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Báo cáo y học: "Optimization principles of dendritic structure" docx

Báo cáo y học:

Báo cáo y học: "Optimization principles of dendritic structure" docx

... Research, Department of Physiology, University College London, UK, 2Department of Physiology, University College London, UK , 3Max-Planck Institute of Neurobiology, Department of Systems and Computational ... integration of spatially dis-tributed inputs are characteristic of many dendrites; these principles may well therefore be applicable for manyother systems. In recent years, a number of approacheshave ... feature of neurons. However, the principles determining their structure are poorly understood. By employing cable theory and, for the firsttime, graph theory, we describe dendritic anatomy solely...
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Báo cáo y học: "Transcriptional control of dendritic patterning in Drosophila neurons" docx

... analyzed the morphology of type I DA neuronsin these mutant flies. In most cases, the mutant alleles pro-duced a phenocopy of the RNAi phenotype, validating theaccuracy of the approach. Analysis ... that affect different aspects of dendrite arborization.But is there any unity of mechanism behind the functionalunity of each group? The answer is likely to be yes. Forinstance, several group ... functions of each transcription factorgroup in dendritic patterning of type I DA neurons in the Drosophilaperipheral nervous system. Subtypes of DA neurons have simple andstereotyped branching...
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Báo cáo y học: "Design principles of molecular networks revealed by global comparisons and composite motifs" pdf

... cell separates theAnalysis of the essentiality of hubs and composite hubsFigure 2Analysis of the essentiality of hubs and composite hubs. (a) Comparison of the percentages of essential genes in ... revealed by global comparisons and composite motifsHaiyuan Yu¤, Yu Xia¤, Valery Trifonov and Mark GersteinAddress: Department of Molecular Biophysics and Biochemistry, Whitney Avenue, Yale ... Zhang M, Iyer V, Anders K, Eisen M, BrownP, Botstein D, Futcher B: Comprehensive identification of cellcycle-regulated genes of the yeast Saccharomyces cerevisiaeby microarray hybridization....
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Báo cáo Y học: Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIa doc

Báo cáo Y học: Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIa doc

... very high pKavalue of Tyr16 can only beattributed to a highly desolvated environment, contributedby hydrophobic residues from both monomers. The rolethat Tyr16 plays in the structure of ... highly charged and has not been the subject of detailed study. The hydrophobic and charged faces of theRIIa D/D are diametrically opposed to each other.Interestingly, phosphorylation of RIIa by ... earlystudies indicated that only the type IIa regulatory subunitsare targeted, the recent discovery of dual-specificity AKAPs(D-AKAPs) indicates that the type I enzyme may also belocalized [4].The...
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Báo cáo y học: "Hormonal regulation of alveolarization: structure-function correlation" ppt

... University of Pennsylvania School of Medicine, Philadelphia, PA, USA and 3Division of Neonatal-Perinatal Medicine, Division of Pulmonary and Vascular Biology, Room K4.224, University of Texas ... signifi-cant cause of morbidity and mortality affecting as many as30–40% of infants born less than 30 weeks gestation [1].While the pathophysiology of BPD includes both inflam-matory and fibrotic ... Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA, 2Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia,...
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Báo cáo y học: " The discovery of endogenous retroviruses" docx

... ret-roviral envelope glycoproteins of at least one of them(HERV-W and possibly ERV-3) may be involved in naturalsyncytium induction to form the syncytiotrophoblast [61-63].Murine mammary tumor virus ... phylogenyHost phylogenyRetrovirology 2006, 3:67 http://www.retrovirology.com/content/3/1/67Page 4 of 11(page number not for citation purposes)Temin's provirus hypothesis vindicated by ... colonized by multiple sets of retrovirus. Phylo-genetic studies of viral genomes indicate that the intro-duction of ERV proceeds in waves with relatively rapidamplification of copy numbers and dispersal...
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Báo cáo y học: "The complexity of anatomical systems" docx

... Complex systems admit many descriptions (ways of looking at thesystem) each of which is only partially true. Each way of looking at a complex system requires itsown description, its own mode of analysis ... which the principles of the thermodynamics of "closed" systems studied by physicists do not apply.Unlike closed systems (in which a state of equilibrium isestablished), open systems ... of kinematics and dynamics of anatomical forms, that of speed of their changes, and that of scale of their observation.The complexity of living systemsUnlike an anatomical entity, and despite the fact...
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Báo cáo y học: "Translational regulation of gene expression" docx

... regulation of translation of maternally inherited mRNAby cytoplasmic polyadenylation in Xenopus oocytes.Polyadenylation is required before the mRNA can be trans-lated, and regulation of this ... therefore necessary foroocyte maturation and embryonic development. Cytoplas-mic polyadenylation depends on phosphorylation of CPEB, aprotein that is bound to specific cytoplasmic polyadenylationelements ... a property previouslydescribed only for cellular mRNAs. RNA-binding proteins have key roles in the regulation of nearly every aspect of gene expression. They often display amodular architecture,...
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Báo cáo y học: "Optimization of 5-fluorouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer"

... matrix of SLNs is composed of solid li-pids. The majority of lipids commonly used are trig-lyceride esters of hydrogenated fatty acids. Hydro-genated cottonseed oil (Lubritab™ or Sterotex™), hydrogenated ... poly-dispersity and entrapment efficiency for all the pre-pared formulae. The polydispersity index is a meas-ure of the width of the dispersion of particles. Narrow dispersions comprise polydispersity ... both types of Dynasan. Table 2. Entrapment efficiency, particle size and polydis-persity for each of the prepared formulae Formulation % EE %DL Particle size (nm) Polydispersity F1 24.75...
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Báo cáo y học: "Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity" potx

... Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells inautoimmunity. Journal of Inflammation 2010 ... advan-tages of targeting DCs is their role as key initiators of adaptive immunity, t hereby positioned upstream of theeffector cells in e.g. autoimmunity [1,8]. FurthermoreDCs have a relatively short ... USA).Analyses of cytokines secreted from T-cells in MLRSupernatants from the mixed lymphocyte cultures w ereselected on day 5 and measured for levels o f TNFa,IL-13 (R&D Systems) and IFNg by...
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