... chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS).
A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam and 50 ng of
alprazolam were added ... described. In addition, the LC/MS analysis of triazolam, and its metabolites 4-hydroxy-
triazolam and α-hydroxytriazolam is also presented.
GC/MS analysis of ben...
... dissolved in 100 µL methanol, and a 1- L aliquot of it is injected into GC.
For quantitation, the peak area ratio of a target compound to IS is obtained.
vi. For quantitative analysis, a 1 0- L of IS ... method using a DB-1 capillary column. Many compounds ap-
peared as sharp peaks. With an intermediately polar DB-17 capillary column, sharp peaks also
appeared. By usi...
... Shinozuka T, Terada M (1995) Standard methods of chemical analysis in poisoning VII, analgesics and anti-
pyretics, the 115th Annual Meeting of the Pharmaceutical Society of Japan, the data of ... Table 2.1) are non-steroidal and anti-
in ammatory drugs. As one of mechanisms of their pharmacological actions, inhibition
of prostaglandin biosynthesis can be mentioned. A...
... admission.
Notes
a) e APAP metabolites (APAP-glucuronide, catechol 3-hydroxyaminophen, APAP-N-sul-
fate, 3-cysteinyl APAP, 3-methoxy APAP and APAP-3-mercapturic acid) are not commer-
cially available; ... metabolites in urine [4]
Reagents and their preparation
• APAP (Eastmann, Rochester, NY, USA) and APAP metabolites
a
(APAP-glucuronide, cat-
echol 3-hydroxyaminophen, APAP-N-sul...
... described in Chapter 4 can be also used for analysis of sali-
cylic acid. Methyl salicylate, being used as a topical analgesic-antiphlogistic drug, is also me-
tabolized into salicylic acid; therefore, ...
tinnitus, bradyacusia, amblyopia and sweating [1].
For analysis of salicylic acid, HPLC methods were reported [2–7]. In this chapter, a method
for HPLC analysis of s...
... phenylbutazone, mefenamic acid and ca eine. e total analysis time per sample
was less than 25 min.
HPLC-UV analysis of cephem antibiotics in plasma with a column-switching system
400 β-Lactam antibiotics
Poisoning ... Application of ion-exchange cartridge clean-up in food analysis. IV. Confirmatory
assay of benzylpenicillin, phenoxymethylpenicillin, oxacillin, cloxacil...
... wrist of about 4 cm length; X-ray photographs, no nding in the chest and intestinal gas
observable in the abdomen.
A er admission, gastrolavage and administration of activated charcoal and ... 9,10-dimethoxy-2-anthracene sulfonate (DMAS)
as a uorogenic reagent with excitation at 383 nm and emission at 459 nm.
Poisoning case, and toxic and fatal concentrations
Pois...
... Poisons in Humans
A Handbook of Practical Analysis
Osamu Suzuki and Kanako Watanabe
Drugs and Poisons
in Humans
A Handbook of Practical Analysis
With 236 Figures and 90 Tables
123
Prof. Osamu ... Suzuki and Dr. Watanabe have gathered an extensive array of methods for the measure-
ment of xenobiotics and metabolites in biological matrices. Dr...
... superior vena cava and aorta [31].
Postmortem diff usion of drugs from the trachea into heart blood
22 Pitfalls and cautions in analysis of drugs and poisons
In Japan, Xylocaine
TM
jelly is usually ... during in vitro
storage of specimens obtained from a nitrazepam user at autopsy
Specimen Immediately after autopsy 10 days after autopsy*
Nitrazepam 7-Aminonitrazep...
... hydrophobic
Silica Normal phase: polar and neutral
Florisil Normal phase: polar and weakly basic
Alumina A Normal phase: polar and acidic
Cation exchanger Cation exchange
Anion exchanger Anion exchange
Mixed ... septum cap, and warmed (or heated) in a water bath
or on a block heater. A er a suitable time of warming, a needle of a syringe is inserted through
the se...