UNIVERSITY Health Heart Health Interpretation and Interventions Lesson Overview Lab Work Interpretation CBC- Erythrocytosis Lipid Panel- Dyslipidemia Hypertension Vitamin D Status Erythrocytosis and Polycythemia Hematocrit Normal range: Males: 42-54% Females: 38-48% Hematocrit is the proportion by volume of blood that contains red blood cells Erythrocytosis is defines as Hemoglobin level >18.5g/dl or Hematocrit level >52% in men Increased blood viscosity risk for venous thromboembolism, MI, and CVA, evidence is limited Symptoms: Headaches, Lethargy, Dizziness, Increased Blood Pressure TRT cut off point is Hematocrit >54% Erythrocytosis and Polycythemia Mechanisms: Managing Erythrocytosis Ensure Proper Hydration Stable AAS blood levels, limit short acting esters Control Estradiol levels Modulate AAS stack from heavy DHT based and aromatizing compounds Limit excessive Iron intake males >8mg per day (high ferritin (iron storage) levels) Sleep apnea and hypoxia (increased CO2 on labs) Blood Donation every 8-12 weeks or time frame to stay below 55% hematocrit, based on lab work (controversial) Drugs: Angiotensin II Renin Blockers (ARBs) lower hematocrit, can cause anemia Omega Supplementation 2-3g per day 10 Aged Garlic 600-1200mg per day Dyslipidemia Dyslipidemia- abnormal amount of LDL, HDL, triglyceride and/or total cholesterol LDL causal role in atherosclerosis and CHD/CVD Progression HDL may serve a protective role, but therapeutic interventions to increase HDL lack evidence High Triglycerides are associated with CHD/CVD, but if non HDL is corrected for the risk is limited ApoB is a protein found on atherogenic lipoproteins, so it gives a count of the number of these particles LDL still primary target for therapy intervention High sensitivity C Reactive Protein: general measure of inflammation, CVD is an inflammatory condition Independent marker for CVD risk Understanding Lipoproteins image credit: a new perspective on lipid research in age-related macular degeneration - scientific figure on researchgate available from: https://www.researchgate.net/figure/composition-and-mainphysical-chemical-properties-of-major-lipoproteins-classes-left_fig2_324945905 The Lipid Panel Total Cholesterol: Normal range 12—180mg/dL Optimal: 50 females Triglycerides: Normal 0-200mg/dL Optimal