...
architecture
of
tolerance
to
acrolein
in
Drosophila
melanogaster.
Genet.
Sed.
Evol.
(in
press).
Dickinson
W.J.
(1970)
The
genetics
of
aldehyde
oxidase
in
Drosophila
melanogaster.
Genetics ...
for
tolerance
to
acrolein
in
Drosophila
melanogaster.
Genet.
Sec.
Evol.
(in
press)
Togby
A.H.,
Nasrat
G.E.,
Nafei
H.
&
El-Abidin
A.Z.
(1976a...
...
each
generation
in
order
to
avoid
inbreeding
and
prevent
laboratory
drift.
These
mass
populations
were
used
in
the
toxicity
tests.
Simultaneously,
isofemale
lines
were
established ...
Rotman
G
(1987)
Development
of
ethanol
tolerance
in
relation
to
the
alcohol
dehydrogenase
locus
in
Drosophila
melanogaster.
II.
The
influence
of
phenotypic
ada...
... to the nucleus of infected cells.
Mapping of several paramyxovirus N proteins, including
Sendai and measles virus, indicated that the N protein has
two major domains; the amino terminal domain ... responsible
for RNA binding of N-N and N-P binding remain intact,
suggesting that N2 may play an alternative role in cells
during viral infection.
Expression of N1 and N2 open reading fr...
... that activators induce in
the APC core. Finally, it is unclear how E2s are stimulated
upon binding to the RING domain, and the structural
determinants of E2 lysine specificity remain to be
identified. ... resulting
in ubiquitination of multiple lysines. In addition, specific lysines on ubiquitin itself can be modified, resulting in the assembly of polyubiquitin
chains....
... number of physical and biological con-
straints (Figure 1). Trying to identify trends or adaptations
by focus ing on one or two among the many constraints is
akin to examining a piece of music ... in
thermophilic proteins and increased stability [7].
Solubility
Solubility is a critical factor in the evolution of protein
sequences and folds [8]. In general, charges in glo...
...
within
families
WG
Hill
A
Caballero
L
Dempfle
2
1
Institzite
of
Cell,
Animal
and
Population
Biology,
University
of
Edinburgh,
West
Mains
Road,
Edinburgh,
EH9
3JT,
UK;
2
International ...
SDM
because
no
constraints
are
made
on
selecting
the
best
individuals.
Examples
are
given
in
table
I,
assuming
the
population
size
is
large
(so
infinite
popula...
... [29].
Interestingly, two enzymes are involved in the conversion
of methylcitrate into 2-methylisocitrate. PrpD is involved in
the dehydration of (2S,3S)-methylcitrate to 2-methyl-cis-
aconitate. The elimination ... Galactose-binding protein P02927 38
MalE 5.22 40.7 Maltose-binding protein P02928 71
2. Proteins induced at a lower level as compared with growth on acetate:
AdhP 5.94 35...
... [43,44,46]. In account
of our novel observation of RNA binding activity of
CD151, we looked for RNA binding domains on CD151
protein by bioinformatic analysis, we could not find any
known RNA binding ... trypsinization, cells
(5 × 10
5
total) were washed twice in staining solution
(0.1% bovine serum albumin [BSA] in PBS) and blocked
in 3% BSA in staining solution on ice for 1...
... number of positive cells deter-
mined in a blinded fashion. Immunostaining was per-
formed for Vimentin (Dako, Sweden). The per centage of
staining was determined by computerized image analysis
in ... presence in urine is a com-
monly accepted sign of tubular damage [41], their activ-
ity level in the urine revealed a superiority of MP in
maintaining tissue integrity at all...
... no
activating mutations in the tyrosine kinase region of the
c-Met receptor in the RMS cell lines used in our experi-
ments (RD, CW9019 and RH30), and no f unctional
autocrine regulatory loops ... are being explored, includin g the develo pment of
competitors of c-Met/HGF, monoclonal antibodies
directed against HGF and c-Met, and small-molecule
tyrosine kinase inhibitors directed...