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THERAPEUTIC POTENTIAL OF NICOTINE PAGE 7 THERAPEUTIC POTENTIAL OF NICOTINE ANNOUNCEMENT Data in the presentation doesn’t belong to us We simply present our summary from a number of research of other r.
THERAPEUTIC POTENTIAL OF NICOTINE ANNOUNCEMENT: • Data in the presentation doesn’t belong to us We simply present our summary from a number of research of other researchers • Investigation and research on Nicotine is rare Only some of the information below is newly updated • Nicotine’s effect on health is still in research We don’t recommend anyone to try it for self-treatment without professional advice The presentation is for educational purposes only INTRODUCTION: Script: Nicotine is always believed to be a detrimental substance due to its association with smoking It is the most well-known ingredient of tobacco, which makes cigarettes become highly addictive This makes the real health benefits of nicotine are often overlooked or even suppressed Only lately, Nicotine has been investigated for its therapeutic potential for a long list of common ills The list includes Alzheimer disease, Parkinson disease, depression and anxiety, schizophrenia, attention deficit hyperactivity disorder (ADHD), and even pain and obesity TABLES OF CONTENTS CONTENTS OVERALL THERAPEUTIC POTENTIAL OF NICOTINE increased sympathetic nervous system activity like Nicotine and the Brain an elevated heart rate and a Nicotine helps improve concentration blood pressure b Potential therapeutic agents for rewarding cognitive and o Nicotine’s THERAPEUTIC dysfunction POTENTIAL OF addictive qualities are NICOTINE thought Nicotine and weight gain to be linked to its ability to cause increased dopamine levels in areas NICOTINE FUTURE like the nucleus accumbens o Nicotine also increases CONCLUSION acetylcholine release, which might contribute to the enhanced attention and So, let’s have an overview about cognitive function this special substance associated with its use OVERVIEW I OVERVIEW: o Nicotine is the main psychoactive component of tobacco It primarily exerts its effects by binding to nicotinic acetylcholine receptors in the central and peripheral nervous system in brain, muscle, and many other tissues of many organisms The resultant is release of a variety of neurotransmitters o Nicotine acts on nicotinic acetylcholine receptors in the peripheral nervous system, where it can lead to II THERAPEUTIC POTENTIAL OF NICOTINE: PAGE Nicotine and the Brain a Nicotine helps improve concentration - People with depressive-spectrum disorders, schizophrenia, and adult with ADHD tend to smoke heavily, which suggested to researchers that nicotine may soothe their symptoms Similarities between all these disorders is a failure of attention, an inability to concentrate on particular stimuli As we have mentioned above, Nicotine also increases acetylcholine release, which might contribute to the enhanced attention and cognitive function associated with its use - Researchers at the National Institute on Drug Abuse have shown via functional magnetic resonance imaging that nicotine activates specific brain areas during tasks that demand attention (*) This may be because of its effects, shared with many other addictive drugs, on the release of the neurotransmitter dopamine b Potential therapeutic agents for cognitive dysfunction Many research has shown that smokers also have lower rates of neurodegenerative disorders, and nicotine improves cognitive and motor functioning in people with Parkinson disease (*) and Alzheimer disease (**) (*) Parkinson develops when cells in the brain stop working properly and are lost over time These brain cells produce a chemical called dopamine The brain uses dopamine to help control movement, everything from walking to talking, writing to smiling Eventually, the brain cannot make enough dopamine to control movement properly This is when symptoms start to appear (**) Alzheimer is the most common form of neurodegenerative disease, meaning it is characterized by the degeneration and death of neurons Alzheimer’s most often affects adults over the age of 65 It includes difficulty in sleeping, disturbed memory, drastic mood changes and increasing confusion Cause of the disease are not well understood We want to mention again that: Nicotine has been proved to cause increased dopamine levels And, the prevailing hypothesis is that nicotine increases release of neurotransmitters depleted in those diseases Researchers are now wondering that malfunctioning of the dopamine system may be affecting noncognitive aspects of dementia such as depressed mood, and that this might be alleviated by nicotine Scirpt: Nicotine's beneficial effects in patients with neurodegenerative and -mental disorders have been studied a lot and are fairly well-known A much newer topics of academic research is nicotine's potential for treating obesity b Nicotine and weight gain: Nicotine may be the most effective drug around for weight control As ex-smokers know, to their rue, one of the worst things about quitting cigarettes is putting on pounds—as much as 10% of body weight “Something about being addicted to nicotine and then going off it causes massive increase in weight,” Lorna Role and her colleagues at Columbia University in New York City (1998) points out In 2002, Ph.D [Doctor of Philosophy] Young-Hwan Jo from Albert Einstein College of Medicine has assumed that Nicotine may presumably be involved in changing perception and motivation for eating In 2003, Ming Li and his colleagues at the University of Texas in San Antonio, Texas suggest that, among its other effects, nicotine alters fat storage Additionally, nicotine or nicotinic receptor agonism can simultaneously modulate food intake, in terms of both homeostatic and hedonic components (Mineur and colleagues, 2011; Picciotto & Mineur, 2013) FUNFACTS: Although always been blamed for causing addiction among smokers, Nicotine is mainly used to help treat dependence on smoking cigarettes This form of treatment is called nicotine replacement therapy (NRT) NRT products contain less nicotine than cigarettes, and they not contain many of the harmful chemicals typically found in cigarettes, which can come in the form of patches, gum, lozenges, inhalers, and nasal sprays SIDE EFFECTS OF NICOTINE: Along with the possible advantages of nicotine, in fact, it might cause a range of effects on both the body and mind, including: Decreased user’s appetite, abnormal sleep disturbances, or heightened mood Using Nicotine can also increase heart rate and blood pressure, accompanied by sweating Sometimes, it might cause nausea III NICOTINE’S FUTURE: Why has interest in this potential cure-all been slow to develop? One reason: in its current forms the drug offers pharmaceutical companies no possibility of substantial profit In other words, research on Nicotine brings back relatively minimal benefits Developing new drugs that selectively target specific subtypes of nicotine receptors is an expensive, albeit potentially lucrative, proposition And therein lies a question Will nicotine-based therapy consist mostly of costly new drugs from the pharmaceutical industry? Or can less expensive nicotine products like the patch, chewing gum, and nasal spray—which are generally intended for smoking cessation but widely available, usually without prescription—find their way into the world's medicine cabinets? Another, perhaps more important: the drug is regarded as the world's most addictive IV CONCLUSION In conclusion, we want to emphasize that ample evidence has suggested that chronic nicotine use by vaping is associated with increased odds of myocardial infarction, stroke, and circulatory problems, as seen in cigarette smokers (Mayyas and colleagues, 2020; Moheimani and colleagues, 2017) However, it appears that short-term nicotine use might be reasonably safe and can be relatively beneficial Its development is one of the most promising, elegant, and smart strategies for weight management, several mental illnesses and neurodegenerative disorders QUESTION: I have read on the Internet that Nicotine are investigated on its pain relief ability Have you any research about it? Can you tell us a little bit? Nicotine itself has provided modest pain relief in animal studies And now, nicotine is being investigated as an analgesic in humans Pamela Flood, an anesthesiologist at Columbia has said in her research (Dec 2004) “The nice thing about nicotine and drugs like nicotine is that they have opposite side effects to anesthetics Instead of being respiratory depressants, they are respiratory stimulants Instead of being sedating, they increase alertness.” Why is nicotine called poison? Poison, in biochemistry, a substance, natural or synthetic, that causes damage to living tissues and has an injurious or fatal effect on the body, whether it is ingested, inhaled, or absorbed or injected through the skin And, Nicotine itself is a dangerous neurotoxin It is poisonous if ingested, even handling the plant leaves can cause health problems such as headache, nausea, vomiting, and fatigue Is there any other use of Nicotine? Pesticide Recreational: e-cigarettes ... concentration blood pressure b Potential therapeutic agents for rewarding cognitive and o Nicotine? ??s THERAPEUTIC dysfunction POTENTIAL OF addictive qualities are NICOTINE thought Nicotine and weight gain.. .THERAPEUTIC POTENTIAL OF NICOTINE increased sympathetic nervous system activity like Nicotine and the Brain an elevated heart rate and a Nicotine helps improve concentration... come in the form of patches, gum, lozenges, inhalers, and nasal sprays SIDE EFFECTS OF NICOTINE: Along with the possible advantages of nicotine, in fact, it might cause a range of effects on both