Thông tin tài liệu
ENDOMETRIOSIS - BASIC
CONCEPTS AND CURRENT
RESEARCH TRENDS
Edited by Koel Chaudhury
and Baidyanath Chakravarty
Endometriosis - Basic Concepts and Current Research Trends
Edited by Koel Chaudhury and Baidyanath Chakravarty
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
All chapters are Open Access distributed under the Creative Commons Attribution 3.0
license, which allows users to download, copy and build upon published articles even for
commercial purposes, as long as the author and publisher are properly credited, which
ensures maximum dissemination and a wider impact of our publications. After this work
has been published by InTech, authors have the right to republish it, in whole or part, in
any publication of which they are the author, and to make other personal use of the
work. Any republication, referencing or personal use of the work must explicitly identify
the original source.
As for readers, this license allows users to download, copy and build upon published
chapters even for commercial purposes, as long as the author and publisher are properly
credited, which ensures maximum dissemination and a wider impact of our publications.
Notice
Statements and opinions expressed in the chapters are these of the individual contributors
and not necessarily those of the editors or publisher. No responsibility is accepted for the
accuracy of information contained in the published chapters. The publisher assumes no
responsibility for any damage or injury to persons or property arising out of the use of any
materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Bojan Rafaj
Technical Editor Teodora Smiljanic
Cover Designer InTech Design Team
First published May, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Endometriosis - Basic Concepts and Current Research Trends,
Edited by Koel Chaudhury and Baidyanath Chakravarty
p. cm.
ISBN 978-953-51-0524-4
Contents
Preface IX
Section 1 Endometriosis 1
Chapter 1 Endometriosis 3
Mohammad Reza Razzaghi,
Mohammad Mohsen Mazloomfard and Anahita Ansari Jafari
Chapter 2 Urinary Tract Endometriosis 31
Aliasghar Yarmohamadi and Nasser Mogharabian
Chapter 3 Diagnosis and Treatment of Perineal Endometriosis 53
Lan Zhu, Na Chen and Jinghe Lang
Chapter 4 Abdominopelvic Complications of Endometriosis 65
Arturo del Rey-Moreno
Chapter 5 Endometrial Tumors in Postoperative Scars - Pathogenesis,
Diagnostics and Treatment 85
Stanisław Horák and Anita Olejek
Chapter 6 Pathological Aspects of Endometriosis 101
Agatha Kondi-Pafitis
Section 2 Pathogenesis 113
Chapter 7 Involvement of Prostaglandins in
the Pathophysiology of Endometriosis 115
Gabriela F. Meresman and Carla N. Olivares
Chapter 8 Genetic Polymorphisms and
Molecular Pathogenesis of Endometriosis 133
Vijayalakshmi Kodati and Q. Hasan
VI Contents
Chapter 9 Progesterone Resistance and Targeting the Progesterone
Receptors: A Therapeutic Approach to Endometriosis 157
Nick Pullen
Chapter 10 Endometriosis and Angiogenic Factors 183
P. G. Artini, M. Ruggiero, F. Papini,
G. Simi, V. Cela and A. R. Genazzani
Chapter 11 The Local Immune Mechanisms Involved in
the Formation of Endometriotic Lesions 211
Yulia Antsiferova and Natalya Sotnikova
Chapter 12 Virus Infection and Type I Interferon in Endometriosis 245
Pia M. Martensen, Anna L. Vestergaard and Ulla B. Knudsen
Chapter 13 Stem Cell as the Novel Pathogenesis of Endometriosis 263
Eing-Mei Tsai
Chapter 14 Green Tea for Endometriosis 277
Gene Chi Wai Man, Hui Xu and Chi Chiu Wang
Chapter 15 Endometrial Stem Cells and Endometriosis 297
Jafar Ai and Esmaeil Sadroddiny
Section 3 Recent Research Trends 309
Chapter 16 Endometriosis-Associated Ovarian Cancer: The Role of
Oxidative Stress 311
Yoriko Yamashita and Shinya Toyokuni
Chapter 17 Alteration in Endometrial Remodeling: A Cause for
Implantation Failure in Endometriosis? 325
Saikat K. Jana, Priyanka Banerjee, Shyam Thangaraju,
Baidyanath Chakravarty and Koel Chaudhury
Chapter 18 Pathomechanism of Infertility in Endometriosis 343
Hendi Hendarto
Chapter 19 Analysis of Differential Genes of Uyghur Women with
Endometriosis in Xinjiang 355
Aixingzi Aili, Ding Yan, Hu Wenjing,
Yang Xinhua and Hanikezi Tuerxun
Chapter 20 Primary Afferent Nociceptors and Visceral Pain 367
Victor Chaban
Contents VII
Chapter 21 Embryo Quality and Pregnancy Outcome
in Infertile Patients with Endometriosis 383
Veljko Vlaisavljević, Marko Došen and Borut Kovačič
Chapter 22 Endometriosis and Infertility:
The Role of Oxidative Stress 399
Ionara Barcelos and Paula Navarro
Section 4 Diagnosis and Treatment 417
Chapter 23 Current Insights and Future Advances in
Endometriosis Diagnostics 419
Michele Cioffi and Maria Teresa Vietri
Chapter 24 Imaging Tools for Endometriosis: Role of Ultrasound,
MRI and Other Imaging Modalities in
Diagnosis and Planning Intervention 437
Shalini Jain Bagaria,
Darshana D. Rasalkar and Bhawan K. Paunipagar
Chapter 25 Pelvic Endometriosis: A MR Pictorial Review 447
Rosario Francesco Grasso, Riccardo Del Vescovo,
Roberto Luigi Cazzato and Bruno Beomonte Zobel
Chapter 26 Pathophysiological Changes in Early Endometriosis 459
Tao Zhang, Gene Chi Wai Man and Chi Chiu Wang
Chapter 27 Medical Treatment in Endometriosis 475
Elham Pourmatroud
Chapter 28 Sequential Management with
Gonadotropin-Releasing Hormone Agonist
and Dienogest of Endometriosis-Associated
Uterine Myoma and Adenomyosis 485
Atsushi Imai, Hiroshi Takagi,
Kazutoshi Matsunami and Satoshi Ichigo
Preface
Dedication
We dedicate this book to thousands of women all over the world suffering from
endometriosis
Endometriosis is a progressive debilitating disease affecting the physical, social and
psychological aspects of normal life quality in nearly 1 of 7 women of reproductive
age. Endometriosis is considered to be an enigmatic disease owing to the lack of
specific set of symptoms, poorly understood pathogenesis, complexity in diagnosis
and limited therapeutic options available for management of the disorder. The last
three decades we have witnessed a significant volume of research related to
endometriosis. We felt the need to bring together contributions of experts working on
pathophysiology, diagnosis and therapeutic aspects of endometriosis. We genuinely
hope that the readers will enjoy reading these informative articles contributed by
eminent clinicians and scientists. We, as editors, would sincerely feel rewarded if the
readers put to use the contents of the book to alleviate the pain and misery of women
suffering from endometriosis, a disease which still remains a challenge.
We sincerely appreciate the valuable contributions of all the authors who have put in
considerable effort to make the book a success. We are grateful to Dr. Ashalatha Ganesh
for providing her expert opinion and valuable suggestions. We are most thankful to
InTech publisher for providing us with an opportunity to edit a book of such great
clinical relevance. Finally, our sincere thanks to Bojan Rafaj, Publishing Process Manager
for the excellent support extended to us throughout the editing process.
Koel Chaudhury (Editor)
Associate Professor
School of Medical Science and Technology
Indian Institute of Technology, Kharagpur
India
Baidyanath Chakravarty (Co-editor)
Director Institute of Reproductive Medicine
Salt Lake, Kolkata
India
[...]... stromal cells J Clin Endocrinol Metab 86, 576 5-5 773 [30] Noble LS etal (1996) Aromatase expression in endometriosis J Clin Endocrinol Metab 81, 17 4-1 79 [31] Guo SW Epigenetics of endometriosis Mol Hum Reprod 2009 Oct;15(10):58 7-6 07 24 Endometriosis - Basic Concepts and Current Research Trends [32] Seli E, Arici A: Endometriosis: interaction of immune and endocrine systems Semin Reprod Med 21:135,... to creating an environment for induction of progressive endometriosis (63) 7 Patient symptoms Although women with endometriosis may be asymptomatic, symptoms are common and typically include chronic pelvic pain and infertility As previously stated, the current ASRM 12 Endometriosis - Basic Concepts and Current Research Trends classification of endometriosis, which describes the extent of disease bulk,... levels of Cox-2 in endometriosis than in endometrium from controls These data support the conclusion that Cox-2 is induced by endometriosis and leads to higher levels of prostaglandins (42) 5.9 Clinical association between endometriosis and autoimmune diseases Clinical conditions associated with endometriosis by patients, providers, and researchers alike have included headaches, arthralgias and myalgias,... of pelvic pain) and the significant morbidity 4 Endometriosis - Basic Concepts and Current Research Trends associated with this disease, mainly with regard to the possible consequences on reproductive function and on the risk of developing gynecologic tumors, such as ovarian cancer (1 0-1 2) The prevalence in women without symptoms is 2-5 0%, depending on the diagnostic criteria used and the populations... are 16 Endometriosis - Basic Concepts and Current Research Trends present in endothelial cells of endometrial vasculature Finally, it is possible that b receptor acts intracellularly as an ERa inhibitor, by dimerizing with the ERa molecules to form a faulty product (87) b - Antiprogestins: Danazol 40 0-8 00 mg/day Gestrinone 1.2 5-2 .5 Twice /week The first medication approved for the treatment of endometriosis. .. associated to endometriosis [98] 18 Endometriosis - Basic Concepts and Current Research Trends Aromatase inhibitors have similar hypoestrogenic side-effect profiles as GnRH agonists, but hold promise in severe, refractory cases of endometriosis Treatment of rats with induced endometriosis using the nonsteroidal aromatase inhibitor fadrozole hydrochloride or YMsl l resulted in a dose-dependent volume... myalgias, allergies, eczema, hypothyroidism, 10 Endometriosis - Basic Concepts and Current Research Trends fibromyalgia, chronic fatigue syndrome, and susceptibility to vaginal candidiasis These often ill-defined entities carry an allure of mystery, paralleling many nonspecific symptoms encountered by patients with known autoimmune disease Because of this parallelism, and with no alternative explanation for... Barakat H, Dousset B, Pansini V, Vacher-Lavenu MC, Dubuisson JB Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification Hum Reprod 2003;18(1):15 7-6 1 26 Endometriosis - Basic Concepts and Current Research Trends [67] Koninckx PR, Meuleman C, Demeyere S, Lesaffre E, Cornillie FJ Suggestive evidence that pelvic endometriosis is a progressive disease,... women have some degree of retrograde menstruation but only a little percentage has endometriosis and the presence of the disease in absence of menses However, the absence of endometriosis in other tissues derived from coelomic epithelium argues against this theory (22) 8 Endometriosis - Basic Concepts and Current Research Trends 5.4 Induction theory The theory of endometrial stem cells or transient amplifying... of steroids such as estrogen, progesterone and androgen are mediated through their respective receptors - Estrogen Receptors (ER), Progesterone Receptors (PR) Endometriosis 9 and Androgen Receptors (AR) - these receptors must be and have shown to be intimately involved in the pathogenesis of endometriosis ERs, PRs and AR, along with glucocorticoid receptor and mineralocorticoid receptor, form the steroid . ENDOMETRIOSIS - BASIC CONCEPTS AND CURRENT RESEARCH TRENDS Edited by Koel Chaudhury and Baidyanath Chakravarty Endometriosis - Basic Concepts and Current Research. orders@intechopen.com Endometriosis - Basic Concepts and Current Research Trends, Edited by Koel Chaudhury and Baidyanath Chakravarty p. cm. ISBN 97 8-9 5 3-5 1-0 52 4-4 Contents. hypothyroidism, Endometriosis - Basic Concepts and Current Research Trends 10 fibromyalgia, chronic fatigue syndrome, and susceptibility to vaginal candidiasis. These often ill-defined entities
Ngày đăng: 30/03/2014, 19:20
Xem thêm: Endometriosis - Basic Concepts and Current Research Trends Edited by Koel Chaudhury and Baidyanath Chakravarty ppt, Endometriosis - Basic Concepts and Current Research Trends Edited by Koel Chaudhury and Baidyanath Chakravarty ppt