[...]... 769 61 Advanced Neuroimaging: PET-MRI Fusion and Diffusion Tensor Imaging Noriko Salamon 785 62 Surgical Treatment of Therapy- Resistant Epilepsy in Children Gary W Mathern and Olivier Delalande 7 91 63 Outcome of Epilepsy Surgery in Childhood Shekhar Patil, J Helen Cross, and William Harkness 8 01 64 Vagus Nerve Stimulation Therapy in Pediatric Patients: Use and Effectiveness James W Wheless 811 xii... others epilepsy is an ever-present burden Evaluating and treating these children in the most appropriate and efficient fashion while avoiding adverse cognitive and psychosocial effects remains both challenging and rewarding, and it requires state-of-the-art knowledge We hope that you will find such knowledge in this book, and we hope that this third edition of Pediatric Epilepsy: Diagnosis and Therapy. .. calcium (13 ), repetitive stimulation (14 ), penicillin, bicuculline, picrotoxin (15 18 ), or high potassium administration (19 ) In vivo studies indicate that, in 2–3-week-old rats, the susceptibility to seizures is higher, and seizures spread more easily than in any other ages in many seizure models including pentylenetetrazol (Figure 1- 1 A), bicuculline, allylglycine, kainic acid, N-methyl-D-aspartate... Older groups than PN10 had neuronal damage in the hippocampal CA1 (2-week-old) (14 9) and lateral thalamus (PN12) (15 1) Adult rats additionally had damage in the piriform cortex and basolateral amygdala, whereas the PN 21 rats displayed neuronal damage also in the entorhinal cortex During the latent period between the status epilepticus and development of spontaneous seizures, in PN 21 and adult rats, there... Injury Kennedy-Krieger Institute Department of Neurology The Johns Hopkins School of Medicine Baltimore, Maryland Chapter 4: Metabolic and Pharmocologic Consequences of Seizures Prakash Kotagal, MD Head, Pediatric Epilepsy Section Epilepsy Center Cleveland Clinic Neurological Institute Cleveland, Ohio Chapter 27: Localization-Related Epilepsies: Simple Partial Seizures, Complex Partial Seizures, and Rasmussen... Edwin Dodson 65 Economics of Pediatric Epilepsy Charles E Begley 8 31 66 Quality of Life in Children with Epilepsy Joan K Austin and Nancy Santilli 837 67 Epilepsy, Cerebral Palsy, and IQ W Edwin Dodson 847 68 Academic Deficits and Interventions in Pediatric Epilepsy Caroline E Bailey and Rochelle Caplan 865 69 Cognitive Side Effects of Antiepileptic Drugs David E Mandelbaum and Christine L Trask Index... N-methyl-D-aspartate (NMDA) (Figure 1- 1 B), and kindling (Figure 1- 2 ) (20–34) These young, 2–3-week-old rats are also more prone to develop Increased susceptibility of immature rats to tonic-clonic seizures induced by pentylenetetrazol or NMDA Increased susceptibility to seizures in immature rats is illustrated using two parameters (A) Male rats at PN12, 18 , 25, and adult rats were injected with 10 0 mg/kg of pentylenetetrazol... consistently develop in PN 21 and older rats subjected to lithiumpilocarpine status epilepticus (13 9, 14 9, 15 0) No spontaneous seizures were observed in those rats subjected to status epilepticus on PN10 (13 9), and the spontaneous seizures developed infrequently (23%) in 2-week-old rats exposed to lithium-pilocarpine status epilepticus (15 0) Similarly, there was no neuronal damage and no metabolic consequences... Orrin Devinsky, Daniel Miles, and Josiane LaJoie 711 56 Zonisamide John F Kerrigan and John M Pellock 727 57 The Ketogenic Diet Douglas R Nordli, Jr and Darryl C De Vivo 739 58 Inflammation, Epilepsy, and Anti-Inflammatory Therapies Stéphane Auvin and Raman Sankar 7 51 59 Antiepileptic Drugs in Development John R Pollard and Jacqueline A French VI 759 EPILEPSY SURGERY AND VAGUS NERVE STIMULATION Section... models of seizures in the developing brain that would 1 • PATHOPHYSIOLOGY OF SEIZURES AND EPILEPSY IN THE IMMATURE BRAIN 5 FIGURE 1- 2 Increased seizure susceptibility of the immature PN15 brain to kindling-related seizures Electrodes were implanted in the amygdala in A, B, and C and into the amygdala and hippocampus in D and E In this composite, the x-axis depicts the severity of kindled seizures using . p.;cm. Includes bibliographical references and index. ISBN -1 3 : 97 8 -1 -9 3386 4 -1 6-7 (hardcover:alk. paper) ISBN -1 0 : 1- 9 3386 4 -1 6-8 (hardcover:alk. paper) 1. Epilepsy in children. I. Pellock, John. requires state-of-the-art knowl- edge. We hope that you will find such knowledge in this book, and we hope that this third edition of Pediatric Epilepsy: Diagnosis and Therapy will help you and your. Arthur L. Prensky and Amir Pshytycky 16 5 11 . Evaluating the Child with Seizure Sejal Jain and Lawrence D. Morton 18 5 12 . The Use of Electroencephalography in the Diagnosis of Epilepsy in Childhood