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Báo cáo y học: "Cross-kingdom patterns of alternative splicing and splice recognition" docx

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Báo cáo y học: "Cross-kingdom patterns of alternative splicing and splice recognition" docx

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Open Access Volume et al McGuire 2008 9, Issue 3, Article R50 Research Cross-kingdom patterns of alternative splicing and splice recognition Abigail M McGuireÔ, Matthew D PearsonÔ, Daniel E Neafsey and James E Galagan Address: The Broad Institute of MIT and Harvard, Cambridge Center, Cambridge, MA 02142, USA Ô These authors contributed equally to this work Correspondence: Abigail M McGuire Email: amcguire@broad.mit.edu Published: March 2008 Received: 15 October 2007 Revised: 28 January 2008 Accepted: March 2008 Genome Biology 2008, 9:R50 (doi:10.1186/gb-2008-9-3-r50) The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2008/9/3/R50 © 2008 Manson McGuire et al.; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited p>

A comprehensive survey of alternate splicing across 42 eukaryotes so as to gain insight into how spliceosomal introns are recognized.

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Từ khóa liên quan

Mục lục

  • Abstract

    • Background

    • Results

    • Conclusion

    • Background

    • Results

      • All eukaryotes exhibit splice variation

      • CE and RI prevalence vary by kingdom and by intron length

      • Variably spliced regions exhibit size constraints

      • Most splice variants are not functional

      • Retained introns are associated with weak splice sites

      • Discussion

        • Splice variation reveals mechanisms of splice site recognition

        • Evolutionary implications of splice variation

        • Conclusion

        • Materials and methods

          • EST alignments

          • Testing retained introns for evidence of selection at the codon level

          • Abbreviations

          • Authors' contributions

          • Additional data files

          • Acknowledgements

          • References

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