... 1C), flanked by strands b4 and b5. The variable
loops n-Src and RT are principal determinants for
ligand recognition, orientation, and specificity of this
domain, with residues Tyr91 and Tyr137 forming
interaction ... 1; Tyr93, Tyr137 and Trp119 form-
ing pocket 2, and the valley between n-Src and RT
loops included by Trp119 and Tyr132 making up the
third interaction pocket...
... diseases
Hirofumi Shoda
1
, Keishi Fujio
1
, Yumi Yamaguchi
1
, Akiko Okamoto
1
, Tetsuji Sawada
1
, Yuta Kochi
2
and Kazuhiko Yamamoto
1
1
Department of Allergy and Rheumatology, Graduate School of ... grateful to Ms Yayoi Tsukahara, Ms Kazumi Abe, and Ms
Kayako Watada for their excellent technical assistance. This study is
supported by Ministry of Health, Labour and Walfare...
... dissection of these traits is hampered by pheno-
copy, incomplete penetrance, and genetic heterogeneity
[9]. The complexity of the genetics of asthma and other
atopy-associated phenotypes is reflected ... Nickel
Department of Pediatric Pneumology and Immunology, Charité, Humboldt University Berlin, Berlin, Germany
Correspondence: Renate Nickel, Department of Pediatric Pneumolo...
... Canada.
3
Department of Physiology,
University of Alberta, Edmonton, AB, T6G 2S2, Canada.
4
Department of
Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.
5
Department of Pharmacology, ... 27:3703-3711.
21. Kitayama H, Miura Y, Ando Y, Hoshino S, Ishiz aka Y, Koyanagi Y:
Human immunodeficiency virus type 1 Vpr inhibits axonal
outgrowth through induct...
... inhibition of CYP3A by ethynylestradiol (B)Figure 5
Non-competitive inhibition of CYP1A by ethynylestradiol (A) and uncompetitive inhibition of CYP3A by ethy-
nylestradiol (B). Dixon plots for ethynylestradiol ... showed that ethynylestradiol acted as a non-competitive
inhibitor of CYP1A activity and as an uncompetitive inhibitor of CYP3A activity.
Conclusions: Ketoconazole, non...
... Hepatocytes Exposed to
Nonylphenol and 3,3',4,4'-Tetrachlorobiphenyl (Congener 77)
Anne S Mortensen and Augustine Arukwe*
Address: Department of Biology, Norwegian University of science and ... performed to study the molecular interactions between
ER and AhR signalling pathways using different concentration of PCB-77 (an AhR-agonist) and time factor,
respectivel...
... vitro
and in vivo. The activity of MMPs is increased by gene
transcription, extracellular activation of the secreted
inactive zymogen form, and reduced activity of tissue
inhibitors of metalloproteinases. ... of OXANO
and markers of arteriosclerosis before, during and af-
ter clamping are given. When analysing the relations
between radical production and concentrati...
... multiple
logistic regression analysis (P = 0.017). There was no
association between dactylitis and deformed joints and,
no other significant associations between the ca rriage of
the risk allele, T, and other ... Dijkmans B, Olivieri I, Pasero G, Veys E, Zeidler H: The European
spondylarthropathy study group preliminary criteria for the classification
of spondylarthropathy. Arth...