/11/104 12/47/56 9/44/62 20/47/48 27/55/33 4/37/74 10/49/56 11/53/51 3/26/86 24/64/27 4/37/74 4/37/74 0/7/108 12/49/54 9/36/70 0/1/114 9/44/62 20/43/52 22/48/45 35/46/33 37/49/23 1/45/69 2/39/74 1/41/73 20/53/42 1/22/92 7/49/59 12/52/51 5/42/68 8/47/60 2/46/67 8/47/60 0/1/113 19/55/41 1/28/86 2/20/93 1/16/98 0/21/94 0/7/108 4/41/70 11/50/54 5/46/64 0/31/84 0/7/108 26/66/23 1/28/84 11/52/52 21/52/42 0/7/105 1/18/96 22/25/68 12/43/60 3/23/89 12/52/51 3/32/80 24/48/43 1/41/73 32/52/31 2/31/82 9/45/60 0/5/106 40/40/35 5/28/82 28/62/25 9/37/68 1/28/86 16/48/51 34/54/27 0/7/108 11/47/57 12/45/58 4/38/72 10/51/54 9/47/59 8/28/79 10/53/52 10/32/73 8/46/61 1/20/94 21/53/41 0/3/112 4/20/91 22/39/54 6/46/60 0/9/106 8/50/57 16/62/37 19/53/43 10/53/52 17/56/42 3/29/83 1/31/83 3/21/91 0/9/106 9/50/56 3/29/83 31/55/29 14/52/49 2/39/74 13/51/51 1/33/81 0/1/112 14/57/44 10/47/58 18/56/41 5/49/61 18/64/33 0/5/110 9/57/49 0/22/93 13/54/45 9/50/56 6/42/67 14/57/44 4/37/74 17/55/42 2/31/82 2/52/61 6/29/78 1/15/99 9/48/58 15/53/47 6/35/74 15/48/52 17/43/55 0/20/93 22/55/38 3/36/76 8/57/50 2/31/82 15/46/54 5/27/83 21/61/33 0/5/110 4/23/88 1/25/89 14/45/56 12/38/65 4/45/66 2/27/86 14/52/49 14/52/49 1/11/103 0/5/110 14/60/41 15/46/53 0/5/110 0/10/105 15/46/54 0/7/108 13/47/55 17/52/46 37/54/24 2/13/97 20/52/43 7/35/73 22/48/45 18/58/39 21/61/33 5/35/75 0/5/109 1/26/88 4/50/61 2/26/87 23/55/37 17/51/47 4/31/80 4/15/96 2/39/74 0/10/102 10/58/47 17/52/46 7/39/69 16/55/44 25/60/30 17/52/46 19/51/45 3/22/90 Trend p OR (95% CI) 0.01095 3.60 1.30 10.00 0.01628 0.59 0.38 0.90 0.002821 NA NA NA 0.01516 1.78 1.12 2.84 0.0002942 2.06 1.40 3.05 0.004655 1.98 1.23 3.16 0.007645 0.59 0.40 0.86 0.01348 0.60 0.41 0.89 0.001867 2.42 1.31 4.47 0.006244 1.79 1.22 2.63 0.01386 0.59 0.39 0.89 0.01402 0.19 0.04 0.85 0.001725 0.40 0.22 0.71 0.008629 1.96 1.21 3.19 0.01705 0.60 0.40 0.91 0.005717 2.05 1.18 3.55 0.0003815 2.02 1.38 2.95 0.01997 1.60 1.05 2.42 0.02658 0.66 0.44 0.97 0.01002 1.66 1.13 2.44 0.001965 0.55 0.37 0.82 0.003486 0.55 0.37 0.82 0.01391 0.33 0.14 0.80 0.0163 1.60 1.09 2.36 0.01223 1.96 1.19 3.24 0.02714 0.62 0.39 0.98 0.007056 3.02 1.31 6.97 0.002187 2.84 1.37 5.89 0.01246 0.57 0.37 0.88 0.008927 0.54 0.34 0.86 0.02666 0.63 0.42 0.94 0.001549 0.53 0.36 0.78 0.0009112 2.06 1.34 3.17 0.00002973 2.25 1.53 3.32 0.01422 0.59 0.39 0.90 0.01119 1.86 1.14 3.04 0.03352 0.67 0.46 0.98 0.0009112 2.06 1.34 3.17 0.0009112 2.06 1.34 3.17 0.03836 0.15 0.02 1.21 0.002682 0.50 0.32 0.78 0.02366 0.57 0.35 0.92 0.02432 7.67 0.94 62.86 0.01443 0.57 0.36 0.90 0.0394 0.63 0.42 0.95 0.01811 0.61 0.41 0.91 0.01118 0.60 0.41 0.88 0.0008372 0.53 0.36 0.78 0.001654 1.95 1.27 2.99 0.0366 0.59 0.34 1.00 0.02494 0.55 0.32 0.94 0.01158 0.59 0.40 0.88 0.0239 0.42 0.19 0.89 0.01112 0.55 0.35 0.87 0.01782 1.59 1.08 2.34 0.01278 0.53 0.32 0.87 0.007017 1.72 1.16 2.56 0.03291 0.60 0.37 0.99 0.007017 1.72 1.16 2.56 0.003425 11.35 1.44 89.44 0.04217 1.50 1.03 2.18 0.007173 1.98 1.20 3.26 0.01575 1.97 1.14 3.40 0.004371 0.22 0.07 0.67 0.002609 2.26 1.29 3.98 0.01233 2.90 1.19 7.08 0.01615 0.54 0.32 0.90 0.01842 0.59 0.39 0.91 0.001391 1.94 1.29 2.91 0.02017 1.71 1.04 2.82 0.01233 2.90 1.19 7.08 0.03872 0.68 0.47 0.99 0.01237 1.82 1.10 3.00 0.0121 0.58 0.38 0.89 0.01455 1.62 1.11 2.35 0.003096 3.52 1.46 8.46 0.003791 2.34 1.32 4.16 0.009336 1.90 1.28 2.80 0.004692 0.50 0.32 0.79 0.007568 2.03 1.23 3.36 0.0124 0.58 0.38 0.88 0.01125 1.77 1.11 2.81 0.02737 0.64 0.43 0.95 0.03274 0.57 0.33 0.97 0.01052 0.61 0.42 0.89 0.001492 0.36 0.18 0.69 0.01449 1.66 1.11 2.48 0.003044 4.41 1.62 12.04 0.00224 0.53 0.36 0.77 0.0179 1.77 1.11 2.81 0.001353 0.55 0.37 0.80 0.01001 1.81 1.20 2.74 0.009696 1.85 1.12 3.06 0.002851 0.52 0.34 0.80 0.03101 0.66 0.45 0.95 0.01233 2.90 1.19 7.08 0.01479 1.60 1.09 2.37 0.001351 1.87 1.27 2.76 0.003466 1.88 1.22 2.90 0.001102 0.48 0.31 0.76 0.01985 1.62 1.09 2.40 0.03819 0.56 0.33 0.95 0.01562 1.66 1.13 2.44 0.04511 1.57 1.03 2.40 0.01606 0.58 0.37 0.91 0.009699 2.02 1.15 3.54 0.003325 1.81 1.24 2.64 0.01695 4.50 1.25 16.16 0.007472 2.06 1.24 3.43 0.01264 0.56 0.37 0.85 0.003819 1.80 1.18 2.72 0.003134 0.00 0.00 nan 0.02802 1.55 1.04 2.30 0.004896 0.58 0.39 0.86 0.02549 0.63 0.42 0.93 0.003936 0.53 0.35 0.83 0.01637 0.60 0.40 0.89 0.001373 2.14 1.34 3.42 0.03098 0.51 0.28 0.95 0.002692 2.21 1.32 3.68 0.02574 2.53 1.13 5.69 0.02156 0.59 0.38 0.92 0.001373 2.14 1.34 3.42 0.02227 0.64 0.44 0.93 0.01617 0.60 0.40 0.91 0.002383 1.91 1.23 2.97 0.008375 1.68 1.15 2.47 0.02026 1.74 1.08 2.81 0.0006686 14.41 1.87 111.10 0.03361 0.66 0.44 0.98 0.01564 1.64 1.11 2.43 0.01392 1.62 1.11 2.35 0.02373 1.61 1.07 2.41 0.01926 0.65 0.44 0.96 0.0284 0.00 0.00 nan 0.005936 0.57 0.38 0.88 0.006008 2.15 1.23 3.75 0.01351 1.64 1.12 2.40 0.01484 0.58 0.37 0.89 0.04977 0.61 0.38 0.98 0.003452 0.55 0.37 0.84 0.01154 0.51 0.30 0.88 0.02155 0.61 0.41 0.92 0.01097 1.86 1.16 2.98 0.03625 1.51 1.00 2.29 0.002065 1.99 1.27 3.12 0.007084 0.24 0.08 0.71 0.008363 1.71 1.15 2.53 0.01002 1.68 1.15 2.45 0.002428 1.91 1.24 2.93 0.04438 0.63 0.42 0.96 0.004063 0.51 0.33 0.78 0.04097 1.86 1.03 3.35 0.02587 1.54 1.06 2.23 0.01587 1.72 1.10 2.69 0.007111 0.57 0.37 0.87 0.01097 1.86 1.16 2.98 0.0265 0.61 0.40 0.93 0.0195 1.78 1.12 2.84 0.002432 0.55 0.38 0.82 0.002505 4.09 1.49 11.22 0.01564 1.83 1.12 3.01 0.02872 1.82 1.07 3.07 0.0129 0.57 0.37 0.87 0.03023 1.56 1.05 2.34 0.01376 1.64 1.08 2.48 0.006108 1.98 1.21 3.24 0.0183 0.61 0.40 0.92 0.0183 0.61 0.40 0.92 0.01651 2.31 1.15 4.62 0.002286 4.34 1.59 11.84 0.0001274 0.46 0.30 0.70 0.04004 0.63 0.42 0.96 0.002505 4.09 1.49 11.22 0.02533 2.37 1.09 5.16 0.0265 0.61 0.40 0.93 0.0262 2.72 1.11 6.70 0.01197 0.57 0.37 0.87 0.03798 1.50 1.03 2.19 0.0007343 0.51 0.35 0.74 0.002115 2.60 1.42 4.77 0.001723 1.81 1.24 2.63 0.003635 1.85 1.21 2.83 0.009325 1.71 1.17 2.49 0.026 1.50 1.03 2.18 0.003627 0.57 0.38 0.83 0.03365 0.56 0.33 0.95 0.00248 4.10 1.49 11.24 0.00351 2.12 1.27 3.52 0.001451 1.89 1.26 2.83 0.03611 1.73 1.04 2.87 0.02784 1.54 1.06 2.23 0.02524 0.63 0.42 0.94 0.02057 1.71 1.08 2.71 0.02051 0.35 0.15 0.79 0.001926 1.94 1.25 3.01 0.008229 2.76 1.29 5.93 0.008825 1.62 1.10 2.37 0.03798 1.50 1.03 2.19 0.01317 0.53 0.32 0.87 0.009837 1.64 1.13 2.40 0.0005113 0.50 0.34 0.74 0.003059 1.77 1.21 2.58 0.02356 0.64 0.43 0.95 0.03311 0.46 0.23 0.92 Russia Cases Genotype count 3/64/532 39/246/314 1/27/571 27/193/379 96/297/206 17/186/397 102/297/200 57/252/289 12/137/450 73/297/226 35/229/335 0/29/570 13/146/440 33/191/375 36/226/335 13/159/427 116/318/165 37/248/315 77/291/232 88/265/246 54/253/292 82/268/249 0/41/558 89/265/245 38/196/366 36/200/358 7/87/505 4/79/516 46/253/301 25/184/390 42/239/317 86/292/221 36/240/322 78/271/250 41/268/289 31/196/371 126/312/162 36/240/323 36/240/322 0/7/593 24/215/360 18/168/414 2/32/566 25/184/390 68/249/282 68/273/259 104/297/198 145/284/170 41/236/322 12/140/446 6/145/449 57/282/259 3/96/499 24/171/404 92/271/236 17/150/432 86/291/221 17/143/438 86/291/221 0/16/584 131/294/175 16/178/405 18/151/431 1/43/555 12/152/434 1/72/525 13/173/413 38/212/350 73/261/265 24/176/398 1/71/527 94/306/200 16/171/413 39/209/350 122/294/182 6/101/492 18/156/425 137/294/168 44/214/341 23/184/392 43/217/339 48/210/341 75/265/259 6/144/447 95/285/219 3/106/490 67/265/268 2/60/537 122/299/178 19/195/383 104/294/201 56/260/283 16/170/414 37/236/326 116/304/178 0/72/527 83/288/229 80/274/245 34/237/324 34/207/356 66/265/267 11/138/450 76/274/249 60/263/276 48/194/358 13/153/433 148/290/161 4/53/542 10/170/419 42/215/341 49/258/292 0/12/587 46/275/279 61/237/301 63/245/291 38/229/332 53/252/295 33/193/372 3/87/510 17/176/406 2/75/522 44/233/321 33/193/372 128/292/179 44/235/319 28/232/339 74/311/214 38/197/365 0/38/561 44/262/294 94/269/237 136/321/141 76/268/255 63/282/255 0/13/587 43/215/342 15/145/439 106/279/215 22/197/381 16/176/408 44/215/339 7/141/451 55/247/297 23/212/364 36/260/302 28/252/320 2/43/554 93/269/236 111/280/208 44/226/329 56/253/291 51/242/306 15/138/447 129/308/163 36/200/363 37/224/338 23/213/363 56/241/302 24/218/357 70/265/262 4/70/525 17/164/416 21/197/381 30/217/351 60/273/266 50/242/307 36/206/357 44/237/318 44/237/318 19/91/487 4/70/525 52/259/288 56/240/302 5/69/525 3/88/509 57/239/301 1/73/524 34/230/335 116/284/200 154/299/146 7/145/447 0/143/456 49/225/325 144/294/161 141/284/174 71/267/261 13/124/463 4/70/525 16/179/404 87/267/245 16/174/410 156/291/153 52/260/287 20/185/395 4/90/505 28/234/337 6/89/504 81/307/211 116/283/200 8/169/421 116/283/200 86/263/249 131/275/193 75/285/240 2/81/517 Stage2 Controls genotype count 0/30/510 66/230/244 0/10/530 18/135/387 74/243/223 15/125/395 115/277/148 74/236/229 5/100/435 51/248/238 48/221/271 0/46/494 16/158/366 20/151/369 48/220/271 8/115/417 96/263/181 24/192/319 94/263/178 54/241/245 61/247/232 88/258/194 2/52/486 54/242/243 22/159/354 37/217/280 4/58/478 2/54/484 54/244/237 29/191/320 59/216/260 102/254/184 28/192/320 61/234/245 67/227/246 20/155/365 146/262/127 28/192/320 28/192/319 0/16/518 37/197/305 26/167/341 0/17/518 29/191/320 75/240/220 85/239/211 119/261/160 152/252/136 25/203/312 9/166/364 16/141/378 83/232/224 3/114/422 28/175/337 54/255/225 16/166/358 58/261/220 22/149/363 58/262/220 0/8/527 103/243/188 15/128/392 11/115/409 0/56/484 8/116/414 2/43/489 26/161/353 42/210/283 51/232/257 19/128/388 2/43/495 107/272/156 6/138/390 47/201/292 83/279/178 4/72/464 13/120/406 127/293/120 51/203/286 18/142/380 47/215/278 31/175/328 82/252/206 16/140/383 105/257/178 9/103/428 47/225/263 0/44/496 120/281/139 13/154/372 105/275/160 40/223/277 7/138/390 50/209/281 127/266/141 2/43/490 68/230/236 55/251/234 28/190/319 37/201/301 47/225/263 13/147/379 63/223/254 47/209/278 34/225/276 11/113/415 115/267/158 3/33/504 9/130/401 43/213/283 40/210/290 0/17/523 36/220/279 63/229/248 66/238/236 42/220/278 56/239/239 21/169/350 1/102/432 17/133/389 1/52/487 47/229/263 21/169/349 140/251/149 46/232/262 26/182/332 60/262/218 25/162/346 0/26/514 53/241/240 65/244/226 111/279/150 47/246/241 72/255/208 1/19/514 41/215/278 8/120/412 78/249/208 34/174/327 26/163/346 41/218/281 14/135/391 57/236/241 19/168/353 35/195/309 27/196/312 0/55/485 68/244/228 84/254/202 32/195/313 67/225/243 51/233/256 11/103/421 100/270/165 24/170/346 37/222/281 21/166/353 58/234/248 23/165/347 78/236/226 3/50/481 13/128/393 21/144/370 37/202/301 42/235/258 34/208/293 20/186/334 44/234/262 44/234/262 10/76/448 3/52/485 56/233/251 58/234/248 3/52/485 3/61/471 57/232/246 0/52/482 32/230/278 79/269/187 136/256/148 11/106/423 0/121/419 37/192/306 126/299/115 113/247/175 78/235/225 12/131/392 3/52/485 17/138/385 62/251/227 15/130/390 122/262/150 58/240/241 15/148/371 7/91/442 26/190/324 2/73/465 78/236/221 81/271/188 15/155/365 86/266/188 72/265/203 103/254/181 74/269/192 1/89/445 CMH p 0.0000152 0.0000483 0.0001983 0.0002163 0.0004109 0.0005453 0.0007386 0.0007622 0.000788 0.0009836 0.001372 0.001388 0.001529 0.00155 0.001691 0.001709 0.001757 0.001766 0.001832 0.001893 0.001895 0.002341 0.002372 0.002436 0.002613 0.002691 0.002717 0.003033 0.003153 0.003213 0.003238 0.003322 0.003336 0.003378 0.003392 0.003499 0.003515 0.003569 0.003587 0.003616 0.003624 0.003724 0.00397 0.004035 0.004236 0.004267 0.004454 0.004492 0.004668 0.004731 0.005115 0.005244 0.005251 0.005443 0.005544 0.005612 0.005838 0.005849 0.006061 0.006128 0.006147 0.006187 0.006308 0.006368 0.006401 0.006513 0.006661 0.006799 0.006816 0.00686 0.007005 0.007023 0.007038 0.007142 0.007241 0.007296 0.007351 0.007359 0.007533 0.007577 0.007603 0.007648 0.007717 0.008166 0.008362 0.008784 0.008786 0.008857 0.009051 0.009158 0.009607 0.009656 0.009769 0.009779 0.009839 0.009947 0.01015 0.01019 0.01033 0.01046 0.01072 0.01091 0.01094 0.01102 0.01122 0.01154 0.01168 0.01192 0.01226 0.01239 0.01245 0.01306 0.01321 0.01342 0.01342 0.01354 0.01385 0.01386 0.01414 0.01441 0.01447 0.01465 0.01466 0.01466 0.01514 0.01524 0.01564 0.01567 0.01575 0.01594 0.01607 0.01611 0.01646 0.01668 0.01668 0.01671 0.01687 0.01706 0.01721 0.01722 0.0173 0.01736 0.01738 0.01768 0.01775 0.01792 0.01796 0.01805 0.01915 0.01944 0.01975 0.01981 0.01986 0.01987 0.02053 0.02056 0.02075 0.02078 0.0208 0.02086 0.02101 0.02103 0.0214 0.02192 0.02222 0.02228 0.02362 0.02365 0.02365 0.0237 0.02383 0.02406 0.02421 0.02424 0.02576 0.02582 0.0259 0.026 0.02662 0.02726 0.0273 0.02741 0.02806 0.02822 0.02858 0.02883 0.02903 0.02904 0.0293 0.02946 0.02966 0.03035 0.03052 0.03061 0.03082 0.03221 0.03244 0.03293 0.03308 0.03337 0.03345 0.03426 0.03441 0.03464 0.03477 OR 2.36 0.71 3.46 1.44 1.32 1.43 0.77 0.76 1.50 1.30 0.76 0.49 0.71 1.36 0.76 1.42 1.27 1.32 0.78 1.28 0.78 0.79 0.57 1.28 1.34 0.76 1.57 1.59 0.78 0.76 0.78 0.80 1.30 1.27 0.78 1.33 0.80 1.30 1.30 0.32 0.77 0.75 2.21 0.76 0.79 0.80 0.80 0.80 1.28 0.74 0.74 0.80 0.69 0.77 1.25 0.75 1.25 0.75 1.25 2.74 1.24 1.33 1.35 0.60 1.36 1.61 0.76 0.79 1.25 1.32 1.60 0.81 1.33 0.79 1.23 1.46 1.34 1.23 0.79 1.31 0.79 1.28 0.81 0.75 0.81 0.72 1.24 1.61 0.82 1.29 0.82 1.24 1.31 0.80 0.82 1.57 1.23 1.23 1.26 0.80 1.24 0.76 1.23 1.24 0.80 1.33 1.21 1.63 1.31 0.81 1.24 0.42 1.23 0.82 0.82 0.81 0.82 1.26 0.72 1.29 1.50 0.81 1.26 0.83 0.81 1.25 1.21 1.26 1.77 0.82 1.21 1.20 1.22 0.83 0.45 0.81 1.31 1.21 0.80 0.79 0.81 0.77 0.82 1.26 1.23 1.24 0.64 1.21 1.20 1.23 0.82 0.82 1.31 1.20 1.24 0.82 1.25 0.82 1.25 0.83 1.47 1.28 1.26 0.82 1.21 1.22 1.24 0.83 0.83 1.34 1.45 0.83 0.83 1.45 1.40 0.83 1.46 0.82 1.19 0.84 1.29 1.27 1.21 1.18 1.18 0.84 0.78 1.43 1.25 1.19 1.26 1.18 0.84 1.24 0.74 1.21 1.36 1.18 1.18 0.80 1.18 0.85 1.18 0.85 0.74 (95% CI) 1.58 3.52 0.60 0.84 1.72 6.96 1.19 1.76 1.13 1.54 1.17 1.75 0.66 0.90 0.65 0.89 1.18 1.90 1.11 1.53 0.64 0.90 0.31 0.76 0.58 0.88 1.12 1.65 0.64 0.90 1.14 1.77 1.09 1.48 1.11 1.57 0.67 0.91 1.10 1.50 0.66 0.91 0.67 0.92 0.39 0.82 1.09 1.50 1.11 1.61 0.64 0.91 1.17 2.12 1.17 2.16 0.66 0.92 0.63 0.91 0.66 0.92 0.68 0.93 1.09 1.55 1.08 1.48 0.67 0.92 1.10 1.61 0.69 0.93 1.09 1.54 1.09 1.54 0.14 0.72 0.64 0.92 0.62 0.91 1.27 3.85 0.64 0.92 0.68 0.93 0.68 0.93 0.69 0.93 0.69 0.93 1.08 1.53 0.60 0.91 0.60 0.91 0.68 0.94 0.53 0.90 0.64 0.92 1.07 1.46 0.62 0.92 1.07 1.46 0.61 0.92 1.07 1.46 1.29 5.83 1.06 1.44 1.08 1.63 1.09 1.68 0.41 0.87 1.09 1.70 1.14 2.26 0.63 0.93 0.66 0.94 1.06 1.47 1.08 1.61 1.13 2.26 0.70 0.94 1.08 1.64 0.66 0.94 1.06 1.43 1.11 1.94 1.08 1.66 1.06 1.43 0.67 0.94 1.07 1.59 0.67 0.94 1.07 1.53 0.69 0.95 0.61 0.93 0.70 0.95 0.56 0.92 1.06 1.46 1.12 2.31 0.70 0.95 1.07 1.57 0.70 0.95 1.05 1.47 1.07 1.62 0.68 0.95 0.70 0.95 1.11 2.22 1.05 1.44 1.05 1.44 1.06 1.50 0.67 0.95 1.05 1.45 0.61 0.94 1.05 1.44 1.05 1.46 0.67 0.95 1.07 1.66 1.04 1.41 1.11 2.40 1.06 1.62 0.68 0.95 1.05 1.46 0.21 0.85 1.04 1.45 0.69 0.96 0.70 0.96 0.68 0.96 0.69 0.96 1.05 1.52 0.55 0.94 1.05 1.58 1.08 2.07 0.69 0.96 1.05 1.52 0.71 0.96 0.69 0.96 1.04 1.49 1.04 1.42 1.04 1.51 1.10 2.83 0.70 0.96 1.04 1.42 1.04 1.40 1.04 1.43 0.71 0.97 0.23 0.88 0.68 0.96 1.05 1.63 1.03 1.41 0.67 0.96 0.65 0.96 0.69 0.96 0.62 0.96 0.70 0.97 1.04 1.51 1.04 1.46 1.04 1.47 0.45 0.93 1.03 1.41 1.03 1.40 1.03 1.46 0.70 0.97 0.70 0.97 1.04 1.65 1.03 1.39 1.03 1.49 0.69 0.97 1.03 1.50 0.70 0.97 1.03 1.50 0.71 0.97 1.06 2.04 1.04 1.57 1.03 1.53 0.68 0.97 1.03 1.42 1.03 1.44 1.03 1.49 0.70 0.97 0.70 0.97 1.04 1.74 1.05 2.01 0.71 0.98 0.70 0.98 1.05 2.01 1.04 1.89 0.70 0.98 1.04 2.04 0.69 0.98 1.02 1.39 0.73 0.98 1.03 1.62 1.03 1.57 1.02 1.44 1.02 1.38 1.02 1.38 0.72 0.98 0.63 0.98 1.04 1.99 1.02 1.53 1.02 1.40 1.02 1.54 1.02 1.37 0.71 0.98 1.02 1.51 0.57 0.97 1.02 1.45 1.03 1.81 1.01 1.38 1.01 1.38 0.66 0.98 1.01 1.37 0.72 0.99 1.01 1.37 0.72 0.99 0.56 0.98 Risk allele A A G C G A A G A C G A G C G C A C C G G C G C A A A G G A A G G A A G T A G C C A G A A A G G C A C G A A A G G C G G A C G A G A G A A C G G G A G A A G A G A A A A A G C A A G A A G G G G A C A A A A A A A G C G G C A G C G A G G A A A A A A C G G A A A G A A G A A A A C A C A A G A A C G G A G G A A G G A A C A A A G C A G A G A A G A A C A A A A G A G C A A C G C A A G C G G G A C C A A G G A G A C G Allele frequency 0.000692329 0.351842 0.00276625 0.316685 0.179601 0.336056 0.319502 0.378079 0.164454 0.345739 0.0993084 0.1005 0.0525879 0.231132 0.0993075 0.27953 0.299972 0.0167405 0.349654 0.112203 0.38005 0.113957 0.107726 0.112725 0.170911 0.232143 0.145528 0.153868 0.0390149 0.169803 0.12046 0.408324 0.447703 0.0730493 0.492667 0.26131 0.399197 0.4553 0.455137 0.292636 0.0769657 0.0586445 0.109635 0.169388 0.360872 0.281224 0.219424 0.311514 0.483532 0.14946 0.495012 0.204206 0.0161781 0.0448629 0.480088 0.0622407 0.340205 0.260653 0.34057 0.284154 0.391027 0.295732 0.181831 0.213001 0.022419 0.243916 0.197645 0.476303 0.43468 0.350416 0.244398 0.335134 0.370745 0.403681 0.456269 0.0913993 0.405402 0.401689 0.48617 0.372508 0.419087 0.371713 0.397234 0.494186 0.392241 0.0452407 0.313071 0.00554631 0.329552 0.00207584 0.262254 0.447871 0.370981 0.134765 0.283896 0.243636 0.258176 0.465541 0.347453 0.238649 0.314938 0.06934 0.129148 0.387275 0.271733 0.1928 0.140742 0.000692137 0.044175 0.0939142 0.42956 0.0243632 0.0457815 0.331903 0.431416 0.370227 0.296758 0.0868603 0.383679 0.348795 0.123997 0.449045 0.0864317 0.292717 0.468318 0.271381 0.343577 0.136037 0.106886 0.287216 0.351467 0.257819 0.255325 0.381375 0.163827 0.030324 0.209499 0.177683 0.400581 0.342877 0.0715276 0.148174 0.298782 0.178384 0.322983 0.321162 0.0381743 0.354415 0.281977 0.349072 0.409607 0.247093 0.237542 0.287119 0.317691 0.448405 0.178245 0.102656 0.143352 0.301328 0.14821 0.0680055 0.109574 0.130995 0.417266 0.0960155 0.370227 0.468023 0.468188 0.0537247 0.148907 0.28611 0.102795 0.14762 0.0903431 0.102823 0.28759 0.148035 0.370745 0.479674 0.0728155 0.402712 0.154676 0.404538 0.0416436 0.302271 0.0167544 0.148907 0.306969 0.242739 0.361787 0.228706 0.331487 0.00415053 0.238829 0.271116 0.042197 0.159462 0.370709 0.126556 0.295046 0.38895 0.495436 0.0660299 0.207192 controls HWE p 0.1062 5.193E-18 0.6603 0.8148 0.2658 0.359 0.7229 0.7518 0.2025 0.2743 0.7457 0.2017 0.14 0.005335 0.5494 0.6803 0.6485 0.653 0.396 0.9313 0.3577 0.8486 0.4707 0.005388 0.4121 0.41 0.118 0.388 0.4816 0.6017 0.5773 0.05186 0.4441 0.4734 0.6847 0.4028 0.3944 0.3673 0.4442 0.2003 0.0007939 0.08803 0.6352 0.264 0.7041 0.8837 1 0.8869 0.5467 0.7945 0.3546 0.8759 0.8122 0.1205 0.6848 1 0.9485 0.1279 0.9241 0.4399 0.098 0.1952 0.4489 0.4942 0.924 0.5521 0.658 0.2766 0.04629 0.2008 0.5946 0.9181 0.04725 0.5062 0.1669 0.4274 0.5834 0.7448 0.0504 0.7733 0.4793 0.6246 0.3787 0.897 0.4634 0.6327 0.5296 0.8414 0.4435 0.4706 0.4232 0.8817 0.7182 0.818 0.553 0.0007976 0.6791 0.9236 0.1773 0.8314 0.3611 0.4675 0.4772 0.1087 0.006851 0.7405 0.2702 0.5644 0.8192 0.8115 0.7167 0.6746 0.8089 0.9092 0.4989 0.7574 0.04535 0.02891 0.5863 0.5089 0.6225 0.06132 0.2031 0.854 0.6994 0.6163 0.004974 0.6602 0.8269 0.5694 0.6403 0.1609 0.0141 0.6205 0.09506 0.1503 0.3871 0.006204 0.1711 0.9235 0.9124 0.5747 0.4445 0.8046 0.8072 0.6965 0.7594 0.7385 0.7029 0.014 0.7103 0.3514 0.1716 0.5765 0.7582 0.1717 0.7612 0.7759 0.03798 0.1065 0.09553 0.1379 0.7095 0.4308 0.1201 0.8257 0.3052 0.7096 0.1322 0.5594 0.4732 0.3797 1 0.0533 0.6286 0.1671 0.0009531 0.04279 7.412E-10 0.5696 0.1254 0.2964 0.2515 0.5711 Cases Genotype count 0/3/1830 224/848/765 4/0/1833 192/784/861 65/503/1267 189/848/796 172/806/859 266/873/697 54/492/1291 221/842/773 27/334/1475 25/322/1481 4/169/1662 87/636/1107 27/334/1475 143/746/948 159/795/882 0/46/1790 206/838/793 24/383/1429 276/868/692 21/357/1457 30/327/1478 26/382/1429 56/540/1239 94/650/1092 32/471/1332 38/451/1306 3/135/1699 49/505/1282 26/413/1396 291/900/646 352/944/539 10/251/1575 458/902/476 126/715/992 304/887/644 377/919/540 376/919/540 157/781/899 10/253/1573 3/205/1628 27/348/1461 49/503/1284 228/834/770 145/728/962 83/625/1129 184/766/885 420/930/486 42/463/1331 463/903/471 78/596/1161 1/59/1777 3/164/1668 425/896/516 15/195/1627 198/819/820 124/714/998 198/819/820 162/751/924 289/876/670 179/734/918 59/565/1213 80/605/1152 1/84/1752 114/676/1047 73/595/1167 432/913/488 358/881/597 197/869/767 115/676/1046 217/826/793 252/837/746 299/844/694 359/934/544 13/323/1501 298/892/645 306/872/655 428/863/475 261/871/703 318/867/652 266/871/697 285/898/653 462/903/471 275/865/661 2/158/1677 182/774/877 0/20/1814 197/841/798 1/10/1826 127/703/1005 376/913/548 247/822/729 35/401/1397 145/763/929 114/676/1047 118/692/1023 416/907/513 227/828/780 104/694/1036 189/773/874 11/223/1581 26/393/1418 269/859/708 139/726/969 70/570/1192 44/434/1357 0/3/1833 14/127/1681 17/308/1512 317/888/631 2/91/1744 4/159/1674 201/805/829 316/920/601 245/901/690 142/772/918 9/284/1544 266/876/695 237/845/752 34/393/1409 380/882/574 9/283/1541 153/763/919 400/937/500 140/729/968 208/840/787 32/424/1380 21/341/1475 143/743/951 227/836/772 118/706/1012 101/740/996 273/886/674 44/538/1250 0/95/1742 84/626/1127 61/541/1235 296/867/674 222/834/780 8/253/1573 46/469/1321 148/771/917 63/545/1228 197/816/821 206/781/850 2/133/1702 230/837/767 143/744/950 223/823/789 313/879/644 103/662/1070 91/712/1032 154/732/949 184/792/859 365/918/550 63/545/1228 13/374/1450 42/438/1355 146/770/921 36/469/1329 4/245/1586 23/366/1448 22/413/1401 325/886/626 10/312/1514 248/875/713 398/937/500 399/938/500 7/169/1658 36/470/1329 153/750/932 13/374/1448 34/466/1337 22/312/1502 13/374/1450 159/743/887 36/479/1320 263/821/753 423/910/504 9/231/1595 312/869/654 46/493/1297 307/874/655 4/146/1685 147/773/917 0/70/1765 36/471/1329 172/787/878 111/678/1048 231/859/747 101/645/1091 206/854/775 0/9/1828 97/664/1070 140/727/968 3/139/1693 49/526/1259 263/821/752 1/460/1375 158/763/915 273/846/716 453/954/430 9/221/1606 75/593/1169 Indonesia and Russia Combined Stage3 Controls genotype count 0/2/1776 234/777/763 6/0/1772 181/759/837 60/543/1170 192/817/769 198/764/816 244/839/694 48/493/1237 204/807/767 20/290/1469 17/317/1435 3/197/1578 106/644/1024 20/289/1465 150/689/939 181/692/903 1/73/1704 225/828/725 20/340/1418 252/823/703 27/370/1379 25/341/1410 20/341/1417 48/487/1243 106/627/1043 36/444/1296 48/447/1187 8/125/1644 60/504/1213 19/366/1387 320/831/628 345/898/536 11/235/1532 433/877/468 123/670/977 291/806/679 376/865/536 375/866/535 150/719/906 11/261/1504 4/205/1570 25/340/1411 60/503/1214 250/809/710 133/747/896 114/567/1096 191/735/852 413/898/466 46/441/1290 433/878/461 72/580/1127 0/56/1723 3/148/1625 417/892/470 5/215/1558 215/814/748 127/668/983 217/814/748 137/706/936 280/810/686 153/736/888 53/526/1200 84/607/1087 0/76/1700 103/654/1022 56/574/1145 389/882/504 327/890/560 242/783/752 104/653/1021 177/805/791 244/850/684 299/877/600 382/881/513 11/290/1478 287/865/623 271/875/632 440/846/491 224/850/703 322/883/573 230/823/726 297/810/672 435/873/468 271/773/635 5/155/1617 172/779/827 0/20/1752 188/771/819 0/3/1773 140/657/979 345/884/550 244/850/685 38/426/1313 148/703/926 102/653/1022 129/677/969 366/893/518 218/792/767 93/636/1049 171/784/824 11/231/1534 29/431/1319 278/847/654 126/707/945 63/551/1151 31/433/1314 0/2/1774 11/140/1615 14/309/1455 353/876/548 0/81/1694 1/162/1615 197/796/783 355/858/566 232/821/725 159/768/850 12/302/1464 246/874/658 177/846/754 28/379/1370 349/903/523 12/298/1461 156/733/887 379/890/508 124/704/948 207/812/758 34/427/1316 20/350/1409 153/741/883 226/797/754 122/677/978 131/642/1005 267/786/722 46/455/1247 2/120/1652 68/583/1123 51/520/1208 271/896/612 215/771/793 9/229/1535 34/442/1302 163/766/848 37/544/1196 181/758/834 177/775/826 2/135/1641 230/804/745 147/713/915 207/838/731 272/910/594 114/689/974 82/658/1037 163/707/905 181/773/823 345/895/532 37/543/1197 11/320/1446 36/441/1298 174/768/835 42/443/1284 10/218/1547 21/338/1418 33/422/1316 311/858/608 20/322/1436 236/833/709 378/892/507 378/893/507 12/181/1584 42/450/1286 152/708/919 11/321/1447 43/447/1287 11/275/1492 11/321/1444 132/668/876 36/447/1296 229/874/673 395/923/461 16/244/1510 267/883/628 42/449/1287 298/840/640 6/135/1638 173/770/831 1/49/1726 42/449/1286 153/783/843 98/659/1021 228/838/711 98/611/1070 179/770/827 0/21/1756 90/683/999 123/705/948 6/148/1625 22/483/1270 229/873/674 4/445/1330 161/731/885 267/883/626 428/866/484 11/216/1549 84/587/1107 CMH p #N/A 0.8888 #N/A 0.8098 0.1106 0.7752 0.2312 0.4222 0.7897 0.4702 0.06609 0.7237 0.09103 0.04575 0.06577 0.7928 0.5477 0.004517 0.08141 0.1607 0.2448 0.1596 0.5208 0.1433 0.1269 0.4265 0.9339 0.08601 0.8132 0.1951 0.09415 0.3869 0.8019 0.8056 0.663 0.6352 0.1502 0.9448 0.9638 0.2981 0.3877 0.6588 0.9647 0.1849 0.1111 0.4708 0.3865 0.6441 0.7923 0.9109 0.6411 0.8591 0.7734 0.534 0.3993 0.7352 0.07787 0.8025 0.06745 0.1106 0.3624 0.6483 0.3547 0.3099 0.5623 0.686 0.3695 0.1511 0.9664 0.3045 0.6777 0.138 0.3413 0.05087 0.2415 0.2726 0.9715 0.5932 0.9118 0.2122 0.08377 0.05597 0.6314 0.5744 0.9541 0.6428 0.6293 #N/A 0.2173 #N/A 0.7611 0.3453 0.3823 0.1166 0.5874 0.6449 0.3224 0.1589 0.7304 0.1489 0.7929 0.5263 0.03821 0.2174 0.7123 0.8087 0.7175 #N/A 0.4953 0.8123 0.008316 0.3979 0.9062 0.5741 0.1131 0.1307 0.1125 0.1605 0.9209 0.05224 0.6822 0.7532 0.1939 0.7867 0.4413 0.5229 0.8091 0.4501 0.47 0.1649 0.9992 0.8052 0.8311 0.1021 0.09978 0.02352 0.1601 0.5262 0.5365 0.3588 0.5287 0.2605 0.127 0.3351 0.1999 0.5123 0.6841 0.8761 0.7533 0.5436 0.9633 0.03608 0.2262 0.48 0.7482 0.8601 0.3191 0.07917 0.8001 0.02124 0.8482 0.7335 0.471 0.09533 0.8857 0.1057 0.5864 0.4708 0.456 0.1433 0.7525 0.7632 0.08059 0.5676 0.04361 0.08791 0.09441 0.6219 0.4599 0.7825 0.1001 0.4761 0.2559 0.9009 0.8764 0.02609 0.1169 0.7894 0.8696 0.6406 0.6792 0.6888 0.01477 #N/A 0.378 0.5205 0.2589 0.0113 0.4864 #N/A 0.8325 0.08918 0.06225 0.7738 0.29 OR #N/A 1.01 #N/A 1.01 0.91 0.99 0.94 1.04 0.98 1.04 1.16 1.03 0.84 0.89 1.16 1.01 1.03 0.59 0.92 1.11 1.06 0.90 0.95 1.12 1.10 0.96 1.01 0.89 0.97 0.92 1.13 0.96 1.01 1.02 1.02 1.03 1.07 1.00 1.00 1.06 0.93 0.96 1.00 0.92 0.92 0.96 0.95 0.98 0.99 0.99 1.02 1.01 1.06 1.07 0.96 0.97 0.92 1.01 0.91 1.09 1.05 1.02 1.06 0.94 1.10 1.02 1.06 1.07 1.00 0.95 1.02 1.08 0.95 0.91 0.95 1.09 1.00 1.03 1.01 1.06 0.92 1.10 1.02 1.03 1.00 0.95 0.98 #N/A 1.06 #N/A 0.98 1.05 0.96 0.90 1.03 1.03 0.95 1.07 1.02 1.08 0.99 0.94 0.86 0.94 1.02 1.02 1.03 #N/A 0.92 0.98 0.88 1.14 0.99 0.97 0.93 1.08 0.92 0.89 1.00 1.10 1.03 0.99 0.90 0.99 1.04 1.03 0.99 0.95 0.95 0.93 1.00 0.99 1.01 1.08 1.11 0.73 1.09 1.04 0.97 1.05 1.06 1.08 0.92 1.06 1.07 1.03 0.95 0.99 0.98 0.97 1.00 0.89 1.07 0.96 0.98 1.01 1.06 1.15 0.98 0.89 0.99 1.03 1.06 0.89 1.01 0.88 1.03 1.04 1.04 0.86 0.98 1.02 1.15 0.96 1.18 1.14 1.09 1.03 0.96 0.99 0.86 1.04 1.08 1.01 1.02 0.89 1.34 0.98 1.01 1.03 0.98 1.02 1.13 #N/A 0.95 1.04 0.88 1.18 0.97 #N/A 0.99 0.92 1.09 0.97 0.94 (95% CI) CMH p OR #N/A #N/A #N/A #N/A 0.91 1.11 0.05556 0.92 #N/A #N/A #N/A #N/A 0.92 1.12 0.0582 1.09 0.80 1.02 0.3665 1.05 0.89 1.09 0.2113 1.06 0.85 1.04 0.4009 1.04 0.95 1.14 0.3032 0.96 0.87 1.11 0.1776 1.08 0.94 1.14 0.0195 1.10 0.99 1.35 0.4182 0.95 0.88 1.20 0.4533 0.95 0.68 1.03 0.0006019 0.77 0.80 1.00 0.8759 0.99 0.99 1.35 0.4437 0.96 0.91 1.12 0.1145 1.08 0.93 1.14 0.02618 1.10 0.41 0.85 0.113 1.13 0.83 1.01 0.001924 0.88 0.96 1.29 0.001629 1.19 0.96 1.16 0.5738 0.98 0.78 1.04 0.001816 0.84 0.82 1.11 0.08037 0.88 0.96 1.29 0.001676 1.19 0.97 1.24 0.003249 1.17 0.86 1.07 0.02335 0.90 0.88 1.15 0.1988 1.08 0.78 1.02 0.7122 0.98 0.77 1.23 0.009587 0.84 0.82 1.04 0.006778 0.87 0.98 1.30 0.5085 0.96 0.87 1.05 0.02289 0.91 0.92 1.11 0.1127 1.07 0.86 1.22 0.01845 1.15 0.93 1.12 0.07073 0.93 0.92 1.14 0.06553 1.09 0.98 1.18 0.005658 1.12 0.91 1.10 0.1566 1.06 0.91 1.10 0.1628 1.06 0.95 1.17 0.5453 1.03 0.78 1.10 0.008226 0.85 0.79 1.16 0.01765 0.85 0.86 1.16 0.4463 1.06 0.81 1.04 0.007041 0.87 0.84 1.02 0.004622 0.89 0.87 1.07 0.02924 0.91 0.85 1.06 0.3216 1.05 0.88 1.08 0.2416 1.05 0.90 1.08 0.1183 1.07 0.87 1.13 0.1122 0.91 0.93 1.12 0.5053 0.97 0.90 1.13 0.1293 0.93 0.73 1.52 0.03459 0.80 0.86 1.34 0.08253 0.88 0.88 1.05 0.03301 1.09 0.80 1.17 0.03001 0.86 0.83 1.01 0.9871 1.00 0.91 1.13 0.2996 0.95 0.83 1.01 0.9375 1.00 0.98 1.20 0.04407 1.11 0.95 1.15 0.4996 0.97 0.93 1.13 0.1018 1.08 0.94 1.19 0.03373 1.12 0.84 1.06 0.07606 0.91 0.80 1.50 0.01044 1.27 0.92 1.14 0.2142 1.07 0.94 1.18 0.559 0.97 0.98 1.17 0.998 1.00 0.91 1.10 0.1644 1.06 0.86 1.05 0.8276 1.01 0.92 1.14 0.2135 1.07 0.98 1.19 0.007111 1.12 0.87 1.05 0.792 1.01 0.83 1.00 0.66 0.98 0.86 1.04 0.01728 0.91 0.93 1.28 0.02268 1.18 0.91 1.10 0.2761 1.05 0.93 1.13 0.3419 0.96 0.92 1.10 0.1756 0.95 0.97 1.17 0.02141 1.11 0.84 1.01 0.808 1.01 1.00 1.21 0.003094 1.14 0.93 1.13 0.07811 1.08 0.94 1.13 0.6055 0.98 0.91 1.10 0.1344 1.06 0.76 1.19 0.03525 0.84 0.88 1.08 0.3408 1.04 #N/A #N/A #N/A #N/A 0.96 1.17 0.7043 0.98 #N/A #N/A #N/A #N/A 0.89 1.09 0.08655 0.93 0.95 1.15 0.038 1.09 0.87 1.06 0.7722 1.01 0.78 1.03 0.004298 0.86 0.93 1.14 0.3094 0.96 0.92 1.14 0.2119 1.07 0.85 1.05 0.02391 0.90 0.97 1.17 0.01233 1.11 0.92 1.12 0.1242 1.07 0.97 1.21 0.9273 1.00 0.89 1.09 0.2715 1.05 0.79 1.13 0.03309 0.86 0.75 0.99 0.9133 1.01 0.86 1.04 0.8298 1.01 0.92 1.13 0.3324 0.96 0.90 1.14 0.1668 1.08 0.90 1.17 0.1648 0.93 #N/A #N/A #N/A #N/A 0.74 1.16 0.1718 1.11 0.84 1.15 0.05953 0.89 0.80 0.97 0.0004397 1.16 0.84 1.54 0.7715 0.96 0.79 1.23 0.05689 1.14 0.88 1.07 0.07894 0.93 0.85 1.02 0.009365 0.90 0.98 1.18 0.8961 1.01 0.83 1.02 0.007544 0.89 0.75 1.05 0.5778 1.04 0.91 1.09 0.3631 0.96 1.00 1.21 0.004772 1.13 0.90 1.18 0.1749 1.09 0.90 1.08 0.143 0.94 0.76 1.06 0.5329 1.04 0.89 1.09 0.1121 0.93 0.95 1.14 0.6148 0.98 0.93 1.15 0.07724 1.08 0.90 1.09 0.1368 0.94 0.83 1.09 0.4349 1.04 0.82 1.10 0.9538 1.00 0.84 1.03 0.0149 0.90 0.91 1.10 0.2046 1.06 0.89 1.10 0.1123 0.93 0.91 1.12 0.2528 0.95 0.98 1.19 0.8692 1.01 0.98 1.26 0.2508 1.08 0.56 0.96 0.00125 0.79 0.97 1.22 0.0189 1.13 0.92 1.17 0.04953 1.10 0.88 1.07 0.102 0.93 0.95 1.15 0.8154 0.99 0.89 1.27 0.1889 0.92 0.95 1.23 0.7877 0.98 0.84 1.02 0.01014 0.89 0.94 1.20 0.03482 1.12 0.97 1.18 0.02196 1.11 0.94 1.14 0.08299 1.08 0.75 1.21 0.1005 0.85 0.90 1.09 0.2646 1.05 0.89 1.09 0.2964 1.05 0.88 1.07 0.5346 1.03 0.91 1.10 0.2281 1.05 0.80 0.99 0.00233 0.87 0.96 1.19 0.0344 1.11 0.87 1.07 0.05812 0.92 0.89 1.09 0.3992 1.04 0.92 1.11 0.3514 0.96 0.94 1.20 0.0352 1.12 0.98 1.34 0.7813 0.98 0.86 1.12 0.2646 1.06 0.80 0.98 0.001413 0.87 0.87 1.12 0.4838 1.04 0.86 1.24 0.0764 1.13 0.91 1.22 0.05073 1.13 0.78 1.02 0.006275 0.86 0.92 1.11 0.2061 1.05 0.75 1.03 0.7279 1.02 0.93 1.13 0.1224 1.07 0.94 1.14 0.6409 0.98 0.94 1.14 0.6565 0.98 0.70 1.05 0.7838 1.02 0.86 1.12 0.5661 1.04 0.92 1.13 0.3494 0.96 0.98 1.33 0.809 0.99 0.85 1.10 0.7375 1.02 1.01 1.39 0.004845 1.23 0.98 1.33 0.801 0.99 0.98 1.21 0.02187 1.12 0.91 1.18 0.3482 0.95 0.88 1.06 0.07193 0.93 0.90 1.08 0.159 0.95 0.72 1.03 0.9525 1.00 0.94 1.14 0.8125 1.01 0.95 1.22 0.02786 1.12 0.92 1.11 0.2057 1.05 0.81 1.28 0.07909 0.89 0.81 0.99 0.002231 0.88 0.93 1.92 0.2907 0.90 0.86 1.12 0.5581 1.04 0.91 1.11 0.2638 1.05 0.92 1.14 0.11 1.08 0.89 1.08 0.5752 1.03 0.92 1.14 0.332 0.96 1.02 1.25 0.3212 1.04 #N/A #N/A #N/A #N/A 0.85 1.06 0.09724 0.92 0.93 1.15 0.103 1.08 0.70 1.10 0.6456 1.04 1.04 1.34 0.0009807 1.18 0.88 1.06 0.08555 0.93 #N/A #N/A #N/A #N/A 0.89 1.09 0.1719 0.94 0.84 1.01 0.01038 0.90 1.00 1.20 0.6176 0.98 0.81 1.17 0.06751 0.89 0.84 1.05 0.07526 0.91 (95% CI) #N/A #N/A 0.85 1.00 #N/A #N/A 1.00 1.19 0.95 1.15 0.97 1.16 0.95 1.13 0.88 1.04 0.97 1.20 1.02 1.20 0.85 1.07 0.82 1.09 0.67 0.90 0.90 1.09 0.85 1.07 0.98 1.18 1.01 1.20 0.97 1.33 0.81 0.95 1.07 1.32 0.90 1.06 0.76 0.94 0.77 1.02 1.07 1.32 1.05 1.29 0.82 0.99 0.96 1.22 0.87 1.10 0.73 0.96 0.78 0.96 0.87 1.07 0.84 0.99 0.98 1.16 1.02 1.30 0.86 1.01 0.99 1.20 1.03 1.21 0.98 1.15 0.98 1.15 0.93 1.14 0.75 0.96 0.74 0.97 0.92 1.22 0.78 0.96 0.82 0.96 0.83 0.99 0.96 1.15 0.97 1.14 0.98 1.16 0.82 1.02 0.89 1.06 0.85 1.02 0.65 0.98 0.76 1.02 1.01 1.18 0.75 0.99 0.92 1.09 0.87 1.05 0.92 1.08 1.00 1.23 0.90 1.05 0.99 1.18 1.01 1.24 0.81 1.01 1.06 1.52 0.96 1.18 0.88 1.07 0.92 1.09 0.98 1.15 0.93 1.10 0.96 1.18 1.03 1.22 0.93 1.10 0.90 1.07 0.84 0.98 1.02 1.35 0.96 1.14 0.89 1.04 0.87 1.03 1.02 1.21 0.93 1.10 1.04 1.24 0.99 1.17 0.90 1.06 0.98 1.15 0.71 0.99 0.96 1.13 #N/A #N/A 0.91 1.07 #N/A #N/A 0.85 1.01 1.01 1.18 0.93 1.11 0.77 0.95 0.88 1.04 0.96 1.18 0.83 0.99 1.02 1.20 0.98 1.16 0.91 1.09 0.96 1.14 0.75 0.99 0.91 1.12 0.93 1.10 0.88 1.05 0.97 1.19 0.84 1.03 #N/A #N/A 0.95 1.30 0.80 1.01 1.07 1.26 0.73 1.26 1.00 1.30 0.85 1.01 0.83 0.97 0.93 1.09 0.82 0.97 0.92 1.17 0.88 1.05 1.04 1.24 0.96 1.24 0.87 1.02 0.92 1.18 0.86 1.02 0.90 1.06 0.99 1.19 0.87 1.02 0.94 1.16 0.87 1.16 0.82 0.98 0.97 1.15 0.86 1.02 0.87 1.04 0.93 1.09 0.95 1.22 0.68 0.91 1.02 1.25 1.00 1.21 0.86 1.01 0.91 1.08 0.81 1.04 0.88 1.10 0.82 0.97 1.01 1.23 1.02 1.20 0.99 1.18 0.69 1.03 0.97 1.14 0.96 1.14 0.94 1.12 0.97 1.14 0.80 0.95 1.01 1.23 0.85 1.00 0.95 1.13 0.89 1.04 1.01 1.23 0.88 1.10 0.95 1.18 0.80 0.95 0.93 1.18 0.99 1.30 1.00 1.27 0.77 0.96 0.97 1.14 0.91 1.15 0.98 1.16 0.90 1.06 0.91 1.06 0.87 1.20 0.92 1.17 0.88 1.05 0.88 1.10 0.91 1.15 1.06 1.41 0.88 1.10 1.02 1.24 0.86 1.06 0.86 1.01 0.87 1.02 0.87 1.16 0.93 1.10 1.01 1.24 0.97 1.14 0.79 1.01 0.81 0.95 0.75 1.09 0.92 1.17 0.96 1.15 0.98 1.18 0.94 1.12 0.88 1.05 0.96 1.13 #N/A #N/A 0.83 1.02 0.99 1.18 0.87 1.25 1.07 1.30 0.86 1.01 #N/A #N/A 0.87 1.03 0.83 0.98 0.91 1.06 0.79 1.01 0.82 1.01 rs10510398 rs7041338 rs984922 rs93059 rs3923056 rs1933703 rs7442554 rs1990524 rs1812576 rs1343456 rs789350 rs2211533 rs1418267 rs1558020 rs10488970 rs735403 rs725850 rs714246 rs4795858 rs7741731 rs10493872 rs2333686 rs6985962 rs717987 rs1107768 rs8094618 rs3897767 rs9314327 rs805658 rs10510932 rs4608374 rs7162157 rs2336980 rs1508394 rs1502702 rs1461502 rs1337005 rs10502080 rs2912332 rs6897242 rs225563 rs2388847 rs499224 rs10507336 rs3912537 rs4532251 20 12 4 13 4 7 17 1 18 10 17 15 11 11 18 12 10 13 SRGAP3 TXNDC4 CBLN4 NFKB1 OR6C76 RGS13 C1QTNF7 C1QTNF7 MGC34646 LINGO2 ANAPC10 PCDH9 TXNDC4 N/A C1QTNF7 MANBA N/A N/A ACCN1 EPB41L2 ABCD3 NCF2 PENK RUNX2 PDZRN3 HRH4 PRELID2 ADRA1A SLK ADAMTS9 MAP2K4 KIAA1199 CNBD1 PTPRG C9orf47 C11orf63 CRB1 GUCY1A2 DSG1 PRELID2 TMEM132B TCERG1L N/A SPATA13 MGC34646 HS3ST1 Legend: chr- chromosome LD- linkage disequilibrium r2 – R square D' – D prime CMH- Cochran-Mantel-Haenszel p- p-value OR- odds ratio 95% CI 95% confidence G C A A A A A G A G A C A C A G G G A G A A C G A G G G C G G A G A G C G G G G A A A A G A 0.05 0.11 0.14 0.31 0.38 0.08 0.25 0.25 0.27 0.09 0.26 0.49 0.12 0.16 0.25 0.37 0.16 0.16 0.19 0.34 0.02 0.28 0.13 0.19 0.12 0.01 0.11 0.13 0.20 0.07 0.18 0.07 0.22 0.05 0.04 0.45 0.19 0.43 0.29 0.14 0.42 0.23 0.23 0.44 0.28 0.32 0.007857 0.5667 0.5326 0.4054 1 0.7508 0.002866 0.3829 0.4889 0.01382 0.497 0.5134 0.497 0.497 0.4233 0.7774 1 0.8358 0.661 0.04117 0.3406 0.5838 0.5834 0.2267 0.348 0.3458 0.1836 1 0.6624 0.2322 0.3816 0.59 0.3594 0.5973 0.04662 0.3516 0.3816 0.7519 0.8451 1/21/86 7/25/76 3/28/77 14/50/44 21/58/29 2/20/86 6/36/66 6/36/66 4/42/62 0/9/98 5/42/61 17/53/38 7/25/75 4/37/67 6/38/64 20/50/27 4/37/67 4/37/67 3/26/79 9/44/55 0/0/108 9/38/61 3/28/75 1/28/79 1/36/71 0/9/90 5/23/80 3/14/88 9/38/58 0/9/99 6/35/67 0/8/100 1/37/70 0/12/95 0/12/96 26/60/22 3/20/85 10/51/47 11/48/43 6/29/73 15/47/46 2/28/78 4/37/66 25/54/29 4/42/62 6/50/52 0/12/103 0/15/100 0/18/97 13/36/66 11/53/51 0/10/105 10/58/47 10/58/47 14/52/49 3/18/94 9/58/48 35/49/31 0/15/100 0/25/90 10/59/46 15/41/54 0/25/90 0/25/90 8/42/65 22/49/44 0/5/110 14/57/43 0/20/95 6/40/67 0/23/92 0/2/106 1/18/96 5/33/77 4/31/79 1/20/94 3/24/88 1/19/95 12/45/58 0/2/112 0/3/112 17/54/44 5/39/71 19/62/34 4/46/59 1/21/93 27/53/35 9/38/67 8/50/56 16/49/50 14/52/49 20/47/48 0.03104 0.0005227 0.009199 0.04761 0.002481 0.008501 0.005161 0.005161 0.006329 0.01794 0.02776 0.01955 0.0004564 0.003007 0.007232 0.004567 0.003007 0.003007 0.007692 0.01237 0.0284 0.01069 0.0178 0.01283 0.01289 0.02037 0.0427 0.009831 0.01917 0.02467 0.01884 0.02045 0.003224 0.003909 0.0113 0.00335 0.01087 0.01685 0.02546 0.009532 0.02454 0.01257 0.04941 0.00683 0.006329 0.04351 2.17 3.16 2.20 1.53 1.78 2.75 0.56 0.56 0.56 0.38 0.64 0.63 3.19 2.16 0.58 1.82 2.16 2.16 0.52 0.59 0.00 0.59 2.01 0.54 1.92 5.10 1.89 0.46 1.76 0.41 1.85 0.38 0.51 6.71 4.45 1.74 0.51 0.64 1.59 2.11 0.64 0.53 0.65 1.71 0.56 0.66 1.05 1.69 1.20 1.02 1.21 1.28 0.37 0.37 0.37 0.17 0.42 0.43 1.71 1.27 0.38 1.22 1.27 1.27 0.32 0.40 0.00 0.39 1.12 0.33 1.10 1.09 1.05 0.26 1.11 0.18 1.12 0.17 0.33 1.49 1.24 1.19 0.30 0.43 1.04 1.22 0.44 0.33 0.42 1.17 0.37 0.44 4.47 5.92 4.03 2.29 2.62 5.90 0.85 0.85 0.86 0.83 0.97 0.92 5.99 3.66 0.87 2.71 3.66 3.66 0.83 0.88 nan 0.88 3.61 0.89 3.35 23.88 3.42 0.81 2.79 0.91 3.06 0.88 0.80 30.35 16.00 2.53 0.85 0.94 2.42 3.65 0.93 0.86 1.01 2.50 0.86 0.98 1/63/536 11/120/468 10/156/433 70/245/284 85/295/219 5/90/502 37/210/352 37/210/352 40/236/322 15/101/477 41/213/345 146/307/143 11/120/467 15/166/417 37/210/351 93/269/237 15/166/418 15/166/418 20/182/397 57/284/258 0/19/580 45/232/321 11/140/448 22/173/390 11/130/459 0/16/583 8/123/467 11/124/464 29/198/372 3/71/526 25/171/404 1/71/527 31/198/369 2/64/533 3/46/550 132/284/183 24/175/400 101/304/194 61/235/301 17/146/436 92/305/203 32/203/364 29/209/359 134/271/194 42/235/321 61/246/293 1/44/490 13/93/433 7/126/407 43/229/262 78/242/220 2/73/464 35/206/299 35/206/299 45/216/278 8/60/467 35/222/283 118/277/142 13/94/432 14/133/393 35/207/298 66/255/216 14/133/393 14/133/393 25/168/347 69/243/227 0/26/514 45/222/273 8/111/416 22/173/336 5/109/421 1/8/531 3/101/430 8/130/402 18/174/347 5/72/455 18/142/375 1/77/462 35/181/324 1/48/491 0/37/503 101/271/167 27/166/347 101/274/158 43/209/283 7/133/400 96/269/170 40/181/319 28/208/299 105/255/180 45/217/278 57/240/238 0.0349 0.03617 0.03652 0.03675 0.03711 0.03729 0.03756 0.03756 0.03863 0.03864 0.03883 0.03915 0.03965 0.03967 0.04001 0.04103 0.04121 0.04121 0.04206 0.04248 0.0428 0.04334 0.0436 0.04363 0.04366 0.04423 0.04437 0.04451 0.04456 0.04528 0.04559 0.04561 0.04572 0.04597 0.04685 0.04721 0.04723 0.04762 0.048 0.04852 0.0486 0.04873 0.04874 0.04946 0.04967 0.04975 1.44 1.29 1.27 1.19 1.18 1.35 0.83 0.83 0.84 1.33 0.84 1.17 1.28 1.24 0.83 1.18 1.24 1.24 0.82 0.85 0.55 0.84 1.26 0.82 1.27 1.99 1.28 0.80 1.21 0.74 1.22 0.73 0.83 1.43 1.50 1.17 0.82 0.86 1.18 1.24 0.86 0.83 0.84 1.16 0.85 0.85 1.02 1.02 1.01 1.01 1.01 1.02 0.70 0.70 0.71 1.02 0.70 1.01 1.01 1.01 0.70 1.01 1.01 1.01 0.68 0.72 0.31 0.71 1.01 0.68 1.01 1.00 1.01 0.64 1.00 0.55 1.00 0.54 0.70 1.00 1.00 1.00 0.68 0.74 1.00 1.00 0.74 0.70 0.70 1.00 0.71 0.72 2.02 1.63 1.58 1.40 1.38 1.80 0.99 0.99 0.99 1.74 0.99 1.36 1.62 1.53 0.99 1.38 1.53 1.53 0.99 0.99 0.99 0.99 1.59 0.99 1.60 3.97 1.63 0.99 1.46 0.99 1.49 0.99 1.00 2.05 2.24 1.36 1.00 1.00 1.40 1.54 1.00 1.00 1.00 1.36 1.00 1.00 G C A A A A A G G G A C A C A A G G A G A A C G A G G G C G G A G A G C G G G G A G A A C A 0.219668 0.407141 0.230556 0.430294 0.380748 0.0413669 0.354115 0.354213 0.162607 0.296455 0.344408 0.318157 0.39521 0.267303 0.354172 0.498063 0.267249 0.267165 0.13029 0.169065 0.262524 0.378079 0.15423 0.152655 0.237812 0.0706973 0.289612 0.235758 0.170559 0.010122 0.460432 0.0981748 0.402189 0.0344398 0.146001 0.401245 0.472045 0.406693 0.106203 0.360404 0.355519 0.391443 0.236238 0.0803547 0.161406 0.316256 0.06163 0.552 0.5422 0.4212 0.1626 0.677 0.6389 0.206 0.9098 0.56 0.8698 0.6157 0.5011 0.6767 0.9622 0.5402 0.5401 0.3324 0.7419 0.2151 0.2879 0.05516 2.704E-10 0.6064 0.09979 0.7731 0.6918 0.04437 1 0.4937 0.5554 0.7218 0.5063 0.4933 0.7753 0.1834 0.351 0.607 0.6389 0.8036 0.146 0.2688 0.2357 0.7806 85/635/1113 321/890/624 109/643/1084 349/892/592 257/879/698 3/134/1700 233/844/754 233/846/754 46/480/1310 176/729/928 227/834/774 178/813/846 305/884/646 126/745/965 233/844/757 444/934/457 126/745/963 126/745/966 30/433/1374 43/516/1277 139/703/993 275/849/712 40/517/1279 5/545/1287 98/657/1079 11/240/1585 163/736/935 86/701/1050 56/541/1229 0/34/1802 395/894/548 16/336/1485 296/865/672 2/121/1714 43/451/1343 276/882/679 409/911/515 315/864/650 24/367/1445 237/852/748 244/835/758 277/879/679 111/652/1074 10/270/1555 45/477/1314 185/821/829 72/637/1068 273/864/641 86/633/1058 323/869/583 267/822/687 6/147/1624 214/818/746 213/818/744 43/517/1217 159/742/877 208/784/785 178/774/824 255/851/671 117/700/959 214/817/742 445/888/446 117/698/960 117/699/959 33/383/1362 56/508/1214 128/660/990 239/855/683 48/419/1302 11/527/1241 109/646/1021 4/241/1533 146/737/893 94/644/1041 35/504/1232 0/39/1731 380/884/513 19/304/1456 288/870/618 1/122/1655 41/436/1299 295/877/606 401/880/497 304/827/641 21/310/1444 235/809/733 222/797/750 276/842/658 109/616/1053 8/274/1492 43/513/1220 165/763/848 0.9953 0.07169 0.4175 0.5614 0.8639 0.1627 0.506 0.5006 0.1185 0.7612 0.2388 0.9896 0.03682 0.4124 0.5837 0.8004 0.3744 0.413 0.3174 0.2389 0.3482 0.6001 0.04708 #N/A 0.2861 0.8228 0.9972 0.7024 0.05968 0.4507 0.7205 0.5588 0.3952 0.8397 0.9681 0.05719 0.8665 0.7821 0.05673 0.9186 0.4086 0.8582 0.7283 0.6955 0.1078 0.117 1.00 1.09 1.05 1.03 0.99 0.85 1.03 1.03 0.91 0.98 1.06 1.00 1.11 1.05 1.03 0.99 1.05 1.05 1.07 0.93 1.05 1.03 1.14 #N/A 0.94 1.02 1.00 1.02 1.13 0.84 0.98 1.05 0.96 0.97 1.00 0.91 0.99 1.01 1.16 1.01 1.04 0.99 1.02 0.97 0.90 1.08 0.89 0.99 0.94 0.94 0.90 0.67 0.94 0.94 0.80 0.89 0.96 0.91 1.01 0.94 0.93 0.90 0.94 0.94 0.94 0.82 0.95 0.93 1.00 #N/A 0.85 0.85 0.90 0.92 1.00 0.53 0.90 0.90 0.87 0.76 0.88 0.83 0.90 0.92 1.00 0.91 0.95 0.90 0.91 0.82 0.80 0.98 1.12 1.20 1.17 1.13 1.09 1.07 1.14 1.14 1.03 1.09 1.17 1.10 1.22 1.16 1.13 1.08 1.16 1.16 1.23 1.05 1.17 1.13 1.29 #N/A 1.05 1.22 1.11 1.14 1.27 1.33 1.08 1.22 1.06 1.26 1.14 1.00 1.09 1.11 1.35 1.11 1.15 1.09 1.14 1.15 1.02 1.20 0.5151 0.01398 0.09857 0.12 0.346 0.8173 0.658 0.6649 0.9593 0.6484 0.9887 0.2559 0.006659 0.09688 0.5946 0.202 0.08652 0.09852 0.7054 0.0295 0.5828 0.5821 0.006269 #N/A 0.9165 0.454 0.4421 0.5903 0.0073 0.0368 0.6031 0.6898 0.09513 0.3136 0.5058 0.556 0.3143 0.4347 0.006085 0.3733 0.7239 0.4451 0.4577 0.237 0.887 0.7791 1.04 1.12 1.09 1.07 1.04 1.02 0.98 0.98 1.00 1.02 1.00 1.05 1.13 1.08 0.98 1.05 1.09 1.08 0.98 0.90 1.03 0.98 1.17 #N/A 0.99 1.07 1.04 0.97 1.15 0.77 1.02 0.97 0.93 1.11 1.04 0.98 0.96 0.97 1.17 1.04 0.99 1.03 0.97 1.07 0.99 1.01 0.93 1.02 0.98 0.98 0.96 0.85 0.90 0.90 0.90 0.93 0.92 0.97 1.03 0.99 0.90 0.97 0.99 0.99 0.88 0.81 0.93 0.90 1.05 #N/A 0.90 0.90 0.94 0.88 1.04 0.60 0.94 0.85 0.86 0.90 0.92 0.90 0.88 0.89 1.05 0.95 0.91 0.95 0.88 0.96 0.90 0.93 1.15 1.22 1.20 1.16 1.13 1.22 1.07 1.07 1.10 1.12 1.09 1.14 1.23 1.19 1.06 1.14 1.19 1.19 1.09 0.99 1.14 1.06 1.31 #N/A 1.10 1.27 1.14 1.07 1.28 0.98 1.11 1.12 1.01 1.37 1.18 1.06 1.04 1.05 1.31 1.14 1.07 1.12 1.06 1.20 1.10 1.10 . 2. 36 89 /26 5 /24 5 54 /24 2 /24 3 0.0 024 36 1 .28 1.09 1.50 C 0.1 127 25 1 26 /3 82/ 1 429 20 /341/1417 0.1433 1. 12 0.96 1 .29 0.001676 1.19 1.07 1. 32 rs9306509 22 LOC388915 A 0 .21 0.481 7/34/63 4 /22 /87 0.0 122 3 1.96. 9/39/60 20 /43/ 52 0.0394 0.63 0. 42 0.95 68 /24 9 /28 2 75 /24 0 /22 0 0.00 423 6 0.79 0.68 0.93 A 0.3608 72 0.44 42 228 /834/770 25 0/809/710 0.1111 0. 92 0.84 1. 02 0.004 622 0.89 0. 82 0.96 rs2070 527 21 ERG A. 57 /28 2 /25 9 83 /23 2 /22 4 0.00 524 4 0.80 0.68 0.94 G 0 .20 420 6 0.8837 78/596/1161 72/ 580/1 127 0.8591 1.01 0.90 1.13 0. 129 3 0.93 0.85 1. 02 rs9 322 676 6 GRIK2 A 0.10 0. 129 3 01/08/99 1 /22 / 92 0. 023 9 0.42