... the thoracic aorta during endotoxic
shock. Circ Shock 1991, 35:25-30.
Key messages
• In our model of endotoxinic shock, aPC increases the
sensitivity to vasoconstriction.
• aPC restores endothelial ... fenofibrate,
protects endothelium in rabbit Escherichia coli endotoxin-
induced shock. Intensive Care Med 2005, 31:1269-1279.
13. Wiel E, Vallet B, Ten Cate H: The endothelium...
... original work is properly cited.
Abstract
Introduction Successful treatment of severe sepsis and septic
shock remains a major challenge in critical care medicine. The
recently introduced recombinant ... microcirculation, particularly of
the intestine, in septic conditions [4,6,8,9]. There is an
increasing body of evidence that activated protein C (APC)
exerts beneficial effects in t...
... antigen in both healthy men and indi-
viduals with protein C deficiency suggesting that the circu-
lating protein C concentration is the limiting factor in the
rate of activation of protein C [33]. ... This interaction is a critical step in
the host defence against sepsis since inhibition of protein
C binding to EPCR (in baboon model) is shown to con-
vert the respo...
... ECM, Brandjes DPM, Büller HR, Levi M: Effects
on coagulation and fibrinolysis induced by influenza in mice with a
reduced capacity to generate activated protein C and a deficiency in
plasminogen ... treated mice
and B. recombinant murine activated protein C treated mice (original magnification × 100). C. Total pathology score (described in methods section)
48 and 96 hour...
...
thrombin formation could prevent the activation of throm-
bin activatable fi brinolysis inhibitor. Activated throm bin
activatable fi brinolysis inhibitor inhibits the chemotactic
factors C3 a and C5 a, ...
of brinolysis in addition to systemic in ammation
and intense neutrophil in ux into the lung. Activated
protein C attenuates coagulation activation and
restores brinoly...
... In the present issue of Critical Care, Pettila and colleagues
report the fi rst single-centred pilot randomized
controlled trial of activated protein C (APC) in alcohol-
induced acute pancreatitis ... characterizes severe sepsis. Activated
protein C (APC) has pleotropic e ects on the immune,
coagulation, in ammatory and apoptotic pathways,
and has been postulated to bene t...
... Physicians;
American College of Emergency Physicians; Canadian Critical Care Society;
European Society of Clinical Microbiology and Infectious Diseases; European
Society of Intensive Care Medicine, et ... Versailles. Activated protein C and corticosteroids for
human septic shock (APROCCHS). [http://clinicaltrials.gov/ct2/show/
NCT00625209].
19. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fe...