[...]... (Hematology): The late Professor Susumu Shibata, Drs Osamu Yamada, Atsushi Togawa, Shunsuke Koresawa, Sumire Hasegawa, Yoshinobu Takemoto, Masahiro Yoshimoto, Kazuyuki Mitani, Kosuke Miyashima, Masakiyo Mannoji, Takashi Sugihara, Nobumasa Inoue, Masaoo Shimoda, Akio Kanzaki, Masashi Hashimoto, Hiroo Mori, Takemi Otsuki, Kazuyuki Ata, Hideho Wada, Akiyo Otsuka (Ikeda), Lisa Shirato, the late Kimiko Ikoma, Takafumi... Takafumi Inoue, Naoto Okamoto, Ikuyo Higo, Mika Takahashi, Mayumi Kaku, Masami Uno (Takezono), Kenichiro Yata, Hidekazu Nakanishi, Yoshimasa Suetsugu, Makoto Mikami, Takayuki Tsujioka, and Shinichiro Suemori, Ms Mayumi Aizawa (Takahara), Chie Kawasaki and Sakura Eda Kawasaki Medical School (Research Center for Electron Microscopy): Mr Kenzo Uehira and Taiji Suda Kawasaki Medical School (Secretarial works):... swollen, then normalized, and then became further shrunken during their in vitro incubation They also observed a decreased intracellular potassium content with an increased intracellular sodium content in these red cells, and confirmed the results previously reported by Castle et al that the increased osmotic fragility in hereditary spherocytosis red cells was due to the decreased membrane surface /cell. .. important structure There is a special emphasis on the red cell membrane skeleton and membrane diseases These are areas in which Prof Yawata is particularly expert He was first introduced to red cell membranes in the early 1970’s, during his training with Dr Harry S Jacob in Minnesota Following his return to Kawasaki Medical School, he established a laboratory devoted to the study of red cell membrane... resistance, increased sodium influx, and a compensatory increase in glycolysis in these red cells, and proposed the theory that the basic pathogenesis of hereditary spherocytosis lies in the “leaky membrane” of these red cells [16] At this point, a possible causal pathogenesis of hereditary spherocytosis as a red cell membrane disorder was formally proposed During this time period, Prankerd, as a red cell enzymologist,... band 3 proteins, such as band 3 Memphis and band 3 Tuscaloosa, in which the protein 4.2 content was also markedly decreased, because the mutated site of band 3 appeared to be a binding site for protein 4.2, as with band 3 Montefiore reported by Rybicki et al Palek et al investigated Southeast Asian ovalocytosis (SAO) in Papua New Guinea, and discovered marked abnormalities in the band 3 molecule [61]... micropipettes to examine the rheological properties of normal and abnormal red cells During this period, the name of Jiri Palek, who was born in Czechoslovakia, began to appear in the literature on red cell membrane research [20] It became the general consensus that red cell deformability is dependent on the level of intracellular ATP, and that, when the ATP content is decreased, increased free calcium is bound... membrane research as a basic science had been achieved 1.3 The Dawn of Red Cell Membrane Research As mentioned previously, Chauffard (1907) and other scientists in Europe actually initiated the elucidation of the pathophysiology of red cell abnormalities in hereditary spherocytosis However, Castle et al (1937), of the American school, also made significant contributions to this field of research [10] They... discovered that the membrane surface /cell volume ratio was reduced concurrently with loss of the discoid form of these red cells with hereditary spherocytosis Ham et al (1940) pointed out that the increased propensity for hemolysis in the patient’s red cells was dependent not on the increased red cell volume but on the decreased effective cell surface of these abnormal red cells [11] Eric Ponder made a. .. 4.1 was rigorously investigated by Conboy, Chasis, Takakuwa, and others along with Mohandas Protein 4.2 was first recognized by its deficiency, which was discovered independently by Hayashi et al and Nozawa et al The structural and functional characteristics of protein 4.2 were investigated in particular by Carl Cohen, and Cathy Korsgren in Boston Glycophorins were initially expected to play a crucial . Koresawa, Sumire Hasegawa, Yoshinobu Takemoto, Masahiro Yoshimoto, Kazuyuki Mitani, Kosuke Miyashima, Masakiyo Mannoji, Takashi Sugihara, Nobumasa Inoue, Masaoo Shimoda, Akio Kanzaki, Masashi Hashimoto,. Kenichiro Yata, Hidekazu Nakanishi, Yoshimasa Suetsugu, Makoto Mikami, Takayuki Tsujioka, and Shinichiro Suemori, Ms. Mayumi Aizawa (Takahara), Chie Kawasaki and Sakura Eda. Kawasaki Medical School. 3-527-30463-0 Yoshihito Yawata Cell Membrane The Red Blood Cell as a Model Prof. Dr. Yoshihito Yawata Kawasaki College of Allied Health Professions 316 Matsushima Kurashiki City, 701-0194 Japan This book was carefully