SOLID PHASE ORGANIC SYNTHESIS PREPARATION OF ORGANOMETALLIC COMPOUNDS • Usually generated on insoluble supports only as synthetic intermediates, and not as target molecules. • Highly versatile reagents. Group I and II Organometallic Compounds • Metallated, cross-linked polystyrene reacts smoothly with a wide range of electrophiles. • Lithiation of polystyrene-bound arenes and heteroarenes. Group I and II Organometallic Compounds • Halogen-metal exchange Group I and II Organometallic Compounds Transmetallation and direct Lithiation Group III Organometallic Compounds • Reaction of resin-bound organolithium compounds with chlorosilanes • Hydrosilylation of resin- bound alkenes Group IV Organometallic Compounds Group IV Organometallic Compounds • Hydrolyses of organometallic compounds • Reductions • Hydrogenations • Coupling reactions PREPARATION OF HYDROCARBON: ALKANE . SOLID PHASE ORGANIC SYNTHESIS PREPARATION OF ORGANOMETALLIC COMPOUNDS • Usually generated on insoluble