Báo cáo y học: "Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment" docx
... non-
phosphorylated proteins of Akt.
The targeted mutation gene of the Akt mutant is Akt1 , and the
Akt antibody used for the western blot assay reacted with
Akt1 , Akt2 , and Akt3 . The masking of specific Akt ... that activation of the serine/threonine kinase/protein
kinase B (Akt) and endothelial nitric oxide synthase (eNOS) pathways was also involved in...
... generalized WG, in which clinical
manifestations of frank autoimmune vasculitis prevail, for
example pulmonary–renal syndrome. An autoantibody,
namely antineutrophil cytoplasmic antibody specific ... respiratory tract,
may precede ‘classical’ generalized WG. Observation of a
disease course of localized WG without progression for
several years has remained a rare finding [1]. The d...
... for-
mation of the C3 convertase by binding to C4b; accelerating
the natural decay of the classical pathway C3 convertase; and
as a cofactor for the serine proteinase factor I in the proteolytic
inactivation ... the
hemolytic assays and assisted in interpreting the data.
RAW generated the knockout mice, assisted in interpreting
the data, and critically reviewed the manuscrip...
... interests
The authors declare that they have no competing interests.
Authors' contributions
CA-V and JJ designed the study. CA-V, GA and RB-D ana-
lyzed the data. GA, RB-D, LF-S and AR collected data ... analysis and interpretation. JJ
and JC supervised the laboratory determinations. All
authors have read and approved the final manuscript.
Publish with BioMed Central and ev...
... 166:1077-1088.
6. Watanabe H, Hata M, Terada N, Ueda H, Yamada N, Yamanegi K,
Ohyama H, Kakihana M, Okamura H, Nakasho K: Transdifferentiation into
biliary ductular cells of hepatocytes transplanted into the ... biliary injury in terms of serum
bilirubin was apparent by 24 h and consistently stayed
high till 48 h after DAPM (Figure 1A) . By day 7, rats
appeared to recover from toxicit...
... formation of n itric
oxide from nNOS either p lay a role in the fundamental
physiology o f the animal, and/ or are part o f t he defence
arsenal to combat attack by predators, both small and large.
ACKNOWLEDGEMENT
Amphibian ... assays
Antimicrobial testing. Synthetic lesueurin was t ested for
antibiotic activity by the M icrobiology D epartment o f the
Institute of Medical and...
... Fukunaga K, Wakaki M, Kagyo J, Takihara T,
Ueda S, Nakajima T, Oguma T, Suzuki Y, Shiomi T, Sayama K, Kagawa S,
Ikeda E, Hirai H, Nagata K, Nakamura M, Miyasho T, Ishizaka A:
Cyclooxygenase-2/prostaglandin ... expression
and activity of iNOS and COX-2 in lipopolysaccharide (LPS)-activated macrophages.
Methods: We used nitrate and prostaglandin E
2
(PGE
2
) assays to examine inhib...
... ischemia, microinfarct and papillary necrosis [5,6].
Patients with SCD have impaired urinary concentrating
ability, defects in urinary acidification and potassium
excretion and supranormal proximal ... data and was involved in patient care and in
drafting the manuscript. PLS provided general support. MKK provided
technical help and writing assistance. All authors read and...
... suggestive of a cardiogenic mecha-
nism [7]. Pathologically, there is alveolar inflammation and
injury leading to increased pulmonary capillary permeability
and resultant accumulation of alveolar fluid ... with iNO [32]. Early
ischaemia-reperfusion injury after lung transplantation
manifests clinically as pulmonary oedema and is a cause of
significant morbidity and mortality...
... from epidermal carcinoma A4 31 cells, lung
adenocarcinoma A5 49 cells, and bladder carcinoma T24 cells was analyzed by
immunoblotting with antibodies as indicated. The activation of Met and EGFR ... stay out of lipid
rafts, leading to their activation in a ligand-independent manner.
Background
Aberrant activation of receptor tyrosine kinases (RTKs) is one of the majo...