UNIVERSITY PEDs Cycle Progression: DHT Derivatives Lesson Overview Cycle Progression after a Testosterone as a Base Why DHT as a secondary compound? Proviron Deployment Masteron Deployment Primobolan Deployment Anavar Deployment Sample Cycle Design Cycle Progression Established testosterone is a base growth anchor in our cycle to support optimal estrogen and DHT levels A base testosterone cycle might be cycle and 2, with escalated dosages The need for escalating the dosage to continue to grow might be needed, however continuing to raise testosterone presents issue with estrogenic side effects The next compound to introduce into the cycle would be a DHT derivative Why DHT as a Second Compound Does not aromatize to estrogen Increase anabolic activity of cycle, limit androgen activity Can modulate effect of estrogen and prolactin Can compete for aromatize and SHBG, making testosterone more effective If cycling on and off, DHT derivatives are far less suppressive compared to nandrolone and trenbolone Nandrolone and trenbolone are more advanced in side effect management so should be saved for when more experienced (can bind to the AR, ER, and Progestin receptor) Proviron (Mesterolone) Clinical Application 1934 first AAS to be marketed Declining mental capacity, androgen insufficiency, infertility (increasing sperm quality and quantity) Clinical dosing 25mg TID 450mg per day for depression Properties Non aromatizing compound, competes with aromatase enzyme, lowers estrogen levels Competes with SHBG, increase amount of free androgens 4x higher binding affinity than DHT Potentiates other androgens effected by alpha reductase Not c17aa, low liver toxicity Dosages >100mg can alter lipid profile (6 months 65.5% increase LDL, and 35.75 HDL decrease) Highly androgenic, acne and hair loss sensitive individuals be considerate Can increase Prolactin (50mg per day) Does not suppress endocrine testosterone at dosages up 150mg, 300mg can be suppressive Poor anabolic as 3α -hydroxysteroid dehydrogenase (3α-HSD) breaks it down in skeletal muscle to a weak androgen Bodybuilding Application Offseason: TRT or blast setting to potentiate free testosterone and offset estrogen (gyno management) *Caveat higher test dosages can suppress SHBG and saturate aromatase, benefit might be lessened Libido support, especially in setting of low DHT cycles (great application in nandrolone cycles) 25mg daily can be used throughout year (Much less than clinical dosing, low risk compound) Contest Prep: Off set Androgen: Estrogen ratio and decrease Cortisol for “harder” look (lowered water retention) Libido support Last 3-4 weeks of Prep dosage can increase from 25mg up to 50mg Masteron (Drostanolone) Clinical Application Introduced for medical use in 1961 Inoperable breast cancer dosage 300mg per week No longer in clinical usage as Aromatase Inhibitors and SERMS took its place Properties Non aromatizing compound, competes with aromatase enzyme, lowers estrogen levels Typically propionate or enanthate ester for IM injection Low androgenic profile, designed for androgen sensitive females in mind Methyl group addition on C2, stabilizes the keto group limiting 3α -hydroxysteroid dehydrogenase (3α-HSD) activity in skeletal muscle, improving anabolic property compared to DHT Can modulate prolactin levels Bodybuilding Application Offseason: Increase anabolic profile of stack and modulate estrogen levels Builds tissue while limiting water retention via no aromatization Additional Neural drive benefit for strength gains 200-300mg per week as a starting point for a blast phase, can be tapered up in advanced user to 300-500mg per week Misconception: “purely cosmetic compound”, this is not the case Contest Prep: Utilize as needed in initial phase of prep for estrogen modulation Deployed or tapered up in dosage in later stages of prep to increase androgen: estrogen ratio for decreased water retention “hardness” Starting at 200mg per week up to 400mg per week Primobolan (Methenolone) Clinical Application Came to market in 1962 Application in breast cancer, wasting conditions (hemiplegia, stroke), osteoporosis, and anemia Used in premature infants to promote weight gain Dosages: 100-200mg per week (highest clinical trial 1200mg/wk compared to 300mg/wk of testosterone in female breast cancer patients) Properties Non aromatizing compound, competes with aromatase enzyme, lowers estrogen levels Typically enanthate ester for IM injection Low androgenic profile, designed for androgen sensitive females in mind Added double bond between carbon and 2, stabilizes the keto group limiting 3α -hydroxysteroid dehydrogenase (3α-HSD) activity in skeletal muscle, improving anabolic property compared to DHT Less estrogen modulation effect than masteron, comparative in muscle building capacity *anecdotal note Highly faked and expensive Bodybuilding Application Offseason: Increase anabolic profile of stack and slight modulation of estrogen Builds tissue while limiting water retention via no aromatization 300-400mg/wk as a starting point for a blast phase, can be tapered up in advanced user to 400-800mg per week Advanced level: application to cruise on test and primo as bridge into prep Contest Prep: Great muscle retention for implementing start of prep, limiting water when body fat is higher, and aromatization is high Can be continued to show or swapped to masteron, for great estrogen modulation Start of prep 300-400mg/wk, higher dosages based on advancement Anavar (Oxandrolone) Clinical Application Ca me to ma rket i n 19060s FDA a pproved for lean mass preservation i n AIDS wasting, alcoholic hepatitis, turner’s syndrome i n females, delayed growth a nd puberty i n boys Burn pa tients for yea rs post burn Us ed in premature i nfants to promote weight gain Dos ages: 2.5-20mg per day for 2-12 weeks Properties C17a a oral, mild liver toxi city (12-week HIV study with 20,40,80mg/day; 20mg d no l iver elevation, 40mg 30-50% i ncrease, 80mg 50-100% i ncrease) CVD: 20mg enough to decrease HDL 30% Mi l dly s uppressive on endocrine testosterone, 20mg a nd 40mg ca used a 45% reduction Two Pha se half l ife: Rapid peak hours post i ngestion, time dosage prior to training a nd s econd dosage later i n day; 300mg of ca ffeine may enhance bioavailability Offs et catabolism via glucocorticoid receptor Non a romatizing compound Low a ndrogenic profile, designed for a ndrogen sensitive females and children i n mind Added Oxygen a tom at carbon 2, s tabilizes the keto group l imiting 3α -hydroxys teroid dehydrogenase (3α-HSD) a ctivi ty i n s keletal muscle, improving anabolic property compared to DHT Noti ceable strength i ncrease Bodybuilding Application Offseason: Minimal application, limit oral usage to preserve lipid profile 4-6 week minicut may have application to preserve performance, at higher levels of advancement Contest Prep: Implemented when needing to preserve training performance Last 6-8 weeks of contest prep Dosing: 20-50mg 1-hour pre training w/ 300mg of caffeine Sample Cycle Progression Offseason Cycle Test cypionate 250mg/wk Cycle Test cypionate 350mg/wk *noted water retention and likely upper level of estrogen Cycle Test cypionate 350mg/wk Masteron or Primobolan 300mg/wk *noticed less estrogenic side effect, titrate up test dosage Cycle Test cypionate 400mg/wk Masteron or Primobolan 400mg/wk Proviron 25mg/day *added for libido and potentiate testosterone Sample Cycle Progression Contest Prep Beginner/early intermediate 16 weeks out Test cypionate 300mg/wk Primobolan 200mg /wk 10 weeks out Test cypionate 300mg/wk Primobolan 200mg/wk Masteron 200mg/wk *added to modulate estrogen and nitrogen retention weeks out Test cypionate 300mg/wk *drop test weeks out if needed for water retention Primobolan 200mg/wk Masteron 200mg/wk Anavar 30mg/day *add to maintain performance Summary Testosterone is our established growth anchor A DHT derivative like proviron, anavar, primobolan and/or masteron are secondary compounds to deploy We advance up in dosage until we must see out our goals with more AAS By this time we should be experienced in what testosterone and DHT derivatives for us regarding growth and sides DHT derivates Anadrol and Winstrol will be covered in phase dependent drug lectures Next, we will deploy 19-Nors for more advanced cycle design References Proviron: Itil TM, Michael ST, Shapiro DM, Itil KZ The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study) Methods Find Exp Clin Pharmacol 1984 Jun;6(6):331-7 PMID: 6431212 Saartok T, Dahlberg E, Gustafsson JA Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin Endocrinology 1984 Jun;114(6):2100-6 doi: 10.1210/endo-114-6-2100 PMID: 6539197 Jockenhövel F, Bullmann C, Schubert M, Vogel E, Reinhardt W, Reinwein D, Müller-Wieland D, Krone W Influence of various modes of androgen substitution on serum lipids and lipoproteins in hypogonadal men Metabolism 1999 May;48(5):590-6 doi: 10.1016/s0026-0495(99)90056-2 PMID: 10337859 Masteron Bennett MB, Helman P, Palmer P Hormonal therapy of breast cancer with special reference toMasteril therapy S Afr Med J 1975 Nov 15;49(49):2036-40 PMID: 1242823 Dugeroglu H, Ozturk M, Atmaca M, Seven I Mesterolone treatment of aging male syndrome improves lower urinary tract symptoms J Pak Med Assoc 2014 Dec;64(12):1366-9 PMID: 25842579 Primobolan: Shimodozono M, Kawahira K, Ogata A, Etoh S, Tanaka N Addition of an anabolic steroid to strength training promotes muscle strength in the nonparetic lower limb of poststroke hemiplegia patients Int J Neurosci 2010 Sep;120(9):617-24 doi: 10.3109/00207454.2010.505352 PMID: 20707637 Kennedy BJ, Yarbro JW Effect of methenolone enanthate (NSC-64967) in advanced cancer of the breast Cancer 1968 Feb;21(2):197-201 doi: 10.1002/10970142(196802)21:23.0.co;2-r PMID: 4952912 Anavar Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebocontrolled study J Acquir Immune Defic Syndr 2006 Mar;41(3):304-14 doi: 10.1097/01.qai.0000197546.56131.40 PMID: 16540931 Reeves PT, Herndon DN, Tanksley JD, Jennings K, Klein GL, Mlcak RP, Clayton RP, Crites NN, Hays JP, Andersen C, Lee JO, Meyer W, Suman OE, Finnerty CC FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL Shock 2016 Apr;45(4):367-74 doi: 10.1097/SHK.0000000000000517 PMID: 26506070; PMCID: PMC4792676 Strawford A, Barbieri T, Van Loan M, Parks E, Catlin D, Barton N, Neese R, Christiansen M, King J, Hellerstein MK Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial JAMA 1999 Apr 14;281(14):1282-90 doi: 10.1001/jama.281.14.1282 PMID: 10208143 Laboratorio de Analises de Dopagem, IDP, Lisboa, Portugal B Slema Oxandrolone excretion: effect of caffeine dowing Published: www.adop.pt Books: Llewellyn W Anabolics Jupiter, FL: Molecular Nutrition LLC; 2017 Bond P Book on Steroids: A complete evidence based reference PeterBond.org; 2020  ... Overview Cycle Progression after a Testosterone as a Base Why DHT as a secondary compound? Proviron Deployment Masteron Deployment Primobolan Deployment Anavar Deployment Sample Cycle Design Cycle Progression. .. 300mg of caffeine Sample Cycle Progression Offseason Cycle Test cypionate 250mg/wk Cycle Test cypionate 350mg/wk *noted water retention and likely upper level of estrogen Cycle Test cypionate 350mg/wk... Established testosterone is a base growth anchor in our cycle to support optimal estrogen and DHT levels A base testosterone cycle might be cycle and 2, with escalated dosages The need for escalating