CANCER BIOCHEMISTRY Nguyen Huu Ngoc Tuan, MD, PhD Objectives Ability to: Describe the basic biochemical alterations in a transformed malignant cell Analyze the interaction between fundamental changes (genomic level) & subsequent manifestations Refs Harper’s illustrated biochemistry – 28th ed Molecular biology of the cell – 5th ed Holland-Frei Cancer Medicine – 8th ed Huge global health issue! Globocan 2008 http://globocan.iarc.fr/factsheet.asp Important VN health issue! Globocan 2008 http://globocan.iarc.fr/factsheet.asp Tumour vs Cancer? bert-firebert.blogspot.com medicaljournalonline.blogspot.com occupiedmedia.us Growth vs Neoplasm www.healthywomenlife.com medicalxpress.com Etiology Chemical agents Physical agents Infectious diseases Germline genetic factors Somatic cell genetics Critical cell problem Genetic modifications favor cell proliferation & survival emt.bu.edu  Cancer = Cellular Pathology Cancer = Genomic Pathology Risks External environment Internal environment Genetics Outcome of Cancer Death esteedv.wordpress.com Treatment = Cancer Cell Elimination Surgery www.cancer8.com www.stephenmcculley.co.uk Treatment = Cancer Cell Elimination Radiotherapy healthymemos.com Treatment = Cancer Cell Elimination Chemotherapy www.glogster.com www.de-amazones.nl How does life begin? The central dogma of biology Relationship of molecules CH HEMOGLOBIN CH GLUCID DNA PROTEIN CH LIPID CH PROTEIN CH NĂNG LƯỢNG CH AXIT NUCLEIC Cancer = Cellular Pathology Cancer = Genomic Pathology Transformed malignant cells In vitro Cytological changes Alteration in growth characteristics Changes in cell membrane Loss of cell-cell / cell – extra cellular matrix interaction Loss of differentiation-inducing agents Altered signal transduction mechanism Ability to produce tumor in experimental animals