Date of Document: December 31, 2021 CURRICULUM VITAE Calvin B Williams MD, PhD Chief, Professor Department of Pediatrics Division of Rheumatology OFFICE ADDRESS: Children's Corporate Center 999 N 92 St Milwaukee, WI 53226 EDUCATION: 1978 - 1983 BA, California State University, Fullerton, CA 1983 - 1991 MD, University of California, Irvine, CA 1983 - 1991 PhD, University of California, Irvine, CA POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 1991 - 1992 Intern in Pediatrics, St Louis Children’s Hospital, St Louis, MO 1992 - 1993 Junior Pediatric Resident, St Louis Children’s Hospital, St Louis, MO 1993 - 1994 Clinical Fellow in Pediatric Immunology and Rheumatology, Dept of Pediatrics, Washington University School of Medicine, St Louis, MO 1994 - 1996 Research Fellow in Pediatric Immunology and Rheumatology, Center for Immunology, Washington University School of Medicine, St Louis, MO 1996 - 1999 Postdoctoral fellow, Washington University School of Medicine, St Louis, MO FACULTY APPOINTMENTS: 1996 Instructor in Pediatrics, Washington University School of Medicine, St Louis, MO 1998 Assistant Professor of Pediatrics, Washington University School of Medicine, St Louis, MO 2002 Associate Professor of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 2003 - Present Associate Professor of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 2011 - Present Professor of Pediatrics, Microbiology and Molecular Genetics, Microbiology and Molecular Genetics, Milwaukee, WI ADMINISTRATIVE APPOINTMENTS: 2002 - Present Chair, Rheumatology, D.B and Marjorie Reinhart Family Foundation 2002 - Present Section Chief, Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: 2003 - 2013 Director, Pediatric Rheumatology Fellowship Training Program, Medical College of Wisconsin, Milwaukee, WI 2011 - Present Associate Director Medical Scientist Training Program, Medical College of Wisconsin, WI 53226 HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: 1997 - 2000 1997-2000 Director, Rheumatology Service, Shriner’s Hospital for Children, St Louis, MO RESEARCH ADMINISTRATIVE APPOINTMENTS: 1996 - Present NIH-funded Principle Investigator 2008 - Present Associate Director, Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI 2012 - 2013 Interim Chief Scientific Officer, Children's Hospital of Wisconsin Research Institute, WI 53226 2012 - Present Associate Dean of Research, Medical College of Wisconsin, Milwaukee, WI 53226 2013 - Present Vice Chair for Research, Department of Pediatrics, Medical College of Wisconsin, WI 53226 2013 - Present Chief Scientific Officer, Children's Hospital of Wisconsin Research Institute, WI 53226 HOSPITAL STAFF PRIVILEGES: 1996 - 2002 St Louis Children’s Hospital, St Louis, MO 1997 - 2002 Shriner’s Hospital for Children, St Louis, MO 2002 - Present Children’s Hospital of Wisconsin, Milwaukee, WI SPECIALTY BOARDS AND CERTIFICATION: Board Certified American Board of Pediatrics American Board of Pediatrics – Sub-board in Pediatric Rheumatology American Board of Pediatrics – Sub-board in Pediatric Rheumatology Recertified Licensure Missouri License Wisconsin License Illinois License Number 108030 44530-020 026-107992 Issue Date 01/1995 05/2002 07/2002 Issue Date Expiration 10/1998 10/2005 11/2000 11/2007 11/2008 11/2014 Expiration 01/2004 10/2011 07/2008 AWARDS AND HONORS: 1982 - Present Summer Fellowship, California Foundation for Biochemical Research 1989 - Present Earl C Anthony Dissertation Fellowship 1990 - Present 1990 MRES Medical Scientist Student Scholarship 1992 - Present Vincent P Carroll Jr., Memorial Research Award for Outstanding Research 1997 - Present Scholar of the Center for Child Health Research at Washington University 1999 - Present Basil O’Connor Research Award, March of Dimes 2002 - Present D.B and Marjorie Reinhart Family Foundation Chair in Pediatric Rheumatology 2004 - Present Outstanding Health Professional Award , Wisconsin Chapter of the Arthritis Foundation 2010 - Present Best Doctors in America, Woodward/Wite Inc., Aiken, SC MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: 2001 - Present American Association of Immunologists (Member) 2001 - Present American College of Rheumatology (Member) 2002 - Present Childhood Arthritis & Rheumatology Research Alliance (Member) 2003 - Present Society for Pediatric Research (Member) EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: Journal Review 2005 - Present Blood 2006 - Present Journal of Immunology 2008 - Present Pediatric Research LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 2003 - Present founding member, Committee on Immunology, Medical College of Wisconsin, Milwaukee, WI 2004 - 2007 Member, Board of Directors, Arthritis Foundation, Wisconsin Chapter 2004 - Present Member, Board of Directors, Lupus Foundation of America, Wisconsin Chapter 2008 - Present Chair, Committee on Immunology, Medical College of Wisconsin, Milwaukee, WI 2008 - Present Ad Hoc Reviewer, Advancing a Healthier Wisconsin, Medical College of Wisconsin NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 2008 - Present Abstract Reviewer, Annual Scientific Meeting, American College of Rheumatology 2009 - Present Ad Hoc Grant Reviewer, Netherlands Organization for Scientific Research 2009 - Present Ad Hoc Grant Reviewer, Health Research Board of Ireland RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: Active Peer Review Title: Mechanisms of disease pathogenesis in regulatory T cell deficiency Source: NIH NIAID R01 AI085090-01 Role: Principal Investigator PI: Multiple PI with Talal A Chatila Dates: 12/10/2009 - 05/31/2015 Direct Funds: $1,250,000 (CBW $625,000) Title: Source: Role: PI: Dates: Direct Funds: Regulatory T cell populations in graft versus host disease NIH NHLBI HL064603 Co-investigator William Drobyski 05/27/2013 - 07/31/2017 $1,190,000 (CBW $100,000) Title: Source: Role: Dates: Direct Funds: In vivo control of induced regulatory T cell differentiation and function Crohn's and Colitis Foundation Principal Investigator 01/01/2014 - 12/31/2016 $315,900 Title: Source: Role: PI: Dates: Direct Funds: Platelet-derived FVIII gene therapy of Hemophilia A NIH NHLBI 2R01 HL102045-06 Co-investigator Qizhen Shi 05/01/2015 - 04/30/2019 $1,250,000 (CBW $100,000) Non-Peer Review Title: Source: Role: PI: Dates: Direct Funds: Regulatory T cell development and function Children’s Hospital of Wisconsin endowed chair Principal Investigator Self 01/01/2004 - Present $504,649 ((total for all years to date)) Prior Peer Review Title: Source: Role: Mechanism of T Cell Tolerance NIH NIAMS K08 AR01998 Principal Investigator PI: Dates: Direct Funds: Self 08/01/1996 - 07/31/2000 $325,852 Title: Source: Role: PI: Dates: Direct Funds: Lymphocyte Selection in the Developing Immune System March of Dimes Basil O’Connor Research Award Principal Investigator Self 02/01/1999 - 01/31/2001 $90,908 Title: Source: Role: PI: Dates: Direct Funds: Selection and Survival of T Lymphocytes NIH NIAID RO1 AI47154 Principal Investigator Self 08/01/2000 - 05/31/2005 $1,000,000 Title: Source: Role: PI: Dates: Direct Funds: Gene Expression in Pediatric Arthritis NIH, Subcontract Co-Investigator Colbert, Cincinnati 07/01/2003 - 06/30/2009 $189,650 Title: Source: Role: PI: Dates: Direct Funds: Meaningful Outcome Measures for Pediatric Lupus Trials NIH-RO1 AR051868-01 Subcontract Co-Investigator Brunner, Cincinnati 04/01/2005 - 06/30/2008 $46,911 Title: Source: Role: PI: Dates: Direct Funds: Triptorelin for Ovary Protection in childhood onset lupus FDA, Subcontract (PI – Brunner, Cincinnati) Site Principal Investigator Self 09/30/2005 - 09/29/2007 $17,124 Title: Source: Role: PI: Dates: Direct Funds: Generation and decay of memory T cells in children with juvenile rheumatoid arthritis NIH NIAID NO1-A1-50032 (PD-Gorski, Blood Research Institute) Project Principal Investigator (objectives - 4) Self 09/30/2005 - Present $1,243,604 (total for all years - objectives - 4) Title: Source: Role: PI: Dates: Direct Funds: Towards Biomarkers for Lupus Renal Disease Alliance for Lupus Research Subcontract Co-Investigator Dr Brunner, Cincinnati 03/2006 - 05/2009 $23,236 Title: Source: Role: PI: Dates: Direct Funds: Lymphocyte Selection in the Developing Immune System March of Dimes Principal Investigator Self 06/01/2007 - 05/31/2004 $229,847 Title: Source: Role: PI: Dates: Direct Funds: The role of induced regulatory T cells in dominant immunologic tolerance Advancing a Healthier Wisconsin Initiative Principal Investigator Self 07/01/2008 - 06/30/2011 $130,000 Title: Source: Role: Dates: Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis Subcontract on NIH-NIAMS-2P60AR047784-06A2 (Grom PI) Co-Investigator 08/18/2008 - 07/31/2013 Title: Source: Role: Dates: Multidisciplinary clinical research centers: Improved understanding of the biology and use of the TNF inhibition in JRA Subcontract on NIH-NIAMS-2P60AAR047784-06A2 (PI-Lovell, Cincinnati) Co-Investigator 08/18/2008 - 07/31/2013 Title: Source: Role: PI: Dates: Direct Funds: Regulatory T cell selection and specificity NIH NIAID R01 AI073731-01A2 Principal Investigator (dual PI award with Talal A Chatila) Self 08/11/2009 - 07/31/2011 $500,000 ((total for all years, CBW $250,000, TAC $250,000)) Title: Source: Role: PI: Dates: Direct Funds: Induced and natural regulatory T cells in the treatment of colitis Crohn’s and Colitis Foundation of America Principal Investigator Self 07/01/2010 - 06/30/2013 $243,000 Non-Peer Review Source: Role: Dates: Direct Funds: Open-label extension treatment with TNFR:Fc for participating patients in TNFR:Fc clinical trials Immunex Corporation Co-Investigator 1998 - 2007 $36,108 Title: Source: Role: Dates: Direct Funds: Registry of etanercept (Enbrel) in children with juvenile rheumatoid arthritis Immunex Corporation Co-Investigator 06/01/2001 - 05/2009 $45,000 Title: Source: Role: Dates: Direct Funds: A Phase III, Multi-Center, Multi-National, Randomized, Withdrawal Study to Evaluate the Safety and Efficacy of BMS-188667 in Children and Adolescents with Active Polyarticular JRA Bristol-Myers Squibb Co-Investigator 05/12/2004 - 08/01/2007 $13,328 Title: Source: Role: PI: Dates: Direct Funds: Mechanisms of disease pathogenesis in regulatory T cell deficiency NIH NIAID R01 AI085090-01S1 Principal Investigator Self 07/01/2010 - 06/30/2011 $100,000 ((CBW $50,000, TAC $50,000)) Title: Source: Role: PI: Dates: Direct Funds: Regulatory T cell selection and specificity NIH NIAID R01 AI073731-01A2S1 Principal Investigator Self 07/11/2010 - 06/30/2011 $135,898 ((CBW $67,949, TAC $67,949)) Title: INVITED LECTURES/WORKSHOPS/PRESENTATIONS: Local Selection and Maintenance of the T Cell Repertoire, Blood Center of SE Wisconsin, Blood Research Institute, Milwaukee, WI, 12/2002 - Present Selection and Maintenance of the T Cell Repertoire, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, 01/28/2003 - Present Juvenile Arthritis, Family Day Winter Fun Day – Sponsored by the Wisconsin Chapter of the Arthritis Foundation, Wisconsin Dells, WI, 01/2003 - Present T Cell Receptor Antagonism: A Potential Therapy for Autoimmune Disease?, Department of Pediatrics Research Conference, Medical College of Wisconsin, Milwaukee, WI, 02/21/2003 - Present Pediatric Lupus, Lupus Education Day – Sponsored by the Lupus Foundation, Children’s Hospital of Wisconsin, Milwaukee, WI, 05/10/2003 - Present Childhood Arthritis, 2003, More Life Less Limits - Wisconsin Chapter Annual Meeting– Sponsored by the Wisconsin Chapter of the Arthritis Foundation Wisconsin Athletic Club, Milwaukee, WI, 05/2003 Present Research in Pediatric Rheumatology, CHW Foundation All Staff Meeting, Oakwood Bldg – Research Park, 06/18/2003 - Present Lupus in Children, Lupus Foundation of America, Wisconsin Chapter, Inc Medical Symposium, Froedtert Memorial Lutheran Hospital, Milwaukee, WI, 10/18/2003 - Present Selection and Maintenance of the T Cell Repertoire, Biomedical Resource Center, Medical College of Wisconsin, Milwaukee, WI, 12/2004 - Present Regulatory T Cell Control of Immune Responses, Department of Pediatrics Research Conference, Medical College of Wisconsin, Milwaukee, WI, 07/2006 - Present The Role of Foxp3 in Regulatory T Cell Development, Children’s Research Institute Annual Symposium, Children’s Hospital of Wisconsin, Milwaukee, WI, 04/2008 - Present Training Grant in Immunology, Department of Pediatrics, Section Chief Retreat, Medical College of Wisconsin, Milwaukee, WI, 08/2008 - Present The Requisite Role of Induced Regulatory T Cells in Immunologic Tolerance, Children’s Research Institute Research Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 11/2009 - Present The Requisite Role of Induced Regulatory T Cells in Immunologic Tolerance, Allergy and Immunology Grand Rounds, Medical College of Wisconsin, Milwaukee, WI, 04/2010 - Present Regional Systemic Lupus Erythematosus, Clinical Case Conference, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 10/21/1997 - Present The role of Self Peptides in T Cell Development and Tolerance, Research Retreat, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 03/14/1998 - Present Horror Autotoxicus, Grand Rounds, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 06/19/1998 - Present Pediatric Rheumatology: Juvenile Rheumatoid Arthritis, Early Bird Rounds, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 12/11/1998 - Present Thymocyte Selection in the Developing Immune System, Work-in-progress, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 11/08/2000 - Present X-linked Severe Combined Immunodeficiency, Clinical Case Conference, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 11/28/2000 - Present The Selection and Survival of T Lymphocytes, Work-in-progress, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 04/24/2002 - Present Pediatric Autoimmune Disease: Mechanisms and Therapy, Grand Rounds, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, 05/24/2002 - Present Chronic Arthritis in Children, Pediatric Grand Rounds – St Therese Medical Center, Waukegan, IL, 10/2004 - Present Juvenile Idiopathic Arthritis, Pediatric Grand Rounds, Condell Medical Center, Libertyville, IL, 05/2008 - Present International Systemic Lupus Erythematosus in Children, Polish-American Pediatric Conference, Rzeszow, Poland, 05/2010 - Present Juvenile Ideopathic Arthritis, Polish-American Pediatric Conference, Rzeszow, Poland, 05/2010 - Present PEER REVIEWED WORKSHOPS/PRESENTATIONS: Local Altered Peptide Ligands Affect T Cell Development and Tolerance, Annual Retreat, Washington University Immunology Program, Washington University School of Medicine, St Louis, MO, 02/20/1998 - Present An Essential Role for Induced Regulatory T Cells in Dominant Tolerance, Immunology Research Symposium, University of Wisconsin-Madison, 05/2000 - Present National An endogenously expressed T cell receptor antagonist inhibits T cell proliferation and the formation of T cell memory, Podium Presentation, Pediatric Rheumatology 2003: Park City and Beyond, Snowmass, CO, 03/2003 - Present Central Tolerance Fails in Dual Receptor T cells Resulting in an Autoimmune-Prone Phenotype in Mice, American College of Rheumatology Annual Scientific Meeting, San Antonio, TX, 11/2004 - Present International Altered Peptide Ligands Limit T Cell Selection and Repertoire Diversity, Mini-symposium 12th International Congress of Immunology, Montreal, Canada, 07/2004 - Present COMMITTEE SERVICE: Medical College of Wisconsin 2003 - Present Chair, Committee on Immunology, Medical College of Wisconsin 2004 - Present co-chair, Innovations Task Force, Pediatric Research, Medical College of Wisconsin 2006 - 2007 BRC Director, Search Committee, Medical College of Wisconsin 2006 - Present Member, Search Committee, BRI Immunology Faculty, Medical College of Wisconsin MEDICAL COLLEGE TEACHING ACTIVITIES: Resident and Fellow Education 1996 - Present Attending physician at WUSTL and MCW, responsible for teaching pediatric residents and pediatric rheumatology fellows 8-10 weeks per year EXTRAMURAL TEACHING: Medical Student Education 1996 - 2002 St Louis Children’s Hospital, St Louis, MO, Attending Physician, General Pediatrics, General Pediatrics ward attending 4-6 weeks per year 1996 - 2002 St Louis Children’s Hospital, St Louis, MO, Attending Physician, Pediatric Immunology/Rheumatology 1998 - 2002 Washington University School of Medicine, St Louis, MO, Lecturer, Clinical Correlates in Immunology 2002 - Present Attending Physician, pediatric rheumatology service, responsible for teaching medical students on the general outpatient pediatrics rotation and on rheumatology elective 8-10 weeks per year 2004 - Present Medical College of Wisconsin, Milwaukee, WI, Lecturer, Clinical Correlates in Immunologic Tolerance, Medical Microbiology Resident and Fellow Education 2003 - Present Medical College of Wisconsin and the Children’s Hospital of Wisconsin, Milwaukee, WI, Director, Pediatric Rheumatology Fellowship Program Responsibilities include recruitment, curriculum content, program development, scheduling, fellow evaluation, and mentorship/advice Continuing Medical Education 2009 - Present Organize and schedule the Children’s Research Institute weekly research seminar series Duties include maintaining CME compliance and CME annual accreditation reports Graduate Student Education 2004 - Present Medical College of Wisconsin, Milwaukee, WI, Lecturer, Cellular and Molecular Immunology (M&MG 05-234) 2010 - Present Medical College of Wisconsin, Milwaukee, WI, Course Director and lecturer, Immunological Tolerance (M&MG 05-265) 2010 - Present Course Director and lecturer, Developmental Immunology (M&MG 05-264), Medical College of Wisconsin, Milwaukee, WI Postdoctoral Fellow Education 2004 - Present four MCW departments and the Blood Research Institute, Organize, schedule and run the weekly Immunology Work-in-progress meeting for the campus MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: Medical Students Derrick Siebert, Medical College of Wisconsin, 2005 - Present Summer research student mentor Drew Hietpas, Medical College of Wisconsin, 2006 - Present Summer research student mentor Lance Relland, Medical College of Wisconsin, 2009 - 2011 Physician Scientist Pathway mentor Elisabeth Sederberg, Medical College of Wisconsin, 2009 - Present Summer research student mentor Elica Inagaki, Medical College of Wisconsin, 2010 - 2011 Physician Scientist Pathway mentor Graduate Students MS Students Advised Louise Markey Pathway, Medical College of Wisconsin, 1998 - 2002 Robert Latek, Medical College of Wisconsin, 1998 - 2002 Holly L Hanson, Medical College of Wisconsin, 1998 - 2002 Tom Rummel, Medical College of Wisconsin, 2003 - Present Rebecca Moyer, Medical College of Wisconsin, 2004 - Present Lance Relland, Medical College of Wisconsin, 2004 - Present Suzan Salti, Medical College of Wisconsin, 2005 - Present Sreemanti Basu, Medical College of Wisconsin, 2007 - Present Erica Treslley-Schmitt, Medical College of Wisconsin, 2007 - Present Daniel Sanfelippo, Medical College of Wisconsin, 2009 - Present Clinical/Research Fellows Andrew J White MD, Medical College of Wisconsin, 1996 - 1999 Advisor (WUSTL) Vidya Raman MD, Medical College of Wisconsin, 1999 Advisor (WUSTL) Anthony R French MD, Medical College of Wisconsin, 2000 - 2003 Advisor (WUSTL) Fei F Shih MD, Medical College of Wisconsin, 2000 - 2003 Advisor (WUSTL) Diane Brown MD, Medical College of Wisconsin, 2001 - 2004 Advisor (WUSTL) Sheetal Vora MD, Medical College of Wisconsin, 2005 - 2008 Advisor (MCW) Eli Eisenstein MD, Medical College of Wisconsin, 2006 - 2008 Advisor (MCW) Grant Syverson MD, Medical College of Wisconsin, 2008 - Present Advisor (MCW) Dominic Co MD PhD, Medical College of Wisconsin, 2009 - Present Advisor (MCW) Elizabeth Kessler MD, Medical College of Wisconsin, 2010 - Present Advisor (MCW) EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: Graduate Students PhD Students Advised Lance Relland, 07/2004 - 06/2009 “The role of Ligand Affinity in Regulatory T Cell Selection and Function” Erica Treslley-Schmitt, 07/2008 - Present student PhD Committees Leah Shriver, 2004 - 2009 Amy Beres, 2009 - Present Jamie Wieting, 2010 - Present Postdoctoral Students Dipica Haribhai DVM, 2001 - 2006 Research mentor Merav Lidar MD, 2002 - 2004 Research mentor Manoj K Mishra PhD, 2002 - 2006 Research mentor Eli M Eisenstein MD, 2007 - 2008 Research mentor Christopher G Mayne PhD, 2009 - Present Research mentor Dominic Co MD PhD, 2010 - Present Research mentor Faculty James Verbsky MD PhD, 2005 - Present Research mentor Sheetal Vora MD, 2008 - Present Clinical mentor Nita Salzman MD PhD, 2008 - Present Collaborator/mentor Veronica Flood MD, 2008 - Present Mentor committee PROGRAMMATIC DEVELOPMENTS: Educational Programs Fellow 2003 - Present Pediatric Rheumatology Fellowship Program Research Programs 2003 - Present Committee on Immunology Regulatory T Cell Biology CRI Flow Cytometry Facility Clinical Programs 2002 - Present Dr Williams is the Section Chief of Pediatric Rheumatology Community Programs Dr Williams and his nursing staff support the local chapter of the Arthritis foundation by attending the week-long Camp MASH every summer COMMUNITY SERVICE ACTIVITIES: 2004 - 2007 Board of Directors, Arthritis Foundation, Wisconsin Chapter, Milwaukee, WI 2004 - Present Board of Directors, Lupus Foundation of America, Wisconsin Chapter, Milwaukee, WI BIBLIOGRAPHY Refereed Journal Publications/Original Papers Williams, C.B and Gutman, G.A T cell receptor beta chain genes in the rat: Availability and pattern of utilization of variable gene segments differs from that in the mouse J Immunol 142:1027-1035, 1989 Chandy, K.G., Williams, C.B., Spencer, R.H., Aguilar, B., Ghanshani, S., Tempel, B.L and Gutman, G.A A family of three mouse potassium channel genes with intronless coding regions Science 247:973975, 1990 Williams, C.B., Khurana, S and Gutman, G.A Duplication of T cell receptor alpha-chain variable gene segments in the rat Immunogenetics 32:134-137, 1990 Williams, C.B., Blankenhorn, E.P., Byrd, K.E., Levinson, G and Gutman, G.A Organization and nucleotide sequence of the rat T cell receptor beta-chain complex J Immunol 146:4406-4413, 1991 Blankenhorn, E.P., Smith, P.D., Williams, C.B., Gutman, G.A Alleles of the rat T-cell receptor beta chain gene complex Immunogenetics 35:324-331, 1992 Vidal, K., Hsu, B., Williams, C.B., and Allen, P Endogenous altered peptide ligands can affect peripheral T cell responses J Exp Med 183:1311-1321, 1996 Williams, C.B., and Allen, P.M The study of self-tolerance using murine hemoglobin as a model self antigen CIBA Foundation Symposium N 215 Immunological Tolerance 1997, Pg 41-46 Williams, C.B., Vidal, K., Donermeyer, D., Peterson, D.A., White, J.M., Allen, P.M In Vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery J Immunol 161:128-137, 1998 Basu, D., Williams, C.B., and Allen, P.M In vivo antagonism of a T cell response by an endogenously expressed ligand Proc Natl Acad Sci USA 95:14332-14336, 1998 10 Williams, C.B., Engle, D.L., Kersh, G.J., White, J.M., and Allen, P.M A kinetic threshold between negative and positive selection based on the longevity of the TCR-ligand complex J Exp Med 189:1531-1544, 1999 11 Plas, D.R., Williams, C.B., Kersh, G.J., White, L.S., White, J.M., Paust, S., Ulyanova, T., Allen, P.M and Thomas, M.L Cutting Edge: The tyrosine phosphatase SHP-1 regulates thymocyte positive selection J Immunol 162:5680-5684, 1999 12 Marcelino, J., Carpten, J.D., Suwairi, W.M., Gutierrez, O.M., Schwartz, S., Robbins, C., Sood, R., Makalowska, I., Baxevaris, A., Johnstone, B., Laxer, R.M., Zemel, L., Kim, C.A., Herd, J.K., Ihle, J., Williams, C.B., Johnson, M., Ramen, V., Alonso, L.G., Brunoni, D., Gerstein, A., Papadopoulos, N., Bahabri, S.A., Trent, J.M and Warman, M.L CACP, encoding a secreted proteoglycan, is mutated in camtodactyly-arthropathy-coxa vara-pericarditis syndrome Nature Genetics 23:319-322, 1999 13 Kersh, G.J., Engle, D.L., Williams, C.B and Allen, P.M Ligand-specific selection of MHC class IIrestricted thymocytes in fetal thymic organ culture J Immunol 164:5675-5682, 2000 14 Raman, V., Blaeser F., Ho, N., Engle, D.L., Williams, C.B., and Chatila, T.A Requirement for CaMKIV/Gr in setting the thymocyte selection threshold J Immunol 167:6270-6278, 2001 15 Haribhai, D.H., Meyer, M., Engle, D., White, M and Williams, C.B A threshold for central T cell tolerance to an inducible serum protein J Immunol 170:3007-14, 2003 16 Singh, J., Williams, C.B and McAlister, W.H Talo-patello-scaphoid osteolysis, synovitis and short fourth metacarpals in sisters: a new syndrome? Am J Med Gen., 121A:118-125, 2003 17 Haribhai, D., Edwards, B., Williams, M.L., Williams, C.B.: "Functional reprogramming of the primary immune response by T cell receptor antagonism" J Exp Med., 200(11):1371-1382, 2004 18 Lin, W., Truong, N., Grossman, W.J., Haribhai, D., Williams, C.B., Wang, J., Martin, M.G., and Chatila, T.A Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice J Allergy Clin Immunol 116:1106-15, 2005 19 Haribhai, D., Lin, W., Relland, L.M., Truong, N., *Chatila, T.A., and *Williams, C.B., Regulatory T cells dynamically control the primary immune response to foreign antigen J Immunol 178:2961-2972, 2007 * corresponding authors 20 Lin, W Haribhai, D., Relland, L.M., Truong, N., Carlson, M.R., *Williams, C.B., and *Chatila, T.A., Regulatory T cell development in the absence of a functional Foxp3 protein Nature Immunol 8:359-368, 2007 *corresponding authors 21 Schulteis, R.D., Chu, H., Dai, X Chen, Y., Edwards, B., Haribhai, D., Williams, C.B., Malarkannan, S., Hessner, M.J., Glisic-Milosavljevic, S., Jana, S Kerschen, E.J., Ghosh, S., Wang, D., 2, Kwitek, A.E., Lernmark, A., Gorski, J., and Weiler, H Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking gimap5 Blood 112:4905-4914, 2008 22 Relland, L.M., Mishra, M.K., Haribhai, D., Edwards, B., Ziegelbauer, J., and Williams, C.B Affinitybased selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression J Immunol 182:1341-1350, 2009 (Featured article: "In this Issue" section) 23 Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., Salzman, N.H., Carlson, M.R., *Chatila, T.A., and *Williams, C.B A central role for induced regulatory T cells in tolerance induction in experimental colitis J Immunol 182:3461-3468, 2009 *corresponding authors 24 Eisenstein, E.M., and Williams, C.B The Treg/Th17 cell balance: A new paradigm for autoimmunity Pediatr Res 65:26R-31R, 2009 25 Jana, S., Jailwala, P., Ehlenbach, S., Haribhai, D., Waukau, J., Glisic-Milosavljevic, S., Grossman, W.J., Verbsky, J W., Wen, R., Wang, D., Williams, C.B., and Ghosh, S The role of Smad3 and NFkB in the regulation of Foxp3 expression in effector cells Eur J Immunol 39:1-13, 2009 (Featured article: "In This Issue") 26 Salzman, N.H., Hung, K., Haribhai, D Chu, H., Karlsson-Sjoberg, Amir, E, Teggatz, P., Barman, M., Hayward, M., Stoel, M., Sodergren, E., Bevins, C.L., Weinstock, G.M., Williams, C.B., and Bos, N.A Enteric defensins are essential regulators of intestinal microbial ecology Nature Immunol 11: 76-82, 2010 (Featured article: "New and Views") 27 Fu, G., Chen, Y, Yu, M., Podd, A., Schuman, J., He, Y., Di, L., Y, Yassai, M., Haribhai, D., North, P.E., Gorski, J, Williams, C.B., Wang, D., Wen, R Phospholipase C1 is essential for T-cell development, activation and tolerance J Exp Med 207:309-318, 2010 28 Mayne, C.G., Spanier, J.A., Relland, L.M., Williams, C.B., and Hayes, C.E., 1,25-Dihydroxyvitamine D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis Eur J Immunol 41:822-832, 2011 29 Eisenstein, E M., Syverson, G.D., Vora, S.S., and Williams, C.B Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis J Rheum 38:782783, 2011 30 Haribhai, D., Williams J.B., Jia, S., Nickerson, D., Schmitt, E.G., Edwards, B., Ziegelbauer, J., Yassai, M , Li, S., Relland, L.R., Wise, P.M., Chen, A., Zheng, Y., Simpson, P.M., Gorski, J., Salzman, N.H., Hessner, M.J., *Chatila, T.A., and *Williams, C.B A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity Immunity (2011), DOI:10.1016/j.immuni.2011.03.029 31 Ray A, Basu S, Williams CB, Salzman NH, Dittel BN A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand J Immunol 2012 Apr 01;188(7):3188-98 PMCID: PMC3311743 32 Bonacci B, Edwards B, Jia S, Williams CB, Hessner MJ, Gauld SB, Verbsky JW Requirements for growth and IL-10 expression of highly purified human T regulatory cells J Clin Immunol 2012 Oct;32(5):1118-28 PMCID: PMC4271826 33 Chatila TA, Williams CB Foxp3: shades of tolerance Immunity 2012 May 25;36(5):693-4 PMCID: PMC3868336 34 Jeschke JC, Williams CB Editorial: Crossing the divide: a novel Cd8 enhancer with activity in CTLs and CD8αα+ dendritic cells J Leukoc Biol 2015 Apr;97(4):623-5 35 Brunner HI, Silva CA, Reiff A, Higgins GC, Imundo L, Williams CB, Wallace CA, Aikawa NE, Nelson S, Klein-Gitelman MS, Rose SR Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus Arthritis Rheumatol 2015 May;67(5):1377-85 PMCID: PMC4414812 36 Chatila TA, Williams CB Regulatory T cells: exosomes deliver tolerance Immunity 2014 Jul 17;41(1):3-5 PMCID: PMC4130330 37 Sreedharan R, Chen S, Miller M, Haribhai D, Williams CB, Van Why SK Mice with an absent stress response are protected against ischemic renal injury Kidney Int 2014 Sep;86(3):515-24 PMCID: PMC4149847 38 Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo J Invest Dermatol 2014 Nov;134(11):2814-2822 39 Williams CB, Chatila TA Editorial: Optimizing iTreg differentiation: STATs in the balance J Leukoc Biol 2014 Feb;95(2):197-8 40 Schmitt EG, Haribhai D, Jeschke JC, Co DO, Ziegelbauer J, Yan K, Iwakura Y, Mishra MK, Simpson P, Salzman NH, Williams CB Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression J Immunol 2013 Dec 01;191(11):5460-76 PMCID: PMC3893829 41 Schmitt EG, Williams CB Generation and function of induced regulatory T cells Front Immunol 2013;4:152 PMCID: PMC3685796 42 Mayne CG, Williams CB Induced and natural regulatory T cells in the development of inflammatory bowel disease Inflamm Bowel Dis 2013 Jul;19(8):1772-88 PMCID: PMC3690174 43 Williams CB, Chatila TA Fox family ties Cell Res 2013 Apr;23(4):452-4 PMCID: PMC3616439 44 Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy J Immunol 2012 Dec 15;189(12):5638-48 PMCID: PMC3537488 45 Relland LM, Williams JB, Relland GN, Haribhai D, Ziegelbauer J, Yassai M, Gorski J, Williams CB The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct J Immunol 2012 Oct 01;189(7):3566-74 PMCID: PMC3538134 46 Beres AJ, Haribhai D, Chadwick AC, Gonyo PJ, Williams CB, Drobyski WR CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity J Immunol 2012 Jul 01;189(1):464-74 PMCID: PMC3381996 Books, Chapters, and Reviews Williams, C.B., The development of the immune system Rudolph's Pediatrics, 21st edition, Rudolph, C.D., Rudolph A.M., Hostetter, M.K., Lister, G.E., and Siegel, N.J editors, McGraw Hill Medical, New York, NY, 2003 Williams, C.B and Cole, F.S Immunology of the Fetus and Newborn Avery's Diseases of the Newborn, 8th edition, Taeusch, H.W., Ballard, R.A., Gleason, C.A., and Avery, M.E editors, Elsevier Health Sciences, Philadelphia, PA, 2005 Eisenstein, E.M and Williams, C.B The development of the immune system Rudolph's Pediatrics, 22nd edition, Rudolph, C D., Rudolph, A.M., Lister, G.E, First, L., and Gershon, A.A editors, McGraw Hill Professional, New York, NY, 2011 Williams, C.B Eisenstein, E.M and Cole, F.S Immunology of the Fetus and Newborn Avery's Diseases of the Newborn, 9th edition, Taeusch, H.W., Ballard, R.A., and Gleason, C.A., editors, Elsevier Health Sciences, Philadelphia PA (in press) Abstracts Haribhai, D., Meyer, M.M., and Williams, C.B., An endogenously expressed TCR antagonist inhibits T cell proliferation, B cell Help and the formation of T cell memory 31st Annual Autumn Immunology Conference, Chicago, IL 2002 Haribhai, D., Williams, M.L., Edwards, B and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response 32nd Annual Autumn Immunology Conference, Chicago, IL 2003 Haribhai, D., Meyer, M.M., and Williams, C.B., Endogenous expression of a TCR antagonist inhibits antigen-specific T cell proliferation, secondary B cell follicle formation and T cell memory, Keystone Symposia: Mechanisms of Immunologic Tolerance and Its Breakdown (A2), Snowbird, UT 2003 Haribhai, D., Meyers, M.M., and Williams, C.B., An endogenously expressed T cell receptor antagonist inhibits T cell proliferation and the formation of T cell memory Pediatric Rheumatology 2003: Park City and Beyond, Snowmass, CO, 2003 Lidar M., Haribhai, D.H., and Williams, C.B., Central tolerance fails in dual receptor T cells resulting in an autoimmune-prone phenotype in mice American College of Rheumatology 68th Annual Meeting, San Antonio TX 2004 Haribhai, D., Williams, M.L., Edwards, B and Williams, C.B., T cell receptor antagonists modulate homeostatic proliferation in lymphopenic hosts 12th International Congress of Immunology, Montreal, Canada 2004 Mishra, M.K and Williams, C.B., Altered peptide ligands limit T cell selection and repertoire diversity 12th International Congress of Immunology, Montreal, Canada 2004 Haribhai, D., Williams, M.L., Edwards, B and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response Keystone Symposia: Lymphocyte Activation and Signaling (A3), Steamboat Springs, CO 2004 Haribhai, D., Williams, M.L., Edwards, B., and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response Pediatric Academic Societies' Annual Meeting, San Francisco, CA 2004 10 Mishra, M.K Haribhai, D., Relland, L.R., and Williams, C.B., Peripheral tolerance in a transgenic mouse model of pulmonary disease 34th Annual Autumn Immunology Conference, Chicago IL 2005 11 Haribhai, D., Ziegelbauer, J Edwards, B., Williams, M.L., and Williams, C.B., Defining the relationship between TCR/ligand affinity and homeostatic expansion in lymphopenic hosts Experimental Biology and the American Association of Immunologists Annual Meeting, San Diego CA 2005 12 Haribhai, D., Ziegelbauer, J Edwards, B., Williams, M.L., and Williams, C.B., Conversion of conventional T cells into Foxp3+ regulatory T cells requires agonist ligands and occurs in vivo American Association of Immunologists Annual Meeting, Boston MA 2006 13 Mishra, M.K Haribhai, D., Relland, L.R., and Williams, C.B., Peripheral tolerance in a transgenic mouse model of pulmonary disease American Association of Immunologists Annual Meeting, Boston MA 2006 14 Relland, L.M., W Lin, D Haribhai, N Truong, Chatila, T.A., and Williams, C.B Visualizing regulatory T cell responses in vivo using a bicistronic Foxp3EGFP reporter allele American Association of Immunologists Annual Meeting, Boston MA 2006 15 Haribhai, D., Lin, W., Relland, L.M., Truong, N., Chatila, T.A., and Williams, C.B., Regulatory T cells dynamically control the immune response to foreign antigen Keystone Symposia on Regulatory T Cells (B3), Vancouver, Canada 2007 16 Relland, L.M., Haribhai, D., Mishra, M.K., and Williams, C.B., Agonists and Altered Peptide Ligands Fail to Promote Positive Selection of N3.L2 Natural Regulatory T Cells Keystone Symposium on Regulatory T Cells (B3), Vancouver, Canada 2007 17 Relland, L.M., Mishra, M.K., Haribhai, D., Edwards, B., Ziegelbauer, J., and Williams, C.B., Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression Keystone Symposium on Regulatory T Cells (C5), Keystone, CO 2009 18 Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., Salzman, N.H., Carlson, M.R., Chatila, T.A., and Williams, C.B., A central role for induced regulatory T cells in tolerance induction in experimental colitis Keystone Symposium on Regulatory T cells (C5), Keystone CO 2009 19 Treslley-Schmitt, E., Haribhai, D., Relland, L.R., and Williams, C.B., Characterization of a transgenic mouse model of lymphocytic interstitial pneumonitis 38th Annual Autumn Immunology Conference, Chicago, IL 2009 20 Relland, L.R., Williams, J.B., Haribhai, D., Yassai, M., Gorski, J., and Williams C.B Antigen-specific regulatory and conventional T cells express distinct T cell receptor repertoires 38th Annual Autumn Immunology Conference, Chicago, IL 2009 21 Haribhai, D., Edwards, B., Ziegelbauer, J., Hessner, M., Chatila, T.A., and Williams, C.B., Induced regulatory T cells contribute to tolerance 38th Annual Autumn Immunology Conference, Chicago, IL 2009