[...]... field of neurobiology of Alzheimer s disease Alzheimer s disease attracted researchers from diverse academic fields, including clinical, basic and social sciences It is essential to promote the understanding of this formidable disease and to share new findings among researchers in the field Clinical and basic research of Alzheimer s disease has been the main interest of the Department of Psychiatry and. .. aiming to elucidate the pathogenesis of Alzheimer s disease Major topics of neurobiological study of Alzheimer s disease include the unraveling of the molecular mechanisms of neurofibrillary tangle formation in neuronal and glial cells; the molecular processing of amyloid precursor protein in intracellular organelles and in extracellular space, and the molecular mechanism of neuronal loss In this book, these... clinical and basic fields of dementia study The three-day meeting program included two official symposia entitled Neurobiology of Amyloid and Presenilins’ and ‘Neurodegeneration Mechanism with Tau, Syneclein and Neurofilaments’, two satellite symposia entitled ‘Early Diagnosis of Alzheimer s Disease and ‘Treatment of Alzheimer s Disease , four luncheon seminars of ‘Strategy for BPSD’, ‘Neuroimaging of. .. Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, CREST, Japan Science and Technology Corporation, Osaka, Division of Structural Cell Biology, Nara Institute of Science and Technology (NAIST), Takayama, Department of Clinical Neuroscience, Psychiatry, Graduate School of Medicine, Osaka University, Suita, Japan and Department of Biochemistry and Molecular Biology,... BPSD’, ‘Neuroimaging of Dementia’, ‘Normal Pressure Hydrocephalus’, and ‘Treatment of Vascular Dementia’, in addition to 85 general presentations In conjunction with the 21st Annual Meeting of the Dementia Study Academy of Japan, we organized an International Symposium on the Molecular Neurobiology of Alzheimer Disease and Related Disorders The articles in this book were selected from papers presented... Molecular Neurobiology of Alzheimer Disease and Related Disorders Basel, Karger, 2004, pp 1–16 Methods of Regulating Alzheimer Pathogenesis: Diet, Oxidative Damage and Inflammation Greg M Cole, Takashi Morihara, Giselle P Lim, Frederic Calon, Bruce Teter, Fusheng Yang, Sally A Frautschy VA Medical Center, GRECC, Greater Los Angeles Healthcare System, Sepulveda, Calif., USA The Amyloid Cascade in Alzheimer s... Graduate School of Medicine, since the time of Professor Jiro Kaneko and Professor Tsuyoshi Nishimura, and it has been our great pleasure to compile this book as a mile stone of the activity in our Department In October 2002, the Department of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine organized the 21st Annual Meeting of the Dementia Study Academy of Japan, in... Alzheimer s Disease – Inflammation, Oxidative Damage and Synapse Loss While the most obvious lesions diagnostic of Alzheimer s disease (AD) are extracellular ␤-amyloid plaques containing large deposits of aggregated, fibrillar amyloid-␤ protein (A␤) and neurofibrillary tangles of filamentous ‘hyperphosphorylated’ ␶-protein, synapse loss appears to be a better and more proximal correlate of cognitive... DA, Aggarwal N, Wilson RS, Wilson RS, Scherr PA: Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study JAMA 2002;287:33230–33237 Engelhart MJ, Geerlings MI, Ruitenberg A, van Suiten JC, Hofman A, Witteman JCM, Breteler MMB: Dietary intake of antioxidants and risk of Alzheimer disease JAMA 2002; 287:3223–3229 Sano M, Ernesto C, Thomas RG, Klauber... N Jr, Litman B, Kim HY, Gawrisch K: Mechanisms of action of docosahexaenoic acid in the nervous system Lipids 2001;36:945–959 Horrocks LA, Yeo YK: Health benefits of docosahexaenoic acid (DHA) Pharmacol Res 1999;40:211–225 Otsuka M: Analysis of dietary factors in Alzheimer s disease: Clinical use of nutritional intervention for prevention and treatment of dementia (in Japanese) Nippon Ronen Igakkai . Molecular Neurobiology of Alzheimer Disease and Related Disorders To Megumi Takeda (September 12, 1957 – February 4, 2002) Molecular Neurobiology of Alzheimer. pathogenesis of Alzheimer s disease. Major topics of neurobiological study of Alzheimer s disease include the unraveling of the molecular mechanisms of neurofibrillary tangle