Đang tải... (xem toàn văn)
u mạch máu ở mô vú, mô gan, các mô trong cơ thế, thấy trên MRI và các phương tiện hình ảnh học khác, bài báo được đăng trên các trang báo nổi tiếng thế giới Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017) Vascular lesions of the breast (seminars in diagnostic pathology) (2017)
Author’s Accepted Manuscript Vascular Lesions of the Breast Gabrielle M Baker, Stuart J Schnitt www.elsevier.com/locate/serndb PII: DOI: Reference: S0740-2570(17)30073-4 http://dx.doi.org/10.1053/j.semdp.2017.05.013 YSDIA50525 To appear in: Seminars in Diagnostic Pathology Cite this article as: Gabrielle M Baker and Stuart J Schnitt, Vascular Lesions of the Breast, Seminars in Diagnostic Pathology, http://dx.doi.org/10.1053/j.semdp.2017.05.013 This is a PDF file of an unedited manuscript that has been accepted for publication As a service to our customers we are providing this early version of the manuscript The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain Vascular Lesions of the Breast Gabrielle M Baker, M.D and Stuart J Schnitt, M.D Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Corresponding Author: Stuart J Schnitt, M.D Departmen of Pathology Beth Israel Deaconess Medical Center 330 Brookline Avenue Boston, MA 02215 Phone: 617-667-4344 Fax: 617-975-5620 E-mail: sschnitt@bidmc.harvard.edu Vascular lesions of the breast comprise a heterogeneous group that includes a variety of benign, atypical, and malignant lesions The presentation of these lesions ranges from those that are microscopic and discovered incidentally, to large tumors that may extensively involve the breast parenchyma and skin In addition, some breast lesions have features that may mimic those of vascular lesions and need to be distinguished from them in order to avoid an erroneous diagnosis In this review, we discuss the spectrum of vascular lesions of the breast with particular emphasis on those lesions of greatest clinical importance, angiosarcoma and atypical vascular lesions We also discuss lesions that may be mistaken for vascular lesions BENIGN VASCULAR LESIONS Benign vascular lesions of the breast are relatively uncommon and several categories have been recognized including perilobular hemangioma, hemangioma (capillary, cavernous, complex, and venous types), and angiomatosis [1-4] The major clinical importance of benign vascular lesions is that they must be distinguished from angiosarcoma As a general rule, benign vascular lesions are circumscribed and lack the interanastomosing channels and the endothelial atypia and proliferation seen in angiosarcomas [5] However, some angiosarcomas have areas that are very well-differentiated and feature a deceptively bland appearance simulating benign blood vessels Conversely, some benign vascular lesions may show atypical cytologic and/or architectural features [6] For these reasons, the distinction between a benign vascular lesion and angiosarcoma may be difficult or impossible in limited samples, such as core needle biopsy specimens In this regard, some authors have suggested that all vascular lesions found in core needle biopsy specimens require excision due to the possibility of sampling error Others believe that excision may not be necessary in cases in which there is radiologic-pathologic concordance supporting a benign diagnosis such as hemangioma However, this is likely to be an infrequent occurrence [7] Perilobular hemangiomas are the most common vascular lesions of the breast Their reported frequency ranges from as low as 1.2% to as high as 11% of breast specimens [8, 9] Perilobular hemangiomas are always incidental microscopic findings, typically measuring